Article
Biochemistry & Molecular Biology
Karina Lindbog Madsen, Oke Gerke, Poul F. Hoilund-Carlsen, Birgitte Brinkmann Olsen
Summary: Cancer stem cells (CSCs) are resistant to conventional therapy and responsible for cancer relapse. Auger electron emitters show promising potential in eradicating resistant lung cancer CD44(+) populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Beinuo Wang, Ruijie Zhang, Yao Wang, Hang Qian, Di Wu, Binfeng He, Hu Liao
Summary: Overcoming cisplatin-based drug resistance in lung cancer remains a challenge globally. Recent studies have shown that Rab GTPases play a role in multiple aspects of tumor progression, including drug resistance. In this study, a nanosystem was developed using Rab26 siRNA-loaded nanoparticles, which effectively transfected cisplatin-resistant lung cancer cells and induced apoptosis while inhibiting autophagy disruption. The combination therapy of siRab26 knockdown with cisplatin improved antitumor therapy in vitro and in vivo. These findings suggest that siRNP is an effective platform for lung cancer therapy in cases of drug resistance.
Article
Biology
Huiling Zhou, Li Zhou, Qing Guan, Xuyang Hou, Cong Wang, Lijun Liu, Jian Wang, Xinfang Yu, Wei Li, Haidan Liu
Summary: Skp2, an E3 ligase, is overexpressed in NSCLC and is associated with the downregulation of MLKL, a regulator of necroptosis. Inhibition of Skp2 enhances the efficacy of cisplatin, a chemotherapy drug, in NSCLC and inhibits tumor growth. Mechanistically, Skp2 promotes the ubiquitination-mediated degradation of MLKL in cisplatin-resistant NSCLC cells.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shiqing Liu, Chengping Hu, Min Li, Wolong Zhou, Ronghao Wang, Yao Xiao
Summary: Lung cancer is the most common malignancy and is still the leading cause of cancer-related deaths worldwide. The androgen receptor (AR) has been shown to potentially play a role in the progression of non-small cell lung cancer (NSCLC). This study discovered that AR can suppress NSCLC cell invasion and increase cisplatin response by downregulating the expression of circular RNA (circRNA) SLCO1B7. The results suggest that targeting the AR/circ-SLCO1B7/miR-139-5p/TPD52 signaling pathway may be a new therapeutic strategy for NSCLC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Swati Misri, Kirti Kaul, Sanjay Mishra, Manish Charan, Ajeet Kumar Verma, Martin P. Barr, Dinesh K. Ahirwar, Ramesh K. Ganju
Summary: This study demonstrates that cannabidiol (CBD) inhibits the growth and metastasis of drug-resistant non-small cell lung cancer cells (NSCLC) and induces apoptosis of cisplatin-resistant cells. It acts through the TRPV2 receptor and modulates oxidative stress pathways. CBD could be a promising therapeutic strategy for cisplatin-resistant NSCLC.
Article
Chemistry, Inorganic & Nuclear
Ricardo G. Teixeira, Dimas C. Belisario, Xavier Fontrodona, Isabel Romero, Ana Isabel Tomaz, M. Helena Garcia, Chiara Riganti, Andreia Valente
Summary: Platinum-based therapies are the main treatment for non-small cell lung cancers (NSCLC), but multidrug resistance often leads to treatment failure. In this study, two sets of organometallic Ru(II) compounds were synthesized and tested on NSCLC cell lines, showing strong activity against cisplatin-resistant cells by inhibiting transporters MRP1 and P-gp. These compounds act as MDR-selective compounds and have the potential to enhance cisplatin cytotoxicity significantly.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Medicine, General & Internal
Chayarani Kelgeri, Michael Couper, Girish L. Gupte, Alexandra Brant, Mitul Patel, Lauren Johansen, Joseph Valamparampil, Evelyn Ong, Hermien Hartog, M. T. P. R. Perera, Darius Mirza, Indra van Mourik, Khalid Sharif, Jane Hartley
Summary: Between January and April 2022, a liver-transplantation center in the U.K. received a total of 44 children with acute hepatitis, with 6 of them undergoing liver transplantation. Most of the children presented with symptoms such as jaundice, vomiting, and diarrhea. Human adenovirus was detected in a majority of the children, although its role in the pathogenesis of the illness is still unknown.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jaemoo Chun
Summary: Isoalantolactone, a compound derived from Inula helenium L., has been identified as a potential glycolysis inhibitor to overcome cisplatin resistance in ovarian cancer. It effectively targets key glycolytic enzymes and enhances sensitivity to cisplatin-induced apoptosis. In vivo studies demonstrate its ability to suppress tumor growth in cisplatin-resistant ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Luca Jaromi, Veronika Csongei, Monika Vesel, ElHusseiny Mohamed Mahmud Abdelwahab, Amina Soltani, Zsofia Torok, Gabor Smuk, Veronika Sarosi, Judit Erzsebet Pongracz
Summary: This study found that KRAS and EGFR driver mutations have differential effects on drug transporter expression and cisplatin-induced WNT signaling microenvironment in lung adenocarcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jianling Li, Qianyao Chen, Dan Shi, Xuemei Lian
Summary: This study investigates the effect of concomitant treatment with time-restricted feeding (TRF) plus cisplatin (DDP) on lung cancer growth in DDP-resistant and DDP-sensitive lung cancer cells. The results show that TRF significantly enhances the drug susceptibility of DDP in DDP-resistant cells and inhibits cell proliferation, migration, and promotes apoptosis. The synergistic anti-tumor effect of combined DDP and TRF is greater than that of combined DDP and simulated fasting condition (STS). Furthermore, the combination of TRF and DDP upregulates the P53 protein expression without changing mRNA levels, indicating its potential as a novel therapeutic strategy for lung cancer patients.
Article
Integrative & Complementary Medicine
Yuanyuan Luo, Tinghe Yu, Xinya Li, Guanhua Qian
Summary: Thioridazine enhances the sensitivity of cisplatin-resistant human lung cancer cells to cisplatin by reducing detoxification and DNA repair capacity, thereby increasing cisplatin-induced DNA damage in resistant cells.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Oncology
Claudia Owczarek, Elena Ortiz-Zapater, Jana Kim, Efthymia Papaevangelou, George Santis, Maddy Parsons
Summary: The coxsackie and adenovirus receptor (CAR) is highly expressed in lung cancer and may promote tumor growth and regulate epithelial mesenchymal transition (EMT). Our study demonstrates that CAR contributes to lung cancer metastasis through promoting cell-matrix adhesion, providing new insights into the cooperation between cell-cell and cell-matrix proteins in tumorigenesis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lei Xu, Ying Xu, Jianbing Zheng, Yun Zhao, Hongcai Wang, Yushu Qi
Summary: The combination of dacomitinib and cisplatin significantly reduced the viability of drug-resistant OC cells and promoted cell apoptosis. Additionally, dacomitinib was able to regulate CDH1 and P-GP protein levels, and inhibit the EGFR signaling pathway.
Article
Biotechnology & Applied Microbiology
Disha Mittal, Largee Biswas, Anita Kamra Verma
Summary: The study aimed to sensitize cisplatin-resistant ovarian cancer cells towards cisplatin using cisplatin-loaded nanostructured lipid carriers. The results showed that the synthesized cisplatin-loaded nanostructured lipid carriers successfully enhanced the sensitivity of the resistant cancer cells by modifying reactive oxygen species levels and increasing apoptosis in the cells.
Article
Oncology
Ria Winkelmann, Katrin Bankov, Claudia Doering, Jaroslav Cinatl, Sebastian Grothe, Florian Rothweiler, Martin Michaelis, Christina Schmitt, Peter J. J. Wild, Melanie Demes, Jindrich Cinatl Jr, Stefan Vallo
Summary: In this study, a cell line with acquired resistance to chemotherapy was generated to investigate the mechanism of chemotherapy resistance in penile cancer and identify potential alternative treatments.
