Metformin alters DNA methylation genome-wide via the H19/SAHH axis

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Repurposing metformin: an old drug with new tricks in its binding pockets

(2015) R. Pryor et al.   BIOCHEMICAL JOURNAL

Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis

(2015) Bo Su et al.   HEPATOLOGY

DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer

(2015) Callie R. Merry et al.   HUMAN MOLECULAR GENETICS

Meta-analysis of gene expression profiles indicates genes in spliceosome pathway are up-regulated in hepatocellular carcinoma (HCC)

(2015) Weijin Xu et al.   MEDICAL ONCOLOGY

The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

(2015) Eli Raveh et al.   Molecular Cancer

H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase

(2015) Jichun Zhou et al.   Nature Communications

Effects of metformin on endometrial cancer cell growth in vivo: A preoperative prospective trial

(2014) Akira Mitsuhashi et al.   CANCER

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies

(2014) M. Poulain et al.   MOLECULAR HUMAN REPRODUCTION

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells

(2014) Yuan Gao et al.   NUCLEIC ACIDS RESEARCH

Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation

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Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression

(2013) Ming Luo et al.   CANCER LETTERS

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion

(2013) Guocan Wang et al.   NATURE GENETICS

Identification of Novel Genetic Alterations in Samples of Malignant Glioma Patients

(2013) Vedrana Milinkovic et al.   PLoS One

Cancer epigenomics: beyond genomics

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Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells

(2012) Bilian Jin et al.   Cell Reports

Micro(mi)RNA expression profile of breast cancer epithelial cells treated with the anti-diabetic drug metformin: Induction of the tumor suppressor miRNA let-7a and suppression of the TGFβ-induced oncomiR miRNA-181a

(2011) Cristina Oliveras-Ferraros et al.   CELL CYCLE

Hormonal Therapy Promotes Hormone-Resistant Phenotype by Increasing DNMT Activity and Expression in Prostate Cancer Models

(2011) Giovanni Luca Gravina et al.   ENDOCRINOLOGY

A DNA methylation fingerprint of 1628 human samples

(2011) A. F. Fernandez et al.   GENOME RESEARCH

mRNA Degradation Plays a Significant Role in the Program of Gene Expression Regulated by Phosphatidylinositol 3-Kinase Signaling

(2010) J. R. Graham et al.   MOLECULAR AND CELLULAR BIOLOGY

EGFR isoforms and gene regulation in human endometrial cancer cells

(2010) Lina Albitar et al.   Molecular Cancer

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer

(2009) Wing Pui Tsang et al.   CARCINOGENESIS

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE