Article
Multidisciplinary Sciences
Xu Li, Shu Zhuo, Ting Zhuang, Yong Suk Cho, Guojin Wu, Yuchen Liu, Kun Mu, Kai Zhang, Peng Su, Yingzi Yang, Cheng Cheng Zhang, Jian Zhu, Jin Jiang
Summary: Hippo signaling restricts tissue growth by inhibiting YAP, which also functions as a tumor suppressor in ER+ breast cancer by interfering with the TEAD-ERα signaling axis.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Seng Chuan Tang, Quentin Lion, Olivier Peulen, Philippe Chariot, Arnaud Lavergne, Alice Mayer, Paula Allepuz Fuster, Pierre Close, Sebastian Klein, Alexandra Florin, Reinhard Buettner, Ivan Nemazanyy, Kateryna Shostak, Alain Chariot
Summary: COP1 acts as an oncogenic E3 ligase by promoting ERα signaling but also acts as a tumor suppressor candidate by preventing EMT, reflecting a dual role of COP1 in breast cancer that has sparked widespread interest in the academic community.
Article
Biochemistry & Molecular Biology
Penghe Yang, Xiao Yang, Dehai Wang, Huijie Yang, Zhongbo Li, Chenmiao Zhang, Shuqing Zhang, Jian Zhu, Xin Li, Peng Su, Ting Zhuang
Summary: In this study, we identified a novel positive feedback loop between PSMD14 and ER alpha signaling in breast cancer progression, and found that blockade of PSMD14 could be a plausible strategy for luminal breast cancer.
Review
Plant Sciences
Zahra Iqbal, Anjuman Gul Memon, Ausaf Ahmad, Mohammed Shariq Iqbal
Summary: Exposure of plants to low temperatures adversely affects plant growth, development, and productivity. Calcium signaling plays a crucial role in the plant response to cold stress, activating Ca2+ channels and/or pumps and inducing Ca2+ signatures in plant cells. These Ca2+ signatures are decoded by specific Ca2+ sensors, leading to the regulation of transcription factors and downstream gene expression.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Pauliina M. Munne, Lahja Martikainen, Iiris Raty, Kia Bertula, Nonappa, Janika Ruuska, Hanna Ala-Hongisto, Aino Peura, Babette Hollmann, Lilya Euro, Kerim Yavuz, Linda Patrikainen, Maria Salmela, Juho Pokki, Mikko Kivento, Juho Vaananen, Tomi Suomi, Liina Nevalaita, Minna Mutka, Panu Kovanen, Marjut Leidenius, Tuomo Meretoja, Katja Hukkinen, Outi Monni, Jeroen Pouwels, Biswajyoti Sahu, Johanna Mattson, Heikki Joensuu, Paivi Heikkila, Laura L. Elo, Ciara Metcalfe, Melissa R. Junttila, Olli Ikkala, Juha Klefstrom
Summary: Researchers found that matrix stiffness regulates ERα expression via stress-mediated p38 activation and H3K27me3-mediated epigenetic regulation, revealing a crucial mechanobiological component in hormonal signaling in breast tissue.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Jinhui Lue, Qian Zhao, Yuefan Guo, Danni Li, Heying Xie, Cuicui Liu, Xin Hu, Suling Liu, Zhaoyuan Hou, Xunbin Wei, Deyou Zheng, Richard G. Pestell, Zuoren Yu
Summary: This study identified a miR-29a-PTEN-AKT axis as a downstream signaling pathway of ER alpha in breast cancer metastasis. Low level of miR-29a was associated with reduced metastasis and better survival in ER alpha+ luminal subtype of BC, while high level of miR-29a was detected in ER alpha- triple negative breast cancer (TNBC) with distant metastasis and poor survival. Targeting miR-29a suppressed cellular invasion, EMT and lung metastasis in TNBC cells in vitro and in TNBC tumor-bearing mice in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zao-zao Zheng, Lin Xia, Guo-sheng Hu, Jun-yi Liu, Ya-hong Hu, Yu-jie Chen, Jia-yin Peng, Wen-juan Zhang, Wen Liu
Summary: This study uncovers the critical role of a super-enhancer-associated positive feedback loop constituting BRD4/ERα-RET-ERα in ERα-positive breast cancer and suggests that targeting components in this loop would provide a new therapeutic avenue for treating ERα-positive breast cancer in the clinic.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Shiqin Liu, Busola Ruth Alabi, Qingqing Yin, Tanya Stoyanova
Summary: Prostate cancer is a common cancer in men in the United States and often leads to cancer-related deaths. Androgen deprivation therapy is the standard treatment for advanced prostate cancer, but some patients develop castration-resistant prostate cancer and even neuroendocrine prostate cancer. Neuroendocrine prostate cancer is characterized by the expression of neuroendocrine markers and the absence of androgen receptor, and is often associated with aggressive tumors, therapy resistance, and poor clinical outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Environmental Sciences
Bingli Lei, Lanbing Xu, Xiaolan Zhang, Wei Peng, Qianqian Tang, Chenglian Feng
Summary: The study revealed that fluoxetine activates the PI3K/AKT and ERK signaling cascades via GPR30 to induce breast cancer cell proliferation, which can be attenuated by inhibitors.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Oncology
Jianing Ding, Peng Kuang
Summary: ERα plays a crucial role in breast tumor development, and HOIL-1 is involved in modulating ERα signaling, showing good prognosis in ERα positive breast cancer but poor outcome in patients receiving endocrine therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Brittany Cain, Brian Gebelein
Summary: Metazoans express multiple Hox transcription factors to specify cell fate along the anterior-posterior axis. Understanding how Hox factors regulate target genes for morphogenesis poses challenges on distinguishing their roles in activating/repressing genes for distinct segment identities and impacting organ development in a cell type-specific manner. Recent studies suggest Hox factors modify gene chromatin and utilize interactions with co-activators and co-repressors for accurate transcriptional outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jake June-Koo Lee, Youngsook Lucy Jung, Taek-Chin Cheong, Jose Espejo Valle-Inclan, Chong Chu, Doga C. Gulhan, Viktor Ljungstrom, Hu Jin, Vinayak V. Viswanadham, Emma V. Watson, Isidro Cortes-Ciriano, Stephen J. Elledge, Roberto Chiarle, David Pellman, Peter J. Park
Summary: This study reveals that focal copy-number amplifications in breast cancer often originate from a mechanism called translocation-bridge amplification, involving inter-chromosomal translocations leading to dicentric chromosome bridge formation and breakage. The model explains the amplifications of key oncogenes and suggests a role of estrogen in generating the initial translocations in breast cancer.
Review
Chemistry, Multidisciplinary
Sergio M. Viafara Garcia, Muhammad Saad Khan, Ziyad S. Haidar, Juan Pablo Acevedo Cox
Summary: This article introduces oxygen nanobubbles (OnB) as an emerging oxygen delivery platform for addressing hypoxia-related pathologies. It explores the strategies and systems of OnB oxygen delivery, and delves into their role in mitochondrial metabolism, hypoxic responses, and chronic pathologies.
Review
Oncology
Tracey Immanuel, Jixia Li, Taryn N. Green, Anna Bogdanova, Maggie L. Kalev-Zylinska
Summary: This review outlines the regulation of calcium signaling in hematologic neoplasms and summarizes the changes in various calcium homeostatic mechanisms and calcium responsive pathways in these types of cancers. The aim of this study is to increase awareness of the deregulation of calcium signaling in hematologic neoplasms and to encourage further clinical research.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Muhammad Tufail, Jia Cui, Changxin Wu
Summary: Breast cancer affects a large number of women in the US, and drug-resistant cancer cells are a major cause of death. Scientists are developing combination therapies to overcome resistance, and clinical research has shown their effectiveness in improving survival rates. This review highlights the importance of combination therapy in breast cancer treatment and discusses the issue of drug resistance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Endocrinology & Metabolism
Lucie Malbeteau, Ha Thuy Pham, Louisane Eve, Michael R. Stallcup, Coralie Poulard, Muriel Le Romancer
Summary: Steroid receptors (SRs) are important members of the nuclear hormonal receptor family, regulating various physiological functions essential for human health. Dysregulation of SRs may contribute to a wide range of pathologies, highlighting the significance of understanding their regulatory mechanisms.
Article
Chemistry, Multidisciplinary
Stephen J. Walsh, Soleilmane Omarjee, Friederike M. Dannheim, Dominique-Laurent Couturier, Dorentina Bexheti, Lee Mendil, Gemma Cronshaw, Toby Fewster, Charlotte Gregg, Cara Brodie, Jodi L. Miller, Richard Houghton, Jason S. Carroll, David R. Spring
Summary: The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody-drug conjugates (ADCs) with in vivo efficacy and tolerability is reported. Detailed structural characterization of the synthesized ADCs was first conducted, followed by in vitro and in vivo evaluation of the ADCs' ability to safely and selectively eradicate target-positive tumors.
CHEMICAL COMMUNICATIONS
(2022)
Article
Oncology
Anja Kathrin Wege, Eva-Maria Rom-Jurek, Paul Jank, Carsten Denkert, Peter Ugocsai, Christine Solbach, Jens-Uwe Blohmer, Bruno Sinn, Marion Mackelenbergh, Volker Moebus, Andreas Trumpp, Elisabetta Marangoni, Nicole Pfarr, Christoph Irlbeck, Jens Warfsmann, Bernhard Polzer, Florian Weber, Olaf Ortmann, Sibylle Loibl, Valentina Vladimirova, Gero Brockhoff
Summary: The study aimed to discover and validate biomarkers associated with tumor progression and clinical outcome in Luminal breast cancer, with findings showing that an elevated mdm2 gene was linked to tumor growth and metastasis in mice, as well as correlated with prognosis and treatment response in patients.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Kolesnikova Olga, Zachayus Amelie, Pichard Simon, Osz Judit, Rochel Natacha, Rossolillo Paola, Kolb-Cheynel Isabelle, Troffer-Charlier Nathalie, Compe Emmanuel, Bensaude Olivier, Berger Imrev, Poterszman Arnaud
Summary: The Baculovirus/insect cell expression system is a powerful technology for reconstituting eukaryotic macromolecular assemblies. We have established an open source multigene-expression toolbox using homologous recombination, which simplifies the generation of recombinant baculoviruses into a single-step procedure and shortens the time from cloning to protein production.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Organic
Uxia Gomez-Bouzo, Alioune Fall, Judit Osz, Yagamare Fall, Natacha Rochel, Hugo Santalla
Summary: This study describes the synthesis of six novel Gemini cholesterol analogues and investigates the binding mode of one of them with ROR gamma.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Meeting Abstract
Oncology
Anja Kathrin Wege, Valentina Vladimirova, Christine Solbach, Eva-Maria Rom-Jurek, Jens-Uwe Blohmer, Paul Jank, Bruno Sinn, Andreas Trumpp, Elisabetta Marangoni, Knut Engels, Wilko Weichert, Nicole Pfarr, Christoph Irlbeck, Bernhard Polzer, Olaf Ortmann, Marion van Mackelenbergh, Carsten Denkert, Sibylle Loibl, Gero Brockhoff
Article
Chemistry, Medicinal
Rita Sigueiro, Laurent Bianchetti, Carole Peluso-Iltis, Sandra Chalhoub, Annick Dejaegere, Judit Osz, Natacha Rochel
Summary: This study reveals the structural differences between VDR from the basal vertebrate sea lamprey and VDR from higher vertebrates through crystal structure comparison, and analyzes the impact of these differences on transcriptional responses.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Joseph C. J. Bergin, Kean Kan Tan, Anya K. Nelson, Cristina-Andreea Amarandei, Veronique Hubscher-Bruder, Jeremy Brandel, Varvara Voinarovska, Annick Dejaegere, Roland H. Stote, David Tetard
Summary: Two new compounds with potential dual mode of action against Parkinson's disease have been designed and synthesized, and are promising candidates for further evaluation.
Article
Genetics & Heredity
Justine Marsolier, Pacome Prompsy, Adeline Durand, Anne-Marie Lyne, Camille Landragin, Amandine Trouchet, Sabrina Tenreira Bento, Almut Eisele, Sophie Foulon, Lea Baudre, Kevin Grosselin, Mylene Bohec, Sylvain Baulande, Ahmed Dahmani, Laura Sourd, Eric Letouze, Anne-Vincent Salomon, Elisabetta Marangoni, Leila Perie, Celine Vallot
Summary: The persistence of drug-resistant cancer cells is a major clinical challenge, particularly in triple-negative breast cancer. This study reveals that the repressive histone mark H3K27me3 plays a crucial role in regulating cell fate and chemotherapy tolerance in cancer cells. Manipulating H3K27me3 levels effectively enhances the potential of cancer cells to tolerate chemotherapy and delays tumor recurrence. These findings underscore the importance of understanding chromatin landscapes in shaping cancer cell response to initial therapy.
Article
Oncology
Ian S. Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Roisin M. Dwyer, Annette T. Byrne
Summary: The study showed that aspirin could delay metastasis in HER2+ breast cancer and reduce the growth of primary tumors in HER2+/TNBC. However, no survival benefit was observed in aspirin pre-treated animals that also received standard of care chemotherapy. Aspirin altered breast tumor biology through various mechanisms but may not be an effective chemopreventive agent in HER2+ or TNBC setting.
Article
Oncology
Paula Azorin, Florian Bonin, Zakia Tariq, Ambre Petitalot, Florence Coussy, Elisabetta Marangoni, Veronique Becette, Yves Denoux, Anne Vincent-Salomon, Christophe Le Tourneau, Linda Larbi Cherif, Jerzy Klijanienko, Maud Kamal, Ivan Bieche, Rosette Lidereau, Keltouma Driouch
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yang Wu, Zheqi Li, Abdalla M. Wedn, Allison N. Casey, Daniel Brown, Shalini Rao, Soleilmane Omarjee, Jagmohan Hooda, Jason S. Carroll, Jason Gertz, Jennifer M. Atkinson, Adrian Lee, Steffi Oesterreich
Summary: Estrogen receptor alpha (ER/ESR1) mutations are common in endocrine resistant ER-positive breast cancer. Forkhead box A1 (FOXA1) plays a role in ER-chromatin interactions and endocrine response, but its role in ESR1-mutant breast cancer is unclear. This study shows that FOXA1 redistribution is associated with transcriptomic alterations caused by ESR1 mutations and suggests targeting the retinoid X receptor (RXR) pathway as a therapeutic strategy for breast tumors with ESR1 mutation.
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Negar Khazan, Emily R. R. Quarato, Niloy A. A. Singh, Cameron W. A. Snyder, Taylor Moore, John P. P. Miller, Masato Yasui, Yuki Teramoto, Takuro Goto, Sabeeha Reshi, Jennifer Hong, Naixin Zhang, Diya Pandey, Priyanka Srivastava, Alexandra Morell, Hiroki Kawano, Yuko Kawano, Thomas Conley, Deepak M. M. Sahasrabudhe, Naohiro Yano, Hiroshi Miyamoto, Omar Aljitawi, Jane Liesveld, Michael W. W. Becker, Laura M. M. Calvi, Alexander S. S. Zhovmer, Erdem D. D. Tabdanov, Nikolay V. V. Dokholyan, David C. C. Linehan, Jeanne N. N. Hansen, Scott A. A. Gerber, Ashoke Sharon, Manoj K. K. Khera, Peter W. W. Jurutka, Natacha Rochel, Kyu Kwang Kim, Rachael B. B. Rowswell-Turner, Rakesh K. K. Singh, Richard G. G. Moore
Summary: The study identifies vitamin D/VDR as the driver of PD-L1 expression in AML and other cancers. They have developed a small molecule inhibitor called MeTC7 to target PD-L1 and inhibit tumorigenesis driven by PD-L1/PD-1. This provides a potential alternative to antibodies for controlling immune evasion in tumors.
Article
Oncology
Guus J. J. E. Heynen, Kamil Lisek, Regina Vogel, Annika Wulf-Goldenberg, Joshua Alcaniz, Elodie Montaudon, Elisabetta Marangoni, Walter Birchmeier
Summary: This study found that the phosphatase SHP2 plays a crucial role in resistance to PI3K inhibitors in breast cancer. Combination treatment with PI3K and SHP2 inhibitors can overcome resistance to PI3K inhibitors and significantly improve therapies for breast cancer.
BREAST CANCER RESEARCH
(2022)