PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

(2015) Valentina E. Schneeberger et al.   Oncotarget

The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling

(2015) Layka Abbasi Asbagh et al.   Oncotarget

The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

(2014) Hong-Mei Wang et al.   CELL RESEARCH

Genetic alterations of protein tyrosine phosphatases in human cancers

(2014) S Zhao et al.   ONCOGENE

Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer

(2014) V. W. Y. Lui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging approaches for treating HER2-positive metastatic breast cancer beyond trastuzumab

(2013) W. J. Gradishar   ANNALS OF ONCOLOGY

PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy

(2013) Yi-Teng Huang et al.   Journal of Translational Medicine

Tyrosine phosphatase PTPα contributes to HER2-evoked breast tumor initiation and maintenance

(2013) D S Meyer et al.   ONCOGENE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Effects of Membrane Trafficking on Signaling by Receptor Tyrosine Kinases

(2013) M. Miaczynska   Cold Spring Harbor Perspectives in Biology

Computational Analysis of the Regulation of EGFR by Protein Tyrosine Phosphatases

(2012) Calixte S. Monast et al.   BIOPHYSICAL JOURNAL

Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3

(2012) Jiajie Hou et al.   HEPATOLOGY

Expression Profiling during Mammary Epithelial Cell Three-Dimensional Morphogenesis Identifies PTPRO as a Novel Regulator of Morphogenesis and ErbB2-Mediated Transformation

(2012) M. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

Improving Treatment of HER2-Positive Cancers: Opportunities and Challenges

(2012) H. M. Stern   Science Translational Medicine

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Aberrant methylation of the PTPRO gene in peripheral blood as a potential biomarker in esophageal squamous cell carcinoma patients

(2011) Yan-Jie You et al.   CANCER LETTERS

Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase

(2011) Tingting Sun et al.   CELL

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Prognostic Impact of Phosphorylated HER-2 in HER-2+ Primary Breast Cancer

(2011) N. Hayashi et al.   ONCOLOGIST

Proximity ligation assays: a recent addition to the proteomics toolbox

(2010) Irene Weibrecht et al.   Expert Review of Proteomics

Protein-tyrosine Phosphatase PTPN9 Negatively Regulates ErbB2 and Epidermal Growth Factor Receptor Signaling in Breast Cancer Cells

(2010) Taichang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells

(2009) L. E. Arias-Romero et al.   CANCER RESEARCH

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

(2009) Nicholas J. Anthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

(2009) S. Veeriah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein in Human Pancreatic Cancer Cells

(2008) P. Chaturvedi et al.   CANCER RESEARCH

Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer

(2008) Kirstine Roepstorff et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Estrogen-Mediated Suppression of the Gene Encoding Protein Tyrosine Phosphatase PTPRO in Human Breast Cancer: Mechanism and Role in Tamoxifen Sensitivity

(2008) Bhuvaneswari Ramaswamy et al.   MOLECULAR ENDOCRINOLOGY

Tyrosine1248-phosphorylated HER2 expression and HER2 gene amplification in female invasive ductal carcinomas

(2008) Kiyomi Taniyama et al.   Breast Cancer