Article
Microbiology
Simran Preet Bhalla, Ann Maria Shaju, Carlos Marcelo da Silva Figueredo, Leticia Algarves Miranda
Summary: C5a levels were significantly increased in both gingival crevicular fluid and saliva of patients with periodontal disease, indicating a potential role of this molecule in the pathogenesis of the disease.
Article
Dentistry, Oral Surgery & Medicine
Ayaz Enver, Nurdan Ozmeric, Sila Cagri Isler, Murat Toruner, Cigdem Fidan, Gulsah Demirci, Serenay Elgun, Andre Paes B. da Silva
Summary: This study aimed to evaluate the levels of cytokines in saliva and gingival crevicular fluid (GCF) in patients with ulcerative colitis (UC), Crohn disease (CD), and non-IBD, and analyze their associations with periodontal conditions. The study found that UC and CD patients with periodontitis and gingivitis had higher levels of TNF-alpha and lower levels of IL-10 compared to non-IBD patients. Additionally, UC patients with periodontitis had higher scores of bleeding on probing and increased levels of IL-1 beta in saliva and GCF compared to CD patients. The study concluded that in the presence of periodontal diseases, UC and CD patients showed different expression levels of TNF-alpha, IL-1 beta, and IL-10 in oral secretions compared to non-IBD patients.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Buket Acar, Ersin Gumus, Selcen Ozcan-Bulut, Cansu Ozsin-Ozler, Meryem Seda Boyraz, Cagman Tan, Ismail Yaz, Begum Ozbek, Deniz Cagdas, Inci Nur Saltik-Temizel, Hulya Demir, Hasan Ozen, Erdem Karabulut, Ilhan Tezcan, Aysel Yuce, Ezel Berker
Summary: The cytokine profile in gingival crevicular fluid and serum of pediatric inflammatory bowel disease (IBD) patients was evaluated, with 50 IBD patients and 21 healthy children enrolled in the study. Patients with IBD were categorized into subgroups based on disease activity and response to treatment, and the levels of pro- and anti-inflammatory cytokines were measured. Results showed that disease activity might impact gingival inflammation in pediatric patients with IBD due to increased cytokine interactions and severity of inflammation.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Melissa M. Grant, John J. Taylor, Katrin Jaedicke, Andrew Creese, Catherine Gowland, Bernard Burke, Khawla Doudin, Upen Patel, Paul Weston, Michael Milward, Susan M. Bissett, Helen J. Cooper, Gerben Kooijman, Amir Rmaile, Marko de Jager, Philip M. Preshaw, Iain L. C. Chapple
Summary: Differential protein biomarkers in saliva and gingival crevicular fluid can be used to objectively distinguish between periodontal health and disease states.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zeynep Pinar Keles Yucel, Beral Afacan, Harika Atmaca Ilhan, Timur Kose, Gulnur Emingil
Summary: This study found elevated levels of TFF-1, TFF-3, and IL-1 beta in periodontitis patients compared to healthy controls and gingivitis group across GCF, saliva, and serum samples. These findings suggest the involvement of these peptides in host response during periodontal tissue destruction.
Review
Dentistry, Oral Surgery & Medicine
Pingping Han, Peter Mark Bartold, Saso Ivanovski
Summary: Periodontitis is a chronic inflammatory disease associated with microbial dysbiosis and immune response. Current diagnosis lacks real-time molecular biomarkers, making the discovery of new diagnostic biomarkers crucial. Small extracellular vesicles from oral biofluids have potential as biomarkers for periodontal disease, with cargo like proteins, genetic material, and lipids from parent cells.
JOURNAL OF PERIODONTAL RESEARCH
(2022)
Article
Medicine, General & Internal
Xuanzhi Zhu, Chao-Jung Chu, Weiyi Pan, Yan Li, Hanyao Huang, Lei Zhao
Summary: The concentrations of cfDNA in GCF, saliva, and plasma are significantly increased in patients with periodontal disease, and there is a positive correlation between cfDNA levels in GCF and saliva and periodontal parameters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Hyun-Duck Kim, Sandeep Karna, YooJin Shin, Huong Vu, Hyun-Jae Cho, Sungtae Kim
Summary: This study compared the association and screening ability of S100A8 and S100A9 in saliva, blood, and gingival crevicular fluid for periodontitis status. Salivary S100A8 was significantly higher in established periodontitis, while GCF S100A8 and S100A9 were higher in no or initial periodontitis. Salivary S100A8 could be a potential diagnostic marker for established periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Hazal Ustunel Akkaya, Huriye Erbak Yilmaz, Figen Narin, Mehmet Saglam
Summary: This clinical research compared the GCF levels of galectin-3, PAD4, and TNF-alpha in individuals with stage III grade C periodontitis, gingivitis, and healthy periodontium. The study found that galectin-3 levels were elevated in periodontitis, while PAD4 and TNF-alpha levels showed no significant difference between gingivitis and healthy periodontium. Galectin-3 may be associated with periodontal disease pathogenesis and can be used as a diagnostic biomarker.
JOURNAL OF PERIODONTOLOGY
(2022)
Article
Multidisciplinary Sciences
Adam D. Lietzan, Joshua B. Simpson, William G. Walton, Parth B. Jariwala, Yongmei Xu, Marcella H. Boynton, Jian Liu, Matthew R. Redinbo
Summary: Periodontitis is a chronic inflammatory disease associated with oral microbial dysbiosis. The human beta-glucuronidase (GUS) can be used as a biomarker for its severity. This study examines the role of GUS enzymes encoded by the human microbiome in periodontal disease and identifies oral GUS activity as a biomarker for clinical monitoring and treatment of periodontitis.
Article
Dentistry, Oral Surgery & Medicine
Nil Yakar, Gulnur Emingil, Asena Turedi, Cagdas Sahi, Timur Kose, Nagihan Bostanci, Angelika Silbereisen
Summary: This study aimed to investigate the association of GCF TREM-1, PGLYRP1, and IL-1 β levels with periodontal health in pre- and postmenopausal women. The results showed that there were no significant differences in GCF levels of TREM-1, PGLYRP1, and IL-1 β between pre- and postmenopausal women. However, higher GCF TREM-1 levels were observed in women with periodontitis, indicating that TREM-1 may be an indicator for periodontitis in both pre- and postmenopausal women.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jie Zhang, Wenjing Li, Hongye Lu, Ruifang Lu, Yalin Zhan, Huanxin Meng
Summary: The level of platelets in the GCF of patients with periodontitis is higher than that of healthy individuals. Platelets can interact with periodontal pathogens and neutrophils, and promote the formation of NETs.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ionut Luchian, Ancuta Goriuc, Darius Sandu, Mihai Covasa
Summary: Severe periodontitis is a destructive inflammatory disease that affects 11% of the global population. Metalloproteinases play a crucial role in cellular development and are associated with periodontal diseases. MMP-8 and MMP-9 are valuable diagnostic tools for periodontitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Pasquale Santamaria, Aysegul Sari, Luigi Nibali
Summary: The aim of this study was to assess the differential molecular profiling of gingival crevicular fluid (GCF) from infrabony and suprabony periodontal defects compared with healthy sites. The results showed that 14 biomarkers levels were elevated in GCF from infrabony and suprabony defects compared with healthy sites, while the difference between infrabony and suprabony defects was not significant in biomarker changes.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Hiroshi Ito, Yukihiro Numabe, Shuichi Hashimoto, Sunao Uehara, Ya-Hsin Wu, Tomohisa Ogawa
Summary: The study suggests that the presence of hemoglobin in gingival crevicular fluid may indicate slight tissue damage in pre-symptomatic periodontal disease, even in healthy sites without bleeding on probing. Therefore, hemoglobin examination could be a promising candidate marker for early detection of periodontal disease.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dermatology
Mehmet Saglam, Serhat Koseoglu, Tugba Pekbagriyanik, Levent Savran, Sukru Enhos
JOURNAL OF COSMETIC AND LASER THERAPY
(2017)
Article
Dentistry, Oral Surgery & Medicine
M. Saglam, S. Koseoglu, I. Tasdemir, H. Erbak Yilmaz, L. Savran, R. Sutcu
JOURNAL OF PERIODONTAL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
Cuneyt Asim Aral, Kubra Aral, Arzu Yay, Ozge Ozcoban, Afig Berdeli, Recep Saraymen
JOURNAL OF PERIODONTOLOGY
(2018)
Article
Engineering, Biomedical
Ezgi Doganay Yildiz, Hakan Arslan, Serhat Koseoglu, Taner Arabaci, Dursun Anil Yildiz, Levent Savran
LASERS IN MEDICAL SCIENCE
(2019)
Article
Dentistry, Oral Surgery & Medicine
Kuebra Aral, Cueneyt Asim Aral, Yvonne Kapila
JOURNAL OF PERIODONTOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Kubra Aral, Cuneyt A. Aral, Yvonne Kapila
Article
Dentistry, Oral Surgery & Medicine
Hakan Arslan, Serhat Koseoglu, Ezgi Doganay Yildiz, Taner Arabaci, Levent Savran, Dursun Anil Yildiz, Gozde Veyisoglu
BRAZILIAN ORAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
Gozde Veyisoglu, Levent Savran, Figen Narin, Huriye Erbak Yilmaz, Candeger Avsar, Mehmet Saglam
JOURNAL OF PERIODONTOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Serhat Koseoglu, Levent Savran, Bilal Yasa
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Kubra Aral, Eynar Berdeli, Paul Roy Cooper, Michael Robert Milward, Yvonne Kapila, Beyza Karadede Unal, Cuneyt Asim Aral, Afig Berdeli
JOURNAL OF PERIODONTOLOGY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Digdem Kucuk, Levent Savran, Utku Kursat Ercan, Ziysan Buse Yarali, Ozan Karaman, Alpdogan Kantarci, Mehmet Saglam, Serhat Koseoglu
CLINICAL ORAL INVESTIGATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Cuneyt Asim Aral, Sude Nur Olcer, Kubra Aral, Yvonne Kapila
Article
Dentistry, Oral Surgery & Medicine
Ayse Toraman, Ebru Saglam, Levent Savran, Mehmet Saglam, Serhat Koseoglu
Summary: Salivary levels of NLRC4 and IL-1 beta were significantly higher in patients with gingivitis and periodontitis compared to the healthy group. Positive correlations were observed between salivary levels of NLRC4 and IL-1 beta and clinical parameters. This suggests that salivary NLRC4 may serve as a potential marker for detecting the presence and/or severity of periodontal disease.