Journal
OCULAR SURFACE
Volume 14, Issue 2, Pages 255-263Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jtos.2015.12.005
Keywords
dietary supplements; dry eye; Schirmer test; tears
Categories
Funding
- Wakamoto Pharmaceutical Co. Ltd.
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Purpose: To examine the effect of a combined dietary supplement containing fish oil, lactoferrin, zinc, vitamin C, lutein, vitamin E, gamma-aminobutanoic acid, and Enterococcus faecium WB2000 on dry eye. Methods: A preliminary study in a rat model and a prospective, randomized, double-blind, placebo-controlled study in humans were conducted. Forty Japanese volunteers aged 22 to 59 years were randomized into combined dietary supplement (2 capsules/day; 20 participants) and placebo (vehicle; 19 participants) groups and treated once daily for 8 weeks. Rats received the combined dietary supplement components (10 or 50 mg/kg orally) or vehicle (2% DMSO), and dry eye was mechanically induced for 2 days. Tear production was measured in rats after dry eye was induced. Humans were assessed at baseline and weeks 4 and 8 post-supplementation based on keratoconjunctival epithelial damage; fluorescein tear film breakup time; tear production; biochemical data; information regarding subjective dry eye symptoms by answering a questionnaire; and information regarding adverse events via medical interviews. Results: Supplementation dose-dependently mitigated the decrease in tear production in rats. Among subjects with confirmed dry eye, clinical symptoms improved at weeks 4 and 8 more significantly in the supplementation group than in the placebo group (P<.05). The rate of increase in the Schirmer value was greater in the supplementation group. No adverse events occurred. Conclusion: Supplementation improved objective and subjective dry eye symptoms.
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