Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 51, Issue 4, Pages 385-388Publisher
SPRINGER
DOI: 10.1007/s10593-015-1712-7
Keywords
doxapram; lactam; intramolecular alkylation; stereoselective synthesis
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The use of LiHMDS with equimolar amount of sparteine in toluene results in the formation of enantiomerically enriched gamma-lactam, a useful synthon for the synthesis of (R)-(+)-doxapram.
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