Article
Medicine, General & Internal
Krupa Madhvani, Silvia Fernandez Garcia, Borja M. M. Fernandez-Felix, Javier Zamora, Tyrone Carpenter, Khalid S. S. Khan
Summary: This study developed and validated multivariable logistic regression models to predict major complications of laparoscopic or abdominal hysterectomy for benign conditions. The models showed consistent discrimination in the development cohort and similar or better discrimination in the validation cohort. Adhesions were the most predictive factor for complications in both models.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2022)
Article
Obstetrics & Gynecology
Maria C. Cusimano, Sarah E. Ferguson, Rahim Moineddin, Maria Chiu, Suriya Aktar, Ning Liu, Nancy N. Baxter
Summary: Bilateral salpingo-oophorectomy at the time of benign hysterectomy can significantly reduce the incidence and death rate of ovarian cancer, especially for postmenopausal women aged 50 or above, with a higher degree of risk reduction.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Rebekah M. Summey, Jordyn Pike, Christina Salazar
Summary: Compared with non-Hispanic white patients, Hispanic women undergoing hysterectomy have a higher risk of requiring blood transfusion, but a lower or equal risk of other postoperative complications.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)
Article
Medicine, General & Internal
Jae Suk Kim
Summary: This study aimed to investigate the relationship between female reproductive hormones, especially estrogen, and the incidence of cataracts. The results showed that the incidence of cataracts was significantly lower in the group with hysterectomy than in the control group, but the difference was subtle. These findings contribute to understanding the role of female reproductive hormones in cataract development.
MEDICINA-LITHUANIA
(2023)
Editorial Material
Obstetrics & Gynecology
Sarah E. Andiman, Anthony H. Bui, Anne Hardart, Xiao Xu
Summary: The risk of unanticipated uterine and cervical cancers in women undergoing hysterectomy for pelvic organ prolapse is 0.53% and 0.09% respectively, with higher likelihood in women over 60 years old and those with heavier uterine weight. Preoperative evaluation and counseling should take these risks into account for patient interactions.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2021)
Editorial Material
Obstetrics & Gynecology
Maria C. Cusimano, Sarah E. Ferguson, Rahim Moineddin, Maria Chiu, Suriya Aktar, Ning Liu, Nancy N. Baxter
Summary: Opportunistic bilateral salpingo-oophorectomy (BSO) is a common surgery to prevent ovarian cancer in nonpregnant women. It has been shown to reduce the rates of ovarian cancer and death in women with BRCA1 and BRCA2 pathogenic genes. However, the risk-to-benefit ratio of BSO is unclear for non-high-risk women. This study aimed to determine the risk and benefit of BSO on the incidence and death of ovarian cancer.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Article
Obstetrics & Gynecology
James L. Whiteside, Dmitry Tumin, Samuel F. Hohmann, Alyssa Harris
Summary: This study aims to identify surgeon-level variation in the cost of producing an outpatient hysterectomy for benign indications in the United States. The primary factor influencing cost differences is the surgical approach, and there are significant unexplained differences among surgeons. Standardization of surgical approach and technique, as well as increased awareness of surgical supply costs among surgeons, could address these unexplained cost variations.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Gaby N. Moawad, Jordan S. Klebanoff, Olga Muldoon, Alexandra North, Richard Amdur, Paul Tyan
Summary: The study retrospectively analyzed laparoscopic hysterectomy procedures conducted at an academic university hospital from 2012 to 2018, revealing a significant decrease in the use of opioids during both intraoperative and postoperative periods. Intraoperative opioid administration was found to be correlated with immediate postoperative opioid consumption, while Body Mass Index was significantly associated with perioperative opioid administration.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Lior Lowenstein, Omer Mor, Emad Matanes, Roy Lauterbach, Sari Boulus, Zeev Weiner, Jan Baekelandt
Summary: This study assessed the feasibility and safety of the Hominis surgical system for RvNOTES hysterectomy. The positive results indicate that this new technology is a safe and effective tool for surgeons to operate vaginally.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Lisa M. Pollack, Jerry L. Lowder, Matt Keller, Su-Hsin Chang, Sarah J. Gehlert, Margaret A. Olsen
Summary: This study aimed to evaluate the differences in surgical complications and postoperative hospitalization rates after hysterectomy for benign conditions by race/ethnicity. The results showed that black and Asian/Pacific Islander women had a higher risk of surgical complications compared to white women, while black and Hispanic women had a higher risk of posthysterectomy hospitalization. Addressing disparities in pre-existing conditions/comorbidities could help reduce these racial/ethnic differences in outcomes.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Nieves Cabezas, Ana Lopez-Picazo, Patricia Diaz, Beatriz Valero, Maria Jose Rodriguez, Ana Redondo, Begona de la Noval, Maria Angela Pascual, Silvia Ajossa, Stefano Guerriero, Juan Luis Alcazar
Summary: The objective of this study was to determine the percentage of benign myomas that appear suspicious for uterine sarcoma on ultrasound examination. It was found that approximately 5% of benign uterine myomas may exhibit sonographic suspicion of sarcoma.
Article
Obstetrics & Gynecology
Yoko Tsuzuki, Takumi Hirata, Shinya Tsuzuki, Shinichiro Wada, Akiko Tamakoshi
Summary: This study identified current smoking, use of Seprafilm, CRP level on postoperative day 2, and vaginal cuff hematoma as significant risk factors for vaginal cuff infection within 30 days after total laparoscopic hysterectomy in Japanese women with benign indications.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Oncology
Yuanyuan Ding, Yana Han, Sanyuan Zhang, Xiaorong Shi
Summary: The aim of this study was to evaluate the incidence of unexpected uterine malignancies in patients undergoing hysterectomy for benign indications and to assess their clinical characteristics. The results showed that the incidence of unexpected uterine malignancies was very low, and preoperative examination should be approached with caution.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Abdelrahman AlAshqar, Brian Wildey, Golsa Yazdy, Metin E. Goktepe, Gokhan S. Kilic, Mostafa A. Borahay
Summary: The study identified robotic-assisted hysterectomy, shorter operative time, and minimal blood loss as key factors associated with same-day discharge after minimally invasive hysterectomy, while later procedure start time and postoperative complications decreased the likelihood of same-day discharge. The surgeon's number of years in practice was found to be the strongest predictor of same-day discharge.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Rui Wang, Paul Tulikangas, Heidi S. Harvie
Summary: This study assessed the cost effectiveness of performing routine concurrent apical support procedures at the time of hysterectomy for benign indications. The results showed that concurrent apical support had higher costs but was more effective than hysterectomy alone, and it remained cost effective in sensitivity analyses. Encouraging concurrent apical support procedures at the time of hysterectomy is a cost-effective strategy in preventing posthysterectomy vaginal prolapse.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Oncology
Anna L. Beavis, Ting-Tai Yen, Rebecca L. Stone, Stephanie L. Wethington, Caitlin Carr, Ji Son, Laura Chambers, Chad M. Michener, Stephanie Ricci, Wesley C. Burkett, Debra L. Richardson, Allison-Stuart Staley, Susie Ahn, Paola A. Gehrig, Diogo Torres, Sean C. Dowdy, Mackenzie W. Sullivan, Susan C. Modesitt, Catherine Watson, Ashely Veade, Jessie Ehrisman, Laura Havrilesky, Angeles Alvarez Secord, Amy Loreen, Kaitlyn Griffin, Amanda Jackson, Akila N. Viswanathan, Leah R. Jager, Amanda N. Fader
GYNECOLOGIC ONCOLOGY
(2020)
Article
Oncology
Ji Son, Laura M. Chambers, Caitlin Carr, Chad M. Michener, Meng Yao, Anna Beavis, Ting-Tai Yen, Rebecca L. Stone, Stephanie L. Wethington, Amanda N. Fader, Wesley C. Burkett, Debra L. Richardson, Allison S. Staley, Susie Ahn, Paola A. Gehrig, Diogo Torres, Sean C. Dowdy, Mackenzie W. Sullivan, Susan C. Modesitt, Catherine Watson, Ashley Veade, Jessie Ehrisman, Laura Havrilesky, Angeles Alvarez Secord, Amy Loreen, Kaitlyn Griffin, Amanda Jackson, Akila Viswanathan, Stephanie Ricci
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2020)
Article
Oncology
Krishnansu S. Tewari, Michael W. Sill, Bradley J. Monk, Richard T. Penson, David H. Moore, Heather A. Lankes, Lois M. Ramondetta, Lisa M. Landrum, Leslie M. Randall, Ana Oaknin, Mario M. Leitao, Eric L. Eisenhauer, Paul DiSilvestro, Linda Van Le, Michael L. Pearl, James J. Burke, Ritu Salani, Debra L. Richardson, Helen E. Michael, David W. Kindelberger, Michael J. Birrer
MOLECULAR CANCER THERAPEUTICS
(2020)
Meeting Abstract
Oncology
Devalingam Mahalingam, Vivek Subbiah, Taofeek K. Owonikoko, Susanna Varkey Ulahannan, Debra L. Richardson, Aparna Kalyan, Mary Frances Mulcahy, Catherine A. Wheeler, Satoshi Matsushima, Takeaki Suzuki, Ruth Ann Subach, Mary Johansen, Timothy Madden, Cheung Kin, David S. Wages
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Alan Loh Ho, Marshall R. Posner, Jiaxin Niu, Siqing Fu, Rom S. Leidner, Alexander T. Pearson, Ki Y. Chung, Debra L. Richardson, Ding Wang, Agustin Pimentel, Jorge J. Nieva, Ari Rosenberg, Bharat Burman, Corinne Iacobucci, Xiaoping Qing, Andy Hwang, Kia Katchar, Katia Schlienger, Igor Matushansky, David G. Pfister
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Debra L. Richardson, Erika P. Hamilton, Ana Oaknin, Leslie M. Randall, Susana N. Banerjee, Sara Kristina Taylor, Linda R. Mileshkin, Robert L. Coleman, Bradley J. Monk, Mansoor Raza Mirza, Patricia Bernardo, Rebecca Mosher, Valerie Malyvanh Jansen, Antonella Savarese, Toon Van Gorp, Radoslaw Madry, Isabelle Laure Ray-Coquard, Nicole Concin
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Camille Catherine Jackson, Leigh Cantrell, Britt Kristina Erickson, Kathleen N. Moore, Linda R. Duska, Debra L. Richardson, Lisa Michelle Landrum, Laura L. Holman, Joan L. Walker, Robert S. Mannel, Katherine M. Moxley, Lurdes Queimado, Kai Ding, Andrew Cohoon, Sara Vesely, Lauren E. Dockery
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Meeting Abstract
Oncology
Filip Janku, Erika P. Hamilton, Cara Amanda Mathews, Christina Chu, Jennifer Robinson Diamond, John L. Hays, Rebecca Christian Arend, Massimo Cristofanilli, Andrea Jewell, William Reichmann, Keisuke Kuida, Haroun Achour, Rodrigo Ruiz-Soto, Debra L. Richardson
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
Melissa M. Hardesty, Thomas C. Krivak, Gail S. Wright, Erika Hamilton, Evelyn L. Fleming, Jimmy Belotte, Erika K. Keeton, Ping Wang, Divya Gupta, Aine Clements, Heidi J. Gray, Gottfried E. Konecny, Richard G. Moore, Debra L. Richardson
Summary: This study evaluated the safety and efficacy of Niraparib + bevacizumab as a first-line maintenance therapy for newly diagnosed advanced ovarian cancer patients. The results showed promising PFS outcomes and the safety profile was consistent with the monotherapy of these drugs.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Susana Banerjee, Ronny Drapkin, Debra L. Richardson, Michael Birrer
Summary: This article discusses the research progress on NaPi2b as a novel biomarker for treatment and patient selection in ovarian cancer. NaPi2b is highly expressed in ovarian tumors and can be used for tumor mapping and therapeutic targeting. Clinical trial results have shown successful detection of NaPi2b in ovarian cancer patients, and it has the potential to elicit therapeutic responses.
CANCER TREATMENT REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Xiaofei Zhou, Debra L. Richardson, Afshin Dowlati, Sanjay Goel, Solmaz Sahebjam, James Strauss, Sant Chawla, Ding Wang, Diane R. Mould, Vivek Samnotra, Douglas Faller, Karthik Venkatakrishnan, Neeraj Gupta
Summary: The study assessed the effect of pevonedistat on heart rate-corrected QT interval in cancer patients. The results showed that pevonedistat did not cause clinically relevant effects on heart rate or cardiac repolarization.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2023)
Editorial Material
Obstetrics & Gynecology
Debra L. Richardson
Summary: Recently, two antibody drug conjugates have been approved by the FDA for the treatment of recurrent gynecologic malignancies. However, these new agents are associated with ocular toxicity. Fortunately, ocular toxicity can be prevented and mitigated by following recommended eye care strategies.
GYNECOLOGIC ONCOLOGY REPORTS
(2023)
Meeting Abstract
Oncology
Manish R. Patel, Vicky Makker, Ana Oaknin, Sandro Pignata, Floor Jenniskens Backes, Antonio Gonzalez Martin, Ramez Nassef Eskander, Bhavana Pothuri, Debra L. Richardson, Angeles Alvarez Secord, Els Van Nieuwenhuysen, Joyce F. Liu, Fernanda Musa, Richard T. Penson, Kenton Wride, Denise M. Lepley, Rachel Dusek, Teresa Cameron, Erika P. Hamilton, Nicole Concin
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Siqing Fu, Lisle Nabell, Alexander T. Pearson, Rom Leidner, Douglas Adkins, Marshall R. Posner, Jorge J. Nieva, Debra L. Richardson, Agustin Pimentel, Sanjay Goel, Stuart J. Wong, Alan Loh Ho, Ari Rosenberg, Matthew H. Taylor, Raghad Abdul-Karim, Corinne Iacobucci, Xiaoping Qing, Kia Katchar, Katia Schlienger, David G. Pfister
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Filip Janku, Erika Paige Hamilton, Christina Chu, Debra L. Richardson, Rebecca Christian Arend, Keisuke Kuida, Haroun Achour, Rodrigo Ruiz-Soto, John L. Hays
JOURNAL OF CLINICAL ONCOLOGY
(2020)