Article
Chemistry, Applied
Hong-Rui Li, Yu-Kui Li, Jian Xiao, Cui Yang, Meng-Yuan Jiang, Kai Tian, Wei Wang, Yan-Hong Li, Xiang-Zhong Huang
Summary: A pilot study on the ethanol extracts of Agrimonia pilosa revealed anti-α-glucosidase and anti-inflammatory activities, with a new phenylethyl isocoumarin glycoside (1) and eight known compounds (2-9) being isolated. Compound 1 showed modest α-glucosidase inhibitory activity, while most compounds exhibited weak anti-inflammatory effects, except for compounds 3 and 6 which were inactive.
NATURAL PRODUCT RESEARCH
(2022)
Review
Chemistry, Medicinal
Ting Huang, Chun-Cao Zhao, Man Xue, Yun-Feng Cao, Liang-Kang Chen, Jian-Xing Chen, Yi-Jie Sun, Jia Zeng
Summary: Agrimonolide (AM), derived from isocoumarins, is a lipophilic compound found in Agrimonia pilosa Ledeb. It has shown potential as a multitarget natural treatment for diseases such as cancer, inflammation, hepatic injury, myocardial damage, and diabetes mel litus. However, there is a lack of substantial animal or human data regarding its pharmacological activities, mechanisms of action, and safety. The review emphasizes the need for further investigation into AM and discusses potential strategies to address previous research limitations.
Article
Nanoscience & Nanotechnology
Yu Zhang, Li Cui, Yizeng Lu, Jixiang He, Hidayat Hussain, Lei Xie, Xuan Sun, Zhaoqing Meng, Guiyun Cao, Dawei Qin, Daijie Wang
Summary: The present study successfully synthesized silver nanoparticles (LLJ-AgNPs) using L. japonica leaves as a reducing agent, and characterized their physicochemical properties. The LLJ-AgNPs exhibited excellent antioxidant properties, antibacterial properties, and anticancer potential.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Plant Sciences
Jing-Hui Feng, Hyun-Yong Kim, Su-Min Sim, Guang-Lei Zuo, Jeon-Sub Jung, Seung-Hwan Hwang, Youn-Gil Kwak, Min-Jung Kim, Jeong-Hun Jo, Sung-Chan Kim, Soon-Sung Lim, Hong-Won Suh
Summary: The study demonstrated that the mixture extract from Agrimonia pilosa Ledeb. and Salvia miltiorrhiza Bunge showed significant anti-inflammatory and antinociceptive effects, indicating its potential as a therapeutic for arthritis treatment.
Review
Multidisciplinary Sciences
Sihua Wen, Xiaofei Zhang, Yanan Wu, Shangshang Yu, Wei Zhang, Ding Liu, Kai Yang, Jing Sun
Summary: This review provides an overview of the traditional uses, botanical and chemical composition, extraction methods, and pharmacological and toxicological progress of Agrimonia pilosa Ledeb. The review also discusses future research trends and development prospects of this plant.
Article
Medicine, Research & Experimental
Su Su Thae Hnit, Rongzhen Ding, Ling Bi, Chanlu Xie, Mu Yao, Paul De Souza, Ling Xu, Zhong Li, Qihan Dong
Summary: The study identified that agrimol B derived from Agrimonia pilosa Ledeb in the Astringent recipe can trap prostate and lung cancer cells in G(0) phase, influencing key regulators and inhibiting cancer cell growth successfully.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemical Research Methods
Nguyen Quang Hop, Ninh The Son
Summary: Hairy agrimony is a traditional medicinal plant used in Eastern Europe and Eastern Asia. It has various pharmacological activities and contains more than 160 secondary metabolites. The plant and its extracts have shown potential in treating cancer, microbial infections, inflammation, diabetes, and other health conditions.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Food Science & Technology
Peng Xu, Zhentao Zhang, Xueyuan Peng, Junling Yang, Xiaoqiong Li, Tiejian Yuan, Xiaohan Jia, Yaoyang Liu, Olim Abdullaev, Janar Jenis
Summary: This study investigated the vacuum drying mechanism of Lonicera japonica Thunb. aqueous extracts and found that it differs from the drying mechanism of conventional porous media. The optimal vacuum drying process for the aqueous extracts was determined to be 30 minutes, 4 mm thickness, 120 degrees Celsius temperature, and 10 kPa pressure.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Tingwang Guo, Yun Pan, Lin Yang, Gang Chen, Jia Deng, Liancai Zhu
Summary: Research has shown that Flavonoid component extracted from Agrimonia pilosa Ledeb can significantly improve glucose metabolism and reduce insulin resistance. It achieves these effects by suppressing oxidative stress and inflammation, regulating insulin signaling pathways, increasing PPAR expression, and improving oxidative homeostasis. Additionally, Flavonoid component also decreases the expression and secretion of inflammatory cytokines and regulates the JNK/PI3K/Akt signal pathway in adipocytes and adipose tissue, improving metabolic function.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Nutrition & Dietetics
Xiaodan Qi, Yang Yu, Xinyi Wang, Jialei Xu, Xiang Wang, Zhangkai Feng, Yifa Zhou, Hongxing Xiao, Lin Sun
Summary: In this study, a pectin fraction with antioxidant activity was purified from Lonicera japonica Thunb. The purified fraction consisted of different pectin domains, and de-esterified oligogalacturonides showed superior antioxidant activity and reduced reactive oxygen species production in cells.
FRONTIERS IN NUTRITION
(2022)
Article
Environmental Sciences
Mengdi Xie, Xiaoyu Gao, Saiwei Zhang, Xiaohua Fu, Yiquan Le, Lei Wang
Summary: Due to the close relationship between plant physiology and metabolism, it is important to understand how endophytes coordinate with plant intrinsic mechanisms to support plant productivity under stress. This study investigated the impact of different levels of Cd exposure on the growth, metabolic pathways, and endophyte community structure and function in Lonicera japonica. The results showed that the endophytes expressed antioxidative regulators to detoxify Cd and increase plant resistance to metal-induced stress.
Article
Biochemistry & Molecular Biology
Chen Li, Meng Wang, Junkang Sui, Yongkun Zhou, Wei Chen
Summary: The study found that Agrimonia pilosa may protect against UC by suppressing the NF-kappa B and NLRP3 signaling pathways, alleviating the severity of DSS-induced colitis, reducing the production of inflammatory factors, and protecting intestinal integrity.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Plant Sciences
Zhouli Liu, Qinglin Chen, Maosen Lin, Mengdi Chen, Cong Zhao, Qingxuan Lu, Xiangyu Meng
Summary: This study found that an appropriate electric field can improve the growth, hyperaccumulation, and photosynthetic ability of L. japonica. Additionally, low Cd supply and medium voltage can enhance plant growth and photosynthetic capacity.
Article
Agricultural Engineering
Fuqing Huang, Tianwei Wang, Jiaqi Zhang, Muhammad Tahir, Jiahao Sun, Yayong Liu, Fangfei Yun, Tianqi Xia, Kunling Teng, Jiwen Wang, Jin Zhong
Summary: This study aimed to effectively use discarded Lonicera japonica Thunb. residues by anaerobic fermentation. It was found that fermentation decreased the abundance of undesirable bacteria and increased Lactobacillus abundance, while compound additive use improved fermentation and nutrient quality without impairing metabolites.
BIORESOURCE TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Muqing Zhang, Jian Chen, Yanwei Wang, Guobin Kang, Yixin Zhang, Xue Han
Summary: The present study used network pharmacology approach and validation experiment to investigate the potential mechanisms of Agrimonia pilosa Ledeb. (APL) extract against acute myocardial infarction (AMI). It was found that APL extract exhibited a protective effect against AMI through antioxidant and anti-apoptosis actions involving the activation of the PI3K/Akt signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)