Review
Biochemistry & Molecular Biology
Eleni A. Karatrasoglou, Maria Dimou, Alexia Piperidou, Eleftheria Lakiotaki, Penelope Korkolopoulou, Theodoros P. Vassilakopoulos
Summary: This review focuses on discussing the oncogenic mechanisms of the PI3K/v-akt/mTOR pathway in B cell non-Hodgkin lymphoma (NHL), and summarizes the clinical applications of mTOR inhibitors in B cell NHLs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Xiao-Yang Chen, Puay Hoon Tan
Summary: Despite advances in breast cancer diagnosis and treatment, it remains the most frequently diagnosed malignancy in females globally, with the highest cancer-related mortality rate. Immunotherapy has shown potential in clinical management by leveraging the complex interactions between breast cancer and the immune system. The effectiveness of immunotherapies is influenced by the immunological profile of the tumour and its tumour microenvironment.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Marco V. Haselager, Eric Eldering
Summary: This review provides an overview of the role of NF-kappa B-inducing kinase (NIK) in non-canonical NF-kappa B signaling and its association with various malignancies. It discusses the current research on NIK activation, stability, and its potential as a therapeutic target for B cell malignancies. The review also compares different inhibitors targeting NIK and emphasizes the need for further in vitro and in vivo studies as well as clinical trials with NIK inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Valentina Novak, Boris Rogelj, Vera Zupunski
Summary: ALS and FTD are severe neurodegenerative disorders with limited treatment options. Polyphenols have been found to have neuroprotective functions, potentially leading to better treatment options.
Review
Biochemistry & Molecular Biology
Roberta Giordo, Angelo Zinellu, Ali Hussein Eid, Gianfranco Pintus
Summary: In COVID-19 infection, coagulation disorders, endotheliopathy, and inflammation are the most common hallmarks. Dysfunctions of endothelial cells and platelets contribute to the systemic inflammatory response, which is both a cause and consequence of COVID-19-associated coagulation disorders and thrombotic events. Elevated levels of circulating inflammatory cytokines are often associated with abnormal coagulation parameters in COVID-19 patients.
Review
Nutrition & Dietetics
Italo Rennan Sousa Vieira, Leticia Tessaro, Alan Kelbis Oliveira Lima, Isabela Portella Silva Velloso, Carlos Adam Conte
Summary: Nanotechnology approaches, such as encapsulating polyphenols in nanocarriers, show enhanced anticancer activity and pro-apoptotic effects against various cancer cells, surpassing free bioactive compounds. Polymeric, lipid-based, inorganic, and carbon-based nanomaterials are commonly used nanocarriers. These innovative approaches have significant implications for clinical cancer research.
Review
Medicine, Research & Experimental
Ali Zarezadeh Mehrabadi, Reza Ranjbar, Mahdieh Farzanehpour, Alireza Shahriary, Ruhollah Dorostkar, Mohammad Ali Hamidinejad, Hadi Esmaeili Gouvarchin Ghaleh
Summary: CAR-T cell therapy shows great potential in cancer treatment, but faces challenges in treating solid tumors. Combining with other therapeutic approaches may enhance the efficacy of CAR-T cells, but further research is needed to determine their safety and effectiveness.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Takahiro Matsuyama, Hiromi Matsuyama, Yoichi Dotake, Koichi Takagi, Kentaro Machida, Hiromasa Inoue
Summary: T helper type 2 cells and group 2 innate lymphoid cells play a crucial role in asthma, particularly in airway eosinophilic inflammation. These cells are activated by cytokines released by airway epithelial cells and produce high levels of type 2 cytokines. ILC2s induce airway inflammation independently of antigens and may contribute to steroid resistance. Biologics targeting these cytokines and/or their receptors have shown promise in reducing asthma exacerbations and improving lung function and quality of life in asthmatic patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Marco M. Buhler, Jose Martin-Subero, Qiang Pan-Hammarstrom, Elias Campo, Richard Rosenquist
Summary: Histopathologic examination is important for the diagnosis of lymphoid malignancies, but recent advances in high-throughput technologies have improved our understanding of these tumors. Certain genomic alterations can provide diagnostic information and others can indicate prognosis or treatment response. Comprehensive molecular profiling may pave the way for precision diagnostics and medicine.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sabrina Bianca Bennstein, Markus Uhrberg
Summary: ILCs play crucial roles in controlling infectious diseases, cancer, and allergy/autoimmunity, with ILC3s involved in gut-immune interactions and ILC2s contributing to inflammatory responses linked to asthma and allergies.
Review
Oncology
Aneta Szudy-Szczyrek, Sean Ahern, Magdalena Koziol, Daria Majowicz, Michal Szczyrek, Janusz Krawczyk, Marek Hus
Summary: This review discusses the role of innate lymphoid cells (ILCs) in the pathogenesis and therapy of multiple myeloma (MM), highlighting their potential key role in MM pathophysiology and the clinical benefits of targeting ILCs.
Review
Biochemistry & Molecular Biology
Hamed Baharara, Prashant Kesharwani, Thomas P. Johnston, AmirHossein Sahebkar
Summary: The aim of this review was to discuss the effects of various phytochemicals on mutated membrane channels and their potential to improve transmembrane conductance in CF patients. The study utilized keyword searches in four databases and also checked additional sources for related articles. While curcumin, genistein, and resveratrol have shown effectiveness, other herbal medicines like coumarins and quercetin also have beneficial effects. The research highlights the need for further studies to understand the mechanism of action and therapeutic effects of phytochemicals on CF patients.
Article
Cell Biology
Ashu Singh, Alpana Sharma
Summary: Tumor cells are dynamic and can escape from immune surveillance. Understanding the mechanism of tumor cell spreading within lymph vessels is crucial for treating metastatic cancer patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Himanshu Gandhi, Shikha Mahant, Abhishek Kumar Sharma, Deepak Kumar, Kamal Dua, Dinesh Kumar Chellappan, Sachin Kumar Singh, Gaurav Gupta, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Deepak N. Kapoor
Summary: Piceatannol is a natural compound found in fruits and vegetables, with a wide range of beneficial effects such as anti-inflammatory, antioxidant, anti-aging, and antidiabetic properties. It has shown promising potential in inhibiting the growth of various cancers. However, its bioavailability is lower compared to resveratrol, and further research is needed to enhance its effectiveness.
Review
Biochemistry & Molecular Biology
Mohamad Hossein Pourhanifeh, Kazem Abbaszadeh-Goudarzi, Mohammad Goodarzi, Sara G. M. Piccirillo, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Zatollah Asemi, Hamed Mirzaei
Summary: Melanoma, the most life-threatening skin malignancy, has steadily increasing incidence. Resveratrol, a polyphenol found in grapes, exhibits anti-cancer properties but requires more clinical trials for efficacy validation.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Gastroenterology & Hepatology
Lei Chen, Heng Lu, Dunfa Peng, Long Long Cao, Farah Ballout, Kannappan Srirmajayam, Zheng Chen, Ajaz Bhat, Timothy C. Wang, Anthony Capobianco, Jianwen Que, Oliver Gene McDonald, Alexander Zaika, Shutian Zhang, Wael El-Rifai
Summary: This study investigates the role of acidic bile salts in activating NOTCH signaling in oesophageal adenocarcinoma (EAC). The researchers found that there is a crosstalk between APE1 redox function, reflux-induced inflammation, and DLL1 upregulation, which promotes cancer cell stem-like properties in EAC. The overexpression of APE1 and DLL1 is associated with poor overall survival in EAC patients.
Review
Medicine, Research & Experimental
Takwa Bedhiafi, Sourour Idoudi, Queenie Fernandes, Lobna Al-Zaidan, Shahab Uddin, Said Dermime, Nashiru Billa, Maysaloun Merhi
Summary: Vitamin C is a crucial nutrient in humans with important physiological functions. However, its therapeutic applications are limited due to low chemical stability. Although there are some nano-encapsulation techniques described in the literature, there are few clinical investigations on the therapeutic applications of nano-encapsulated vitamin C. Further research is needed to explore the potential clinical benefits of nano-encapsulated vitamin C.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Ava Nasrolahi, Shirin Azizidoost, Klaudia Radoszkiewicz, Sajad Najafi, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Seyed Esmaeil Khoshnam, Maryam Farzaneh, Shahab Uddin
Summary: Glioma is a common malignant brain tumor that arises from glial tissue. Glioma cancer stem cells (GCSCs) have been identified as playing important roles in tumor initiation and metastasis. Targeting GCSCs and their associated signaling pathways, as well as non-coding RNAs, could be a novel strategy for glioma treatment. In this review, critical signaling pathways involved in GCSC tumorigenesis and invasiveness are summarized.
CELLULAR SIGNALLING
(2023)
Article
Immunology
Shayista Akbar, Afsheen Raza, Reyad Mohsin, Aladdin Kanbour, Shahnaz Qadri, Aijaz Parray, Abdul Rehman Zar Gul, Anite Philip, Suma Vijayakumar, Maysaloun Merhi, Shereena Hydrose, Varghese Philipose Inchakalody, Rajaa Al-Abdulla, Wafa Abualainin, Shaza Abu Sirriya, Issam Al-Bozom, Shahab Uddin, Omar Muhammad Khan, Mohamed Izham Mohamed Ibrahim, Ussama Al Homsi, Said Dermime
Summary: This study evaluated the levels of 27 serum-derived exosomal immuno-oncological proteins and 44 cytokines/chemokines in NSCLC patients before and after ICIs therapy, in order to identify surrogate biomarkers for treatment response and monitoring. The results showed that exosomal immuno-oncological proteins/cytokines can be potential biomarkers to predict the clinical outcomes and monitor response to ICIs therapy in NSCLC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sarra Mestiri, Maysaloun Merhi, Varghese P. Inchakalody, Nassiba Taib, Maria K. Smatti, Fareed Ahmad, Afsheen Raza, Fatma H. Ali, Shereena Hydrose, Queenie Fernandes, Abdul W. Ansari, Fairooz Sahir, Lobna Al-Zaidan, Munir Jalis, Mokhtar Ghoul, Niloofar Allahverdi, Mohammed U. Al Homsi, Shahab Uddin, Andrew Martin Jeremijenko, Mai Nimir, Laith J. Abu-Raddad, Fatma Ben Abid, Ahmed Zaqout, Sameer R. Alfheid, Hassan Mohamed Hassan Saqr, Ali S. Omrani, Ali Ait Hssain, Muna Al Maslamani, Hadi M. Yassine, Said Dermime
Summary: This study analyzed the humoral and cellular immune responses in six healthy recipients of the BNT162b2 mRNA vaccine. The results showed heterogeneity in the spike-specific immune responses among vaccinated individuals. The study also demonstrated the correlation between anti-spike antibody levels and neutralizing activity, as well as the enhanced T cell responses against known human common viruses induced by the vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Multidisciplinary Sciences
Munazza Tamkeen Fatima, Ajaz Ahmad Bhat, Sabah Nisar, Khalid Adnan Fakhro, Ammira Sarah Al-Shabeeb Akil
Summary: A healthy diet is crucial for cellular health and oxidative stress plays a significant role in various diseases. Antioxidants, found in dietary foods such as tea, coffee, wine, oils, and honey, can reduce oxidative stress and combat type 2 diabetes and neurodegenerative disorders.
Article
Orthopedics
Arshad Bashir, Mudasir Ahmad Parry, Ajaz Ahmad Bhat
Summary: The objective of this study was to evaluate the functional outcome of percutaneous repair in patients with acute and closed Achilles tendon ruptures. The results showed that the percentage of patients with excellent or good ATRS scores at 3, 6, and 12 months were 0%, 16%, and 100%, respectively. The AOFAS hind foot scores at these time points were 77.9, 92.04, and 96.16, respectively. Most patients did not experience complications, and only 2 patients (8%) had sural nerve injury which was resolved in subsequent follow-ups.
INDIAN JOURNAL OF ORTHOPAEDICS
(2023)
Article
Medicine, Research & Experimental
Sahar I. Da'as, Ikhlak Ahmed, Waseem H. Hasan, Doua A. Abdelrahman, Elbay Aliyev, Sabah Nisar, Ajaz Ahmad Bhat, Mugdha V. Joglekar, Anandwardhan A. Hardikar, Khalid A. Fakhro, Ammira S. Al-Shabeeb Akil
Summary: This study identifies miR-223-3p as a potential biomarker for glycemic control and beta cell function in type 2 diabetes (T2D) patients, and reveals its association with diabetic retinopathy (DR) development. Functional validation in a zebrafish model demonstrates that overexpression of miR-223-3p leads to hyperglycemia and degenerated retinal vasculature. Targeting miR-223-3p may be a promising therapeutic strategy for controlling DR in T2D patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pathology
Maryam Farzaneh, Tariq Masoodi, Farhoodeh Ghaedrahmati, Klaudia Radoszkiewicz, Amir Anbiyaiee, Mohadeseh Sheykhi-Sabzehpoush, Niloofar Khoshdel Rad, Shahab Uddin, Seyedeh Pardis Motiee Jooybari, Seyed Esmaeil Khoshnam, Shirin Azizidoost
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in cancer tumorigenesis and progression. Recent studies have shown that nuclear paraspeckle assembly transcript 1 (NEAT1) as an lncRNA can regulate cell proliferation, migration, and EMT in tumor cells. NEAT1 regulates cancer cell behavior by targeting several miRNA/mRNA axes. Therefore, NEAT1 may serve as a potential biomarker for predicting and treating certain human cancers. In this review, we provide an overview of various NEAT1-related signaling pathways that are critical in cancer initiation and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Nazima Akhtar, Ajaz Ahmad Bhat
Summary: This research article introduces a new Pranav power series class of distributions, obtained by compounding one parameter Pranav and power series distributions. The study explores various statistical properties of the proposed model, including closed-form expressions for density, distribution, survival, hazard rate functions, and moments of order statistics. The flexibility and potentiality of the PPS distribution are demonstrated using two real life data sets.
JOURNAL OF SCIENCE AND ARTS
(2023)
Article
Immunology
Sobia Naz Shaukat, Faizan Nasir, Afsheen Raza, Rafiq Khanani, Shahab Uddin, Shahana Urooj Kazmi
Summary: This study aimed to evaluate the association between KIR3DS1 and KIR3DL1 with IFN-y/IL-10 in HIV-1 and TB infections. The results showed that expression of KIR3DS1 was associated with low HIV-1 viral load, while expression of KIR3DL1 was significantly upregulated in HIV-1. In addition, IFNy expression was decreased in TB but increased in HIV-1/TB, while IL-10 expression was increased in HIV-1 and HIV-1/TB. It suggests that KIR3DS1/L1 expression is associated with IFNy/IL-10 responses and modulates disease severity in HIV-1 and TB infections.
MICROBIAL PATHOGENESIS
(2023)
Meeting Abstract
Oncology
Ravi Chauhan, Lakshay Malhotra, Ashna Gupta, Ajaz Bhat, Gunjan Dagar, Tariq Masoodi, Muzafar A. Macha, Ethayathulla Abdul Samath, Atul Batra, Mehar Chand Sharma, Mohammad Haris, Ammira Al-Shabeeb Akil, Tej K. Pandita, Shahab Uddin, Mayank Singh
Article
Computer Science, Information Systems
Vaisali Chandrasekar, Mohammed Yusuf Ansari, Ajay Vikram Singh, Shahab Uddin, Kirthi S. Prabhu, Sagnika Dash, Souhaila Al Khodor, Annalisa Terranegra, Matteo Avella, Sarada Prasad Dakua
Summary: Due to limited drug testing options for pregnant women, the development of computational algorithms is vital in predicting drug behavior in the placental barrier as an alternative to animal testing. The ability of a molecule to cross the placental barrier and affect the fetus is crucial in determining its toxicological effects. Through analyzing publicly available datasets, this study explores different machine learning models, fingerprints, and toolkits to find the most suitable models. Neural network-based models show effective predictions of permeability. Among them, K-nearest neighbor (KNN), standard vector classifier (SVC), and Multi-layer perceptron (MLP) perform the best with prediction percentages of 82%, 86.4%, and 90.8% respectively. Comparison of different models reveals negative permeability predictions for drugs like Aliskiren, certain insulin secretagogues, and glucocorticoids.
Review
Oncology
Maryam Farzaneh, Ava Nasrolahi, Farhoodeh Ghaedrahmati, Tariq Masoodi, Sajad Najafi, Mohadeseh Sheykhi-Sabzehpoush, Mahrokh Abouali Gale Dari, Klaudia Radoszkiewicz, Shahab Uddin, Shirin Azizidoost, Seyed Esmaeil Khoshnam
Summary: Long non-coding RNAs (lncRNAs) are a type of non-coding RNA that do not code for proteins and contain more than 200 nucleotides. They can have both oncogenic and tumor-suppressive properties in tumorigenesis. XIST, a known lncRNA involved in X chromosome silencing in female cells, has been associated with an increased risk of various cancers. This review aims to summarize the emerging roles of XIST in human cancers.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)