Article
Chemistry, Multidisciplinary
Amalia Coro, Ada Herrero Ruiz, Mateo Pazo-Gonzalez, Alonso Sanchez-Cruz, Tobias Busch, Alejandro Hernandez Medel, Erving C. Ximendes, Dirk H. Ortgies, Rosalia Lopez-Mendez, Ana Espinosa, Dorleta Jimenez de Aberasturi, Daniel Jaque, Nuria Fernandez Monsalve, Enrique J. de la Rosa, Catalina Hernandez-Sanchez, Emma Martin Rodriguez, Beatriz H. Juarez
Summary: In this study, the application of Ag2S nanoparticles in ocular imaging was extended by preparing them with a biocompatible amphiphilic block copolymer. This method protects the photoluminescence properties of the nanoparticles and allows for the controlled preparation of submicrometric scattering centers, enhancing colloidal stability and biocompatibility. The resulting nanoparticles exhibit improved contrast for optical coherence tomography and near-infrared imaging.
Article
Environmental Sciences
Pravalika Butreddy, Swaroop Chakraborty, Pushpanjali Soppina, Rakesh Behera, Virupakshi Soppina, Superb K. Misra
Summary: This study developed a dual-labelling technique for CuO nanoparticles, allowing for the measurement of uptake, accumulation, and biodistribution at low concentrations. The experiment demonstrated the stability and distribution of the nanoprobes in vivo, indicating their potential as novel nanoprobes for toxicological studies.
Article
Optics
Jun Yu, Zhengxiang Shen, Zhanshan Wang
Summary: This Letter reports a dual band/dual FOV infrared imaging system with a freeform prism, which folds the optical path to enhance detection capability. The system offers advantages of smaller volume, higher integration, and optical efficiency compared to traditional infrared imaging systems.
Review
Radiology, Nuclear Medicine & Medical Imaging
Mariza Vorster
Summary: Inflammation plays a crucial role in various chronic diseases, especially within the cardiovascular system. Early detection and monitoring of inflammation can improve patient management and outcomes. Key factors involved in inflammation pathophysiology include chemokines, macrophages, neutrophils, fibroblasts, integrins, and reactive oxygen species.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Ruixue Wei, Yang Liu, Jinhao Gao, V. Wee Yong, Mengzhou Xue
Summary: The study developed iron-based nanoparticles for dual brain MRI and fluorescence imaging studies to improve the accuracy of brain disease diagnosis. The nanoparticles displayed good biocompatibility, enabling simultaneous MRI and fluorescence imaging, and showed high sensitivity and accuracy in imaging mouse brain tumors.
Article
Biotechnology & Applied Microbiology
Hyla Allouche-Arnon, Olga Khersonsky, Nishanth D. Tirukoti, Yoav Peleg, Orly Dym, Shira Albeck, Alexander Brandis, Tevie Mehlman, Liat Avram, Talia Harris, Nirbhay N. Yadav, Sarel J. Fleishman, Amnon Bar-Shir
Summary: This research utilizes the MRI system GeneREFORM for two-color imaging, improving the detection of transgene expression in live animals. By designing orthogonal reporter genes and reporter probes, dynamic proton exchange MRI imaging is achieved, paving the way for future deep-tissue multiplexed imaging of gene expression in live animals.
NATURE BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jin Wang, Yinhang Jia, Qiyue Wang, Zeyu Liang, Guangxu Han, Zejun Wang, Jiyoung Lee, Meng Zhao, Fangyuan Li, Ruiliang Bai, Daishun Ling
Summary: The article introduces a T-1-T-2 dual-mode contrast agent designed for ultrahigh-field MRI, which not only improves resolution and signal-to-noise ratio, but also effectively displays microvasculature structures with high sensitivity and accuracy in detecting tumor vascular permeability.
ADVANCED MATERIALS
(2021)
Article
Polymer Science
Pengcheng Yuan, Xiaodan Xu, Bing Xiao, Xueying Shi, Wei Zhang, Hongxia Xu, Ying Piao, Youqing Shen, Nigel K. H. Slater, Jianbin Tang
Summary: This study for the first time employed a dual-channel NIR probe for effective prolonged hypoxia ratio imaging. The probe had hypoxia targeting and activation capacity, allowing monitoring of probe distribution and activation in the hypoxic tumor microenvironment.
Article
Nanoscience & Nanotechnology
Kristopher Amrhein, Mitchell Lee Taylor, Raymond Wilson, Caleb Edward Gallops, Assam Annamer, Vojtech Vinduska, Elyahb Allie Kwizera, Hongmei Zhang, Yongmei Wang, Thang Ba Hoang, Xiaohua Huang
Summary: Dual imaging single vesicle technology (DISVT) enables accurate detection and monitoring of cancer-associated extracellular vesicles (EVs) in body fluids. It uses plasmonic gold nanoparticles (AuNPs) to label and detect surface protein markers on individual EVs, allowing for fast analysis through fluorescence and light scattering imaging. DISVT can effectively detect early stage HER2-positive breast cancer and differentiate between HER2-positive and HER2-negative breast cancer. Furthermore, DISVT can quantify tumor-associated EVs and has shown triple the amount in locally advanced patients compared to early-stage patients. This highlights the potential of DISVT as a facile and highly sensitive method for early cancer detection and quantitative monitoring.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Yuemei Li, Yongmei Li
Summary: This study presents a new method that simultaneously alters multicolor upconversion luminescence (UCL) and improves overall UCL intensity, with a particular focus on enhancing the red-emission bands. By doping with transition metal Cu2+, a remarkably enhanced temperature sensitivity at ultralow temperatures was observed in Yb/Cu co-doped NaErF4. Varying the Cu2+ concentration effectively controlled the structure, allowing for blue, green, and red UCL output. Cu2+-doped upconversion nanoparticles (UCNPs) showed a large enhancement across the entire UCL spectrum compared to UCNPs without Cu2+ doping, which resulted from non-radiative energy transfer between Cu2+ and Er3+.
Article
Chemistry, Multidisciplinary
Trevon Badloe, Yeseul Kim, Joohoon Kim, Hyemi Park, Aleksandr Barulin, Yen N. Diep, Hansang Cho, Won-Sik Kim, Young-Ki Kim, Inki Kim, Junsuk Rho
Summary: In this paper, a dual-mode metalens integrated with a liquid crystal cell capable of electrically switching between bright-field and edge-enhanced imaging on the millisecond scale is designed and experimentally realized. The metalens, designed using the concepts of geometric and propagation phase and physically encoded with hydrogenated amorphous silicon, demonstrates the ability to focus and generate vortex under different states of circular polarization, proving its use for biological imaging. This work provides a compact form factor for in vivo observation and monitoring of cell response and drug screening.
Article
Optics
Jilian Xu, Zhiyuan Yue, Peiyao Lu, Rui Wu, Kun Jiang, Xiquan Jiang, Shuyun Teng
Summary: In this study, optical imaging with wavelength multiplexing and polarization multiplexing was performed using holographic metasurfaces. Different imaging effects were achieved, and the compact structure and low noise of the metasurface were confirmed.
CHINESE OPTICS LETTERS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Young-Do Kwon, Youngjoo Byun, Hee-Kwon Kim
Summary: Dual positron emission tomography (PET)/optical imaging techniques have attracted scientific interest for clinical applications. The use of F-18-labelled BODIPY dyes has been proven to be practical as a hybrid PET/optical imaging probe.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Peng Zhang, Yaowei Zhu, Chunsheng Xiao, Xuesi Chen
Summary: Theranostics has attracted great attention for its ability to combine real-time cancer diagnosis with efficient treatment. Activatable dual-functional molecular agents can be synthesized by combining imaging agents, therapeutic agents, stimuli-responsive linkers, and/or targeting molecules. These agents can be activated by overexpressed physiological stimuli or external triggers at tumor sites to release imaging agents and cytotoxic drugs, offering advantages such as a high signal-to-noise ratio, low toxicity, and improved therapeutic effects. This review summarizes recent advances in dual-functional molecular agents for cancer theranostics, including molecular designs, synthetic strategies, activatable mechanisms, and biomedical applications, as well as discussing challenges and opportunities in this field.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Analytical
Shan Mao, Huaile Nie, Tao Lai, Na Xie
Summary: This study investigates the influence of ambient temperature on the diffraction efficiency of multi-layer diffractive optical elements (MLDOEs) and proposes a computational imaging method to improve the imaging quality.
