Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity

DNA damage foci: Meaning and significance

(2015) Kai Rothkamm et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

(2015) Marcel Reuter et al.   JOURNAL OF CELL BIOLOGY

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

A mechanism for the suppression of homologous recombination in G1 cells

(2015) Alexandre Orthwein et al.   NATURE

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Rad51 Paralog Complexes BCDX2 and CX3 Act at Different Stages in the BRCA1-BRCA2-Dependent Homologous Recombination Pathway

(2012) J. Chun et al.   MOLECULAR AND CELLULAR BIOLOGY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51

(2011) Kazuhiko Ochiai et al.   FEBS LETTERS

Comprehensive Genomic Analysis of a BRCA2 Deficient Human Pancreatic Cancer

(2011) Louise J. Barber et al.   PLoS One

Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms

(2011) A. Carreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasticity of BRCA2 Function in Homologous Recombination: Genetic Interactions of the PALB2 and DNA Binding Domains

(2011) Nicolas Siaud et al.   PLoS Genetics

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Purified human BRCA2 stimulates RAD51-mediated recombination

(2010) Ryan B. Jensen et al.   NATURE

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA

(2010) Jie Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA

(2010) Tina Thorslund et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination

(2010) Rémi Buisson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

(2010) Eloïse Dray et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The BRC Repeats of BRCA2 Modulate the DNA-Binding Selectivity of RAD51

(2009) Aura Carreira et al.   CELL

DNA-binding Domain within the Brh2 N Terminus Is the Primary Interaction Site for Association with DNA

(2009) Qingwen Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase

(2009) Eeson Rajendra et al.   NUCLEIC ACIDS RESEARCH

Linking the Cellular Functions of BRCA Genes to Cancer Pathogenesis and Treatment

(2008) Ashok R. Venkitaraman   Annual Review of Pathology-Mechanisms of Disease

A Syngeneic Variance Library for Functional Annotation of Human Variation: Application to BRCA2

(2008) T. Hucl et al.   CANCER RESEARCH

The consequences of Rad51 overexpression for normal and tumor cells

(2008) Hannah L. Klein   DNA REPAIR

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

(2008) Wataru Sakai et al.   NATURE