Article
Fisheries
Lalitphan Kitsanayanyong, Yuki Ishikawa, Toshiaki Ohshima
Summary: This study aimed to investigate the molecular information and gene expression of putative ETTs in three commercially important salmonid species, and develop a universal primer set for these fish species. Results showed the presence of putative ETT genes in these salmonids, with a correlation between ETT expression and ET concentration. The study provides insights into the potential supplementation of ET in salmonid aquaculture to prevent oxidative damage and discoloration of flesh.
Article
Agricultural Engineering
Tommaso Cogliano, Rosa Turco, Vincenzo Russo, Martino Di Serio, Riccardo Tesser
Summary: This study proposes a H-1 NMR-based method for rapid determination of conversion, yield, and selectivity in the epoxidation of organic substrates. Comparisons with traditional volumetric methods validate the feasibility of the proposed method.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Microbiology
Taghreed Khaled Abdelmoneim, Mahmoud S. M. Mohamed, Ismail Abdelshafy Abdelhamid, Sara Fareed Mohamed Wahdan, Mohamed A. M. Atia
Summary: The structure and dynamic of soil bacterial community are crucial for soil health and plant productivity. However, there is a gap in studying the un-/or reclaimed soil bacteriome and its impact on future plant performance. This study aims to validate taxon-specific qPCR primer-panel and analyze the physicochemical properties, bacteriome composition, and wheat productivity in three soils in Egypt. The results show that the taxon-specific qPCR primer-panel is a cheaper and accurate alternative to 16S NGS analysis, and the abundance of Proteobacteria and Actinobacteria in 'Q' soil positively impact wheat productivity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Maja Frankiewicz, Malgorzata Sznitowska
Summary: The Design of Experiment was used to optimize the fluid bed coating process for minitablets, indicating critical process parameters for different types of minitablets through statistical analysis. This optimization process allows for the prediction of values necessary to obtain high-quality products.
Article
Biochemistry & Molecular Biology
Tomasz Wozniak, Weronika Sura, Marta Kazimierska, Marta Elzbieta Kasprzyk, Marta Podralska, Agnieszka Dzikiewicz-Krawczyk
Summary: In this study, we developed an online tool called transCRISPR for searching sequence motifs and designing sgRNAs in user-provided genomic regions. The tool provides user-friendly tables and visualizations summarizing the features of identified motifs and designed sgRNAs. Experimental validation showed that sgRNAs designed by transCRISPR efficiently disrupted MYC binding sites and affected the expression of MYC-regulated genes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Alice Kasemiire, Hermane T. Avohou, Charlotte De Bleye, Pierre-Yves Sacre, Elodie Dumont, Philippe Hubert, Eric Ziemons
Summary: The optimization of pharmaceutical bioprocesses faces challenges such as complexity and regulatory approval, but statistical design of experiments (DoE) is a powerful tool that can help scientists understand the impact of critical process parameters on quality attributes. Optimizing bioprocess using DoE methodology can lead to potential benefits.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Biochemical Research Methods
Sofia Persson, Christina Larsson, Magnus Simonsson, Patrik Ellstrom
Summary: This paper presents a new R/Bioconductor package, rprimer, for designing degenerate oligos and PCR assays for sequence variable viruses. It uses a multiple DNA sequence alignment as input and provides comprehensive tables and plots as outputs. The package is praised for its speed, flexibility in oligo design, and capacity for visualization.
BMC BIOINFORMATICS
(2022)
Article
Automation & Control Systems
Chengcai Wang, Wenyu Cai, Jun Lu, Xilun Ding, Jianying Yang
Summary: This article presents the mechatronic design, modeling, formation control, and experiments of multiple autonomous underwater vehicles (AUVs), focusing on the structure of the AUV, mathematical model for tracking control, and control framework based on leader-follower control law and ADRC. The stability and convergence properties of the algorithm have been analyzed using the Lyapunov stability method. Numerical simulations and field experiments show the good motion ability of the self-designed AUVs and verify the feasibility of the proposed control approach.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Nuvia Kantun-Moreno, Guadalupe Ayora-Talavera, Maria del Refugio Gonzalez-Losa, Jesus Gomez-Carballo, Laura Conde-Ferraez
Summary: High-risk Human Papillomavirus (HR-HPV) types 16 and 18 are responsible for a large proportion of HPV-related cancers worldwide. Efforts have been made to study these genotypes, particularly the oncogenic genes in the early region. This data report describes the design of primers for the early region of HPV16 and HPV18, which allows for highly specific and efficient real-time PCR.
Article
Oncology
Michael Yulong Wu, Richard J. Mcgregor, Justin Scott, B. Mark Smithers, Janine Thomas, Adam Frankel, Andrew Barbour, Iain Thomson
Summary: The study evaluated the use of TBO in assessing the outcomes of esophageal cancer surgery in a single specialist unit with low disease incidence, and compared the results with international specialist centers. TBO was found to be associated with improved overall survival and could be used as a benchmark for surgical quality.
Article
Engineering, Industrial
Fan Jiang, Matthias Hwai Yong Tan, Kwok-Leung Tsui
Summary: This article discusses a quality improvement method called Robust Parameter Design (RPD) for mitigating input noise effects on system output quality. It extends the Joseph-Wu formulation of multi-target RPD to multiple functional outputs, utilizing a Gaussian Process emulator for efficient optimization of signal and control factors. The use of a separable GP model and computational efficiency in deriving formulas for posterior means and building credible intervals are key aspects of the approach.
Article
Engineering, Multidisciplinary
Sagar Adatrao, Simone van der Velden, Mark-Jan van der Meulen, Marc Cruellas Bordes, Andrea Sciacchitano
Summary: This paper introduces a statistical tool called design of experiments (DOEs) for uncertainty quantification in particle image velocimetry (PIV). The tool allows for quantifying both the total and systematic uncertainties arising from various experimental factors. By measuring a quantity multiple times while varying the levels of experimental factors, the total variance and uncertainty can be computed using Analysis of Variances. The approach also provides individual variances for each factor, estimating their contributions to the total uncertainty.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Psychology, Mathematical
Inbal Nahum-Shani, John J. Dziak, Hanna Venera, Angela F. Pfammatter, Bonnie Spring, Walter Dempsey
Summary: Psychological interventions often involve multiple components delivered and adapted on different timescales. The hybrid experimental design (HED) is a new approach that allows researchers to study the construction of these interventions. This article highlights the flexibility of HED as a factorial design and explains how data from different types of HEDs can be analyzed to answer various scientific questions about multicomponent interventions.
BEHAVIOR RESEARCH METHODS
(2023)
Article
Construction & Building Technology
James T. O'Connor, Hyun Jeong Koo
Summary: Building projects have become increasingly complex due to improving technology, demand for sophisticated design, and more project stakeholders. This study developed a design quality assessment tool based on causal factors and impacts of high-priority design defects, derived from interviews with industry professionals. The implementation tool enables timely assessment of project design quality and risk prevention.
JOURNAL OF CONSTRUCTION ENGINEERING AND MANAGEMENT
(2021)
Article
Engineering, Mechanical
Quanhui Wu, Yazhou Sun, Baisong Pan, Dawei Gu
Summary: This paper presents a combined design, performance analysis, and experimental verification of an ultra-precision aerostatic turning machine tool (UPATMT). The UPATMT utilizes aerostatic support systems for the spindle system and the feed system. Mathematical and physical models are established, and the dynamic performance of UPATMT is analyzed using the finite element method. The electromechanical control system is simulated and analyzed to improve the dynamic performance. Modal tests and turning experiments are conducted, and the results demonstrate high machining performance with surface roughness meeting the requirements for high-quality optical components.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART C-JOURNAL OF MECHANICAL ENGINEERING SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Hyerin Kim, NaNa Kang, KyuHyeon An, Doyun Kim, JaeHyung Koo, Min-Soo Kim
NUCLEIC ACIDS RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
TaeHo Cho, ChaeEun Lee, NaHye Lee, Yu Ri Hong, JaeHyung Koo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
NaHye Lee, YoonGyu Jae, Minhyung Kim, TaeHo Cho, ChaeEun Lee, Yu Ri Hong, Do Young Hyeon, Sanghyun Ahn, Hongmok Kwon, Kyul Kim, Jae Hoon Jung, Sehyun Chae, Jeong-Oh Shin, Jinwoong Bok, Youngjoo Byun, Daehee Hwang, JaeHyung Koo
Article
Biochemistry & Molecular Biology
YoonGyu Jae, NaHye Lee, Dae Won Moon, JaeHyung Koo
Article
Multidisciplinary Sciences
Sri Murugan Poongkavithai Vadevoo, Gowri Rangaswamy Gunassekaran, ChaeEun Lee, NaHye Lee, Jiyoun Lee, Sehyun Chae, Jae-Yong Park, JaeHyung Koo, Byungheon Lee
Summary: The study suggests that Olfr78 can sense tumor-derived lactate and, in conjunction with Gpr132, mediate the generation of protumoral M2-TAMs. The interaction between Olfr78 and lactate may serve as a therapeutic target for reducing tumor progression and metastasis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Woochan Choi, Sang Eun Ryu, YongJin Cheon, Yeon-Ji Park, Seoyeong Kim, Eunhee Kim, JaeHyung Koo, Hongsoo Choi, Cheil Moon, Kyuhyung Kim
Summary: This study reveals the mechanism by which animals switch their behaviors based on the concentration of a chemical through connecting two different types of chemosensory neurons.
Article
Biochemistry & Molecular Biology
Hyeon Jeong Lee, Cheol Ryong Ku, Arthur Cho, TaeHo Cho, ChaeEun Lee, Chan Woo Kang, Daham Kim, Yoon Hee Cho, JaeHyung Koo, Eun Jig Lee
Summary: By studying the expression of odorant receptor signals and the presence of olfactory marker protein in parafollicular C-cells, researchers have found that OR51E2 may be a novel diagnostic and therapeutic target for medullary thyroid cancer.
Article
Biochemistry & Molecular Biology
Yu Sun Jeong, Sunghyun Huh, Ji Cheol Kim, Ji Ye Park, ChaeEun Lee, Min-Sik Kim, JaeHyung Koo, Yoe-Sik Bae
Summary: In this study, a metabolite called 2-undecanone derived from P. aeruginosa was found to regulate neutrophil activities. While 2-undecanone activated neutrophils, it also inhibited their response to P. aeruginosa by inducing apoptosis. This suggests that P. aeruginosa produces inhibitory metabolites as a strategy to evade the host immune system.
Article
Biochemistry & Molecular Biology
Ju Hun Oh, Ye Eon Han, Ya Ru Bao, Chan Woo Kang, JaeHyung Koo, Cheol Ryong Ku, Yoon Hee Cho, Eun Jig Lee
Summary: The involvement of smell receptors in regulating blood sugar and the release of glucagon suggests that targeting olfactory receptor signaling in the pancreas could potentially reduce excessive glucagon activity, which is associated with diseases such as type 2 diabetes.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Chan Chung, Hee Jin Cho, ChaeEun Lee, JaeHyung Koo
Summary: This review discusses the expression of ORs receptors in various types of cancer and their association with signaling mechanisms. Analysis of gene expression data in cancer patients suggests that ORs receptors may serve as cancer biomarkers and therapeutic targets.
Review
Biochemistry & Molecular Biology
Hee Jin Cho, JaeHyung Koo
Summary: Odorant receptors in glioma exhibit specific expression patterns, serving as potential biomarkers and therapeutic targets for the disease.
Article
Biochemistry & Molecular Biology
Chan Woo Kang, Ye Eon Han, Mi Kyung Lee, Yoon Hee Cho, NaNa Kang, JaeHyung Koo, Cheol Ryong Ku, Eun Jig Lee
EXPERIMENTAL AND MOLECULAR MEDICINE
(2018)
Article
Chemistry, Medicinal
Bernie Byunghoon Park, NaHye Lee, YunHye Kim, YoonGyu Jae, Seunghyun Choi, NaNa Kang, Yu Ri Hong, Kiwon Ok, Jeonghee Cho, Young Ho Jeon, Eun Hee Lee, Youngjoo Byun, JaeHyung Koo
Article
Dentistry, Oral Surgery & Medicine
Doyun Kim, Sena Chung, Sung Ho Lee, Jae Hyung Koo, Jong-Ho Lee, Jeong Won Jahng
ARCHIVES OF ORAL BIOLOGY
(2017)
Article
Medicine, Research & Experimental
NaHye Lee, Moonsun Sa, Yu Ri Hong, C. Justin Lee, JaeHyung Koo
EXPERIMENTAL NEUROBIOLOGY
(2018)