Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathwayin vivo

Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

(2015) R. Somasundaram et al.   BLOOD

Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes

(2015) A. M. Fedoriw et al.   DEVELOPMENT

Combined heterozygous loss ofEbf1andPax5allows for T-lineage conversion of B cell progenitors

(2015) Jonas Ungerbäck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links

(2015) M. Raschle et al.   SCIENCE

Why does the bone marrow fail in Fanconi anemia?

(2013) J. I. Garaycoechea et al.   BLOOD

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

(2012) Raphael Ceccaldi et al.   Cell Stem Cell

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

The Vital Role of Polymerase ζ and REV1 in Mutagenic, but Not Correct, DNA Synthesis across Benzo[a]pyrene-dG and Recruitment of Polymerase ζ by REV1 to Replication-stalled Site

(2012) Keiji Hashimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular pathogenesis and clinical management of Fanconi anemia

(2012) Younghoon Kee et al.   JOURNAL OF CLINICAL INVESTIGATION

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function

(2012) Juan I. Garaycoechea et al.   NATURE

The E3 ubiquitin ligase RAD18 regulates ubiquitylation and chromatin loading of FANCD2 and FANCI

(2011) S. A. Williams et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition

(2011) Komaraiah Palle et al.   CELL CYCLE

Impaired functionality and homing of Fancg-deficient hematopoietic stem cells

(2011) Vilma Barroca et al.   HUMAN MOLECULAR GENETICS

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice

(2011) Frédéric Langevin et al.   NATURE

Expanded roles of the Fanconi anemia pathway in preserving genomic stability

(2010) Y. Kee et al.   GENES & DEVELOPMENT

Rad18-mediated Translesion Synthesis of Bulky DNA Adducts Is Coupled to Activation of the Fanconi Anemia DNA Repair Pathway

(2010) Ihn Young Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAD18-mediated ubiquitination of PCNA activates the Fanconi anemia DNA repair network

(2010) Liyi Geng et al.   JOURNAL OF CELL BIOLOGY

Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1

(2010) Kalindi Parmar et al.   STEM CELLS

Bone marrow lymphoid and myeloid progenitor cells are suppressed in 7,12-dimethylbenz(a)anthracene (DMBA) treated mice

(2010) A.U. N’jai et al.   TOXICOLOGY

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

Differential p53 Engagement in Response to Oxidative and Oncogenic Stresses in Fanconi Anemia Mice

(2008) R. Rani et al.   CANCER RESEARCH

Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks

(2008) Yuri Tsuji et al.   GENES TO CELLS

Rad18 is required for long-term maintenance of spermatogenesis in mouse testes

(2008) Jinghua Sun et al.   MECHANISMS OF DEVELOPMENT

Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A

(2008) Adelina A. Davies et al.   MOLECULAR CELL