Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion

Silencing of the glycerophosphocholine phosphodiesterase GDPD5 alters the phospholipid metabolite profile in a breast cancer modelin vivoas monitored by31P MRS

(2014) J. P. Wijnen et al.   NMR IN BIOMEDICINE

RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch

(2014) L A Walsh et al.   ONCOGENE

EDI3 links choline metabolism to integrin expression, cell adhesion and spreading

(2014) Michaela S Lesjak et al.   Cell Adhesion & Migration

Choline kinase-alpha by regulating cell aggressiveness and drug sensitivity is a potential druggable target for ovarian cancer

(2013) A Granata et al.   BRITISH JOURNAL OF CANCER

High NaCl- and urea-induced posttranslational modifications that increase glycerophosphocholine by inhibiting GDPD5 phosphodiesterase

(2013) S. Topanurak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GDE2 Promotes Neurogenesis by Glycosylphosphatidylinositol-Anchor Cleavage of RECK

(2013) S. Park et al.   SCIENCE

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Evaluation of Breast Cancer Using Proton MR Spectroscopy: Total Choline Peak Integral and Signal-to-Noise Ratio as Prognostic Indicators

(2012) Hee Jung Shin et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy

(2012) Maria D Cao et al.   BMC CANCER

New Opportunities from the Cancer Metabolome

(2012) O. A. Aboud et al.   CLINICAL CHEMISTRY

MR-Spectroscopy at 1.5 tesla and 3 tesla. Useful? A systematic review and meta-analysis

(2012) Pascal A.T. Baltzer et al.   EUROPEAN JOURNAL OF RADIOLOGY

Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer

(2012) Maria D. Cao et al.   NMR IN BIOMEDICINE

Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis

(2012) J. D. Stewart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Integration of Metabolomics and Expression of Glycerol-3-phosphate Acyltransferase (GPAM) in Breast Cancer—Link to Patient Survival, Hormone Receptor Status, and Metabolic Profiling

(2011) Scarlet F. Brockmöller et al.   JOURNAL OF PROTEOME RESEARCH

Predicting long-term survival and treatment response in breast cancer patients receiving neoadjuvant chemotherapy by MR metabolic profiling

(2011) Maria D. Cao et al.   NMR IN BIOMEDICINE

Distinct choline metabolic profiles are associated with differences in gene expression for basal-like and luminal-like breast cancer xenograft models

(2010) Siver A Moestue et al.   BMC CANCER

Activation of Phosphatidylcholine Cycle Enzymes in Human Epithelial Ovarian Cancer Cells

(2010) E. Iorio et al.   CANCER RESEARCH

Choline kinase overexpression increases invasiveness and drug resistance of human breast cancer cells

(2010) Tariq Shah et al.   NMR IN BIOMEDICINE

Noninvasive Detection of Lentiviral-Mediated Choline Kinase Targeting in a Human Breast Cancer Xenograft

(2009) B. Krishnamachary et al.   CANCER RESEARCH

Multivariate Modeling and Prediction of Breast Cancer Prognostic Factors Using MR Metabolomics

(2009) Guro F. Giskeødegård et al.   JOURNAL OF PROTEOME RESEARCH

Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

(2009) A Yalcin et al.   ONCOGENE

Proton MR spectroscopy for monitoring early treatment response of breast cancer to neo-adjuvant chemotherapy

(2008) H.-M. Baek et al.   ANNALS OF ONCOLOGY

GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC

(2008) M. Gallazzini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA