Review
Medicine, General & Internal
Anders Edsjo, Louise Holmquist, Birgit Geoerger, Frederique Nowak, Georgy Gomon, Catherine Alix-Panabieres, Carolin Ploeger, Ulrik Lassen, Christophe Le Tourneau, Janne Lehtio, Patrick A. Ott, Andreas von Deimling, Stefan Froehling, Emile Voest, Frederick Klauschen, Rodrigo Dienstmann, Aisha Alshibany, Lillian L. Siu, Albrecht Stenzinger
Summary: Precision cancer medicine requires the involvement and commitment of many stakeholders and can be improved through advancements in molecular diagnostics and clinical trial concepts. Adaptive profiling strategies and early detection approaches are becoming routine in patient management. Collaborative efforts and multicentric networks are crucial in implementing precision oncology in practice.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
History & Philosophy Of Science
Benjamin Chin-Yee, Anya Plutynski
Summary: This article provides a philosophical analysis of actionability in precision oncology, aiming to clarify its conceptual definition. It identifies distinct concepts of actionability and argues that each concept should be understood as an objective category in specific contexts to minimize conceptual slippage. The article supports interactive pluralism, highlighting the importance of different concepts and their interaction, serving as a case study to examine competing views on scientific pluralism.
PHILOSOPHY OF SCIENCE
(2023)
Article
Medicine, General & Internal
Min Gu Park, Sung Yong Cho, Se Yun Kwon, Hoon Choi, Jeong Woo Lee
Summary: The study found that male patients in the HA group were older, had longer hospital stays, more underlying diseases, and higher rates of bacteremia and intensive care unit admissions. Escherichia coli was the most commonly cultured microorganism. Sensitivity to fluoroquinolone and the proportion of extended-spectrum beta-lactamase-producing bacteria were higher in the CA group than in the HA group.
Article
Medicine, General & Internal
Gregory M. Marcus, David G. Rosenthal, Gregory Nah, Eric Vittinghoff, Christina Fang, Kelsey Ogomori, Sean Joyce, Defne Yilmaz, Vivian Yang, Tara Kessedjian, Emily Wilson, Michelle Yang, Kathleen Chang, Grace Wall, Jeffrey E. Olgin
Summary: The study observed the acute health effects of caffeinated coffee consumption and found that compared to avoiding caffeine, consuming caffeinated coffee resulted in more premature ventricular contractions and more daily steps, but had no significant impact on premature atrial contractions and sleep duration.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
David A. Talan, Salomone Di Saverio
Summary: Treatment options for acute uncomplicated appendicitis include surgery or nonoperative care, with patients advised to consider the advantages and disadvantages of each approach and participate in decision making. Around 30 to 40% of patients treated with antibiotics may undergo appendectomy over a period of 5 years, with rates varying based on patient characteristics and practice patterns.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Tove Wasterlid, Lucia Cavelier, Claudia Haferlach, Marina Konopleva, Stefan Froehling, Paivi Ostling, Lars Bullinger, Thoas Fioretos, Karin E. Smedby
Summary: Precision medicine is improving patient care in cancer by utilizing specific genetic knowledge for accurate diagnosis and treatment choices. However, the complex genetic landscape of hematological malignancies poses challenges for implementing precision medicine.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Automation & Control Systems
Lingchao Mao, Lujia Wang, Leland S. Hu, Jenny M. Eschbacher, Gustavo De Leon, Kyle W. Singleton, Lee A. Curtin, Javier Urcuyo, Chris Sereduk, Nhan L. Tran, Andrea Hawkins-Daarud, Kristin R. Swanson, Jing Li
Summary: Precision medicine aims to provide individualized diagnosis and treatment. Transfer learning (TL) addresses the challenge of limited labeled samples by leveraging information from other patients. We propose a weakly-supervised TL approach that integrates domain knowledge and deals with limited labeled samples in the target domain. Experimental results on brain cancer prediction demonstrate the high accuracy and usefulness of our approach for personalized treatment.
IEEE TRANSACTIONS ON AUTOMATION SCIENCE AND ENGINEERING
(2023)
Review
Dentistry, Oral Surgery & Medicine
P. Mark Bartold, Saso Ivanovski
Summary: P4 Periodontics is a comprehensive, integrative, and proactive approach to periodontal treatment that emphasizes the four pillars of prediction, prevention, personalization, and participation. It is highly aligned with the 2018 Classification of Periodontal Diseases and introduces the concept of a treat-to-target focus for personalized treatment outcomes, as well as the application of personalized regenerative and rejuvenative periodontal therapies.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Health Care Sciences & Services
Marcella J. Jewell, JoAnna Leyenaar, Meng-Shiou Shieh, Penelope S. Pekow, Mihaela Stefan, Peter K. Lindenauer
Summary: This study identified unnecessary antibiotic use in hospitalized children with asthma and found that children with complex chronic conditions, admitted to the ICU, and hospitalized in general hospitals lacking pediatric specialty support were more likely to receive antibiotic treatment.
BMJ QUALITY & SAFETY
(2021)
Review
Genetics & Heredity
Muzamil Khawaja, Rehma Siddiqui, Salim S. Virani, Christopher I. Amos, Dhrubajyoti Bandyopadhyay, Hafeez Ul Hassan Virk, Mahboob Alam, Hani Jneid, Chayakrit Krittanawong
Summary: Acute myocardial infarction is a major contributor to global mortality, with a growing burden. The complex pathophysiology involves various acquired and inherited risk factors. As technology and medical therapy advance, the role of genetics in the development and management of myocardial infarction is increasingly recognized. Genomic studies have expanded the understanding of genetic determinants and the potential for personalized medicine and improved treatment strategies. This article reviews relevant genes and provides updates on gene-guided risk stratification and treatment strategies for acute myocardial infarction.
Article
Oncology
Alice S. Mims, Jessica Kohlschmidt, Uma Borate, James S. Blachly, Shelley Orwick, Ann-Kathrin Eisfeld, Dimitrios Papaioannou, Deedra Nicolet, Krzysztof Mrozek, Eytan Stein, Bhavana Bhatnagar, Richard M. Stone, Jonathan E. Kolitz, Eunice S. Wang, Bayard L. Powell, Amy Burd, Ross L. Levine, Brian J. Druker, Clara D. Bloomfield, John C. Byrd
Summary: This study classified older AML patients based on genomic algorithm and found different outcomes among different genomic groups. Patients with core-binding factor and NPM1-mutated/FLT3-ITD-negative had the best outcomes, while other groups had poorer outcomes. The use of genomic algorithm may guide treatment and research for AML patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Alex Rogers Aguiar Zanin, Danilo Carvalho Neves, Larissa Pereira Ribeiro Teodoro, Carlos Antonio da Silva Junior, Simone Pereira da Silva, Paulo Eduardo Teodoro, Fabio Henrique Rojo Baio
Summary: This study successfully reduced pesticide application and production costs for soybean and maize crops in the Brazilian Cerrado region using a site-specific spraying application based on real-time sensors. The precision spraying system significantly decreased the volume of pesticides used, without affecting crop yields.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Thai Hoa Tran, Stephen P. Hunger
Summary: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and has shown significant improvement in survival rates through risk-adapted chemotherapy, prevention measures, and molecular analysis. However, challenges remain for older patients and relapsed/refractory cases.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Jiani Yang, Shan Huang, Shanshan Cheng, Yue Jin, Nan Zhang, Yu Wang
Summary: Ovarian cancer organoids provide a three-dimensional platform for research, helping to simulate biological characteristics and tumor heterogeneity, contributing to personalized therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Infectious Diseases
Hubert C. Chua, Andy Tse, Nicholas M. Smith, Kari A. Mergenhagen, Raymond Cha, Brian T. Tsuji
Summary: Antimicrobial pharmacokinetics/pharmacodynamics (PK/PD) principles and models play a crucial role in understanding antibiotic killing mechanisms and optimizing dosing regimens for clinical outcomes. Personalized dosing based on proper pharmacokinetic sampling can enhance efficacy and minimize toxicity, while the development of integrated mechanistic models can further improve individualized dosing regimens.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
