Journal
NEW JOURNAL OF CHEMISTRY
Volume 40, Issue 3, Pages 2145-2155Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nj02391b
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Funding
- UGC
- CSIR
- CSIR, New Delhi
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The present study deals with the synthesis of ZnO nanoflowers (ZnO-1 and ZnO-2) at room temperature using new structurally characterized single molecular precursors (1 and 2). 1, 2 and ZnO-1 were explored for their potential to reduce the viability of the Gram-negative bacteria Escherichia coli. 1 and 2 were found to be promising antibacterial agents, while the ZnO nanoflowers demonstrated a relatively nontoxic nature. 1, 2 and ZnO-1 were further evaluated for DNA binding and cleavage behaviour. 1 and 2 showed strong binding affinity towards CT-DNA compared to ZnO-1. In addition, all the three compounds demonstrated oxidative cleavage of pBluescript plasmid DNA in the presence of H2O2.
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