Article
Gastroenterology & Hepatology
Chuan-Guo Guo, Ka Shing Cheung, Feifei Zhang, Esther W. Chan, Lijia Chen, Ian C. K. Wong, Wai K. Leung
Summary: This retrospective study in Hong Kong found that patients failed by initial H. pylori eradication have an increased risk of upper gastrointestinal bleeding compared to patients who responded to the initial therapy, and the risk increased progressively with longer time until retreatment. Therefore, early retreatment within 3 months should be considered to minimize subsequent risk of upper gastrointestinal bleeding.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Josh Orpen-Palmer, Adrian J. Stanley
Summary: Upper gastrointestinal bleeding is a common medical emergency that requires thorough assessment and resuscitation to stabilize the patient. Risk scores are important in distinguishing between low- and high-risk patients, allowing for appropriate outpatient or inpatient management. Advances in machine learning and artificial intelligence show promise in predicting poor outcomes and may be used for dynamic risk assessment in the future.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Sang Yong Jo, Jin Hee Noh, Boram Cha, Ji Yong Ahn, Seung-pyo Oh, Jun-young Seo, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Summary: This study investigated the clinical features of upper gastrointestinal bleeding caused by peptic ulcer or Dieulafoy's lesion (DL) and compared the outcomes of endoscopic treatment. The study found that DL requires more frequent endoscopic hemostasis and has a higher rate of rebleeding, even after therapeutic endoscopy.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ali A. Alali, Alan N. Barkun
Summary: Upper gastrointestinal bleeding (UGIB) is a common gastrointestinal emergency that has significant morbidity and mortality. The epidemiology of UGIB has been changing with a decrease in peptic ulcer disease and an increase in other etiologies. Risk assessment and patient stratification are important for optimal care, with some tools able to identify a low-risk group for outpatient management. Primary care providers play a crucial role in resuscitation, stabilizing patients, providing blood transfusions, and arranging urgent endoscopic assessment and intervention. Managing antithrombotic agents in the acute setting remains challenging.
GASTROENTEROLOGY REPORT
(2023)
Review
Gastroenterology & Hepatology
Vikram Kate, Sathasivam Sureshkumar, Balakrishnan Gurushankari, Raja Kalayarasan
Summary: Acute gastrointestinal bleeding is a common surgical emergency associated with high morbidity and mortality. The controversy remains on various management issues, such as appropriate risk stratification, timing of endoscopy, and choosing intervention methods, while drug management also poses a challenge.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Loren Laine, Alan N. Barkun, John R. Saltzman, Myriam Martel, Grigorios I. Leontiadis
Summary: Systematic reviews were conducted to develop recommendations for the management of patients with overt upper gastrointestinal bleeding, suggesting risk assessment and red blood cell transfusion based on hemoglobin levels. Endoscopic therapy is recommended for ulcers with active bleeding or nonbleeding visible vessels, with repeat endoscopy and transcatheter embolization options available if therapy fails.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Samuel Hui, Andy Lim, Elaine Koh, Joshua Abasszade, Aparna Morgan, Pei Y. Tan, Christopher Lemoh, Marcus Robertson
Summary: The prevalence of Vitamin C deficiency (VCD) is high in patients with upper gastrointestinal bleeding (UGIB) and is associated with poor outcomes, including higher mortality, rebleeding, and prolonged hospitalization.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Marcin Strzalka, Marek Winiarski, Marcin Dembinski, Michal Pedziwiatr, Andrzej Matyja, Michal Kukla
Summary: This study evaluated the usefulness of admission venous lactate level in predicting clinical outcomes in patients with upper gastrointestinal bleeding (UGIB). The results showed a significant association between venous lactate levels and mortality, bleeding recurrence, surgical intervention, and intensive care. Lactate levels had a high predictive value for all outcomes, especially mortality and intensive care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jacob E. Kurlander, Geoffrey D. Barnes, Aaron Fisher, J. Gonzalez Juan, Danielle Helminski, Sameer D. Saini, Neil Sengupta, Yu-Xiao Yang, James Scheiman, Loren Laine
Summary: By conducting a systematic review and meta-analysis of observational studies, it was found that proton pump inhibitors (PPIs) can reduce the risk of upper gastrointestinal bleeding in patients using anticoagulants, especially in those with a higher risk of bleeding.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Eun Jeong Gong, Li-chang Hsing, Hyun Il Seo, Myeongsook Seo, Baek Gyu Jun, Jong Kyu Park, Sang Jin Lee, Koon Hee Han, Young Don Kim, Woo Jin Jeong, Gab Jin Cheon, Min-Ju Kim
Summary: In patients with nonvariceal UGIB, nasogastric lavage is useful for predicting the presence of UGIB, improving the management of patients before endoscopy. However, its clinical utility is limited in high-risk patients with a GBS score of 12 or higher.
BMC GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Nicolas Chapelle, Myriam Martel, Marc Bardou, Majid Almadi, Alan N. Barkun
Summary: This study systematically reviewed the effectiveness of Doppler endoscopic probe (DEP) in nonvariceal upper gastrointestinal bleeding (NVUGIB) and found that DEP-related information improves prediction of rebleeding and DEP-guided management reduces overall rebleeding, bleeding-related mortality, and need for surgery in NVUGIB patients.
DIGESTIVE ENDOSCOPY
(2023)
Article
Pharmacology & Pharmacy
Marcela Forgerini, Gustavo Urbano, Tales Rubens de Nadai, Sabrina Setembre Batah, Alexandre Todorovic Fabro, Patricia de Carvalho Mastroianni
Summary: The study found that genetic variants rs10306114 in PTGS1 and rs2070744 in NOS3 were associated with an increased risk of upper gastrointestinal bleeding. The presence of these genetic variants may modify the risk of upper gastrointestinal bleeding in low-dose aspirin and nonsteroidal anti-inflammatory drugs users.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Aurelio Mauro, Federico De Grazia, Marco Vincenzo Lenti, Roberto Penagini, Roberto Frego, Sandro Ardizzone, Edoardo Savarino, Franco Radaelli, Matteo Bosani, Stefania Orlando, Arnaldo Amato, Marco Dinelli, Francesca Ferretti, Elisabetta Filippi, Maurizio Vecchi, Davide Stradella, Marco Bardone, Lodovica Pozzi, Elena Strada, Antonio Di Sabatino
Summary: Upper gastrointestinal bleeding occurred in nearly 0.5% of COVID-19 inpatients, with the majority being on anticoagulant therapy or thromboprophylaxis. Most patients underwent upper GI endoscopy within 24 hours, revealing peptic ulcer as the most common finding. Mortality rate was 21.7% and did not differ between patients who had early or delayed endoscopy.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Surgery
Carlos Robles-Medranda, Roberto Oleas, Juan Alcivar-Vasquez, Miguel Puga-Tejada, Jorge Baquerizo-Burgos, Hannah Pitanga-Lukashok
Summary: The study showed that OTSC treatment is effective and feasible as a first-line therapy for high-risk bleeding peptic ulcers, with comparable costs and patient outcomes as combined therapy, along with a shorter procedure time.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Endocrinology & Metabolism
Ping-Huei Tseng, Chi-Sheng Hung, Chia-Hung Tu, Chien-Chuan Chen, Wan-Chung Liao, Yi-Chia Lee, Han-Mo Chiu, Wei-Shiung Yang, Ming-Shiang Wu
Summary: The study found that higher levels of plasma hemoglobin A1c (HbA1c) are associated with a higher risk of gastrointestinal disorders, particularly acid-related upper GI disorders. Efforts to improve glycemic control may help prevent the development of such complications.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
