Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 18, Pages 3880-3884Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500768
Keywords
catalysis; C-H activation; Heck-type reaction; rhodium; spiro compounds
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Funding
- CNRS
- ICSN
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The rhodium(III)-catalyzed aromatic C-H activation/intramolecular Heck-type reaction has been studied to synthesize spirocyclic compounds, an important class of molecules in medicinal chemistry and natural product synthesis. This approach was efficient with a variety of substituted N-methoxybenzamides tethered to different cyclic alkenes having a 5-, 6- or 7-membered ring. This practical method affords sterically hindered o-substituted aryl spirocycles that are valuable compounds for further functionalization to access relevant building blocks.
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