Clinical Trials in Neurovirology: Successes, Challenges, and Pitfalls

Maraviroc-intensified combined antiretroviral therapy improves cognition in virally suppressed HIV-associated neurocognitive disorder

(2016) Thomas M. Gates et al.   AIDS

Conducting clinical trials in outbreak settings: Points to consider

(2016) H Clifford Lane et al.   Clinical Trials

A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response

(2016) Scott M Berry et al.   Clinical Trials

Evaluating interventions for Ebola: The need for randomized trials

(2016) Thomas R Fleming et al.   Clinical Trials

Statistical considerations for a trial of Ebola virus disease therapeutics

(2016) Michael A Proschan et al.   Clinical Trials

Clinical validation trial of a diagnostic for Ebola Zaire antigen detection: Design rationale and challenges to implementation

(2016) John Schieffelin et al.   Clinical Trials

Long-Term Mortality in HIV-Infected Individuals 50 Years or Older

(2016) Rebecca A. Legarth et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Could antiretroviral neurotoxicity play a role in the pathogenesis of cognitive impairment in treated HIV disease?

(2015) Jonathan Underwood et al.   AIDS

Exploring the ethical and regulatory issues in pragmatic clinical trials

(2015) Robert M Califf et al.   Clinical Trials

Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation

(2014) Viktor Dahl et al.   AIDS

Treating Progressive Multifocal Leukoencephalopathy With Interleukin 7 and Vaccination With JC Virus Capsid Protein VP1

(2014) Mireia Sospedra et al.   CLINICAL INFECTIOUS DISEASES

Neurocognitive Change in the Era of HIV Combination Antiretroviral Therapy: The Longitudinal CHARTER Study

(2014) R. K. Heaton et al.   CLINICAL INFECTIOUS DISEASES

Cerebral metabolite changes prior to and after antiretroviral therapy in primary HIV infection

(2014) A. C. Young et al.   NEUROLOGY

Treatment of Progressive Multifocal Leukoencephalopathy With Interleukin 7

(2014) Karl B. Alstadhaug et al.   JAMA Neurology

Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection

(2013) Tricia H. Burdo et al.   AIDS

Randomized Trial of Central Nervous System–Targeted Antiretrovirals for HIV-Associated Neurocognitive Disorder

(2013) Ronald J. Ellis et al.   CLINICAL INFECTIOUS DISEASES

Sample size formulae for the Bayesian continual reassessment method

(2013) Ying Kuen Cheung   Clinical Trials

Use of central institutional review boards for multicenter clinical trials in the United States: A review of the literature

(2013) Devon K Check et al.   Clinical Trials

Single-patient (n-of-1) trials: a pragmatic clinical decision methodology for patient-centered comparative effectiveness research

(2013) Naihua Duan et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection

(2013) M. J. Peluso et al.   JOURNAL OF INFECTIOUS DISEASES

Cerebrospinal fluid neopterin decay characteristics after initiation of antiretroviral therapy

(2013) Aylin Yilmaz et al.   Journal of Neuroinflammation

A study of mefloquine treatment for progressive multifocal leukoencephalopathy: results and exploration of predictors of PML outcomes

(2013) David B. Clifford et al.   JOURNAL OF NEUROVIROLOGY

Recent issues in herpes simplex encephalitis

(2013) Peter G. E. Kennedy et al.   JOURNAL OF NEUROVIROLOGY

Rivastigmine for HIV-associated neurocognitive disorders: A randomized crossover pilot study

(2013) S. Simioni et al.   NEUROLOGY

PML diagnostic criteria: Consensus statement from the AAN Neuroinfectious Disease Section

(2013) J. R. Berger et al.   NEUROLOGY

HIV DNA Reservoir Increases Risk for Cognitive Disorders in cART-Naïve Patients

(2013) Victor G. Valcour et al.   PLoS One

Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada

(2013) Hasina Samji et al.   PLoS One

Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load

(2012) Michael J. Peluso et al.   AIDS

EFNS-ENS guidelines for the use of PCR technology for the diagnosis of infections of the nervous system

(2012) I. Steiner et al.   EUROPEAN JOURNAL OF NEUROLOGY

Adaptive trial designs: a review of barriers and opportunities

(2012) John A Kairalla et al.   Trials

Progressive multifocal leukoencephalopathy in transplant recipients

(2011) Farrah J. Mateen et al.   ANNALS OF NEUROLOGY

Management of suspected viral encephalitis in adults – Association of British Neurologists and British Infection Association National Guidelines

(2011) T. Solomon et al.   JOURNAL OF INFECTION

Improved Survival of HIV-1-Infected Patients with Progressive Multifocal Leukoencephalopathy Receiving Early 5-Drug Combination Antiretroviral Therapy

(2011) Jacques Gasnault et al.   PLoS One

Treatment Intensification Has no Effect on the HIV-1 Central Nervous System Infection in Patients on Suppressive Antiretroviral Therapy

(2010) Aylin Yilmaz et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance

(2009) Christina M Marra et al.   AIDS

Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro

(2009) M. Brickelmaier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cidofovir in addition to antiretroviral treatment is not effective for AIDS-associated progressive multifocal leukoencephalopathy: a multicohort analysis

(2008) Andrea De Luca et al.   AIDS

Validation of the CNS Penetration-Effectiveness Rank for Quantifying Antiretroviral Penetration Into the Central Nervous System

(2008) Scott Letendre   ARCHIVES OF NEUROLOGY