Article
Medicine, Research & Experimental
Moe Ijiri, Kazuhiro Yoshinaga, Hiroaki Kawaguchi, Naoto Miyazaki, Maiko Kawaguchi, Yoshikazu Fujimoto, Tomohide Matsuo, Ikuro Maruyama
Summary: Through studies on pigs and humans, it was found that 1,5-anhydro-D-fructose (1,5-AF) can be rapidly metabolized to 1,5-anhydro-D-glucitol (1,5-AG) in the body.
Article
Pharmacology & Pharmacy
Raffaella di Vito, Mattia Acito, Cristina Fatigoni, Carl H. Schiesser, Michael J. Davies, Francesca Mangiavacchi, Milena Villarini, Claudio Santi, Massimo Moretti
Summary: This study evaluated the cytotoxic and genotoxic potential of SeTal in liver cells through in vitro experiments. The results showed that SeTal had minimal impact on cell viability and did not cause clastogenic or aneugenic activity. These findings suggest that SeTal may be a potential active pharmaceutical ingredient.
Article
Pharmacology & Pharmacy
Motoshi Ouchi, Asuka Morita, Keitaro Satoh, Shunsuke Kobayashi, Misao Terada, Hiroe Kon, Keitaro Hayashi, Tatsuya Suzuki, Kenzo Oba, Hitoshi Sugihara, Masahiro Yasutake, Naohiko Anzai, Tomoe Fujita
Summary: This study aimed to assess the effects of short-term stimulation with 1,5-AG on insulin secretion. The results indicated that 1,5-AG had no significant effect on insulin secretion, while stimulation with glimepiride significantly increased insulin secretion.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Felipe de Araujo Nascimento, Daniela de Melo e Silva, Thays Millena Alves Pedroso, Jheneffer Sonara Aguiar Ramos, Michelle Rocha Parise
Summary: Occupational exposure to pesticides in farmers results in significant DNA damage, showing a notable impact and variability in the studies. Smokers who are occupationally exposed to pesticides have slightly reduced DNA damage compared to non-smokers, indicating some genetic toxicity. The study demonstrates a higher risk of occupationally exposed rural workers developing related diseases due to the genotoxic effect of pesticides.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Feng Xu, Li-Hua Zhao, Xiao-Hua Wang, Chun-Hua Wang, Chao Yu, Xiu-Lin Zhang, Li-Yan Ning, Hai-Yan Huang, Jian-Bin Su, Xue-Qin Wang
Summary: This study found a close association between low plasma 1,5-anhydro-d-glucitol (1,5-AG) levels and impaired peripheral nerve function and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes (T2D) under mild-to-moderate hyperglycemia.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Cardiac & Cardiovascular Systems
Tetsuji Morishita, Hiroyasu Uzui, Yasuhiko Mitsuke, Hiroshi Tada
Summary: The study investigates the added benefit of including 1,5-anhydro-d-glucitol (1,5-AG) information in an existing scoring system for acute coronary syndrome (ACS) patients. The results show that combining 1,5-AG with the syntax score does not provide any incremental value. However, 1,5-AG levels are useful for detecting major adverse cardiac and cerebral events (MACCE) in ACS patients.
Article
Environmental Sciences
Claudia Castro, Ana Carvalho, Isabel Gaivao, Jose Lima-Brito
Summary: The study evaluated the tolerance of four wine-producing varieties to different concentrations of Cu by treating V. vinifera cuttings with Cu-rich hydroponic solutions. It was found that 50μM Cu treatment increased DNA damage, with 'Tinto Cao' being the most sensitive variety. Comet-FISH analysis revealed partial damage on rDNA and telomeric DNA in response to Cu treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Cardiac & Cardiovascular Systems
Hsin- Teng, Hsiang-Yao Chen, Chuan-Tsai Tsai, Wei-Chieh Huang, Ying-Ying Chen, Chien-Hung Hsueh, William K. K. Hau, Tse-Min Lu
Summary: This study demonstrated that low serum 1,5-AG levels were associated with an increased risk of CAC as assessed by OCT, especially in diabetic patients. Low serum 1,5-AG levels may predict future major adverse cardiovascular events in diabetic patients undergoing OCT-guided PCI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Vedran Muzinic, Anja Katic, Vilena Kasuba, Vedran Micek, Mirta Milic, Davor Zeljezic
Summary: This study demonstrates that low doses of naturally derived chemical tembotrione pose low risk of DNA damage in offspring of treated dams, while the highest dose significantly affects oxidative stress parameters in pubertal female rats and liver CAT and GSH-Px in male rats, as well as ROS and CAT in dams.
Article
Biochemistry & Molecular Biology
Terezia Zajickova, Eva Horvathova, Stanislav Kyzek, Eva Salyova, Eva Turyova, Andrea Sevcovicova, Eliska Galova
Summary: This study suggests that skyrin, a potential precursor of hypericin, has DNA-protective effects and shows promising potential in anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thi Thanh Le, Manh Tuan Ha, Thao Quyen Cao, Jeong Ah Kim, Jae Sue Choi, Byung Sun Min
Summary: Four undescribed compounds and fourteen known compounds were isolated and identified from leaves of Acer ginnala Maxim. The extracted compounds showed inhibitory effects on both protein tyrosine phosphatase-1B (PTP1B) and alpha-glucosidase, suggesting their potential as anti-diabetic medications. Enzyme kinetic analysis and molecular docking provided additional evidence supporting their inhibitory activities and mechanism.
Article
Biochemistry & Molecular Biology
Mateusz Kciuk, Somdutt Mujwar, Beata Marciniak, Adrianna Gielecinska, Karol Bukowski, Mariusz Mojzych, Renata Kontek
Summary: Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides are a new group of heterocyclic compounds with broad biological activities, including anticancer properties. In this study, the investigated compounds showed antiproliferative activity against BxPC-3 and PC-3 cancer cells at micromolar concentrations. The compounds induced significant DNA damage in cancer cells but not in normal human lung fibroblasts. The study also evaluated the impact of MM compounds on DNA damage response factors using molecular docking and molecular dynamics simulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cigdem Alev Ozel, Fatma Unal, Ece Avuloglu-Yilmaz, Esra Erikel, Semra Mirici, Deniz Yuzbasioglu
Summary: This study utilized the comet assay to evaluate the genotoxic effects of picloram and dicamba on root meristems of Allium cepa. The results showed that both chemicals caused DNA damage in the onion roots at certain concentrations. Therefore, it is important to use appropriate concentrations of these chemicals in agriculture to protect the ecosystem and minimize threats to life.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Chemistry, Physical
Sara Cardoso, Classius F. da Silva, Patricia Severino, Amelia M. Silva, Selma B. Souto, Aleksandra Zielinska, Jacek Karczewski, Eliana B. Souto
Summary: Nanocomposites, such as metal nanoparticles, are widely used in biomedical applications, including drug delivery systems. Green nanocomposites made of biocompatible and biodegradable nanoparticles are considered safer options. However, concerns about the potential health risks, including DNA damage, due to the enhanced reactivity of metal nanoparticles have led to the development of the Comet Assay for genotoxicity assessment. This assay plays a crucial role in evaluating the safety and efficacy of metal nanoparticles in drug delivery systems.
Article
Clinical Neurology
Michal Fila, Aleksandra Jablkowska, Elzbieta Pawlowska, Janusz Blasiak
Summary: Energy generation in the brain to ameliorate energy deficit in migraine leads to oxidative stress and DNA damage, causing single-strand breaks (SSBs) in postmitotic neurons. SSBR is an important element of homeostasis in the central nervous system. Impairment in PARP-1 and XRCC1 may be linked with migraine, and TRPM2 may mediate migraine-related neuroinflammation. Therefore, components of SSBR may be potential druggable targets for migraine treatment.
Review
Biochemistry & Molecular Biology
Juha M. T. Hyttinen, Janusz Blasiak, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is a complex disease characterized by damage to the retina and is a major cause of vision loss in elderly people. This review explores the role of non-coding RNAs in regulating mitochondrial function and antioxidant stress response in AMD. These molecules have the potential to be used as diagnostic markers and therapeutic targets for AMD and other oxidative stress-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Michal Fila, Jan Chojnacki, Piotr Sobczuk, Cezary Chojnacki, Janusz Blasiak
Summary: Targeting CGRP and its receptor with antibodies and antagonists has revolutionized the prevention and treatment of migraines. However, not all migraine patients respond well to CGRP-based therapy and some experience gastrointestinal side effects. CGRP may also be involved in the gut-brain-microflora axis and its secretion can be influenced by dietary compounds.
Article
Biochemistry & Molecular Biology
Grzegorz Galita, Joanna Sarnik, Olga Brzezinska, Tomasz Budlewski, Grzegorz Dragan, Marta Poplawska, Ireneusz Majsterek, Tomasz Poplawski, Joanna S. S. Makowska
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by chronic arthritis and joint deformities. The risk of malignant neoplasms among patients with RA is being studied due to the autoimmune nature of RA and the use of immunomodulatory therapy. Impaired DNA repair efficiency in individuals with RA may contribute to this risk. In our study, we evaluated genetic variation in DNA damage repair genes and found associations between RA occurrence and certain polymorphisms. These findings suggest that DNA damage repair gene polymorphisms may play a role in RA pathogenesis and can potentially serve as markers of RA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Cezary Chojnacki, Aleksandra Blonska, Paulina Konrad, Marcin Chojnacki, Marcin Podogrocki, Tomasz Poplawski
Summary: This study aimed to evaluate the urinary excretion of selected tryptophan metabolites in patients with IBS-C and IBS-D. It was found that changes in tryptophan metabolism occurred in both groups of IBS patients compared to the control group. The 5-HIAA level was correlated with abdominal symptoms and anxiety in IBS-D patients, while the concentration of kynurenines (KYN, QA) in urine was higher in IBS-C patients and correlated with depression.
Article
Nutrition & Dietetics
Cezary Chojnacki, Anita Gasiorowska, Tomasz Poplawski, Aleksandra Blonska, Paulina Konrad, Radoslaw Zajdler, Jan Chojnacki, Janusz Blasiak
Summary: This study examined the effect of reducing TRP intake in the diet on patients with LC. The results showed that dietary intervention significantly improved the gastrointestinal and mental symptoms of LC patients and was correlated with changes in TRP metabolites.
Article
Nutrition & Dietetics
Cezary Chojnacki, Tomasz Poplawski, Aleksandra Blonska, Paulina Konrad, Jan Chojnacki, Janusz Blasiak
Summary: This study evaluated the efficacy of a low-FODMAP diet with a concomitant reduction in tryptophan intake for the treatment of IBS-D. The results showed that limiting tryptophan intake was more effective in improving symptoms in IBS-D patients compared to using only a low-FODMAP diet.
Article
Nutrition & Dietetics
Cezary Chojnacki, Anita Gasiorowska, Tomasz Poplawski, Paulina Konrad, Marcin Chojnacki, Michal Fila, Janusz Blasiak
Summary: This study assessed the impact of a TRP-rich diet on the mental state and TRP metabolism of elderly individuals with mood disorders. The results showed that a TRP-rich diet improved the mental state of individuals with mood disorders and enhanced the metabolism of TRP. Therefore, a TRP-enriched diet can be considered as a component of the treatment for elderly individuals with mood disorders.
Review
Biochemistry & Molecular Biology
Magdalena Wieckowska, Rafal Szelenberger, Marcin Niemcewicz, Piotr Harmata, Tomasz Poplawski, Michal Bijak
Summary: Ochratoxin A (OTA) is a highly toxic mycotoxin produced by fungi, which commonly contaminates food and beverages, posing risks to animal and human health. The exact mechanism of OTA's toxicity and effective preventive measures are still not well understood, highlighting the need for further research.
Article
Biochemistry & Molecular Biology
Grzegorz Mloston, Katarzyna Urbaniak, Marcin Palusiak, Zbigniew J. Witczak, Ernst-Ulrich Wuerthwein
Summary: The in situ-generated N-aryl nitrile imines derived from trifluoroacetonitrile can smoothly undergo (3+2)-cycloadditions onto the enone fragment of the levoglucosenone molecule, yielding the corresponding, five-membered cycloadducts. In contrast to the 'classic' C(Ph),N(Ph) nitrile imine, reactions with fluorinated C(CF3),N(Ar) analogues lead to stable pyrazolines in a chemo- and stereoselective manner. The reaction pathway is determined by kinetic control.
Review
Nutrition & Dietetics
Janusz Blasiak, Jan Chojnacki, Joanna Szczepanska, Michal Fila, Cezary Chojnacki, Kai Kaarniranta, Elzbieta Pawlowska
Article
Biochemistry & Molecular Biology
Anna Macieja, Izabela Gulbas, Tomasz Poplawski
Summary: This study proposes a new approach to increase the sensitivity of CDDP-resistant ovarian cancer cells to combined treatment with CDDP and VP-16 by introducing DSB repair inhibitors. The inhibitors enhance the therapeutic effect and allow for a decrease in the effective dose of the drugs. However, not all resistance can be overcome, and hypoxia conditions may affect the response to treatment.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
