Article
Oncology
Michel Heide Talebnasab, Dan Dupont Hougaard
Summary: Vestibular schwannoma is the most common type of intracranial schwannoma, accounting for about 8% of all intracranial tumors in adults with an estimated incidence rate of around 1.3/100,000. The incidence rates of facial nerve schwannomas and cochlear nerve schwannomas are not well-documented. These three types of nerve tumors often present with unilateral hearing loss, tinnitus, and disequilibrium. Facial nerve palsy is common in facial nerve schwannomas but rare in vestibular schwannomas. The symptoms are usually persistent and progressive, leading to interventions that may cause significant morbidity such as deafness and imbalance.
Article
Clinical Neurology
Kareem O. Tawfik, Marin McDonald, Yin Ren, Omid Moshtaghi, Marc S. Schwartz, Rick A. Friedman
Summary: The study found that preoperative cochlear FIESTA/CISS signal intensity may impact hearing outcomes after surgery for acoustic neuroma. Lower FIESTA/CISS signal ratios were associated with greater declines in hearing, suggesting a potential predictive value for postoperative hearing loss.
OTOLOGY & NEUROTOLOGY
(2021)
Article
Clinical Neurology
Mengtao Song, Dayong Wang, Jin Li, Guohui Chen, Xiaolong Zhang, Hongyang Wang, Qiuju Wang
Summary: In this research, the clinical characteristics, diagnosis, and treatment of patients initially diagnosed with sudden sensorineural hearing loss (SSNHL) were investigated, and it was found that some of these patients were later diagnosed with acoustic neuroma (AN). The study retrospectively reviewed the medical records of patients who underwent magnetic resonance imaging (MRI) and found that the severity of hearing loss and audiogram configurations varied among the patients. All patients showed abnormal auditory brainstem responses (ABR). The treatment outcome revealed that some patients exhibited recovery of hearing, while others did not. Some patients underwent surgical treatment, while others opted for stereotactic radiation therapy or a wait and scan strategy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, General & Internal
Hye Ran Park, Sang Soon Jeong, Jung Hoon Kim, Ho Sung Myeong, Hyun Joo Park, Kwang Hyon Park, Kawngwoo Park, Byung Woo Yoon, Suyeon Park, Jin Wook Kim, Hyun-Tai Chung, Dong Gyu Kim, Sun Ha Paek
Summary: This retrospective study analyzed the long-term outcomes of 106 patients with unilateral sporadic acoustic neuromas who underwent gamma knife radiosurgery (GKS) as an initial treatment. The results showed that GKS could effectively control tumors, preserve serviceable hearing, and prevent cranial neuropathy.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Otorhinolaryngology
Mariko Takahashi, Akira Inagaki, Noritaka Aihara, Shingo Murakami
Summary: This study retrospectively evaluated the incidence of sudden sensorineural hearing loss (SHL) and the recovery rate after treatment in patients diagnosed with acoustic neuromas (ANs). The results showed that 7.7% of ANs patients experienced two or more episodes of SHL, and the recovery rate decreased with each successive occurrence.
ACTA OTO-LARYNGOLOGICA
(2022)
Article
Mathematical & Computational Biology
Cenyi Yang
Summary: This paper proposes a postoperative hearing preservation prediction model based on extreme gradient boost tree (XGBoost) for class-imbalanced hospital real data. The synthetic minority oversampling technique (SMOTE) is applied to address sample imbalance. Multiple machine learning models are used to accurately predict surgical hearing preservation in acoustic neuroma patients. Experimental results show that the proposed model outperforms existing research. In summary, this paper's method contributes significantly to the development of personalized preoperative diagnosis and treatment plans, allowing for effective judgment of hearing retention in patients with acoustic neuroma following surgery, simplifying the lengthy medical process, and saving medical resources.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Review
Multidisciplinary Sciences
Temesgen Yihunie Akalu, Archie C. A. Clements, Adhanom Gebreegziabher Baraki, Kefyalew Addis Alene
Summary: The aim of this systematic review and meta-analysis is to quantify the global burden and types of long-term physical sequelae and financial burden associated with multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). The study will search for studies that report physical and financial sequelae associated with MDR-TB or XDR-TB and conduct a meta-analysis to estimate the prevalence of each physical sequela.
Article
Nutrition & Dietetics
Carmen Morais-Moreno, Ana M. Montero-Bravo, Ana M. Puga, Ma de Lourdes Samaniego-Vaesken, Mar Ruperto, Rocio Marco Mendez, Alvaro Vicente-Arche, Gregorio Varela-Moreiras, Teresa Partearroyo
Summary: Noise-induced hearing loss is a common and preventable occupational disease. Aviation pilots, who spend a lot of time exposed to noise pollution, are particularly vulnerable. This study found that flight hours, serum folate, and homocysteine levels were significantly related to hearing loss in pilots.
Article
Multidisciplinary Sciences
Katayoon Montazeri, Mohammad Farhadi, Zeinab Akbarnejad, Abdoreza Asadpour, Abbas Majdabadi, Reza Fekrazad, Saeid Mahmoudian
Summary: This study compared acoustic ABR and optoacoustic ABR to determine the effects of sodium salicylate-induced tinnitus in rats. The results showed that optoacoustic ABR produced more prominent waveforms and significantly reduced waveform amplitudes in tinnitus patients. Therefore, optoacoustic ABR has the advantage of better tinnitus assessment.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Luc Boullaud, Helene Blasco, Eliott Caillaud, Patrick Emond, David Bakhos
Summary: This study investigated the immediate changes in perilymph metabolism following acoustic trauma using metabolomic analysis. Four metabolites were found to be significantly changed after acoustic trauma, suggesting their potential role in auditory impairment. Metabolomics provides a powerful approach to identify new therapies and therapeutic targets for noise-induced hearing loss.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Seung Ho Shin, Jinsei Jung, Haeng Ran Park, Nam Suk Sim, Jae Young Choi, Seong Hoon Bae
Summary: This study investigated the time-dependent immune cell infiltration, macrophage transformation, and neutrophil involvement following acoustic stimulation. The results showed that inflammatory monocytes infiltrated into the lower portion of the lateral wall within 2 days after acoustic overstimulation, followed by transformation into macrophages at 3-5 days post-stimulation. Additionally, the gene encoding C-C motif chemokine ligand 2 was significantly upregulated as early as 3 hours after acoustic overstimulation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Alexander L. Luryi, Seilesh Babu, Dennis Bojrab, John F. Kveton, Christopher A. Schutt
Summary: The size and growth of vestibular schwannoma are associated with hearing loss in patients. Non-growing tumors smaller than 5 mm do not lead to ongoing hearing loss, while non-growing tumors equal to or larger than 5 mm result in continued hearing decline.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Clinical Neurology
Teresa Y. C. Ching, Vicky W. Zhang, Ronny Ibrahim, Fabrice Bardy, Gary Rance, Bram Van Dun, Mridula Sharma, Donella Chisari, Harvey Dillon
Summary: Objective: This study aims to examine the usefulness of a clinical system for recording acoustic change complex (ACC), an event-related potential recorded by electroencephalography, in assessing speech discrimination in infants. It also investigates the relationship between ACC and functional performance in real life. Methods: The study included 115 infants aged 3-12 months, including 43 with normal hearing and 72 with hearing loss. ACCs were recorded using different stimuli, and assessments were conducted at different ages. Functional performance was evaluated using a parent-report questionnaire, and correlations with ACC were examined. Results: The study found that normal-hearing infants had similar ACC responses to aided infants with mild or moderate hearing loss, but significantly higher than those with severe loss. Higher rates of ACC responses were associated with better functional performance, and this auditory capacity for discrimination was evident by 3-6 months. Significance: ACCs can be used to evaluate the effectiveness of amplification and monitor development in aided hearing-impaired infants.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Justin Tan, Dion Kaiserman, Stephen J. O'Leary, Phillip I. Bird
Summary: Inactivating mutations of the SERPINB6 gene in humans lead to progressive hearing loss, while studies in mouse models have shown that the loss of the Serpinb6a gene results in early onset hearing loss. However, transferring this gene mutation to a different mouse strain background can significantly delay the onset of hearing loss.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Francis A. M. Manno, Raul Rodriguez-Cruces, Rachit Kumar, J. Tilak Ratnanather, Condon Lau
Summary: Hearing loss, a heterogeneous disorder, is found to impact grey and white matter in nearly every brain region according to MRI studies. Congenital loss decreases grey matter in frontal lobe most, while acquired loss shows significant decreases in both frontal and insula grey matter. Different impacts on hemispheres are observed between congenital and acquired hearing loss.