Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 230, Issue -, Pages 50-57Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2015.02.003
Keywords
Mycotoxins; Testes; Reproductive system; Carotenoid; Glutathione
Funding
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS) [1879-25.51/13-6]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [471653/2013-6]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) fellowship
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Male mice received lycopene for 10 days before a single oral administration of zearalenone (ZEA). After 48 h testes and blood were collected. Mice treated with lycopene/ZEA exhibited amelioration of the hematological changes. Lycopene prevented the reduction in the number and motility of spermatozoa and testosterone levels, indicating a protective effect in the testicular damage induced by ZEA. Lycopene was also effective in protecting against the decrease in glutathione-S-transferase, glutathione peroxidase, glutathione reductase and delta-aminolevulinic acid dehydratase activities caused by ZEA in the testes. Exposure of animals to ZEA induced modification of antioxidant and inflammatory status with increase of reduced glutathione (GSH) levels and increase of the oxidized glutathione, interleukins 1 beta, 2, 6, 10, tumor necrosis factor-alpha and bilirubin levels. Lycopene prevented ZEA-induced changes in GSH levels and inhibited the processes of inflammation, reducing the damage induced by ZEA. Altogether, our results indicate that lycopene was able to prevent ZEA-induced damage in the mice. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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