Article
Multidisciplinary Sciences
Luminita Labusca, Camelia Danceanu, Anca Emanuela Minuti, Dumitru-Daniel Herea, Adrian Ghemes, Cristian Rotarescu, Oana Dragos-Pinzaru, Mihai Tibu, Grigoras Marian, Horia Chiriac, Nicoleta Lupu
Summary: Magnetic nanomaterials have a growing impact in the field of biology and medicine due to their versatility in drug delivery, cell targeting, and imaging. This study investigates the use of uncoated nickel nanowires as a mechanically-responsive substrate for inducing osteogenic differentiation of adipose derived-mesenchymal cells (ASCs) through magneto-mechanical stimulation. Preliminary results show a significant increase in osteogenic differentiation of ASCs exposed to a specific magnetic field, while adipogenic differentiation remains unchanged.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Nader Asadian, Majid Jadidi, Manouchehr Safari, Taha Jadidi, Mahbobeh Gholami
Summary: The study revealed that sinusoidal 25 Hz, square 50 Hz, and sinusoidal 75 Hz EMF groups had negative effects on the viability and proliferation rate of bone marrow mesenchymal stem cells (BMMSC), while sinusoidal 50 Hz and 75 Hz groups promoted differentiation into neurons. Different frequencies of EMF had varying impacts on the differentiation into astrocyte cells. Further research on the effects of EMF with broader flux density and frequency on BMMSC is recommended.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Wenfang Bai, Meihui Li, Weicheng Xu, Mingsheng Zhang
Summary: Both 50 Hz LF-EMF and HF-EMF can promote the proliferation of NSCs in vitro and LF-EMF can accelerate NSCs to differentiate into neurons. The LF-EMF group showed significantly higher cell viability and quantity compared to the other groups, while the HF-EMF group exhibited higher proliferation compared to the control group. Additionally, LF-EMF exposure resulted in the highest percentage of Tuj-1 positive cells and expression of Tuj-1 mRNA among the three groups.
NEUROSCIENCE LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Haslinda Abdul Hamid, Vahid Hosseinpour Sarmadi, Vivek Prasad, Rajesh Ramasamy, Azizi Miskon
Summary: With the rapid progress in the fields of osteo- and musculoskeletal therapies, the demand for MSC-based treatment modalities is increasing. Electromagnetic field (EMF) exposure is a promising alternative approach. This review discusses the efficiency, practicability, and limitations of relevant methods, providing insurmountable evidence for the implementation of EMF as a feasible strategy for the expansion of MSCs.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ping Ngai, Angeline Hui Cheng Lee, Jian Xu, Jeffrey Wen Wei Chang, Junqing Liu, Mingxin Hu, Zhenquan Sun, Prasanna Neelakantan, Xuechen Li, Chengfei Zhang
Summary: This study aimed to investigate the effects of L-Chg10-teixobactin on the viability, proliferation, migration, and osteo/odontogenic differentiation of stem cells from apical papilla (SCAPs). The results showed that L-Chg10-teixobactin demonstrated excellent biocompatibility on SCAPs at concentrations from 0.01 to 0.03 mg/mL and potentially enhanced the osteo/odontogenic differentiation of SCAPs, suggesting its promising role as a root canal medicament for regenerative endodontic procedures.
JOURNAL OF ENDODONTICS
(2023)
Article
Veterinary Sciences
Metka Voga, Valerija Kovac, Gregor Majdic
Summary: The study compared the characteristics of adipose-derived MSCs from dogs and domestic cats, revealing a higher percentage of CD44(+)CD90(+) and CD34(-/-) cells in canine MSCs. Additionally, canine ADMSCs demonstrated greater proliferation and differentiation potential compared to feline ADMSCs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Michelle Vanessa Kamga Kapchoup, Juergen Hescheler, Filomain Nguemo
Summary: Hydroxychloroquine (HDQ) has been widely studied for its potential use in the treatment and prevention of COVID-19. This antimalarial drug has shown beneficial effects on stem cell proliferation and cardiomyocyte activity, but it can also be toxic at high concentrations. Identifying risk factors and understanding the cardiotoxic profile of HDQ is challenging.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maryam Adelipour, Leena Regi Saleth, Saeid Ghavami, Keshav Narayan Alagarsamy, Sanjiv Dhingra, Abdolamir Allameh
Summary: This article discusses the importance of autophagy in maintaining cellular homeostasis and stem cell function, and emphasizes the potential of modulating autophagy as a therapeutic approach for cancer and other diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Pharmacology & Pharmacy
Qian Wei, Xia Hao, Benson Wui-Man Lau, Shaoxia Wang, Yue Li
Summary: Baicalin, as a main active ingredient in Radix Scutellariae, plays a significant role in regulating fate specification of stem cell populations, potentially improving the efficiency of stem cell therapy for climacteric syndrome.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Edward J. Calabrese
Summary: This paper provides a thorough assessment of hormetic dose responses in embryonic stem cells, suggesting that this response may serve as a fundamental and highly conserved evolutionary strategy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biotechnology & Applied Microbiology
Rui-Men Zhang, Yu Pan, Chao-Xia Zou, Qiang An, Juan-Ru Cheng, Peng-Ju Li, Zi-Hua Zheng, Yan Pan, Wan-You Feng, Su-Fang Yang, De-Shun Shi, Ying-Ming Wei, Yan-Fei Deng
Summary: This study explores the role of circUBE2Q2 in muscle growth and development. The results show that circUBE2Q2 acts as a sponge for miR-133a, promoting the differentiation of muscle stem cells and inhibiting proliferation. This finding provides new insights into the mechanisms by which mRNA and non-coding RNAs regulate skeletal muscle growth and development.
Article
Cell & Tissue Engineering
Mohamed Elashry, Mebrie Kinde, Michele C. Klymiuk, Asmaa Eldaey, Sabine Wenisch, Stefan Arnhold
Summary: In this study, it was found that exposure to hypoxia enhanced the proliferation and motility of skeletal muscle-derived stem cells, promoted the differentiation of muscle and adipocytes, and improved the efficiency of myoblast differentiation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Ewan A. Ross, Lesley-Anne Turner, Hannah Donnelly, Anwer Saeed, Monica P. Tsimbouri, Karl V. Burgess, Gavin Blackburn, Vineetha Jayawarna, Yinbo Xiao, Mariana A. G. Oliva, Jennifer Willis, Jaspreet Bansal, Paul Reynolds, Julia A. Wells, Joanne Mountford, Massimo Vassalli, Nikolaj Gadegaard, Richard O. C. Oreffo, Manuel Salmeron-Sanchez, Matthew J. Dalby
Summary: This study reveals that nanotopography can regulate the immunomodulatory capacity of MSCs by reducing intracellular tension and increasing oxidative glycolysis, providing an effective approach for large-scale expansion of functional MSCs for therapeutic purposes.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Edward J. Calabrese, Vittorio Calabrese, Gaurav Dhawan, Rachna Kapoor, James Giordano
Summary: The paper provides a detailed analysis of hormetic dose responses in neural stem cells (NSCs) and their implications for enhancing cell proliferation, differentiation, and resilience to inflammatory stresses. Various agents, including dietary supplements, pharmaceuticals, endogenous ligands, environmental contaminants, and physical agents, were found to induce hormetic dose responses in NSCs, suggesting potential therapeutic applications for neurological injury and disease.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Cell Biology
Ying Liu, Leilei Jiang, Wenbo Song, Chenxi Wang, Shiting Yu, Juhui Qiao, Xinran Wang, Chenrong Jin, Daqing Zhao, Xueyuan Bai, Peiguang Zhang, Siming Wang, Meichen Liu
Summary: Recent studies have shown that stem cells have notable abilities of proliferation, differentiation, and self-renewal, making them important in regenerative medicine and anti-aging research. Therefore, there is a growing interest in identifying natural medicines that can influence the fate of stem cells. Ginsenosides, the key components of ginseng, have been extensively studied for their effects on stem cell function and aging resistance. This review aims to summarize the latest progress on the impact of ginsenosides on adult stem cell behavior, particularly in terms of proliferation, differentiation, and self-renewal.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Materials Science, Coatings & Films
S. Garmeh, M. Jadidi, A. Dolatabadi
JOURNAL OF THERMAL SPRAY TECHNOLOGY
(2020)
Article
Engineering, Biomedical
Majid Jadidi, Mahmoud Habibnezhad, Eric Anttila, Kaspars Maleckis, Anastasia Desyatova, Jason MacTaggart, Alexey Kamenskiy
ACTA BIOMATERIALIA
(2020)
Article
Cardiac & Cardiovascular Systems
Bjoern Mueller-Edenborn, Jan Minners, Sascha Kocher, Juan Chen, Wolfgang Zeh, Heiko Lehrmann, Juergen Allgeier, Franz-Josef Neumann, Thomas Arentz, Amir Jadidi
CLINICAL RESEARCH IN CARDIOLOGY
(2020)
Review
Computer Science, Information Systems
Martin Breunig, Patrick Erik Bradley, Markus Jahn, Paul Kuper, Nima Mazroob, Norbert Roesch, Mulhim Al-Doori, Emmanuel Stefanakis, Mojgan Jadidi
ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION
(2020)
Article
Multidisciplinary Sciences
Sahar Jafari, Majid Jadidi, Hadi Hasanzadeh, Tahere Khani, Reza Nasr, Vahid Semnani
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2020)
Article
Endocrinology & Metabolism
Babak Rasouli, Laya Ghahari, Manouchehr Safari, Ebrahim Shahroozian, Saeideh Naeimi
METABOLIC BRAIN DISEASE
(2020)
Article
Environmental Sciences
Sarah Kaykhosravi, Usman T. Khan, Mojgan A. Jadidi
Article
Clinical Neurology
Zahra Rostami, Sahar Ghasemi, Hamed Farzadmanesh, Manouchehr Safari, Ali Ghanbari
PAIN RESEARCH & MANAGEMENT
(2020)
Article
Neurosciences
Nader Asadian, Majid Jadidi, Manouchehr Safari, Taha Jadidi, Mahbobeh Gholami
Summary: The study revealed that sinusoidal 25 Hz, square 50 Hz, and sinusoidal 75 Hz EMF groups had negative effects on the viability and proliferation rate of bone marrow mesenchymal stem cells (BMMSC), while sinusoidal 50 Hz and 75 Hz groups promoted differentiation into neurons. Different frequencies of EMF had varying impacts on the differentiation into astrocyte cells. Further research on the effects of EMF with broader flux density and frequency on BMMSC is recommended.
NEUROSCIENCE LETTERS
(2021)
Article
Orthopedics
Marjan Bahraminasab, Samaneh Arab, Manouchehr Safari, Athar Talebi, Fatemeh Kavakebian, Nesa Doostmohammadi
Summary: The study evaluates the in vivo biological interaction of alumina-titanium biocomposites, showing their positive effects on bone formation and repair. Different composites with varying titanium content demonstrate potential for use in load-bearing orthopedic applications.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Oncology
Tahereh Khani, Majid Jadidi, Hadi Hasanzadeh, Shima Moshfegh, Shima Saeedi, Shoka Shahryari, Raheb Ghorbani
Summary: This study evaluated the effects of hematoporphyrin-mediated sonodynamic and photodynamic therapy (SPDT) on the management of mice breast adenocarcinoma. The results showed that HP-mediated SPDT had a delaying tumor growth effect.
INTERNATIONAL JOURNAL OF CANCER MANAGEMENT
(2022)
Article
Chemistry, Physical
Mastaneh Sanei, Ramezan Ali Ramzanpour, Amir Hosein Goodarzi, Hadi Hasanzadeh
Summary: Radiation dosimetry is crucial for radiobiological experiments and radiotherapy. This study evaluates a novel dosimeter that can be read using both MRI and spectrofluorometer. The results show that the dosimeter performs well under conditions of lower temperature, weak acidity, and lower concentration.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Jared S. Ginsberg, Adam C. Overvig, M. Mehdi Jadidi, Stephanie Malek, Gauri Patwardhan, Nicolas Swenson, Nanfang Yu, Alexander L. Gaeta
2019 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO)
(2019)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
