Article
Neurosciences
Brunno Rocha Levone, John F. Cryan, Olivia F. O'Leary
Summary: Studies have shown that different sub-regions of the hippocampus play distinct roles in stress responses, with the intermediate hippocampus playing a predominant role in stress-induced social avoidance, and the ventral sub-region having a predominant role in active coping behaviors and antidepressant-like behavior.
Article
Biochemistry & Molecular Biology
Xiaoyan Wei, Jiasong Chang, Zhen Cheng, Wenwen Chen, Hao Guo, Zhaoyu Liu, Yuning Mai, Tao Hu, Yuanyuan Zhang, Qinglong Cai, Feifei Ge, Yu Fan, Xiaowei Guan
Summary: Adolescent cocaine abuse increases the risk of addiction in adulthood. A study on mice found that DUSP1 expression was lower in the medial prefrontal cortex of adolescent cocaine-exposed (ACE) mice during adulthood, leading to higher sensitivity to the drug. Regulating neuron activity through DUSP1 might be a potential pharmacological target for predicting and treating susceptibility to addictive drugs caused by adolescent substance use.
Article
Pharmacology & Pharmacy
Yawei Xu, Yalei Ning, Yan Zhao, Yan Peng, Fen Luo, Yuanguo Zhou, Ping Li
Summary: Caffeine as a nonspecific antagonist of the adenosine A(2A) receptor enhances learning and memory function while also correlating with feelings of anxiety. The differential effects of inhibiting A(2A)Rs in the dorsal and ventral hippocampus lead to enhanced memory and increased anxiety, respectively. Optogenetic activation of dorsal or ventral hippocampal A(2A)Rs can reverse these behavioral alterations caused by caffeine intake.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Min Liang, Li Zhu, Rui Wang, Hang Su, Dongliang Ma, Hongyan Wang, Teng Chen
Summary: This study investigated whether mid-to-late adolescent exposure to methamphetamine leads to long-lasting memory impairment. The results showed that exposure to methamphetamine during adolescence impaired the memory ability of mice in their adulthood, possibly due to abnormal changes in the structural plasticity of the dorsal hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Liying Chen, Zhaoyu Liu, Ziheng Zhao, Demin Du, Weichao Pan, Xiaoyan Wei, Jiaxun Nie, Feifei Ge, Jianhua Ding, Yu Fan, Hee Young Kim, Xiaowei Guan
Summary: Adolescent cocaine exposure (ACE) increases the risk of developing anxiety-like behaviors in mice. Inhibiting dopamine receptor 1 (D1R) in the claustrum reduces anxiety-like behaviors in ACE mice. Electro-acupuncture (EA) treatment alleviates ACE-induced anxiety-like behaviors by suppressing claustrum D1R.
Article
Neurosciences
Qi Zhang, Shun-Heng Gao, Zhong-Shan Shen, Yun Wang, Su-Wan Hu, Guang-Bing Duan, Ye Liu, Dan-Ya Zhong, Jing Liu, Meng-Han Sun, Xin Zhang, Tian-Yu Cao, Jun-Li Cao, Qiong-Yao Tang, Zhe Zhang
Summary: Anxiety disorders are mental disorders characterized by anxiety and fear, and their molecular basis is still unclear. The study reveals the role of Slack channels in controlling anxious behaviors by decreasing the excitability of BLA-vHPC glutamatergic projections. This provides a potential target for anxiolytic therapies.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Shih-Te Yang, Hsiu-Yi Hung, Long-Sun Ro, Ming-Feng Liao, Tamara G. Amstislavskaya, Maria A. Tikhonova, Yi-Ling Yang, Kwok-Tung Lu
Summary: Traumatic brain injury (TBI) is a significant cause of mortality and morbidity among young people worldwide, with long-lasting sequelae including paralysis, epilepsy, and mental disorders like major depressive disorder. This study focused on the long-term effects of mild TBI in juvenile animals, revealing that even mild juvenile TBI treatment could lead to sustained adverse effects in adulthood, particularly in terms of depression-like behavior. The chronic administration of the TrkB agonist 7,8-DHF was found to lessen the mTBI-J treatment-induced depression-like behaviors in adult rats, suggesting its potential therapeutic use.
Article
Neurosciences
Brunno Rocha Levone, Gerard M. Moloney, John F. Cryan, Olivia F. O'Leary
Summary: The study found that the ventral hippocampus plays a key role in anxiety-like behavior and its modulation by fluoxetine, while the intermediate and ventral hippocampus play distinct roles in fluoxetine-induced antidepressant-like behaviors.
NEUROBIOLOGY OF STRESS
(2021)
Article
Psychiatry
Andreza M. Cavichioli, Thamyris Santos-Silva, Anthony A. Grace, Francisco S. Guimaraes, Felipe Gomes
Summary: This study suggests that levetiracetam can attenuate the adverse outcomes associated with schizophrenia caused by stress during adolescence, by reversing the behavioral changes, ventral hippocampus hyperactivity, and enhanced ventral tegmental area dopamine system activity.
SCHIZOPHRENIA BULLETIN
(2023)
Editorial Material
Biochemistry & Molecular Biology
Kaue Machado Costa, Geoffrey Schoenbaum
Summary: Hippocampal place cells represent spatial locations, and a recent study shows that place cells in the intermediate hippocampus remap their fields following changes in reward, shedding light on how they incorporate associations between locations and specific outcomes.
Article
Neurosciences
Joao Filipe Viana, Joao Luis Machado, Daniela Sofia Abreu, Alexandra Veiga, Sara Barsanti, Gabriela Tavares, Manuella Martins, Vanessa Morais Sardinha, Sonia Guerra-Gomes, Catia Domingos, Alberto Pauletti, Jerome Wahis, Chen Liu, Corrado Cali, Christian Henneberger, Matthew G. Holt, Joao Filipe Oliveira
Summary: Astrocytes in the brain play important roles in sensing, processing, and responding to surrounding activity, maintaining homeostasis, and regulating synaptic transmission. Recent studies have focused on the dynamic interactions between astrocyte leaflets and synapses, but little is known about the tree-like backbone structure of astrocytes under physiological conditions. This study analyzed the structural diversity of astrocytes in the hippocampal subfields and found heterogeneity across regions, which is conserved along the dorsoventral axis. Furthermore, astrocytes appear to contribute to a signaling loop that maintains the backbone structure in an exocytosis-dependent manner.
Article
Behavioral Sciences
Kati L. Healey, Sandra Kibble, Kira Dubester, Amelia Bell, H. S. Swartzwelder
Summary: Binge patterns of alcohol use among adolescents are associated with a higher risk of developing alcohol use disorders and other psychiatric disorders, such as anxiety and depression. Adverse life events also strongly predict these disorders. Animal models have shown that both binge-like alcohol exposure and stress exposure can increase anxiety-like behaviors. This study investigated the interaction between adolescent intermittent ethanol (AIE) and adult stressors, and found that AIE increased vulnerability to stress-induced anxiety-like behavior in male rats. AIE also produced persistent hippocampal deficits that may contribute to increased anxiety-like behaviors when combined with adult stress.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Houri Hintiryan, Ian Bowman, David L. Johnson, Laura Korobkova, Muye Zhu, Neda Khanjani, Lin Gou, Lei Gao, Seita Yamashita, Michael S. Bienkowski, Luis Garcia, Nicholas N. Foster, Nora L. Benavidez, Monica Y. Song, Darrick Lo, Kaelan Cotter, Marlene Becerra, Sarvia Aquino, Chunru Cao, Ryan P. Cabeen, Jim Stanis, Marina Fayzullina, Sarah Ustrell, Tyler Boesen, Amanda J. Tugangui, Zheng-Gang Zhang, Bo Peng, Michael S. Fanselow, Peyman Golshani, Joel D. Hahn, Ian R. Wickersham, Giorgio A. Ascoli, Li Zhang, Hong-Wei Dong
Summary: The authors used machine-learning based computational techniques to map the connectivity of the basolateral amygdalar complex, identifying distinct domains within the anterior BLA with target-specific projection neurons and morphological features. This study provides insights into the circuitry of BLA projection neurons and their connections to behavior networks within the brain.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shima Kouhnavardi, Maureen Cabatic, M. Carmen Manas-Padilla, Marife-Astrid Malabanan, Tarik Smani, Ana Cicvaric, Edison Alejandro Munoz Aranzalez, Xaver Koenig, Ernst Urban, Gert Lubec, Estela Castilla-Ortega, Francisco J. Monje
Summary: Cortisol is a steroid hormone that affects the central nervous system and plays important roles in brain neuronal synaptic plasticity and emotional and behavioral responses. Dysregulation of cortisol is associated with conditions such as Alzheimer's Disease, chronic stress, anxiety, and depression. The effects of cortisol on hippocampal functions and the mechanisms involved in fine-tuning synaptic responses are poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Anna A. Karan, Yulia S. Spivak, Konstantin A. Gerasimov, Elena M. Suleymanova, Maria N. Volobueva, Alexey A. Kvichansky, Lyudmila V. Vinogradova, Alexey P. Bolshakov
Summary: This study compared neuroinflammatory responses induced by seizures and found that GTCS provoke inflammation in the neocortex, hippocampus, and cortical leptomeninges, while absence-like activity does not. Modulation of CB2 receptors mainly affects seizure-induced neuroinflammation in the hippocampus rather than the neocortex.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.