Article
Psychology, Educational
Anna Meijer, Marsh Konigs, Petra J. W. Pouwels, Joanne Smith, Chris Visscher, Roel J. Bosker, Esther Hartman, Jaap Oosterlaan
Summary: Recent research suggests that cardiovascular fitness and gross motor skill performance are related to neurocognitive functioning. This study investigates the role of resting-state networks (RSNs) in this relationship and finds that brain activity in RSNs mediates the relationship between cardiovascular fitness, gross motor skills, and neurocognitive functioning.
Article
Neurosciences
Bruno Hebling Vieira, Julien Dubois, Vince D. Calhoun, Carlos Ernesto Garrido Salmon
Summary: Predicting general intelligence from resting-state functional magnetic resonance imaging signals using an ensemble of recurrent neural networks and temporal variance of saliencies provides more reliable results than traditional approaches. The model's reliance on network size is a key factor, and the method allows for testing the effects of local alterations on data and derived metrics.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gianpaolo Del Mauro, Ze Wang
Summary: This study examines the relationship between brain entropy (BEN) measured by resting-state fMRI and physiological indices. The results show that respiratory rate (RR) negatively affects BEN, while systolic blood pressure (s-BP) and body mass index (BMI) positively affect BEN. Moreover, after controlling for physiological effects, BEN is still associated with cognitive ability in the fronto-parietal cortex and the sensorimotor system.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Suyu Bi, Yun Guan, Lixia Tian
Summary: Both movie and resting-state functional MRI are effective and promising techniques for predicting brain age, but there are some differences in connectivity properties, particularly involving components of the default mode network.
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Laura M. Tully, Annchen R. Knodt, Janina Jiang, Michael R. Irwin, Camelia E. Hostinar
Summary: The study found associations between peripheral inflammation and adolescent brain connectivity, with higher TNF-α levels linked to changes in neural network connections. Associations with IL-6 and CRP were not significant, suggesting that inflammation may have unique effects on brain connectivity during adolescence.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sabarish Sekar, Santhosh Kumar Kannath, Sushama Ramachandran, Ramshekhar N. Menon, Bejoy Thomas
Summary: Resting-state functional magnetic resonance imaging can evaluate the functional connectivity changes in patients with DAVF before and after treatment, which are related to cognitive impairment and reversible after treatment.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Neurosciences
Bruno Pradier, Lydia Wachsmuth, Nina Nagelmann, Daniel Segelcke, Silke Kreitz, Andreas Hess, Esther M. Pogatzki-Zahn, Cornelius Faber
Summary: In studies on animal models, a combination of low-dose anesthetic isoflurane (ISO) and sedative medetomidine (MED) has been advocated to achieve stable neuronal states and brain networks. Transitioning from anesthesia with 1% ISO to the combined ISO/MED regimen showed stable cortical activity states and networks after 45 minutes of MED infusion, with changes in network signatures likely reflecting different anesthetic mechanisms. Detection of visual stimulation-induced BOLD fMRI suggests a 45-minute waiting period is recommended before rs- or task-induced fMRI experiments.
Article
Neurosciences
Limin Peng, Zhiguo Luo, Ling-Li Zeng, Chenping Hou, Hui Shen, Zongtan Zhou, Dewen Hu
Summary: This study developed a brain parcellation method based on dynamic functional connectivity and created a new functional brain atlas. The atlas can reveal finer functional boundaries that static methods may overlook, and shows good agreement with cytoarchitectonic areas and task activation maps.
Article
Neurosciences
Behzad Iravani, Artin Arshamian, Peter Fransson, Neda Kaboodvand
Summary: Recent advances in non-linear computational and dynamical modeling have made it possible to parameterize dynamic neural mechanisms driving complex behaviors. By applying a newly developed adaptive frequency-based model to whole-brain oscillations from fMRI data, researchers were able to distinguish differences in neural dynamics between healthy controls and ADHD subjects, and identify distinct behavioral phenotypes within the ADHD cohort. This study demonstrates the potential of the new modeling framework in revealing hidden neurophysiological profiles and establishing tailored clinical interventions.
Article
Neurosciences
Guo-Rong Wu, Nigel Colenbier, Sofie Van den Bossche, Kenzo Clauw, Amogh Johri, Madhur Tandon, Daniele Marinazzo
Summary: The study introduces a Matlab and Python toolbox called rsHRF for estimating and deconvolving the HRF from resting-state BOLD signals, aiming to improve the analysis and understanding of the components and variability of BOLD signals.
Article
Neurosciences
Xiaodi Zhang, Eric A. Maltbie, Shella D. Keilholz
Summary: Recent resting-state fMRI studies have shown that brain activity exhibits temporal variations in functional connectivity using various methods. However, the results from these methods are just a simplification of the continuous process of brain activity.
Article
Medicine, General & Internal
Xue Jiao, Ming Yuan, Qiuju Li, Yufei Huang, Miaomiao Ji, Jing Li, Shumin Yan, Hao Sun, Xinyu Wang, Zangyu Pan, Qianhui Ren, Dawei Wang, Guoyun Wang
Summary: This study used resting-state functional magnetic resonance imaging to investigate brain morphological alterations and regional dysfunctions in patients with adenomyosis-related pain. The results showed changes in multiple brain regions associated with pain as well as anxiety and depression symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Xiaole Z. Zhong, J. Jean Chen
Summary: This study investigates the age and sex effects on the frequency content of the rs-fMRI signal using the Leipzig mind-brain-body data set. The findings demonstrate that the rs-fMRI fluctuation frequency is higher in older adults, and men have higher rs-fMRI frequency than women. The effects of age and sex on fMRI frequency vary with frequency band examined.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Matthew Kolisnyk, Karnig Kazazian, Karina Rego, Sergio L. Novi, Conor J. Wild, Teneille E. Gofton, Derek B. Debicki, Adrian M. Owen, Loretta Norton
Summary: Resting-state functional magnetic resonance imaging was used to predict neurologic recovery in unresponsive patients with severe brain injury. The study found that the method accurately predicted the outcome of patients and could affect discussions surrounding withdrawal of life-sustaining measures.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Michael Jacob, Judith Ford, Terrence Deacon
Summary: The brain is a living organ with distinct metabolic constraints. Recent evidence suggests that background activity may play an independent role in assigning significance to changes in neural firing and metabolic energy. Combining EEG with fMRI can provide a new framework for investigating the relationship between ongoing neural activity and metabolism.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Oncology
Florien W. Boele, Patricia W. M. den Otter, Jaap C. Reijneveld, Philip C. de Witt Hamer, Hinke F. van Thuijl, Linda M. C. Lorenz, Pieter Wesseling, Frank J. Lagerwaard, Martin J. B. Taphoorn, Mathilde C. M. Kouwenhoven, Tom J. Snijders, Linda Douw, Martin Klein
Summary: HRQOL and NCF do not appear greatly impacted during long-term survivorship in LGG, but depressive symptoms and fatigue are persistent.
Article
Clinical Neurology
Myrte Strik, Anand J. C. Eijlers, Iris Dekker, Tommy A. A. Broeders, Linda Douw, Joep Killestein, Scott C. Kolbe, Jeroen J. G. Geurts, Menno M. Schoonheim
Summary: This study investigated the functional network predictors and longitudinal network changes related to upper and lower limb progression in multiple sclerosis (MS). The results showed that upper and lower limb progression had unique predictors, possibly indicating different network disturbances underlying these types of progression in MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Meeting Abstract
Oncology
M. Gorter, J. G. Rottgering, V Belgers, M. R. van Lingen, P. C. De Witt Hamer, L. Douw, M. Klein
Meeting Abstract
Oncology
V Belgers, W. van Buijtene, E. Butterbrod, J. G. Rottgering, L. Douw, P. C. De Witt Hamer, G. M. Rutten, M. Klein, W. De Baene, M. C. M. Kouwenhoven, K. Gehring
Editorial Material
Clinical Neurology
Linda Douw, Lucas C. Breedt, Mona L. M. Zimmermann
Article
Multidisciplinary Sciences
Jantine G. Rottgering, Vera Belgers, Mathilde C. M. Kouwenhoven, Maaike Schuur, Tjeerd J. Postma, Claudia M. Nijboer, Myra E. van Linde, Philip C. de Witt Hamer, Linda Douw, Martin Klein
Summary: This study evaluated the frequency and burden of symptoms in glioma patients with stable disease and assessed their willingness to consider treatment. Fatigue, memory problems, reduced physical fitness, concentration problems, and drowsiness were the most common and burdensome symptoms. However, patients had a relatively low inclination for symptom management interventions.
Article
Neuroimaging
Marike R. R. van Lingen, Lucas C. C. Breedt, Jeroen J. G. Geurts, Arjan Hillebrand, Martin Klein, Mathilde C. M. Kouwenhoven, Shanna D. D. Kulik, Jaap C. C. Reijneveld, Cornelis J. J. Stam, Philip C. C. De Witt Hamer, Mona L. M. Zimmermann, Fernando A. N. Santos, Linda Douw
Summary: This study found that frontoparietal network centrality of multilayer networks is related to and predicts executive functioning in glioma patients, but it does not predict postoperative changes in executive functioning.
BRAIN IMAGING AND BEHAVIOR
(2023)
Review
Biochemistry & Molecular Biology
Florian W. Adraoui, Linda Douw, Gerard J. M. Martens, Dorien A. Maas
Summary: Schizophrenia is a devastating psychiatric disorder that affects approximately 1% of the global population. Social-cognitive impairments and abnormalities in brain activity and connectivity contribute to the development of symptoms. The molecular mechanisms underlying these impairments are still not well understood. This study proposes impaired myelination and disinhibition of local microcircuits as potential biological pathways leading to dysconnectivity and abnormal activity in the social brain, and suggests using electroencephalography as a translational technique for pre-clinical drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Jantine Geertruida Rottgering, Martin Klein, Linda Douw
Article
Sport Sciences
Franziska Katharina Haase, Annika Prien, Linda Douw, Nina Feddermann-Demont, Astrid Junge, Claus Reinsberger
Summary: This study compared the brain cortical thickness and neurocognitive performance of retired female soccer players and non-contact sport athletes. The results showed similar cortical thickness and neurocognitive performance between the two groups, except for verbal memory and psychomotor speed. However, frequent headers had increased cortical thickness in the right inferior parietal region. Caution is needed in interpreting these results due to small sample sizes, subjective header assessment, and the case-control study design.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Oncology
J. G. Rottgering, T. M. C. K. Varkevisser, M. Gorter, V. Belgers, P. C. De Witt Hamer, J. C. Reijneveld, M. Klein, T. F. Blanken, L. Douw
Summary: In this study, we used symptom network analysis to explore the relationship between symptoms and health-related quality of life in glioma patients. We found that fatigue, depression, and social functioning were highly correlated with other symptoms. Interestingly, the network connectivity was stronger in fatigued patients compared to non-fatigued patients.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Pharmacology & Pharmacy
Vera Belgers, Jantine G. Rottgering, Linda Douw, Martin Klein, Johannes C. F. Ket, Peter M. van de Ven, Thomas Wurdinger, Myra E. van Linde, Johanna M. Niers, Markus Weber, Marcel G. Olde Rikkert, Jose Lopez-Sendon, Oscar Arrieta, Kristina B. Svendsen, Marcos H. N. Chagas, Carlos M. O. de Almeida, Mathilde C. M. Kouwenhoven, Philip C. de Witt Hamer
Summary: This meta-analysis suggests that cannabinoids do not have a significant effect on HRQoL and mental well-being in patients with cancer or CNS disease.
CANNABIS AND CANNABINOID RESEARCH
(2023)
Meeting Abstract
Oncology
Marike Van Lingen, Lucas Breedt, Jeroen Geurts, Arjan Hillebrand, Mathilde Kouwenhoven, Shanna Kulik, Jaap Reijneveld, Cornelis Stam, Philip De Witt Hamer, Mona Zimmermann, Fernando Santos, Linda Douw
Meeting Abstract
Oncology
Mona Zimmermann, Lucas Breedt, Eduarda Centeno, Shanna Kulik, Fernando Santos, Cornelis Stam, Marike Van Lingen, Arjan Hillebrand, Linda Douw
Meeting Abstract
Clinical Neurology
T. A. Broeders, L. Douw, V. M. Rauh, Y. D. Van der Werf, C. H. Vinkers, J. J. G. Geurts, M. M. Schoonheim
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
