Article
Biophysics
Yingying Luo, Jian Li, Bin Wang, Qin Zhang, Yajie Bian, Ruipei Wang
Summary: Treatment with glycyrrhizin ameliorated mechanical hyperalgesia and joint edema, suppressed serum enzymes and inflammatory mediators, and decreased inflammation markers in serum and cartilage in a rat model of osteoarthritis. The underlying mechanism involved the inhibition of HMGB1 and the TLR4/NF-kappa B signaling pathway.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Medicine, Research & Experimental
Ying Fu, Yu Xiang, Ying Wang, Zhiwen Liu, Danyi Yang, Jie Zha, Chengyuan Tang, Juan Cai, Guochun Chen, Zheng Dong
Summary: This study uncovers the role of the STAT1/HMGB1/NF-?B pathway in chronic kidney problems after long-term use of cisplatin, providing new therapeutic targets for kidney protection in cancer patients receiving cisplatin chemotherapy.
Article
Cell Biology
Peiyao Li, Xuemiao Li, Wenbin Wu, Mengjia Hou, Guanyi Yin, Zhonghang Wang, Ziyu Du, Yuanfang Ma, Yinxiang Wei, Qiang Lou
Summary: This study investigated the impact of Tim-3 on cisplatin-induced acute kidney injury. Tim-3 expression was found to increase in mice kidney tissues and BUMPT cells in response to cisplatin. Knockout of Tim-3 resulted in worsened kidney function and increased cell apoptosis. Intervention with sTim-3 further enhanced cell apoptosis and inflammation markers, while inhibiting anti-inflammatory markers. It was also observed that Tim-3 inhibition reduced renal injury and oxidative stress. These findings suggest that Tim-3 may have a protective effect against cisplatin-induced kidney injury through inhibition of inflammation and oxidative stress mediated by NF-kappa B.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Ae Ryang Jung, Ga Eun Kim, Mee Young Kim, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Yong Hyun Park
Summary: The study found that increased expression of HMGB1 in prostate cancer is associated with aggressive cancer and poor survival outcomes, while inhibiting HMGB1 expression significantly reduces cell proliferation and invasion. The interaction between HMGB1 and TNFR1 can promote tumor progression in prostate cancer through the NF-kappa B signaling pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Abdallah M. Gendy, Hagar M. El-Sadek, Mohamed M. Amin, Kawkab A. Ahmed, Mohamed Kotb El-Sayed, Alaadin E. El -Haddad, Ayman Soubh
Summary: The study reveals the neuroprotective effect of Glycyrrhizin (Glyc) against experimentally induced Huntington's disease (HD), which is achieved through diverse mechanisms including improvement of neurobehavioral deficits, attenuation of oxidative stress, and reduction of inflammation. The findings provide valuable insights into the potential mechanism of action of Glyc against HD.
Article
Pharmacology & Pharmacy
Lu Li, Huiquan Liu, Weili Tao, Su Wen, Xiaofen Fu, Shiying Yu
Summary: This study demonstrates the cachectic role of HMGB1 in colon cancer, whether it is in soluble form or secreted from tumor cells as exosomes. The HMGB1 inhibitor glycyrrhizin shows promise in relieving muscle wasting and attenuating cachexia progression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Ting Zuo, Yinzi Yue, Xiaohui Wang, Huan Li, Shuai Yan
Summary: The study demonstrated that luteolin effectively improved colon health indicators and reduced inflammation levels in the affected areas by regulating the signaling pathways in the intestine to alleviate colitis.
Article
Surgery
Haixia Liu, Yun Shen, Bingkun Zhao, Enoch H. Poon, Shengcai Qi, Dai Fei Elmer Ker, Timothy R. Billiar, Gregory M. Cooper, Yuanzhi Xu, Dan Wang
Summary: This study found that short-term application of saquinavir can improve skull bone repair by promoting osteoclastogenesis and modulating the inflammatory response. This finding is clinically relevant and provides potential for repurposing saquinavir for skeletal repair.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Medicine, General & Internal
Yongge Li, Xiaoming Wei, Qingchun Liu, Shifeng Zhang, Yongchao Deng
Summary: The study found that glycyrrhizin can slow down kainic acid-induced epilepsy in young rats, inhibit hippocampal pathological damage, and decrease the number of Neu-N positive cells. The mechanism may be related to glycyrrhizin's regulation of the HMGB1/TLR4/P-NF-kappa B pathway.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Agriculture, Dairy & Animal Science
Zhanyou Cao, Chenghong Xing, Xinyi Cheng, Junrong Luo, Ruiming Hu, Huabin Cao, Xiaoquan Guo, Fan Yang, Yu Zhuang, Guoliang Hu
Summary: Avian colibacillosis is a major cause of animal death and egg-production decline in the poultry industry. Luteolin has been found to alleviate inflammation and oxidative stress caused by E. coli and may be used as an alternative to antibiotics for controlling avian colibacillosis.
Article
Immunology
Gaoyan Chen, Yan Hou, Xiaogang Li, Rui Pan, Dongchi Zhao
Summary: This study shows that Calycosin can effectively alleviate sepsis-induced acute lung injury in young rats by inhibiting the HMGB1/MyD88/NF-κB pathway and NLRP3 inflammasome activation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biophysics
Yingying Luo, Jian Li, Bin Wang, Qin Zhang, Yajie Bian, Ruipei Wang
Summary: The study demonstrated that treatment with glycyrrhizin alleviated mechanical hyperalgesia and joint edema in a rat model of osteoarthritis, as well as suppressed the release of enzymes and inflammatory markers. Additionally, glycyrrhizin treatment regulated cartilage degeneration and inflammation by inhibiting HMGB1 and the TLR4/NF-kappa B signaling pathway.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2021)
Article
Biochemistry & Molecular Biology
Binchan He, Wei Zhou, Yuwen Rui, Lulu Liu, Bilin Chen, Xin Su
Summary: miR-574-5p can suppress inflammatory response by targeting HMGB1, providing negative feedback to LPS-induced inflammation and relieving ARDS. It may offer new therapeutic strategies for ARDS.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Immunology
Ahmed M. Awad, Sally L. Elshaer, Rajashekhar Gangaraju, Rania R. Abdelaziz, Manar A. Nader
Summary: This study explored the renoprotective effect of montelukast (Mon) in streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats compared to a standard insulin treatment. Mon administration for 8 weeks significantly improved renal function, reduced inflammation and fibrosis, restored redox hemostasis, and ameliorated dysregulation in autophagy. The renoprotective effect of Mon is potentially associated with its modulation of inflammatory cytokines, antioxidant properties, and autophagy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Huaqin Sun, Hongyi Hu, Xiaoping Xu, Mingsun Fang, Tao Tao, Zhehao Liang
Summary: Dexmedetomidine (DEX) has been shown to attenuate acute lung injury (ALI) induced by cecal ligation perforation (CLP) by downregulating HMGB1 and RAGE. The study further revealed that DEX treatment reduced lung tissue damage, inflammatory cell infiltration, and increased lung permeability in ALI mice. DEX also suppressed MPO activity, inflammatory cytokine levels, and activated the HMGB1/RAGE/NF-kappa B pathway to alleviate ALI.
Article
Neurosciences
Dongyu Hua, Shan Li, Shiyong Li, Xuan Wang, Yue Wang, Zheng Xie, Yilin Zhao, Jie Zhang, Ailin Luo
Summary: This study explored the connection between gut microbiota and pain processing as well as cognitive function in patients with chronic neuropathic pain (CNP). The findings suggest that a lower diversity of gut bacteria and an increase in Actinobacteria, Proteus, and Bifidobacterium might contribute to cognitive impairment in CNP patients. Disturbances in the endocannabinoid (eCB) system, lipids, and amino acid metabolism were identified as dominant features of cognitive deficits in CNP patients. Modulating gut microbiota and eCB signaling could serve as therapeutic targets for cognitive deficits in CNP patients.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Dongyu Hua, Ailin Luo, Zifeng Wu, Chaoli Huang, Shan Li, Xiaolin Xu, Jiali Xu, Chun Yang, Di Wang, Cunming Liu
Summary: Anesthesia and surgery are found to cause cognitive dysfunction in patients, especially the elderly. Decreased Keap1-Nrf2 signaling in the medial prefrontal cortex, hippocampus, and liver may contribute to the onset of post-operative cognitive dysfunction (POCD). Sulforaphane shows potential in improving POCD symptoms by increasing Keap1-Nrf2 signaling.
BRAIN RESEARCH BULLETIN
(2022)
Article
Behavioral Sciences
Ailin Luo, Zheng Xie, Yue Wang, Xuan Wang, Shan Li, Jing Yan, Gaofeng Zhan, Zhiqiang Zhou, Yilin Zhao, Shiyong Li
Summary: Type 2 diabetes and its associated cognitive dysfunction have significant impacts on personal health and healthcare systems. This review summarizes potential mechanisms underlying cognitive dysfunction and discusses the potential effects of anti-diabetes methods and neuroprotective natural compounds.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Qiaoqiao Xu, Juan Xiong, Li Xu, Yuanyuan Wu, Man Li, Qinqin Li, Tao Jiang, Ailin Luo, Yi Zhang
Summary: Perioperative neurocognitive disorders commonly occur in elderly patients, and isoflurane could be a risk factor. This study found that the ubiquitin-proteasome system and aging may play a role in the pathogenesis of these disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Anesthesiology
Shuo Wang, Shiyong Li, Yilin Zhao, Xiaoping Zhao, Zhiqiang Zhou, Quanshui Hao, Ailin Luo, Rao Sun
Summary: This study found that a high risk of obstructive sleep apnea (OSA), as determined by screening tools, was associated with higher incidences of postoperative respiratory, cardiac, and neurological complications. However, the quality of evidence was very low, and caution is needed when interpreting the findings.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Medicine, General & Internal
Wenlong Yao, Meihong Li, Chuanhan Zhang, Ailin Luo
Summary: Videolaryngoscopes have played an important role in thoracic airway management, assisting in achieving one-lung ventilation and DLT intubation. They offer advantages in improving success rates in normal airways but have limitations in difficult airways. For patients with difficult airways, videolaryngoscope-guided DLT intubation is a primary and effective method that can be combined with other techniques for lung isolation.
FRONTIERS IN MEDICINE
(2022)
Review
Physiology
Jing Yan, Xiaole Tang, Zhi-qiang Zhou, Jie Zhang, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: SIRTs are a class of NAD+-dependent deacylases that regulate cell functions. CNS decline leads to impaired cognitive and social abilities, so understanding potential targets to promote CNS homeostasis is crucial.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Surgery
Hua Zheng, Xueqin Cao, Feng Gao, Xinhua Li, Li Wan, Ailin Luo
Summary: This case report highlights the potential risk of mannitol-induced hyperkalemia during neurosurgical procedures. The study suggests that male patients or patients with uncontrolled diabetes might be more susceptible to this phenomenon. It also indicates that the high dose and rapid infusion rate of mannitol could contribute to mannitol-induced hyperkalemia. Therefore, caution should be exercised when administering mannitol, especially in patients with uncontrolled diabetes, and continuous monitoring and measurement are necessary for early detection and treatment of potential life-threatening events induced by mannitol-induced hyperkalemia.
FRONTIERS IN SURGERY
(2022)
Article
Multidisciplinary Sciences
Xi Fang, Qiang Han, Shiyong Li, Ailin Luo
Summary: The study suggests that melatonin can alleviate isoflurane-induced ER stress and neuroapoptosis, improving spatial learning and memory impairment in the hippocampus.
Article
Pharmacology & Pharmacy
Zheng Xie, Xuan Wang, Xiaoxiao Luo, Jing Yan, Jie Zhang, Rao Sun, Ailin Luo, Shiyong Li
Summary: This study found that neuronal ferroptosis in the hippocampus contributes to cognitive impairment in a T2D model. Furthermore, activation of AMPK can reduce hippocampal ferroptosis and improve cognitive performance in diabetic mice.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Ailin Luo, Zifeng Wu, Shan Li, Cindy B. McReynolds, Di Wang, Hanyu Liu, Chaoli Huang, Teng He, Xinying Zhang, Yuanyuan Wang, Cunming Liu, Bruce D. Hammock, Kenji Hashimoto, Chun Yang
Summary: This study investigated the relationship between chronic pain and depression and the potential benefits of inhibiting soluble epoxide hydrolase (sEH) signaling. The results showed that sEH expression was associated with pain and depression behaviors, and the sEH inhibitor TPPU improved the symptoms of both. The therapeutic effects of TPPU were mediated through the AHR and TSPO signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yue Wang, Ziwen Cai, Gaofeng Zhan, Xing Li, Shan Li, Xuan Wang, Shiyong Li, Ailin Luo
Summary: Caffeic acid phenethyl ester (CAPE) can mitigate cognitive impairment caused by anesthesia and surgery by suppressing oxidative stress and promoting the switch of microglia in the hippocampus.
Review
Biochemistry & Molecular Biology
Yujuan Li, Mengxin Que, Xuan Wang, Gaofeng Zhan, Zhiqiang Zhou, Xiaoxiao Luo, Shiyong Li
Summary: Astrocytes, the most abundant cells in the brain, play a significant role in sleep regulation but their dysfunction may contribute to sleep disorders and increase the risk of other diseases. This review examines the role of astrocytes in sleep disorders, discusses potential mechanisms, and highlights the importance of further research.
Review
Nutrition & Dietetics
Mingke Guo, Xuan Wang, Yujuan Li, Ailin Luo, Yilin Zhao, Xiaoxiao Luo, Shiyong Li
Summary: As the global population ages, the prevalence of neurodegenerative diseases is increasing. Diet plays a crucial role in the development and progression of these diseases. Intermittent fasting (IF) has shown potential in improving neurological functions and reducing pathological injuries, with the gut microbiota and their metabolites believed to be central in mediating these effects.
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.
