Review
Neurosciences
Matti Nathalie, Sai P. Polineni, Christopher N. Chin, Daniela Fawcett, Helene Clervius, Quesada Sanchez Liz Maria, F. Legnay, Lucas Rego, Anil K. Mahayadi, Walter J. Jermakowicz, SW-T Lee, Shoji Yokobori, Shyam Gajavelli
Summary: Traumatic Brain Injury (TBI) remains the leading cause of mortality and morbidity in young adults globally. While improvements in safety measures and critical care have increased survival chances, several secondary mechanisms contribute to injury in the weeks and months post-TBI. Recent research on TBI inflammation suggests the potential for guiding inflammation towards neural repair and regeneration.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2021)
Review
Immunology
Priyanka Maridhi Nanjireddy, Scott H. Olejniczak, Nataliya Prokopenko Buxbaum
Summary: Genetically engineered CAR T cells have the potential to cure refractory cancers. However, their effectiveness against solid tumors is limited by the immunosuppressive tumor microenvironment. This manuscript provides an overview of CAR T cell metabolism and discusses potential strategies to manipulate metabolic features for improved tumor responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Elizabeth T. C. Lippard, Charles B. Nemeroff
Summary: Childhood maltreatment increases the risk for mood disorders and has a negative impact on the development and course of these disorders. Longitudinal studies support the devastating effects of childhood maltreatment on mood disorders. Risky behaviors following maltreatment can further worsen the disease course. More research is needed on sex differences and the impact of maltreatment on vulnerable populations.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Physiology
Matthew W. Kay, Vivek Jain, Gurusher Panjrath, David Mendelowitz
Summary: This review summarizes the evidence linking autonomic imbalance to cardiorespiratory diseases, with a focus on reduced parasympathetic activity. It also discusses potential mechanisms and targets for restoring parasympathetic activity and improving cardiorespiratory health, from myocytes to the brain.
Article
Hematology
Cameron S. Bader, Lei Jin, Robert B. Levy
Summary: STING, an innate immune sensor, plays a crucial role in regulating GVHD after allo-HSCT and may also be involved in auto-HSCT and SOT. It has unique regulatory functions in various cell types.
Article
Gastroenterology & Hepatology
Sharad Wadhwani, Laura Gottlieb, John C. Bucuvalas, Courtney Lyles, Jennifer C. Lai
Summary: The social determinants of health significantly impact outcomes, especially for children undergoing liver transplant, where those from disadvantaged neighborhoods experience higher morbidity and mortality risks. However, there is still a lack of understanding on how to address these social adversities effectively. More data on specific social risk factors and interventions are needed to improve outcomes for these children.
Article
Psychology, Multidisciplinary
Colleen Stiles-Shields, Sylwia Osos, Anna Heilbrun, Estee C. H. Feldman, Grace Zee Mak, Christopher L. Skelly, Tina Drossos
Summary: This study implemented a 7-week pre-operative cognitive behavioral therapy intervention for pediatric patients with MALS and found that the intervention feasibility was high, despite the presence of chronic pain symptoms and a high prevalence of psychiatric diagnoses in the sample. It is suggested that further evaluation of the intervention efficacy is needed, including stakeholder input in the design and deployment of a pilot efficacy trial.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Medicine, Research & Experimental
Mauro Corrado, Erika L. Pearce
Summary: Vaccination activates specific immune cells to provide protection and promote the development of immune memory against specific pathogens. Recent research has made progress in defining the metabolism of memory T cells and discussed the impact of metabolic abnormalities on infections and vaccine efficacy.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Immunology
Forat Lutfi, Long Wu, Sarah Sunshine, Xuefang Cao
Summary: The article reviews the use of immune checkpoint inhibitor therapies and allogeneic hematopoietic cell transplant in the treatment of malignancies, as well as the therapeutic potential of the CD27-CD70 co-stimulatory pathway. It also discusses the complexity of GVHD and potential approaches for prevention.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Mauro Sousa de Almeida, Eva Susnik, Barbara Drasler, Patricia Taladriz-Blanco, Alke Petri-Fink, Barbara Rothen-Rutishauser
Summary: Nanoparticles have diverse applications, particularly in nanomedicine for detecting and treating diseases like cancer and inflammation. Understanding the mechanisms of cellular uptake and intracellular localization of nanoparticles is crucial for therapeutic applications. Factors such as physicochemical properties, endocytic pathways, and cellular uptake regulators play key roles in the application of nanoparticles in medicine.
CHEMICAL SOCIETY REVIEWS
(2021)
Review
Cardiac & Cardiovascular Systems
Lin Wu, James R. Sowers, Yingmei Zhang, Jun Ren
Summary: Cardiovascular diseases (CVDs) are caused by abnormalities in the genomic, proteomic, and metabolomic aspects. Recent evidence has confirmed the presence of DNA damage in various CVDs. DNA damage triggers a cellular response called DNA damage response (DDR), which can be beneficial for cardiovascular function temporarily, but persistent activation of DDR promotes the onset and development of CVDs. Therefore, targeting DNA damage and DDR could potentially improve cardiovascular dysfunction and disease outcome.
CARDIOVASCULAR RESEARCH
(2023)
Article
Neurosciences
Dardo Tomasi, Corinde E. Wiers, Peter Manza, Ehsan Shokri-Kojori, Yonga Michele-Vera, Rui Zhang, Danielle Kroll, Dana Feldman, Katherine McPherson, Catherine Biesecker, Melanie Schwandt, Nancy Diazgranados, George F. Koob, Gene-Jack Wang, Nora D. Volkow
Summary: The study found that subcortical volumes in AUD patients increased during detoxification, indicating partial recovery. Compared to the healthy control group, subcortical volumes were smaller in AUD patients and showed a stronger age-related decrease. The volume of the amygdala was positively associated with negative urgency and anxiety.
Article
Oncology
Daniele V. F. Tauriello
Summary: The tumor microenvironment plays a crucial role in cancer progression and immune response. This study focuses on targeting cancer-associated fibroblasts to improve immunotherapeutic efficacy and treatment responses to checkpoint inhibitors in gastric tumors. The potential of multitarget tyrosine kinase inhibitors in treating gastrointestinal cancer is also explored.
Review
Chemistry, Multidisciplinary
Elfa Beaven, Raj Kumar, Himanshu N. N. Bhatt, Stephanie V. Esquivel, Md Nurunnabi
Summary: Fibrosis is a disease associated with chronic inflammatory conditions that can develop in different organs and may result in organ failure and death. The identification of biomarkers associated with fibrosis has potential for diagnosis and treatment development. This review discusses various signaling pathways and mechanisms involved in fibrosis development.
CHEMICAL COMMUNICATIONS
(2022)
Article
Food Science & Technology
Paulo Sergio Loubet Filho, Thais Otranto Dias, Vitoria Helena de Oliveira Teixeira Reis, Amanda Maria Tomazini Munhoz Moya, Elisvania Freitas dos Santos, Cinthia Bail Betim Cazarin
Summary: The incidence of inflammatory bowel diseases (IBD) has increased and its etiology remains unknown. Risk factors, including food intake, are associated with developing IBD. Functional foods (FF) can modulate the gut microbiota and improve the health quality of IBD patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
