Article
Green & Sustainable Science & Technology
Lan Lin, Yue Jin, Min Xiong, Shuicai Wu, Shen Sun
Summary: Sustainable cognitive health is affected by cognitive reserve, which delays or reduces cognitive decline by enhancing cognitive function. This study explores whether cognitive reserve moderates the relationship between white matter integrity and cognitive function in older adults. The findings reveal that early fluid intelligence has a significant independent and moderating impact on cognitive performance, making it a suitable individual proxy for cognitive reserve. Additionally, a composite proxy of early fluid intelligence and physical activity shows promise in promoting sustainable cognitive health.
Article
Public, Environmental & Occupational Health
Xingqi Cao, Chen Chen, Liu He, Zhoutao Zheng, Jingyun Zhang, Emiel O. Hoogendijk, Xiaoting Liu, Shujuan Li, Xiaofeng Wang, Yimin Zhu, Zuyun Liu
Summary: This study developed and validated a new functional score based on self-reported cognitive and physical function in the older Chinese population. The score was found to be associated with all-cause mortality risk and showed additional predictive utility beyond age and sex. It was also demonstrated to be a simple and practical tool for assessing functional deterioration.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Yue Jin, Lan Lin, Min Xiong, Shen Sun, Shui-cai Wu
Summary: The study examines the importance of cognitive reserve (CR) for brain integrity and cognitive outcomes using UK Biobank data. The findings suggest that the effects of CR on brain integrity and cognition vary depending on the proxy used, brain integrity indicators, cognitive domain, and age group.
NEUROBIOLOGY OF AGING
(2023)
Article
Geriatrics & Gerontology
Kimberly D. van der Willik, Silvan Licher, Elisabeth J. Vinke, Maria J. Knol, Sirwan K. L. Darweesh, Jos N. van der Geest, Sanne B. Schagen, M. Kamran Ikram, Annemarie Luik, M. Arfan Ikram
Summary: The study revealed that cognitive and motor function decline with age among community-dwelling individuals aged 45-90, with steeper declines seen after ages 65-70. Lower educated participants had lower cognitive function at baseline and experienced a faster decline compared to those with higher education, although this educational effect was not observed in motor function.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Vivian Castillo de Lima, Luz Albany Arcila Castano, Ricardo Aurelio Carvalho Sampaio, Priscila Yukari Sewo Sampaio, Camila Vieira Ligo Teixeira, Marco Carlos Uchida
Summary: Agility training is essential for improving neuromuscular performance and balance in older adults. This study examined the physical and cognitive effects of an agility ladder training program on healthy older adults. The results showed that only the group that received cognitive training alongside agility training showed improvements in cognitive function, while the group that only performed agility training saw improvements in physical performance.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Carlos Marquez, Barbara Angel, Lydia Lera, Rebecca Bendayan, Hugo Sanchez, Cecilia Albala
Summary: This longitudinal study explored the association between vitamin D levels and cognitive performance in older Chilean people and found that low vitamin D levels were a risk factor for mild cognitive impairment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Geriatrics & Gerontology
Sadaf Arefi Milani, Tyler R. Bell, Michael Crowe, Caitlin N. Pope, Brian Downer
Summary: This study aimed to evaluate the bidirectional association between pain interference and cognitive performance. The findings suggest that increased pain interference is associated with greater cognitive decline, while better baseline cognitive performance is related to lower pain interference at follow-up.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Hui Liu, Zhenmei Zhang, Yan Zhang
Summary: The study provides insight into the association between trajectories of marital quality and cognitive functioning among older adults, with a focus on gender differences. Initial positive marital quality correlated with better initial cognition in older adults, while negative marital quality correlated with worse cognition. An increase in positive marital quality was associated with a slower rate of cognitive decline in men, emphasizing the importance of maintaining a good marital relationship for cognitive health in later life.
SOCIAL SCIENCE & MEDICINE
(2021)
Article
Geriatrics & Gerontology
Hyunkyu Kim, Seung Hoon Kim, Wonjeong Jeong, Sung-In Jang, Eun-Cheol Park, Youseok Kim
Summary: This study identified a relationship between changing handgrip strength and cognitive function, with decreasing handgrip strength associated with decline in cognitive function over time.
Article
Nutrition & Dietetics
Keisuke Sakurai, Chutong Shen, Izumi Shiraishi, Noriko Inamura, Tatsuhiro Hisatsune
Summary: The study found a significant correlation between cognitive function in elderly individuals and daily consumption of fat, especially in monounsaturated fatty acids and oleic acid. This suggests that the intake of these fats may have a beneficial effect on cognitive decline in community-dwelling Japanese elderly individuals.
Article
Geriatrics & Gerontology
Linxin Liu, Huichu Li, Hari Iyer, Andy J. Liu, Yi Zeng, John S. S. Ji
Summary: The study found complex relationships among APOE genotype, lipids, glucose, and cognitive function, with possible mediation or effect modification by lipids and glucose levels. However, abnormal lipids or glucose levels were not consistently associated with cognitive dysfunction in this study.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Jingzheng Yan, Fangyun Luan, Meijuan Wang, Wenshuo Dong, Xinyue Zhang, Mengli Li, Yingjuan Cao
Summary: This study investigated the association of standing balance with cognitive functions and the rate of cognitive decline among middle-aged and older Chinese adults. The results showed that good standing balance was significantly associated with higher cognitive function and a lower decline in mental status and global cognition.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Cell Biology
Bhaskar Jyoti Dutta, Pratik Shankar Rakshe, Niyogita Maurya, Shivani Chib, Sanjiv Singh
Summary: Natural stilbenes, particularly pterostilbene (PTE), have shown therapeutic potential in age-associated conditions such as cardiovascular diseases, diabetes mellitus, and cognitive decline. PTE, abundant in grapes and blueberries, modulates hallmark aging processes including oxidative damage, inflammation, telomere attrition, and cellular senescence. It has the ability to penetrate the blood-brain barrier, safeguard neural health, regulate neuronal signaling cascades, synaptic plasticity, and mitochondrial functionality. Engagement with sirtuin proteins allows PTE to enhance cellular resilience, longevity, and metabolic equilibrium. Preclinical studies have demonstrated the potential of PTE in counteracting age-related cognitive decline, enhancing memory consolidation, and ameliorating neurodegenerative diseases such as Alzheimer's. This comprehensive understanding lays a solid groundwork for future clinical inquiries and innovative therapeutic interventions in this field.
AGEING RESEARCH REVIEWS
(2023)
Article
Geriatrics & Gerontology
Ajay Kolli, Mohammed Kabeto, Ryan McCammon, Kenneth M. Langa, Joshua R. Ehrlich
Summary: This study investigated the association between glaucoma and cognitive function using a large sample size, longitudinal follow-up, and repeated measures of cognitive function. The results showed a small and clinically insignificant association between glaucoma and cognitive function.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Geriatrics & Gerontology
Sarah T. Stahl, Helene M. Altmann, Mary Amanda Dew, Steven M. Albert, Meryl Butters, Ariel Gildengers, Charles F. Reynolds, Jordan F. Karp
Summary: Evaluating both gait and psychomotor speed in older adults with medical comorbidities and sub-syndromal depression may predict incident mental illness and inform prevention planning. Further research is needed to validate these findings and explore shared neurobiological mechanisms that explain the increased risk.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Article
Public, Environmental & Occupational Health
Sophia P. Lou, Dingfen Han, Marie F. Kuczmarski, Michele K. Evans, Alan B. Zonderman, Deidra C. Crews
Summary: Higher health literacy (HL) and health numeracy (HN) are associated with greater accordance to the Dietary Approaches to Stop Hypertension (DASH) diet among hypertensive adults. In the sample, 32.5% had limited HL and 14.5% had limited HN. HL was positively correlated with DASH total score in the overall sample, while the relationship between HN and DASH was statistically significant only among White participants. Educational attainment explained both findings.
HEALTH EDUCATION & BEHAVIOR
(2023)
Article
Geriatrics & Gerontology
Botong Shen, Dena G. Hernandez, Kumaraswamy Naidu Chitrala, Marie T. Fanelli-Kuczmarski, Nicole Noren Hooten, Natasha L. Pacheco, Nicolle A. Mode, Alan B. Zonderman, Ngozi Ezike, Michele K. Evans
Summary: This study identified DNA methylation sites in the APOE genomic region that are associated with cognitive performance, indicating a potential link between DNA methylation and cognitive decline. The study also found significant associations between the dietary inflammatory index, cognitive performance, and DNA methylation levels.
NEUROBIOLOGY OF AGING
(2022)
Article
Geriatrics & Gerontology
Natasha L. Pacheco, Nicole Noren Hooten, Yongqing Zhang, Calais S. Prince, Nicolle A. Mode, Ngozi Ezike, Kevin G. Becker, Alan B. Zonderman, Michele K. Evans
Summary: The study revealed sex-specific transcriptional changes in middle-aged frailty, aiding in the understanding of frailty progression and providing potential therapeutic targets for preventing frailty.
Article
Clinical Neurology
Hind A. Beydoun, Nazmus Saquib, Robert B. Wallace, Jiu-Chiuan Chen, Mace Coday, Michelle J. Naughton, May A. Beydoun, Aladdin H. Shadyab, Alan B. Zonderman, Robert L. Brunner
Summary: The use of antidepressants and anxiolytics was associated with an increased risk of incident Parkinson's Disease in older women, while the use of hypnotics showed no significant association.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
May A. Beydoun, Nicole Noren Hooten, Jordan Weiss, Ana I. Maldonado, Hind A. Beydoun, Leslie I. Katzel, Christos Davatzikos, Rao P. Gullapalli, Stephen L. Seliger, Guray Erus, Michele K. Evans, Alan B. Zonderman, Shari R. Waldstein
Summary: The link between plasma neurofilament light chain (NfL) and dementia may be mediated through white matter integrity (WMI). This study found that higher plasma NfL levels were associated with increased global and frontal white matter trace (TR) in middle-aged adults, particularly among males and White individuals. Additionally, African American adults showed a relationship between NfL and greater left temporal lobe TR.
NEUROBIOLOGY OF AGING
(2023)
Article
Immunology
May A. Beydoun, Nicole Noren Hooten, Jordan Weiss, Hind A. Beydoun, Michael Georgescu, David W. Freeman, Michele K. Evans, Alan B. Zonderman
Summary: Serum GDF15 levels are correlated with multiple neurodegenerative diseases. This study examined the association between initial serum GDF15 concentrations and cognitive performance over time in a diverse sample of middle-aged adults. The results showed cross-sectional associations between GDF15 and cognitive performance, but GDF15 did not predict changes in cognitive performance over a 4-year follow-up period. More longitudinal studies are needed to assess the clinical utility of GDF15 as a biomarker for early cognitive defects.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Geriatrics & Gerontology
Anjali M. Byappanahalli, Nicole Noren Hooten, Mya Vannoy, Nicolle A. Mode, Ngozi Ezike, Alan B. Zonderman, Michele K. Evans
Summary: This study investigates the relationship between frailty and mitochondrial DNA (mtDNA) and inflammatory proteins in extracellular vesicles (EVs). The results show that EVs from frail individuals have higher levels of mtDNA and inflammatory proteins. The levels of EV inflammatory proteins are influenced by frailty, race, sex, and poverty status. These findings highlight the importance of EVs in frailty and the impact of social determinants of health, such as poverty, on the inflammatory cargo of EVs.
Article
Neurosciences
Hind A. Beydoun, May A. Beydoun, Ana Maldonado, Marie T. Fanelli-Kuczmarski, Jordan Weiss, Michele K. Evans, Alan B. Zonderman
Summary: This study found that chronic stress has a negative impact on cognitive function. However, this impact does not change over time, and there are no significant differences in its effects based on sex or race.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Nutrition & Dietetics
Marie Fanelli Kuczmarski, May A. Beydoun, Michael F. Georgescu, Nicole Noren Hooten, Nicolle A. Mode, Michele K. Evans, Alan B. Zonderman
Summary: Limited research has been conducted on the trajectories of diet quality in adulthood. This study used data from the HANDLS study to determine the diet quality group trajectories over time. The results showed minimal changes in diet quality regardless of the index used.
Article
Nutrition & Dietetics
Marie Fanelli Kuczmarski, May A. Beydoun, Michael F. Georgescu, Nicole Noren Hooten, Nicolle A. Mode, Michele K. Evans, Alan B. Zonderman
Summary: This study aims to investigate the association between diet quality and frailty status. The results showed that both medium pro-inflammatory and anti-inflammatory diet trajectory groups were positively associated with being non-frail over time, and anti-inflammatory diet quality was associated with lower risk for being pre-frail or frail.
Article
Urology & Nephrology
Tessa K. Novick, James Custer, Alan B. Zonderman, Michele K. Evans, Melissa Hladek, Marie Kuczmarski, Paul J. Rathouz, Deidra C. Crews
Summary: This study aimed to evaluate the association between coping behaviors and incident CKD or rapid kidney function decline. The study found that adaptive coping behaviors were associated with lower odds of incident CKD, while maladaptive coping behaviors were not associated with CKD. No association was found between coping behaviors and rapid kidney function decline.
Article
Cell Biology
May A. Beydoun, Hind A. Beydoun, Nicole Noren Hooten, Ana I. Maldonado, Jordan Weiss, Michele K. Evans, Alan B. Zonderman
Summary: This study found that perceived discrimination among older adults is associated with accelerated aging and depressive symptoms. Particularly among women and white adults, perceived discrimination had a significant adverse effect on epigenetic aging, with a portion of this effect being explained by depressive symptoms.
Article
Obstetrics & Gynecology
Hind A. Beydoun, Michelle J. Naughton, May A. Beydoun, Aladdin H. Shadyab, Robert L. Brunner, Jiu-Chiuan Chen, Mark Espeland, Sally A. Shumaker, Alan B. Zonderman
Summary: This study examined the association between sleep disturbance and Parkinson's disease (PD) and found that sleep disturbance was associated with a 10% to 30% increased risk of PD in postmenopausal women after approximately 16 years of follow-up.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Medicine, General & Internal
Hind A. Beydoun, Shuan Huang, May A. Beydoun, Shaker M. Eid, Alan B. Zonderman
Summary: This study examines the utilization of radiation therapies and stereotactic radiosurgery among U.S. adults hospitalized with brain metastasis before and after the implementation of the Affordable Care Act. The findings suggest that there were changes in the utilization of these treatments, with some traditionally underserved populations being more likely to receive healthcare services post-Affordable Care Act.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Lena Mathews, Dingfen Han, Michele K. Evans, Alan B. Zonderman, Chiadi E. Ndumele, Deidra C. Crews
Summary: The study found that among an urban-dwelling population, Black participants with CAD were less likely to be on aspirin and combination GDMT compared to Whites.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2022)