Article
Ophthalmology
Merry Septemi Ekayanti, Corry Novita Mahama, Denny Jefferson Ngantung
Summary: The study aimed to obtain normative values of VEP latency and amplitude parameters in Indonesian adults and investigate their relationship with factors such as height, weight, BMI, head circumference, and visual acuity. Results showed that gender and age can affect P100 amplitude but not latency, while height, weight, BMI, head circumference, and visual acuity have no impact on P100 latency and amplitude.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Clinical Neurology
Iuri Santana Neville, Alexandra Gomes dos Santos, Cesar Cimonari Almeida, Cintya Yukie Hayashi, Davi Jorge Fontoura Solla, Ricardo Galhardoni, Daniel Ciampi de Andrade, Andre Russowsky Brunoni, Manoel Jacobsen Teixeira, Wellingson Silva Paiva
Summary: This study utilized nTMS to evaluate cortical excitability in brain hemispheres affected by tumors, finding abnormal CE patterns and distinct features in patients with GBM. Tumor biological behavior may play a role in these changes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Mariagiovanna Cantone, Giuseppe Lanza, Francesco Fisicaro, Rita Bella, Raffaele Ferri, Giovanni Pennisi, Gunnar Waterstraat, Manuela Pennisi
Summary: This study provides a set of age- and height-adjusted reference values for motor evoked potential (MEP) latency, central motor conduction time (CMCT), and peripheral motor conduction time (PMCT). The study also highlights the influence of sex on MEP latency and motor conduction time. These reference values are important for clinical studies and evaluation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Bingchuan Liu, Xinyi Yan, Xiaogang Chen, Yijun Wang, Xiaorong Gao
Summary: This study investigated the effect of tACS on healthy human subjects and found that tACS significantly boosted the frequency of SSVEP. Additionally, the aftereffect on SSVEP decreased with time and lasted up to 5 minutes.
JOURNAL OF NEURAL ENGINEERING
(2021)
Review
Engineering, Biomedical
Zhongfei Bai, Jiaqi Zhang, Kenneth N. K. Fong
Summary: This study systematically reviewed the effects of different transcranial magnetic stimulation protocols on cortical excitability in stroke patients. The results showed that most protocols were effective in modulating cortical excitability, except for continuous theta burst stimulation. In particular, inhibitory stimulation had positive effects on the affected motor cortex.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Article
Physiology
Clara Pfenninger, Nathan Grosboillot, Guillaume Digonet, Thomas Lapole
Summary: This study aims to investigate the acute effects of prolonged local vibration on central nervous system excitability. The results suggest that vibration applied to the muscle, whether in a relaxed or contracted state, can decrease motoneuronal excitability and increase cortical excitability.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Jesus Cespon, Maria Concetta Pellicciari, Elias Paolo Casula, Carlo Miniussi
Summary: Understanding the relationship between cortical excitability, executive function, and underlying neural activity in healthy young and older adults may improve interventions aimed at supporting cognitive function in older adults. The study found that older adults exhibited alterations in cortical excitability, resulting in longer reaction times and impaired attentional and inhibitory control compared to young adults.
Article
Neurosciences
Catherine R. Jutzeler, Lukas D. Linde, Jan Rosner, Michele Hubli, Armin Curt, John L. K. Kramer
Summary: The study found that analyzing nociceptive evoked potentials through single-trial averaging can improve the associations with physiological outcomes and should be incorporated as a standard technique in future studies.
Review
Geriatrics & Gerontology
Giuseppe Lanza, Francesco Fisicaro, Raffaele Dubbioso, Federico Ranieri, Andrei V. Chistyakov, Mariagiovanna Cantone, Manuela Pennisi, Alfio Antonio Grasso, Rita Bella, Vincenzo Di Lazzaro
Summary: Although primary degenerative diseases are the main cause of dementia, there is a significant number of patients with a secondary and potentially treatable cognitive disorder. Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological technique that can evaluate motor areas, cortico-spinal tract, and neurotransmission pathways in neurological and neuropsychiatric disorders, including cognitive impairment and dementia. While there is considerable evidence for certain types of dementia, the comprehensive review of TMS studies in other secondary dementias is lacking. We need further research to understand the neurophysiological changes and pathogenic mechanisms in different secondary dementias.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Zhenxing Zhang, Yi Wang, Tao Luo, Huaguang Qi, Lin Cai, Yang Yuan, Jingfeng Li
Summary: The aim of this study was to assess the value of dermatomal somatosensory evoked potentials (DSEPs) and cortical somatosensory evoked potentials (SSEPs) in monitoring spinal cord function for patients with congenital scoliosis (CS). The study found that DSEPs are more sensitive to microscopic posterior column dysfunction in CS patients that cannot be detected by either radiology or routine clinical examination. Therefore, preoperative DSEPs assessment is recommended for intraoperative monitoring.
Article
Clinical Neurology
Vincenzo Rizzo, Carmen Terranova, Giovanni Raffa, Salvatore Massimiliano Cardali, Filippo Flavio Angileri, Giuseppina Marzano, Maria Catena Quattropani, Antonino Germano, Paolo Girlanda, Angelo Quartarone
Summary: Brain tumors can lead to abnormal cortical excitability in affected hemispheres, with decreased SICI, ICF, and SAI. Further research is needed to investigate the relationship between cortical excitability and motor impairment in these patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Sanne Lotte Journee, Henricus Louis Journee, Hanneke Irene Berends, Steven Michael Reed, Wilhelmina Bergmann, Cornelis Marinus de Bruijn, Catherine John Ghislaine Delesalle
Summary: This study provides normative data for trapezius motor evoked potentials (MEP) in horses using transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS). The study also distinguishes between direct and indirect conduction routes using neurophysiological models. The results are important for clinical diagnosis.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tammam Abboud, Thomas Asendorf, Jutta Heinrich, Katharina Faust, Sandro M. Krieg, Kathleen Seidel, Dorothee Mielke, Cordola Matthies, Florian Ringel, Veit Rohde, Andrea Szelenyi
Summary: This study aims to compare transcranial electrical stimulation (TES) and direct cortical stimulation (DCS) in predicting postoperative motor deficits and extent of tumor resection, in order to determine the necessity for a larger confirmatory trial. The study plans to enroll 120 patients within two years, with the primary endpoint being assessment of postoperative motor function at 7 days, and the main secondary endpoint being the extent of tumor resection.
Article
Multidisciplinary Sciences
Anna-Lisa Schuler, Diandra Brkic, Giulio Ferrazzi, Giorgio Arcara, Daniele Marinazzo, Giovanni Pellegrino
Summary: Cortical excitability, commonly measured by magnetic stimulation and behavioral response, can be limited in spatial range and fail to account for intrinsic fluctuations. This study introduces a measure for intrinsic excitability based on phase synchronization and applies it to magnetoencephalography (MEG) recordings during exposure to auditory white noise. Results show a specific pattern of decreased frontal lobe excitability and increased temporal lobe excitability during white noise exposure, providing insight into the effects of specific environmental stimuli on cortical excitability.
Article
Neurosciences
Patrizio Canepa, Charalambos Papaxanthis, Ambra Bisio, Monica Biggio, Christos Paizis, Emanuela Faelli, Laura Avanzino, Marco Bove
Summary: Neural mechanisms at corticospinal levels differ in concentric and eccentric contractions, showing a time-specific modulation of corticospinal excitability during the preparatory phase. Significant changes in CSE were observed only in eccentric contraction around the Go signal, with a decrease before and an increase after it.
Editorial Material
Anesthesiology
Steven P. Cohen, Daniel Ciampi de Andrade
Article
Anesthesiology
Irina Raicher, Alexandra P. Zandonai, Isadora W. Anghinah, Mariana Frassetto, Patrick R. N. A. G. Stump, Maria A. B. Trindade, Simone Harnik, Rodrigo A. Oliveira, Ricardo S. S. Macarenco, Kathrin Doppler, Nurcan Uceyler, Evandro S. Mello, Claudia Sommer, Manoel J. Teixeira, Ricardo Galhardoni, Daniel C. de Andrade
Summary: This study investigated the differences between leprosy patients with and without neuropathic pain (NeP). The results showed that patients with NeP exhibited signs of C-fiber dysfunction and hyperesthesia, while patients without NeP did not. It was also found that the duration of leprosy treatment was associated with the intensity of neuropathy.
Article
Neurosciences
Jennifer S. Lewis, Muhammad Kashif, Aasam Maan, Daniel Ciampi de Andrade, Michelle Casey, Jee Youn Moon, Chih-Peng Lin, Lena Danielsson, Terence Quek, Rodrigo Diez Tafur, Abdelkarim Aloweidi, Frank Birklein, Lone Knudsen, Andreas Goebel
Summary: The aim of the 2021 IASP CRPS SIG Global Series was to facilitate knowledge exchange among clinicians from developing countries and enhance understanding of the clinical presentation of complex regional pain syndrome in regions with less published research. The proceedings include abstracts of online presentations from nine countries across four continents, providing insights into treatments, outcomes, and challenges. Clinicians from Asia, South America, Africa, and Europe shared their experiences in diagnosing and treating CRPS, highlighting its global presence across borders and cultures. These proceedings broaden the international pain community's understanding of and approaches to CRPS.
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda da Valerio, Samira Luisa Apostolos Pereira, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Jr, Adriana Bastos Conforto, Leandro Tavares Lucato, Marcelo Delboni Lemos, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study examined the relationships between symptoms and somatosensory profiles in patients with central neuropathic pain (CNP) caused by different types of lesions to the central nervous system. The results suggest that CNP of different etiologies may have different pain descriptors and somatosensory profiles, likely due to differences in lesion locations.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Anesthesiology
Gabriel T. Kubota, Felipe H. C. Soares, Alessandra S. da Fonseca, Talita dos Santos Rosa, Valquiria A. da Silva, Gisele R. Gouveia, Viviane G. Faria, Pedro H. M. da Cunha, Andre R. Brunoni, Manoel J. Teixeira, Daniel C. de Andrade
Summary: This study describes the different temporal evolutions of chronic pain after COVID-19 and reveals its epidemiological and phenotypical features. The results show that COVID-19-related pain usually follows a chronic non-neuropathic course, and its possible courses and phenotypes are associated with specific clinical and epidemiological features.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Clarice Listik, Eduardo Listik, Flavia de Paiva Santos Rolim, Denise Maria Meneses Cury Portela, Santiago Perez Lloret, Natalia Rebeca de Alves Araujo, Pedro Rubens Araujo Carvalho, Graziele Costa Santos, Joao Carlos Papaterra Limongi, Francisco Cardoso, Veit Mylius, Florian Brugger, Ana Mercia Fernandes, Egberto Reis Barbosa, Manoel Jacobsen Teixeira, Henrique Ballalai Ferraz, Sarah Teixeira Camargos, Rubens Gisbert Cury, Daniel de Ciampi de Andrade
Summary: The aim of this study was to develop a classification and scoring system for chronic pain (CP) in dystonia. The results showed that the developed Dystonia-Pain Classification System (Dystonia-PCS) is a reliable tool for categorizing and quantifying CP impact in dystonia and can help improve clinical trial design and pain management in patients with this disorder.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Luciana Mendonca Barbosa, Fernanda Valerio, Valquiria Aparecida da Silva, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Lin Tchia Yeng, Jefferson Rosi Junir, Adriana Bastos Conforto, Leandro Tavares Lucato, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: Objectives: This study aimed to describe the changes in corticomotor excitability (CE) that are specifically related to central neuropathic pain (CNP). Methods: CE measurements and comprehensive assessments were conducted on patients with CNP associated with brain injury after stroke or spinal cord injury (SCI) due to neuromyelitis optica. Results: Patients with CNP had lower motor evoked potential (MEP) and defective short-interval intracortical inhibition (SICI) compared to patients with non-neuropathic pain and no-pain patients.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Marcelo Luiz da Silva, Ana Mercia Fernandes, Valquiria A. Silva, Ricardo Galhardoni, Valter Felau, Joaci O. de Araujo, Jefferson Rosi Jr, Roger S. Brock, Gabriel T. Kubota, Manoel J. Teixeira, Lin T. Yeng, Daniel Ciampi de Andrade
Summary: This study investigated the clinical pain, conditioned pain modulation (CPM), and cortical plastic changes in patients with three types of low-back pain: non-specific LBP, failed back surgery syndrome (FBSS), and sciatica. The results showed that different types of low-back pain were associated with different clinical, CPM, and cortical excitability profiles, emphasizing the need for further characterization of patients with low-back pain in psychophysics and cortical neurophysiology studies.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Anesthesiology
Daniel Ciampi de Andrade, Veit Mylius, Santiago Perez-Lloret, Rubens G. Cury, Kirsty Bannister, Xavier Moisset, Gabriel Taricani Kubota, Nanna B. Finnerup, Didier Bouhassira, Kallol Ray Chaudhuri, Thomas Graven-Nielsen, Rolf-Detlef Treede
Summary: Parkinson's disease is a common neurological disorder that often leads to chronic pain as a nonmotor symptom, negatively impacting patients' quality of life and functioning. Classifying this pain is challenging due to its diverse mechanisms, but recent research has proposed a classification framework based on mechanistic descriptors. This article provides an overview of the mechanism of pain in Parkinson's disease and discusses the implications of current classification approaches for clinical practice, as well as gaps in knowledge that should be addressed in future research.
Article
Neurosciences
Enrico De Martino, Adenauer Casali, Silvia Casarotto, Gabriel Hassan, Mario Rosanova, Thomas Graven-Nielsen, Daniel Ciampi de Andrade
Summary: Pain-related changes in cortical excitability were investigated in the dorsolateral prefrontal cortex and primary motor cortex using transcranial magnetic stimulation-electroencephalography. Acute pain decreased peak-to-peak amplitude in both M1 and dorsolateral prefrontal cortex, while only M1 showed a reduction in global-mean field power. Participants with the greatest reduction in local cortical excitability under acute pain showed a negative correlation between dorsolateral prefrontal cortex and M1. These findings highlight the differential effects of acute pain on local and global cortical excitability, as well as individual patterns of cortical excitability changes.
Review
Anesthesiology
Daniel Ciampi de Andrade, Luis Garcia-Larrea
Summary: Repetitive transcranial magnetic stimulation (rTMS) applied to the motor cortex provides supplementary relief for some individuals with chronic pain. However, the efficacy at the group-level does not guarantee individual pain relief. Ongoing attempts in personalized medicine aim to overcome this therapeutic challenge.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Clinical Neurology
Victor Rossetto Barboza, Gabriel Taricani Kubota, Valquiria Aparecida da Silva, Luciana Mendonca Barbosa, Debora Arnaut, Antonia Lilian de Lima Rodrigues, Ricardo Galhardoni, Rubens Gisbert Cury, Egberto Reis Barbosa, Andre Russowsky Brunoni, Manoel Jacobsen Teixeira, Daniel Ciampi de Andrade
Summary: This study found that Parkinson's disease patients with nociceptive chronic pain may have distinctive somatosensory and corticospinal excitability profiles compared to those with non-nociceptive pain subtypes.