Upconverting nanoparticles: assessing the toxicity

Dual-Targeting Upconversion Nanoprobes across the Blood–Brain Barrier for Magnetic Resonance/Fluorescence Imaging of Intracranial Glioblastoma

(2014) Dalong Ni et al.   ACS Nano

Surface Interactions with Compartmentalized Cellular Phosphates Explain Rare Earth Oxide Nanoparticle Hazard and Provide Opportunities for Safer Design

(2014) Ruibin Li et al.   ACS Nano

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

(2014) Guanying Chen et al.   CHEMICAL REVIEWS

Anti-Biofouling Polymer-Decorated Lutetium-Based Nanoparticulate Contrast Agents for In Vivo High-Resolution Trimodal Imaging

(2014) Zhen Liu et al.   Small

Air–Blood Barrier Translocation of Tracheally Instilled Gold Nanoparticles Inversely Depends on Particle Size

(2013) Wolfgang G. Kreyling et al.   ACS Nano

Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications

(2013) Zhanjun Gu et al.   ADVANCED MATERIALS

Photon-Upconverting Nanoparticles for Optical Encoding and Multiplexing of Cells, Biomolecules, and Microspheres

(2013) Hans H. Gorris et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biodistribution of sub-10 nm PEG-modified radioactive/upconversion nanoparticles

(2013) Tianye Cao et al.   BIOMATERIALS

Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes

(2013) Zhen Liu et al.   BIOMATERIALS

Conjugation of NaGdF4 upconverting nanoparticles on silica nanospheres as contrast agents for multi-modality imaging

(2013) Fuyao Liu et al.   BIOMATERIALS

Cysteine modified rare-earth up-converting nanoparticles for in vitro and in vivo bioimaging

(2013) Zuwu Wei et al.   BIOMATERIALS

Ultra-small BaGdF5-based upconversion nanoparticles as drug carriers and multimodal imaging probes

(2013) Dongmei Yang et al.   BIOMATERIALS

A systematic in-vivo toxicity evaluation of nanophosphor particles via zebrafish models

(2013) Gun Hyuk Jang et al.   BIOMATERIALS

Size-dependent internalisation of folate-decorated nanoparticles via the pathways of clathrin and caveolae-mediated endocytosis in ARPE-19 cells

(2013) Wai-Leung Langston Suen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Highly bright multicolor tunable ultrasmall β-Na(Y,Gd)F4:Ce,Tb,Eu/β-NaYF4 core/shell nanocrystals

(2013) Su Yeon Kim et al.   Nanoscale

In vitro cell imaging using multifunctional small sized KGdF4:Yb3+,Er3+ upconverting nanoparticles synthesized by a one-pot solvothermal process

(2013) Hon-Tung Wong et al.   Nanoscale

One-step nucleotide-programmed growth of porous upconversion nanoparticles: application to cell labeling and drug delivery

(2013) Li Zhou et al.   Nanoscale

Gadolinium oxysulfide nanoparticles as multimodal imaging agents for T2-weighted MR, X-ray tomography and photoluminescence

(2013) Sèmiyou. A. Osseni et al.   Nanoscale

The impact of shell host (NaYF4/CaF2) and shell deposition methods on the up-conversion enhancement in Tb3+, Yb3+codoped colloidal α-NaYF4core–shell nanoparticles

(2013) Katarzyna Prorok et al.   Nanoscale

Transport of NaYF4:Er3+, Yb3+up-converting nanoparticles into HeLa cells

(2013) Bożena Sikora et al.   NANOTECHNOLOGY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of polystyrene nanoparticles and UV-inactivated antigen-displaying adenovirus for vaccine delivery in mice

(2013) Lena Johrden et al.   Virology Journal

Stem Cell Labeling using Polyethylenimine Conjugated (α-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles

(2013) Liang Zhao et al.   Theranostics

Toxicity Assessments of Near-infrared Upconversion Luminescent LaF3:Yb,Er in Early Development of Zebrafish Embryos

(2013) Kan Wang et al.   Theranostics

Multifunctional core–shell upconversion nanoparticles for targeted tumor cells induced by near-infrared light

(2013) Xiaojun Yang et al.   Journal of Materials Chemistry B

Bifunctional up-converting lanthanide nanoparticles for selective in vitro imaging and inhibition of cyclin D as anti-cancer agents

(2013) Chi-Fai Chan et al.   Journal of Materials Chemistry B

(α-NaYbF4:Tm3+)/CaF2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging

(2012) Guanying Chen et al.   ACS Nano

Cytotoxic aspects of gadolinium oxide nanostructures for up-conversion and NIR bioimaging

(2012) Eva Hemmer et al.   Acta Biomaterialia

Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy

(2012) Jie Shen et al.   ADVANCED DRUG DELIVERY REVIEWS

Water-stable NaLuF4-based upconversion nanophosphors with long-term validity for multimodal lymphatic imaging

(2012) Jing Zhou et al.   BIOMATERIALS

Long-circulating Er3+-doped Yb2O3 up-conversion nanoparticle as an in vivo X-Ray CT imaging contrast agent

(2012) Zhen Liu et al.   BIOMATERIALS

A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging

(2012) Huaiyong Xing et al.   BIOMATERIALS

PEG modified BaGdF5:Yb/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging

(2012) Songjun Zeng et al.   BIOMATERIALS

Endocytosis, intracellular transport, and exocytosis of lanthanide-doped upconverting nanoparticles in single living cells

(2012) Yun Mi Bae et al.   BIOMATERIALS

Long-term in vivo biodistribution and toxicity of Gd(OH)3 nanorods

(2012) Yang Yang et al.   BIOMATERIALS

Long-circulating Gd2O3:Yb3+, Er3+ up-conversion nanoprobes as high-performance contrast agents for multi-modality imaging

(2012) Zhen Liu et al.   BIOMATERIALS

Hydrothermal synthesis of NaLuF4:153Sm,Yb,Tm nanoparticles and their application in dual-modality upconversion luminescence and SPECT bioimaging

(2012) Yang Yang et al.   BIOMATERIALS

Recent advances in synthesis and surface modification of lanthanide-doped upconversion nanoparticles for biomedical applications

(2012) Min Lin et al.   BIOTECHNOLOGY ADVANCES

Rare-Earth Nanoparticles with Enhanced Upconversion Emission and Suppressed Rare-Earth-Ion Leakage

(2012) Ye-Fu Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hybrid mesoporous gadolinium oxide nanorods: a platform for multimodal imaging and enhanced insoluble anticancer drug delivery with low systemic toxicity

(2012) Zhen Liu et al.   JOURNAL OF MATERIALS CHEMISTRY

RGD Peptide-Conjugated Multimodal NaGdF4:Yb3+/Er3+ Nanophosphors for Upconversion Luminescence, MR, and PET Imaging of Tumor Angiogenesis

(2012) J. Lee et al.   JOURNAL OF NUCLEAR MEDICINE

Direct Imaging the Upconversion Nanocrystal Core/Shell Structure at the Subnanometer Level: Shell Thickness Dependence in Upconverting Optical Properties

(2012) Fan Zhang et al.   NANO LETTERS

Upconversion nanoparticles dramatically promote plant growth without toxicity

(2012) Juanjuan Peng et al.   Nano Research

Lanthanide-doped up-converting nanoparticles: Merits and challenges

(2012) Anna Gnach et al.   Nano Today

Fluorescence Imaging of the Lymph Node Uptake of Proteins in Mice after Subcutaneous Injection: Molecular Weight Dependence

(2012) Fang Wu et al.   PHARMACEUTICAL RESEARCH

Upconversion Nanomaterials: Synthesis, Mechanism, and Applications in Sensing

(2012) Jiao Chen et al.   SENSORS

Advances in the Surface Engineering of Upconversion Nanocrystals

(2012) Chao Liu et al.   Science of Advanced Materials

Biological Applications of Rare-Earth Based Nanoparticles

(2011) Cedric Bouzigues et al.   ACS Nano

Effect of Core Diameter, Surface Coating, and PEG Chain Length on the Biodistribution of Persistent Luminescence Nanoparticles in Mice

(2011) Thomas Maldiney et al.   ACS Nano

Toxicology of nanoparticles

(2011) Andreas Elsaesser et al.   ADVANCED DRUG DELIVERY REVIEWS

Pegylated Composite Nanoparticles Containing Upconverting Phosphors and meso-Tetraphenyl porphine (TPP) for Photodynamic Therapy

(2011) Jingning Shan et al.   ADVANCED FUNCTIONAL MATERIALS

Nanotoxicology: An Interdisciplinary Challenge

(2011) Harald F. Krug et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifunctional rare-earth self-assembled nanosystem for tri-modal upconversion luminescence /fluorescence /positron emission tomography imaging

(2011) Qian Liu et al.   BIOMATERIALS

Bioimaging and toxicity assessments of near-infrared upconversion luminescent NaYF4:Yb,Tm nanocrystals

(2011) Jia-Cai Zhou et al.   BIOMATERIALS

Upconversion nanophosphors for small-animal imaging

(2011) Jing Zhou et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of surface amino-functionalized NaGdF4:Ce,Tb nanoparticles and their luminescence resonance energy transfer (LRET) with Au nanoparticles

(2011) Congcong Mi et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Upconverter solar cells: materials and applications

(2011) J. de Wild et al.   Energy & Environmental Science

Controllable synthesis of NaYF4 : Yb,Er upconversion nanophosphors and their application to in vivo imaging of Caenorhabditis elegans

(2011) Jing Chen et al.   JOURNAL OF MATERIALS CHEMISTRY

Biocompatible Fluorescent Hydroxyapatite: Synthesis and Live Cell Imaging Applications

(2011) Hongyan Liu et al.   Journal of Physical Chemistry C

Sub-10 nm Hexagonal Lanthanide-Doped NaLuF4Upconversion Nanocrystals for Sensitive Bioimaging in Vivo

(2011) Qian Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies

(2011) Tore-Geir Iversen et al.   Nano Today

Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation

(2011) Stefaan J. Soenen et al.   Nano Today

Applications of upconversion nanoparticles in imaging, detection and therapy

(2011) Lei Yin Ang et al.   Nanomedicine

In vivopharmacokinetics, long-term biodistribution and toxicology study of functionalized upconversion nanoparticles in mice

(2011) Liang Cheng et al.   Nanomedicine

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

(2011) Christian A. Ruge et al.   Nanomedicine-Nanotechnology Biology and Medicine

Mechanism and determinants of nanoparticle penetration through human skin

(2011) Hagar I. Labouta et al.   Nanoscale

Human skin penetration of gold nanoparticles through intact and damaged skin

(2011) Francesca Larese Filon et al.   Nanotoxicology

Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials

(2011) Feng Zhao et al.   Small

Upconversion Nanocrystals: Synthesis, Properties, Assembly and Applications

(2011) Danny Vennerberg et al.   Science of Advanced Materials

Europium-doped amorphous calcium phosphate porous nanospheres: preparation and application as luminescent drug carriers

(2011) Feng Chen et al.   Nanoscale Research Letters

In Vivo Biodistribution and Clearance Studies Using Multimodal Organically Modified Silica Nanoparticles

(2010) Rajiv Kumar et al.   ACS Nano

Upconversion nanoparticles in biological labeling, imaging, and therapy

(2010) Feng Wang et al.   ANALYST

Toxicology of engineered nanomaterials: Focus on biocompatibility, biodistribution and biodegradation

(2010) Andrea Kunzmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors

(2010) Liqin Xiong et al.   BIOMATERIALS

Dual-modality in vivo imaging using rare-earth nanocrystals with near-infrared to near-infrared (NIR-to-NIR) upconversion luminescence and magnetic resonance properties

(2010) Jing Zhou et al.   BIOMATERIALS

Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging

(2010) Jing Zhou et al.   BIOMATERIALS

Surface-Modified Upconverting Microparticles and Nanoparticles for Use in Click Chemistries

(2010) Heike S. Mader et al.   CHEMISTRY-A EUROPEAN JOURNAL

Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging

(2010) Heike S Mader et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Role of carboxylate chelating agents on the chemical, structural and textural properties of hydroxyapatite

(2010) Karima Achelhi et al.   DALTON TRANSACTIONS

Rare earth upconversion nanophosphors: synthesis, functionalization and application as biolabels and energy transfer donors

(2010) Chao ZHANG et al.   JOURNAL OF RARE EARTHS

Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping

(2010) Feng Wang et al.   NATURE

Morphologically controlled synthesis of colloidal upconversion nanophosphors and their shape-directed self-assembly

(2010) X. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small Upconverting Fluorescent Nanoparticles for Biomedical Applications

(2010) Dev K. Chatterjee et al.   Small

The New Toxicology of Sophisticated Materials: Nanotoxicology and Beyond

(2010) A. D. Maynard et al.   TOXICOLOGICAL SCIENCES

Sunscreens with Titanium Dioxide (TiO2) Nano-Particles: A Societal Experiment

(2010) Johannes F. Jacobs et al.   NanoEthics

Effects of nanomaterial physicochemical properties on in vivo toxicity

(2009) Kristin L. Aillon et al.   ADVANCED DRUG DELIVERY REVIEWS

Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications

(2009) Bengt Fadeel et al.   ADVANCED DRUG DELIVERY REVIEWS

Toxicity Evaluation for Safe Use of Nanomaterials: Recent Achievements and Technical Challenges

(2009) Saber M. Hussain et al.   ADVANCED MATERIALS

High Contrast Upconversion Luminescence Targeted Imaging in Vivo Using Peptide-Labeled Nanophosphors

(2009) Liqin Xiong et al.   ANALYTICAL CHEMISTRY

Potential Health Impact of Nanoparticles

(2009) Tian Xia et al.   Annual Review of Public Health

Synthesis, characterization, and in vivo targeted imaging of amine-functionalized rare-earth up-converting nanophosphors

(2009) Li-Qin Xiong et al.   BIOMATERIALS

Upconverting luminescent nanomaterials: application to in vivo bioimaging

(2009) Scott A. Hilderbrand et al.   CHEMICAL COMMUNICATIONS

Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals

(2009) Feng Wang et al.   CHEMICAL SOCIETY REVIEWS

Shape, Size, and Phase-Controlled Rare-Earth Fluoride Nanocrystals with Optical Up-Conversion Properties

(2009) Fan Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Current Status of Gadolinium Toxicity in Patients with Kidney Disease

(2009) M. A. Perazella   Clinical Journal of the American Society of Nephrology

Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies

(2009) M Jean et al.   GENE THERAPY

In-Vivo Imaging of the Uptake of Upconversion Nanoparticles by Plant Roots

(2009) Anja Hischemöller et al.   Journal of Biomedical Nanotechnology

Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs

(2009) PARESH CHANDRA RAY et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Cationic Nanoparticles Induce Nanoscale Disruption in Living Cell Plasma Membranes

(2009) Jiumei Chen et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Long-term Persistence and Spectral Blue Shifting of Quantum Dots in Vivo

(2009) James A. J. Fitzpatrick et al.   NANO LETTERS

NIR-to-visible upconversion nanoparticles for fluorescent labeling and targeted delivery of siRNA

(2009) Shan Jiang et al.   NANOTECHNOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Effect of Surface Properties on Nanoparticle–Cell Interactions

(2009) Ayush Verma et al.   Small

Nanoparticles in photodynamic therapy: An emerging paradigm

(2008) Dev Kumar Chatterjee et al.   ADVANCED DRUG DELIVERY REVIEWS

Autofluorescence insensitive imaging using upconverting nanocrystals in scattering media

(2008) Can T. Xu et al.   APPLIED PHYSICS LETTERS

Biocompatibility of silica coated NaYF4 upconversion fluorescent nanocrystals

(2008) Rufaihah Abdul Jalil et al.   BIOMATERIALS

Facile Epoxidation Strategy for Producing Amphiphilic Up-Converting Rare-Earth Nanophosphors as Biological Labels

(2008) He Hu et al.   CHEMISTRY OF MATERIALS

In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size

(2008) Ganeshchandra Sonavane et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Biodistribution of colloidal gold nanoparticles after intravenous administration: Effect of particle size

(2008) Ganeshchandra Sonavane et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Lanthanide-doped fluoride nanoparticles: luminescence, upconversion, and biological applications

(2008) Fiorenzo Vetrone et al.   International Journal of Nanotechnology

Biofunctionalization, cytotoxicity, and cell uptake of lanthanide doped hydrophobically ligated NaYF4 upconversion nanophosphors

(2008) Jingning Shan et al.   JOURNAL OF APPLIED PHYSICS

Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells

(2008) Mirjam Kool et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crystal structure mediates mode of cell death in TiO2 nanotoxicity

(2008) Laura K. Braydich-Stolle et al.   JOURNAL OF NANOPARTICLE RESEARCH

Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species

(2008) C. Carlson et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Surface Modification of Hydroxyapatite Nanocrystallite by a Small Amount of Terbium Provides a Biocompatible Fluorescent Probe

(2008) Ling Li et al.   Journal of Physical Chemistry C

Upconversion Multicolor Fine-Tuning: Visible to Near-Infrared Emission from Lanthanide-Doped NaYF4Nanoparticles

(2008) Feng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Versatile Synthesis Strategy for Carboxylic Acid−functionalized Upconverting Nanophosphors as Biological Labels

(2008) Zhigang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells

(2008) Hemant Sarin et al.   Journal of Translational Medicine

In Vivo Skin Penetration of Quantum Dot Nanoparticles in the Murine Model: The Effect of UVR

(2008) Luke J. Mortensen et al.   NANO LETTERS

High Contrast in Vitro and in Vivo Photoluminescence Bioimaging Using Near Infrared to Near Infrared Up-Conversion in Tm3+and Yb3+Doped Fluoride Nanophosphors

(2008) Marcin Nyk et al.   NANO LETTERS

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles

(2008) Ayush Verma et al.   NATURE MATERIALS

Nanoparticle-mediated cellular response is size-dependent

(2008) Wen Jiang et al.   Nature Nanotechnology

Near-Infrared Fluorescent Materials for Sensing of Biological Targets

(2008) Carrie Amiot et al.   SENSORS

Comparison of Molecular and Histological Changes in Zebrafish Gills Exposed to Metallic Nanoparticles

(2008) Robert J. Griffitt et al.   TOXICOLOGICAL SCIENCES

Conclusions and outlook

(2008) H. Norppa et al.   TOXICOLOGY LETTERS

Toxicology of engineered nanomaterials – Introduction

(2008) H.-J. Wiegand et al.   TOXICOLOGY LETTERS

Nanoparticles as vehicles for delivery of photodynamic therapy agents

(2008) Denise Bechet et al.   TRENDS IN BIOTECHNOLOGY

Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals

(2007) D CHATTERJEE et al.   BIOMATERIALS

Acute effects on the lung and the liver of oral administration of cerium chloride on adult, neonatal and fetal mice

(2007) Masami Kawagoe et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Cytotoxicity of Nanoparticles

(2007) Nastassja Lewinski et al.   Small