Multi-platinum anti-cancer agents. Substitution-inert compounds for tumor selectivity and new targets

Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp

(2015) Y. Qu et al.   DALTON TRANSACTIONS

Substitution-Inert Trinuclear Platinum Complexes Efficiently Condense/Aggregate Nucleic Acids and Inhibit Enzymatic Activity

(2014) Jaroslav Malina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding

(2014) John B. Mangrum et al.   CHEMICAL COMMUNICATIONS

Progress in platinum derived drug development

(2014) N.P. Farrell   DRUGS OF THE FUTURE

DNA Condensing Effects and Sequence Selectivity of DNA Binding of Antitumor Noncovalent Polynuclear Platinum Complexes

(2014) Jaroslav Malina et al.   INORGANIC CHEMISTRY

Nucleolar Targeting by Platinum: p53-Independent Apoptosis Follows rRNA Inhibition, Cell-Cycle Arrest, and DNA Compaction

(2014) Erica J. Peterson et al.   MOLECULAR PHARMACEUTICS

The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes

(2014) Andreea Prisecaru et al.   NUCLEIC ACIDS RESEARCH

NanoSIMS multi-element imaging reveals internalisation and nucleolar targeting for a highly-charged polynuclear platinum compound

(2013) Louise E. Wedlock et al.   CHEMICAL COMMUNICATIONS

Exploration of the medical periodic table: towards new targets

(2013) Nicolas P. E. Barry et al.   CHEMICAL COMMUNICATIONS

Recognition of DNA bulges by dinuclear iron(II) metallosupramolecular helicates

(2013) Jaroslav Malina et al.   FEBS Journal

Heparan Sulfate Proteoglycan-Mediated Entry Pathway for Charged Tri-Platinum Compounds: Differential Cellular Accumulation Mechanisms for Platinum

(2012) Heveline Silva et al.   MOLECULAR PHARMACEUTICS

Drug transporters of platinum-based anticancer agents and their clinical significance

(2011) Herman Burger et al.   DRUG RESISTANCE UPDATES

Effects of Noncovalent Platinum Drug–Protein Interactions on Drug Efficacy: Use of Fluorescent Conjugates as Probes for Drug Metabolism

(2011) Brad T. Benedetti et al.   MOLECULAR PHARMACEUTICS

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Excursions in polynuclear platinum DNA binding

(2010) John B. Mangrum et al.   CHEMICAL COMMUNICATIONS

Trends in Risks Associated With New Drug Development: Success Rates for Investigational Drugs

(2010) J A DiMasi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Copper Transporters and the Cellular Pharmacology of the Platinum-Containing Cancer Drugs

(2010) S. B. Howell et al.   MOLECULAR PHARMACOLOGY

The phosphate clamp: a small and independent motif for nucleic acid backbone recognition

(2010) Seiji Komeda et al.   NUCLEIC ACIDS RESEARCH

Cellular imaging with secondary ion mass spectrometry

(2009) John S. Fletcher   ANALYST

Factors Affecting DNA–DNA Interstrand Cross-Links in the Antiparallel 3′–3′ Sense: A Comparison with the 5′–5′ Directional Isomer

(2009) Rasha A. Ruhayel et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nucleolar targeting: the hub of the matter

(2009) Edward Emmott et al.   EMBO REPORTS

Inhibition of transcription by platinum antitumor compounds

(2009) Ryan C. Todd et al.   Metallomics

The Structure of Glycosaminoglycans and their Interactions with Proteins

(2008) Neha S. Gandhi et al.   Chemical Biology & Drug Design

The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy

(2007) Matthew D. Hall et al.   Annual Review of Pharmacology and Toxicology