Article
Chemistry, Multidisciplinary
Doojoon Jang, Chirodeep Bakli, Suman Chakraborty, Rohit Karnik
Summary: Atomically thin membranes with nanopores in a 2D material have the potential to outperform polymeric membranes in various applications. A platform technology has been developed to self-assemble oppositely charged polyelectrolytes in larger nanopores, effectively sealing non-selective transport channels while minimizing the impact on smaller, water-selective pores. This enhanced membrane selectivity allows for efficient desalination with high rejection rates of harmful ions.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Nayeong Kim, Jiho Lee, Xiao Su
Summary: This study demonstrates a polyelectrolyte functionalization approach to achieve multicomponent separation of organic acids in a redox-flow electrodialysis platform. The selectivity of organic acids can be precisely tuned through the control of membrane properties. This method allows for selective recovery of succinic acid with high purity, energy efficiency, and membrane stability.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Lei Tian, Long-Shuai Zhang, Ling-Ling Zheng, Ying Chen, Lin Ding, Jie-Ping Fan, Dai-She Wu, Jian-Ping Zou, Sheng-Lian Luo
Summary: This study proposes a novel strategy to overcome electrostatic interaction via strong complexation, realizing the electrocatalytic reduction of cyanide (CN-) at the cathode and then converting the generated reduction products into nitrogen (N-2) at the anode.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Jia-Qi Xu, Meng-Jiao Gao, Jin-Shuang Guo, Yi-Hua Wang, Ran Wei, Ya-Li Meng, Yan-Fei Kang
Summary: In this study, a ratiometric fluorescent probe JQ-2 was developed for detecting ONOO-. JQ-2 showed a rapid response and high selectivity, and could emit signals in two channels for visualizing ONOO- in vitro and vivo.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Shunan Zhang, Zhaoxuan Wu, Xiaofang Liu, Zilong Shao, Lin Xia, Liangshu Zhong, Hui Wang, Yuhan Sun
Summary: Stable Na-Co2C active sites were obtained by enhancing the interaction between Na and Co species, leading to improved efficiency in CO2 hydrogenation to ethanol.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Chemistry, Analytical
Yuantao Pan, Shan Lei, Jing Zhang, Junle Qu, Peng Huang, Jing Lin
Summary: The study developed an activatable second near-infrared (NIR-II) fluorescence probe LET-7 for sensitive and selective in vivo visualization of GSH. LET-7 can efficiently distinguish GSH from other closely related biothiols with a low detection limit, showing high sensitivity and good selectivity towards GSH in in vivo studies.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Qi Guo, Yang Feng, Hongjie Song, Mingxia Sun, Zixuan Zhan, Yi Lv
Summary: This study presents a novel chemiluminescence probe for the detection of O-2(center dot-) with high sensitivity and selectivity. Water-soluble nanoparticles were prepared using a nanoprecipitation method and successfully applied in vitro and in a mouse model.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Hyunjoong Kim, Ji Mun Yoo, Dong Young Chung, Yongseon Kim, Moonjung Jung, Megalamane S. Bootharaju, Jiheon Kim, Sagang Koo, Heejong Shin, Geumbi Na, Bongjin Simon Mun, Ja Hun Kwak, Yung-Eun Sung, Taeghwan Hyeon
Summary: Sustainable energy conversion and chemical production require catalysts with high activity, durability, and selectivity. Metal/oxide hybrid structures have shown promise in neutral or alkaline electrocatalysis. However, precise modulation of metal/oxide interactions on the nanoscale remains challenging.
Article
Chemistry, Analytical
Shi-Yu Liu, Xiaoting Zou, Yu Guo, Xing Gao
Summary: A novel enzyme-activated fluorescent probe for CES2 activity sensing was designed and constructed, showing high specificity and sensitivity. It can detect endogenous CES2 in living cells, monitor CES2 in zebrafish development, and visualize tissue distribution of CES2 in nude mice.
ANALYTICA CHIMICA ACTA
(2022)
Article
Optics
Faten Bashar Kamal Eddin, Yap Wing Fen, Josephine Ying Chyi Liew, Nurul Illya Muhamad Fauzi, Wan Mohd Ebtisyam Mustaqim Mohd Daniyal, Huda Abdullah
Summary: The rapid and specific detection of dopamine is crucial for diagnosing neurodegenerative diseases. In this study, a sensor chip using graphene oxide was developed for surface plasmon resonance (SPR) sensors, which exhibited excellent performance with high sensitivity (0.2148 degrees /pM), affinity constant (2.148 TM-1), and precision (0.125% RSD). The plasmonic based sensor demonstrated the potential for real time detection of dopamine within 5 minutes, along with reproducibility, repeatability, selectivity, and storage stability.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Chemistry, Physical
Wei Liu, Chang Zhang, Jingjing Zhang, Xiao Huang, Min Song, Jingwen Li, Feng He, Haiping Yang, Jian Zhang, Deli Wang
Summary: In this study, two kinds of Co-N-C materials were designed and the oxygen reduction reaction (ORR) pathway was transformed from four electron (4e(-) ) to two-electron (2e(-) ) by tuning the atomic configuration of the materials. This provided an efficient strategy for tuning oxygen reduction selectivity for specific applications.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Diksha Manhas, Shipra Bhatt, Garima Rai, Vinay Kumar, Sahil Bharti, Sumit Dhiman, Shreyans K. Jain, Deepak K. Sharma, Probir Kumar Ojha, Sumit G. Gandhi, Anindya Goswami, Utpal Nandi
Summary: CYP2C8 is a crucial enzyme responsible for metabolizing substances in the body. Rottlerin, a compound with anticancer properties, was found to strongly inhibit CYP2C8 and affect its gene expression. These findings are important for further research in cancer therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Chemistry, Analytical
Zhenzhou Chen, Baoqu Wang, Yuqing Liang, Liu Shi, Xiaohong Cen, Lu Zheng, En Liang, Lan Huang, Kui Cheng
Summary: Cysteine plays an important role in human physiological activities, but abnormal levels of cysteine are often associated with various diseases. A near-infrared fluorescence/photoacoustic dual-mode probe with high selectivity and sensitivity was developed to effectively detect cysteine. This study not only provides a new method for cysteine imaging but also offers a comprehensive and accurate tool for detecting different analytes and tumors in deep tissues, which contributes to early disease diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Reinaldo S. Theodoro, Bruna S. Sa, Olavo M. Perrone, Tarcisio M. Perfecto, Diogo P. Volanti
Summary: Industrialization poses significant challenges to human well-being due to the emission of toxic VOCs. Therefore, it is crucial to develop VOC sensing devices that are highly selective and reproducible. Semiconductor metal oxides, which can withstand relative humidity variations, offer a potential solution for producing inexpensive sensors with reasonable detection limits and selectivity.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Katrin Pratsch, Chie Unemura, Mana Ito, Stefan F. Lichtenthaler, Naotaka Horiguchi, Jochen Herms
Summary: This study investigated the effect of highly selective BACE1 inhibitors on dendritic spine dynamics in the somatosensory cortex of mice. The results showed that if soluble Sez6 (sSez6) levels drop too much, highly selective BACE1 inhibitors can alter dendritic spine density similar to non-selective inhibitors. Therefore, carefully adjusting the dosing to achieve an appropriate amount of Sez6 cleavage may be reasonable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xiulan He, Andrew G. Ewing
Summary: In the presence of chaotropic anions, the opening of nanometer biological vesicles becomes a two-step process, allowing for independent counting of molecules in each subvesicular compartment. The study revealed a 68% catecholamine binding to the dense-core and differentiated two populations of large dense-core vesicles, with differences in biogenesis speculated to be caused by an increase in electrostatic attraction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biophysics
Amir Hatamie, Xiulan He, Xin-Wei Zhang, Pieter E. Oomen, Andrew G. Ewing
Summary: The study of subcellular targets and biochemical processes within a living cell is valuable for biological and medical research. This review focuses on electrochemical sensors to study the biochemistry and quantification of messenger molecules and other species stored in organelles, providing new trends and developments in this field. The effect of the chemical environment of single cells on regulation of the physical and chemical properties of vesicles is also reviewed.
BIOSENSORS & BIOELECTRONICS
(2023)
Review
Chemistry, Multidisciplinary
Haoyang Zhou, Weiqi Li, Ping Yu
Summary: With the rapid development of nanofluidics, carbon nanotubes (CNTs) have shown exotic properties such as flow enhancement and strong ion exclusion due to their unique water-carbon coupling. This article reviews the recent progress and applications of CNT-based nanofluidic devices, and emphasizes the challenges and opportunities in this field.
Article
Chemistry, Analytical
Huan Wei, Lijuan Li, Yifei Xue, Ping Yu, Lanqun Mao
Summary: Potentiometry based on the galvanic cell mechanism, known as galvanic redox potentiometry (GRP), is a new tool for in vivo neurochemical sensing with high neuronal compatibility and good sensing property. In this study, the stability of the open circuit voltage (E(OC)) in GRP sensing is enhanced by adjusting the redox couple in the indicating electrode. Potassium hexachloroiridate-(IV) (K2IrCl6) shows better chemical stability and produces more stable E(OC) compared to other redox species. Integration with electrophysiology allows for stable neurochemical sensing in vivo.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Inci Barut, Xiulan He, Erol Sener, Sanna Samfors, Andrew G. Ewing, John S. Fletcher
Summary: The abnormal functioning of proteasome is associated with crucial pathological conditions, such as neurodegeneration. However, the complex underlying causes at the cellular level are still unclear, and there are conflicting reports on the neuroprotective and neurodegenerative effects of proteasomal inhibitors like lactacystin, which are used as models for neurodegenerative diseases. The conflicting results may be due to different doses of lactacystin. Hence, a dose-dependent study was conducted to investigate the effects of lactacystin on cell membrane lipid profile and exocytosis dynamics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yuming Zhou, Tianyi Xiong, Jiahao Lu, Ping Yu, Yanan Jiang, Fan Xia, Lanqun Mao
Summary: In this study, a self-assembled two-dimensional metal-organic framework (MOF) membrane was found to be an excellent nanofluidic platform for smart regulation of ion transport. The MOF membrane showed high ion gating ratio and stability in light-controlled ion gating, making it suitable for remote light-switching systems. This research may lead to promising applications of MOF membranes in ion sieving, biosensing, and energy conversion.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Xiulan He, Andrew G. Ewing
Summary: Hofmeister effects play a critical role in various physicochemical and biological phenomena. This minireview focuses on ionic specificity and its impact on biomolecules, regulating cellular exocytosis and vesicle opening. Recent progress in understanding Hofmeister effects on biomacromolecules and their applications in biological systems is summarized. These studies enhance our understanding of Hofmeister effects on cellular processes and highlight the importance of ions in living organisms.
Article
Chemistry, Multidisciplinary
Fei Wu, Ping Yu, Lanqun Mao
Summary: In vivo electrochemistry is a powerful tool for studying the chemical consequences in neural networks of the brain. Over the past 50 years, this field has undergone a technology revolution and witnessed innovations in electrochemical concepts, principles, methods, and devices. Electrochemical approaches now have a wide range of applications, from measuring neurochemical concentrations to modulating and mimicking brain signals.
Article
Multidisciplinary Sciences
Tianyi Xiong, Changwei Li, Xiulan He, Boyang Xie, Jianwei Zong, Yanan Jiang, Wenjie Ma, Fei Wu, Junjie Fei, Ping Yu, Lanqun Mao
Summary: In this study, the neuromorphic functions of ion channel-based neural systems were successfully accomplished using a polyelectrolyte-confined fluidic memristor (PFM). PFM emulated various electric pulse patterns with low energy consumption and allowed for chemical-regulated electric pulses. The PFM also enabled chemical-electric signal transduction with a single device. Its similarity to ion channels and ease of interfacing with biological systems make PFM a versatile tool for building advanced neuromorphic devices.
Article
Nanoscience & Nanotechnology
Yali Li, Ping Yu, Wenjie Ma, Lanqun Mao
Summary: This research discovers that the use of a mixed electronic-ionic conductive metal-organic framework can significantly lower the driving voltage of electrochemical actuators and provide excellent actuation performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Shiyi Wei, Fei Wu, Jing Liu, Wenliang Ji, Xiulan He, Ran Liu, Ping Yu, Lanqun Mao
Summary: This study provides the first direct evidence of neurotoxicity induced by nanoplastics, using single-vesicle electrochemistry. The researchers observed cellular uptake of polystyrene nanoplastics, leading to cell viability loss and reductions in vesicular catecholamine content, exocytotic activity, neurotransmitter release, and fusion pore opening-closing speed. Mechanistic investigations suggest that nanoplastics disrupt F-actin assemblies. This research offers important insights into how nanoplastics affect neurotransmitter secretion and neural functions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jianwei Zong, Wenjie Wu, Lanqun Mao, Ping Yu
Summary: Identifying the active sites of electrocatalysts is crucial for catalyst design, but remains challenging. This study demonstrates a simple and efficient method using stochastic collision electrochemistry to identify the active sites of electrocatalysts, overcoming the limitations of traditional methods caused by the large geometric area and limited exposure of active sites. This work enriches the methodology for identifying active sites.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jianwei Zong, Wenjie Wu, Lanqun Mao, Ping Yu
Summary: Using stochastic collision electrochemistry as a method, the active sites of electrocatalysts can be identified more effectively. Experimental results demonstrate that different active sites play dominant roles in different reactions.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Zhongjie Han, Fei Wu, Ping Yu, Lanqun Mao
Summary: This study explores the interaction between flavin-containing reductive synthase and structurally diverse pi-extended (hetero)cyclic mediators through computer-aided exploration and discovers that heteroatom-bridged cyclic and rotatable conjugated structures can experience large dynamic torsion under biased forces of hydrogen bonding, resulting in shortened electron-tunneling distance and decreased energy level to promote electron abstraction. The efficient distant electron tunneling avoids mediator transport through the substrate channel, broadens the operating concentration range, enables low-potential biosensing of glutamate, and improves selectivity.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Yikuan Liu, Xiaona Liu, An Su, Chengtao Gong, Shenwei Chen, Liwei Xia, Chengwei Zhang, Xiaohuan Tao, Yue Li, Yonghe Li, Tulai Sun, Mengru Bu, Wei Shao, Jia Zhao, Xiaonian Li, Yongwu Peng, Peng Guo, Yu Han, Yihan Zhu
Summary: Covalent organic frameworks are crystalline porous materials with designable structures and functions, which can acquire multifunctionalities and have versatile applications in gas separation/storage, catalysis, and optoelectronic devices.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Heyang Zhang, Jo Vandesompele, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut
Summary: Gene therapy has the potential to revolutionize the treatment of inherited and acquired diseases, but its success rate is currently limited. This review focuses on the obstacles faced by gene therapies in the human body, such as nucleic acid degradation by abundant nucleases, and discusses strategies to reduce degradation and methods to assess nucleic acid integrity.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Chenxi Duan, Chunming Cui
Summary: Low valent group 14 compounds with diazaborolyl substituents exhibit unique structures and reactivity due to the combination of sigma-electron donation and steric hindrance. The modulation of the HOMO-LUMO gap by the diazaborolyl substituents results in novel reaction patterns in the activation of small molecules and inert chemical bonds.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
David E. Salazar Marcano, Nada D. Savic, Kilian Declerck, Shorok A. M. Abdelhameed, Tatjana N. Parac-Vogt
Summary: Metal-oxo clusters have great potential in various fields and can react with biomolecules, making them promising for applications in disease treatment and energy development. They can also be used in the development of inorganic drugs and bioanalytical tools.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Lana K. Moree, Logan A. V. Faulkner, James D. Crowley
Summary: In this tutorial review, the general methods for synthesizing heterometallic metallosupramolecular architectures (MSAs), specifically heterometallic cages, are examined. The intrinsic properties and potential applications of these cages as host-guest systems and reaction catalysts are discussed.
CHEMICAL SOCIETY REVIEWS
(2024)
