Article
Endocrinology & Metabolism
Chung-Hwan Chen, Abdulaziz H. Elsalmawy, Sophia Ish-Shalom, Seung-Jae Lim, Nadia S. AlAli, Joao L. Cunha-Borges, Huilin Yang, Noemi Casas, Lale Altan, Zhanna Belaya, Fernando Marin, Thomas Moll, Sirel Gurbuz, Alan Brnabic, Imre Pavo, Sandra Florez
Summary: The ALAFOS study evaluated the occurrence of clinical fractures and changes in health status in postmenopausal women treated with teriparatide in Asia, Latin America, and the Middle East. Results showed a significant reduction in new clinical fragility fractures after 6 months of teriparatide treatment, along with improvements in back pain and health-related quality of life.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Barbara Hauser, Nerea Alonso, Philip L. Riches
Summary: Teriparatide has been shown to effectively reduce vertebral and non-vertebral fractures in post-menopausal and glucocorticoid-induced osteoporosis in clinical trials. The real-world experience of Teriparatide confirms the benefits seen in clinical trials, with similar outcomes observed in male and glucocorticoid-induced osteoporosis. Limited experience has been reported in pre-menopausal osteoporosis or in using Teriparatide in combination with other therapies, and surveillance studies have not found any safety signals relating to Teriparatide and osteosarcoma. Additionally, there is evidence on predicting response to Teriparatide in order to guide its optimal use in therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Antimo Moretti, Sara Liguori, Marco Paoletta, Giuseppe Toro, Milena Aulicino, Francesca Gimigliano, Giovanni Iolascon
Summary: The objective of this cross-sectional study was to characterize the neuropathic component of chronic back pain in patients with osteoporotic vertebral fractures (OVFs). The study found that the prevalence of neuropathic pain in chronic back pain ranged from 5.5% to 23.6% in patients with OVFs. Further studies should investigate if the characterization of chronic back pain might contribute to appropriateness of interventions for this population.
NEUROREHABILITATION
(2022)
Article
Clinical Neurology
Matthew Smuck, Kevin Barrette, Agnes Martinez-Ith, Geoffrey Sultana, Patricia Zheng
Summary: This study evaluated the reasons for seeking care in patients with back pain and compared them to physicians' assumptions. The results showed that patients placed high importance on the explanation of the pain cause, improvement in pain level, and improvement in daily tasks ability, while they attributed low importance to surgery and medication. Furthermore, physicians underestimated the importance of an explanation for the pain.
Article
Endocrinology & Metabolism
Irene Gagliardi, Mariella Celico, Maria Rita Gamberini, Margherita Pontrelli, Monica Fortini, Aldo Carnevale, Nicola Napoli, Maria Chiara Zatelli, Maria Rosaria Ambrosio
Summary: This study retrospectively evaluated the efficacy and safety of teriparatide (TP) in the treatment of TM-associated osteoporosis in real-life clinical practice. The results showed that TP significantly improved bone mineral density, especially at the lumbar spine, and prevented fractures. However, some patients experienced side effects such as muscle and bone pain.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Review
Medicine, General & Internal
YuLong Ouyang, ShuiLin Chen, Ting Wan, GuiHao Zheng, GuiCai Sun
Summary: The study found that teriparatide was more effective than bisphosphonates in preventing fractures in postmenopausal women with osteoporosis, including vertebral and non-vertebral fractures, with similar rates of adverse effects. More high-quality studies are needed to compare other factors such as costs and adverse reactions.
Article
Biology
Nejc Sarabon, Nace Vrecek, Christian Hofer, Stefan Lofler, Ziga Kozinc, Helmut Kern
Summary: Numerous studies have shown that patients with low back pain exhibit decreased physical abilities such as range of motion, balance, and strength. However, further research is needed to explore differences between subgroups of LBP patients and their implications on biomechanics and function.
Article
Orthopedics
Sang Yeob Lee, Min-Seok Seo, Jun-Il Yoo
Summary: This study investigated the effects of weekly teriparatide administration on bone formation in hip fracture patients. The results showed that the use of teriparatide improved fracture healing, bone formation, and clinical outcomes at 1 year after hip fracture surgery.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
Article
Geriatrics & Gerontology
Tarnjit Khera, Linda P. Hunt, Sarah Davis, Rachael Gooberman-Hill, Howard Thom, Yixin Xu, Zoe Paskins, Tim J. Peters, Jon H. Tobias, Emma M. Clark
Summary: This study developed a clinical tool to assist healthcare professionals in determining which older women with back pain should undergo spinal radiography. The tool, called Vfrac, was found to be valid and its performance was improved by including self-reported back pain symptoms.
Article
Clinical Neurology
Kevin C. Jacob, Madhav R. Patel, Andrew P. Collins, Grant J. Park, Nisheka N. Vanjani, Michael C. Prabhu, Hanna Pawlowski, Alexander W. Parsons, Kern Singh
Summary: This study evaluates the predictors of patient satisfaction after minimally invasive lumbar decompression (MIS-LD) surgery, including the achievement of minimum clinically important difference (MCID) for pain/disability and meeting preoperative expectations. The results show that improvement in pain/disability is strongly correlated with postoperative satisfaction. Meeting expectations and achieving MCID are associated with satisfaction. MCID achievement is equivalent to meeting expectations in predicting satisfaction for pain/disability at all postoperative time points.
WORLD NEUROSURGERY
(2022)
Editorial Material
Medicine, General & Internal
Kristine E. Ensrud, John T. Schousboe
Summary: Medications used to reduce the risk of osteoporosis-related fractures are classified as antiresorptive agents or anabolic therapies. This article focuses on anabolic medications, including specific drugs like teriparatide, abaloparatide, and romosozumab.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Endocrinology & Metabolism
Emily G. Atkinson, Michele Adaway, Daniel J. Horan, Crystal Korff, Angela Klunk, Ashley L. Orr, Katherine Ratz, Teresita Bellido, Lilian I. Plotkin, Alexander G. Robling, Joseph P. Bidwell
Summary: Activation of bone anabolic pathways is a promising strategy for treating severe osteoporosis. The inactivation of the Nmp4 gene enhances the bone anabolic effects of parathyroid hormone (PTH). The Prx1-expressing mesenchymal stem/progenitor cells (MSPCs) play a crucial role in the efficacy of PTH therapy.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Multidisciplinary Sciences
Zhi-Ming Liu, Min Zhang, Yuan Zong, Ding Zhang, Zhu-Bin Shen, Xiao-Qing Guan, Fei Yin
Summary: This study aimed to compare the efficacy of alendronate and teriparatide in the treatment of glucocorticoid-induced osteoporosis. The study found that compared to alendronate, teriparatide could reduce the rate of new vertebral fractures and increase the bone mineral density of the lumbar spine, femoral neck, and total hip. There was no significant difference in the incidence of non-vertebral fractures and adverse events between the two groups.
Article
Cell & Tissue Engineering
JeongHyun Shim, Kyoung-Tae Kim, Kwang Gi Kim, Un-Yong Choi, Jae Won Kyung, Seil Sohn, Sang Heon Lim, Hyemin Choi, Tae-Keun Ahn, Hye Jeong Choi, Dong-Eun Shin, Inbo Han
Summary: In patients with OVCFs, the combination therapy of WJ-MSCs and teriparatide is feasible and tolerable, improving fracture healing and symptom scores.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Alexander J. Rodriguez, Nitesh Nerlekar, Peter R. Ebeling
Summary: This study investigated the cardiovascular safety of osteoporosis medications and found that oral and intravenous bisphosphonates have certain cardiovascular risks, while the cardiovascular safety of teriparatide is unclear.
Article
Biophysics
Seda Cira, Ramazan Yilmaz, Savas Karpuz, Halim Yilmaz, Halil Ekrem Akkurt
Summary: This study is the first randomized study comparing the effects of peloid therapy and paraffin therapy in patients with hallux rigidus. The results showed that both peloid therapy and paraffin therapy combined with exercise therapy have similar effects on hallux rigidus, but further controlled trials are needed to confirm the results.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2022)
Article
Biophysics
Behiye Aksanyar, Halim Yilmaz, Fatih Karaarslan, Ramazan Yilmaz, Savas Karpuz
Summary: This study evaluated the short-term effects of peloid and paraffin treatments on symptomatic hand osteoarthritis. The results showed that both treatments had positive effects on pain relief, improving functional status and hand grip strength. Peloid therapy was found to be superior to paraffin therapy in terms of physical activity and some quality of life parameters in the short term.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2022)
Article
Biophysics
Hasan Koru, Halim Yilmaz, Ramazan Yilmaz, Savas Karpuz
Summary: This study compares the effects of peloidotherapy and extracorporeal shock wave therapy (ESWT) on lateral epicondylitis (LE). Both peloidotherapy and ESWT, as adjuncts to exercise therapy, showed positive short-term effects on pain, quality of life, functional status, and handgrip strength in primary conservative treatment of chronic LE. There was no significant difference in efficacy between the two therapies. Depending on the patient's condition, either peloidotherapy or ESWT may be preferred, with peloidotherapy being advantageous due to its lower side effects and painless nature.
INTERNATIONAL JOURNAL OF BIOMETEOROLOGY
(2023)