Journal
NEUROLOGICAL SCIENCES
Volume 37, Issue 4, Pages 591-595Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-016-2489-x
Keywords
Progressive supranuclear palsy; Vascular parkinsonism; Magnetic resonance imaging morphometry; Magnetic resonance parkinsonism index
Categories
Funding
- AIFA
- Novartis
- Lundbeck
- MIUR-Ministero dell'Istruzione
- dell'Universita e della Ricerca
- Italian Ministry of Foreign Affairs and Lundbeck
- Giovanni Mostile
- Calogero Edoardo Cicero
- Tiziana Cavallaro
- Elisa Bruno
- Valeria Dibilio
- Antonina Luca
- Giorgia Sciacca
- Loredana Raciti
- Donatella Contrafatto
- Ignazio Chiaramonte
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To investigate accuracy of the magnetic resonance parkinsonism index (MRPI) in differentiating progressive supranuclear palsy (PSP) from vascular parkinsonism (VP). We retrospectively analyzed radiological data of 12 PSP patients and 17 VP patients group-matched by age and sex who performed a standardized brain magnetic resonance imaging (MRI). Analysis of selected structures morphometry was performed to all study subjects and the MRPI was calculated for each selected patient. MRI midbrain area as well as superior cerebellar peduncle width were significantly lower in PSP patients compared to VP subjects. MRPI was significantly larger in PSP patients compared to VP subjects. MRPI value a parts per thousand yen13 distinguished the two groups with a sensitivity of 100 % (95 % CI 69.9-100) and a specificity of 100 % (95 % CI 77.1-100). MRPI may represent an accurate tool in differentiating PSP from VP.
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