Article
Chemistry, Multidisciplinary
Kim J. Blomqvist, Moritz O. B. Skogster, Mika J. Kurkela, Marko P. Rosenholm, Fredrik H. G. Ahlstro, Mikko T. Airavaara, Janne T. Backman, Pekka V. Rauhala, Eija A. Kalso, Tuomas O. Lilius
Summary: The blood-brain barrier limits drug delivery to the central nervous system, but the glymphatic system provides a route for drugs to reach deep brain structures. This study found that hyperosmotic interventions can enhance the delivery of intrathecally administered morphine to the spinal cord, improving its efficacy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Urszula Slawinska, Henryk Majczynski, Anna Kwasniewska, Krzysztof Miazga, Anna M. Cabaj, Marek Bekisz, Larry M. Jordan, Malgorzata Zawadzka
Summary: The study found that blockade of 5-HT7 receptors in rats leads to an asynchronous stepping pattern between forelimbs and hindlimbs during quadrupedal locomotion, while blockade of 5-HT2A receptors does not. This suggests that 5-HT7 receptors play an important role in coordination of limb movements and may regulate it through interneurons in the spinal cord.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Xiao Han, Derong Xu, ZhiNan Ren, Xin Chen, Zheng Li, Shugang Li
Summary: This study presented a severe case of lumbar spinal stenosis and spinal epidural lipomatosis, with outstanding clinical outcomes achieved by posterior decompression, internal fixation, and a modified articular fusion technique.
Article
Biotechnology & Applied Microbiology
Claudia A. Angeli, Yury Gerasimenko
Summary: Combining cervical transcutaneous and lumbar epidural stimulation improves voluntary control and coordination during intentional stepping in individuals with chronic motor complete paralysis. The range of motion, motor output amplitude, and coordination are improved in non-weight bearing settings, while coordination and motor output variability are improved in weight-bearing settings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Deqing Peng, Min Yan, Tianjian Liu, Kaichuang Yang, Yuyuan Ma, Xinben Hu, Guangyu Ying, Yongjian Zhu
Summary: This retrospective study analyzed 105 patients admitted for spontaneous spinal epidural hematoma (SSEH) and found that lower thoracic spine location, anticoagulation usage, severe neurologic deficits, sphincter dysfunction, and rapid progression may be associated with poor outcomes. In the subset of patients who underwent surgical decompression, preoperative neurologic deficit and extended paraplegia time were strongly correlated with prognosis.
Article
Biotechnology & Applied Microbiology
Jun Gu, Biao Gao, Hajra Zafar, Bo Chu, Xiaojun Feng, Yinjie Ni, Lin Xu, Rui Bao
Summary: This study reported a method for treating spinal cord injury in rats by combining thermo-sensitive hydrogel with Sonic Hedgehog (SHH) expressed in rat bone-marrow derived mesenchymal stem cells (RMSCs). The results demonstrated that this treatment method could improve the function of spinal cord injury and promote nerve regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Yu-Chen Chen, Yin-Chien Ou, Ju-Chuan Hu, Min-Hsin Yang, Wei-Yu Lin, Shi-Wei Huang, Chih-Chieh Lin, Victor C. Lin, Yao-Chi Chuang, Hann-Chorng Kuo
Summary: Neurogenic lower urinary tract dysfunction is common in chronic spinal cord injury patients, and proper bladder management is crucial for protecting upper urinary tract function, maintaining continence, and improving quality of life while reducing urological complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jonathan S. Calvert, Megan L. Gill, Margaux B. Linde, Daniel D. Veith, Andrew R. Thoreson, Cesar Lopez, Kendall H. Lee, Yury P. Gerasimenko, Victor R. Edgerton, Igor A. Lavrov, Kristin D. Zhao, Peter J. Grahn, Dimitry G. Sayenko
Summary: Transcutaneous and epidural spinal stimulation have shown promising results in restoring motor function in individuals with spinal cord injury, with differences observed in how different types of SCI patients respond to stimulation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study found that in individuals with clinically motor complete spinal cord injury, the extent of recovery of lower limb voluntary movements with scES is significantly influenced by the percentage of lumbosacral enlargement coverage by the electrode array and the position of the electrode relative to the lumbosacral enlargement and conus tip.
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study showed that in individuals with chronic spinal cord injury, there was a significant correlation between the coverage rate of lumbosacral enlargement by the electrode array and the position of the electrode, and the number of joints moved during voluntary lower limb movements. However, there was no significant correlation between the cross-section area of the spinal cord at C3 or the length of severe myelomalacia and the ability to move the lower limbs voluntarily.
Article
Cell Biology
Hongli Chen, Yunhao Wang, Wenjun Tu, Hong Wang, Huijuan Yin, Hong Sha, Yingxin Li
Summary: After spinal cord injury, the combination of human umbilical cord mesenchymal stem cell transplantation and photobiomodulation significantly improved motor function, increased Nissl bodies, and promoted neurofilament repair. The in situ expression of NF-200 and glial fibrillary acidic protein in the damaged area was the highest in the combination treatment group.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biology
Baruch Haimson, Yoav Hadas, Nimrod Bernat, Artur Kania, Monica A. Daley, Yuval Cinnamon, Aharon Lev-Tov, Avihu Klar
Summary: Peripheral and intraspinal feedback are crucial for shaping and updating spinal networks that control motor behavior. dI2 spinal interneurons in chicks receive synaptic input from afferents and premotor neurons, and are involved in local spinal circuits and lumbo-brachial coupling. Silencing these neurons results in destabilized stepping and wide-base walking gait in hatchlings, indicating their contribution to bipedal gait stabilization.
Article
Neurosciences
Jonas L. Olesen, Leif ostergaard, Noam Shemesh, Sune N. Jespersen
Summary: This study reevaluates the assumptions of the standard diffusion model by collecting comprehensive MRI data and proposes three model extensions to address the issues identified. The analysis identifies a three-compartment description as the optimal model, with the third compartment exhibiting slow diffusion and a minor signal fraction. Failure to consider the presence of this compartment can severely misguide inferences about white matter microstructure.
Article
Chemistry, Medicinal
Wan-Yi Rao, Fang Xu, Shao-Bing Dai, Zhong Mei, Xiao-Ping Chen, Chang-Cheng Lv, Chun-Lei Liu, Warwick Ngan Kee, Xin-Zhong Chen
Summary: This study compared three different anesthesia techniques and found that DPE anesthesia had a faster onset, shorter duration of surgical sensory block, lower incidence of intraoperative pain, and higher patient satisfaction compared to EA anesthesia. Additionally, DPE anesthesia had less impact on maternal hemodynamic parameters compared to CSE anesthesia, suggesting its effectiveness in obstetric surgery.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Oncology
James Thomas Patrick Decourcy Hallinan, Shuliang Ge, Lei Zhu, Wenqiao Zhang, Yi Ting Lim, Yee Liang Thian, Pooja Jagmohan, Tricia Kuah, Desmond Shi Wei Lim, Xi Zhen Low, Ee Chin Teo, Nesaretnam Barr Kumarakulasinghe, Qai Ven Yap, Yiong Huak Chan, Jiong Hao Tan, Naresh Kumar, Balamurugan A. Vellayappan, Beng Chin Ooi, Swee Tian Quek, Andrew Makmur
Summary: This study assessed the performance of dedicated radiologist review using CT windowing compared to the original reports for diagnosing metastatic epidural spinal cord compression (MESCC). The study found that the radiologists showed higher agreement and sensitivity, leading to improved early diagnosis of MESCC.