Article
Biochemistry & Molecular Biology
Lekha Saha, Puja Kumari, Kajal Rawat, Vipasha Gautam, Arushi Sandhu, Neha Singh, Alka Bhatia, Shalmoli Bhattacharya, V. R. Sinha, Amitava Chakrabarti
Summary: The study suggests that Berberine (BBR) nanoparticles have a promising effect in controlling seizures and alleviating pathologies and sequelae in the kindling model of epileptogenesis.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mukaddes Pala, Ismail Meral, Nilgun Pala Acikgoz, Senay Gorucu Yilmaz, Semra Karaca Okur, Seyma Acar, Yalcin Polat, Fahri Akbas
Summary: In this study, the effects of miR-342-p on epileptogenesis were analyzed using the PTZ model, and GRM2 was identified as its target gene. The results suggest that downregulation of miR-342-3p may contribute to the upregulation of GRM2 in the PTZ kindling model.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Stephanie M. Staszko, John D. Boughter, Max L. Fletcher
Summary: This study investigated the effect of taste familiarity on population taste coding in the mouse gustatory cortex. The results showed that as animals became familiar with taste stimuli, the number of active cells and taste-responsive cells in the insular cortex decreased significantly. Furthermore, the magnitude of taste-evoked excited responses increased while inhibited responses decreased with experience. The study also identified a subpopulation of stable neurons and characterized their taste coding properties.
Article
Neurosciences
Ka Ng, Michael Pollock, Abraham Escobedo, Brent Bachman, Nanami Miyazaki, Edward L. L. Bartlett, Susan Sangha
Summary: Stressful events can disrupt regulation of fear and reward processing, leading to maladaptive fear responses. Post-traumatic stress disorder (PTSD) is characterized by persistent fear reactions to safety cues. In this study, the necessity of specific projections from the infralimbic cortex (IL) to the basolateral amygdala (BLA) or central amygdala (CeA) during safety recall was tested. The IL->CeA pathway was found to be necessary for suppressing fear responses in the presence of a learned safety cue, similar to the behavioral disruption seen in individuals with PTSD.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Doodipala Samba Reddy, Robert H. Mbilinyi, Sreevidhya Ramakrishnan
Summary: At present, there is no drug therapy available for curing epilepsy. However, recent research has shown the potential of cannabidiol (CBD) in controlling epileptogenesis and reducing seizure burden. CBD can also be used in combination with other antiseizure medications, indicating strong potential as an adjunct therapy.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Jing Wu, Penglai Liu, Chi Geng, Changyu Liu, Jiaxin Li, Qiuju Zhu, Anan Li
Summary: The underlying neural mechanism of seizure generation and propagation in the piriform cortex (PC) remains unclear. In this study, increased excitability in PC neurons during amygdala kindling acquisition was found. Activation of PC pyramidal neurons promoted kindling progression, while inhibition of these neurons retarded seizure activities induced by kindling. Moreover, inhibiting PC pyramidal neurons alleviated the severity of kainic acid-induced acute seizures, providing evidence for their potential as a therapeutic target for epileptogenesis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Clinical Neurology
Holger Joswig, Chloe Gui, Miguel Arango, Andrew G. Parrent, Keith W. MacDougall, Jorge G. Burneo, David A. Steven
Summary: This study aimed to evaluate dream content before and after anterior temporal lobectomy. The results showed a significant decrease in physical aggression in dreams of patients after surgery, while there were no significant changes in dream content in other cases. The study found that the temporal lobe may be associated with aggressive dream content.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Julia L. Napoli, Corrie R. Camalier, Anna-Leigh Brown, Jessica Jacobs, Mortimer M. Mishkin, Bruno B. Averbeck
Summary: The study found that in a spatial selective listening task, primary auditory cortex (AC) encoded the cue and target characteristics before the dorsolateral prefrontal cortex (dlPFC) and the basolateral amygdala (BLA), and also encoded the monkey's choice at an earlier stage. The similarity between AC and dlPFC responses was eliminated during passive sensory stimulation, suggesting that the strong sensory encoding in dlPFC is contextually gated. The study suggests that unlike in the visual domain, the BLA does not appear to be robustly involved in selective spatial processing in this auditory task.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Juliana C. Silva, Yu Shen, Jianxiong Chan, Patrick Kwan, Nigel C. Jones
Summary: In the Tg2576 mouse model, treatment with brivaracetam exhibited significant anti-epileptic effects, including when treatment was ceased prior to initiating kindling. This study suggests that targeting SV2A may represent a potential strategy for preventing epilepsy in patients with Alzheimer's disease.
Article
Multidisciplinary Sciences
Ikuko Takeda, Kohei Yoshihara, Dennis L. Cheung, Tomoko Kobayashi, Masakazu Agetsuma, Makoto Tsuda, Kei Eto, Schuichi Koizumi, Hiroaki Wake, Andrew J. Moorhouse, Junichi Nabekura
Summary: Astrocyte activity modulation can drive synaptic remodeling in the cortex, providing a potential therapeutic approach for chronic pain. By combining peripheral nerve block and astrocyte activation, the authors successfully reversed allodynia-like behavior induced by nerve injury in mice, demonstrating a translational approach for pain modulation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Esther Klingler, Ugo Tomasello, Julien Prados, Justus M. Kebschull, Alessandro Contestabile, Gregorio L. Galinanes, Sabine Fievre, Antonio Santinha, Randal Platt, Daniel Huber, Alexandre Dayer, Camilla Bellone, Denis Jabaudon
Summary: Interconnectivity between neocortical areas is essential for sensory integration and sensorimotor transformations, mediated by heterogeneous inter-areal cortical projection neurons (ICPN) that are anatomically diverse but molecularly homogeneous. The study revealed distinct molecular and functional differentiation paces of different subtypes of ICPN within a single cortical area, impacting circuit connectivities and functions. Dynamic differences in gene expression levels may account for the emergence of intra-type diversity in cortical neurons.
Review
Biology
Kate M. Wassum
Summary: Adaptive reward-related decision making requires accurate consideration of the specific outcome and current desirability of each option. The basolateral amygdala (BLA) and orbitofrontal cortex (OFC) collaborate to encode and use detailed reward memories, supporting prediction and inference in decision making. BLA projections to lateral OFC encode outcome-specific reward memories, while projections to medial OFC regulate the use of these memories for reward pursuit decisions.
Article
Cell Biology
Daniel Udvary, Philipp Harth, Jakob H. Macke, Hans-Christian Hege, Christiaan P. J. de Kock, Bert Sakmann, Marcel Oberlaender
Summary: The wiring specificity in the cerebral cortex is not only determined by synapse formation mechanisms, but also by the morphological properties of the neurons. The morphologically determined wiring specificity is reflected in the axo-dendritic projection patterns, packing density, and cellular diversity of the neurons. These factors determine whether the network topology is recurrent or feedforward.
Article
Multidisciplinary Sciences
Mykhailo Y. Batiuk, Teadora Tyler, Katarina Dragicevic, Shenglin Mei, Rasmus Rydbirk, Viktor Petukhov, Ruslan Deviatiiarov, Dora Sedmak, Erzsebet Frank, Virginia Feher, Nikola Habek, Qiwen Hu, Anna Igolkina, Lilla Roszik, Ulrich Pfisterer, Diego Garcia-Gonzalez, Zdravko Petanjek, Istvan Adorjan, Peter V. Kharchenko, Konstantin Khodosevich
Summary: Schizophrenia is a widespread and complex mental disorder characterized by a reduction in abundance of GABAergic neurons and an increase in principal neurons, especially in the upper cortical layers. Many neuronal subtypes show extensive transcriptomic changes, particularly in upper-layer GABAergic neurons. Transcription factor network analysis reveals the developmental origin of these transcriptomic changes.
Article
Neurosciences
Daniel Reznik, Robert Trampel, Nikolaus Weiskopf, Menno P. Witter, Christian F. Doeller
Summary: This study used MRI to scan four human individuals and discovered three meaningful networks associated with different subregions of the medial temporal lobe (MTL). These findings provide anatomical constraints for human mnemonic functions and are insightful for examining the evolutionary trajectory of MTL connectivity across species.
Article
Materials Science, Biomaterials
Jafar Ai, Ali Farzin, Sina Zamiri, Mahmoudreza Hadjighassem, Somayeh Ebrahimi-Barough, Armin Ai, Sanam Mohandesnezhad, Ahmad Karampour, Morteza Sagharjoghi Farahani, Arash Goodarzi
Summary: The study found that a chitosan scaffold loaded with PRP can promote stem cell viability and enhance regeneration of nerve fibers and angiogenesis in spinal cord injury repair, while also preventing scar tissue formation.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Article
Neurosciences
Amir Rezagholizadeh, Seyed Asaad Karimi, Narges Hosseinmardi, Mahyar Janahmadi, Mohammad Sayyah
Summary: This study investigated the role of glial cells in traumatic brain injury (TBI)-induced cognitive impairment. The results showed that inhibiting glial cells cannot improve memory deficits caused by TBI, and inhibiting glial cells in uninjured animals can impair reversal memory acquisition and retrieval of reference memory.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Soheil Ghassemi, Tara Asgari, Hadi Mirzapour-Delavar, Shayan Aliakbari, Hamid Gholami Pourbadie, Christophe Prehaud, Monique Lafon, Alireza Gholami, Kayhan Azadmanesh, Nima Naderi, Mohammad Sayyah
Summary: The study demonstrates that the rabies virus glycoprotein (RVG) affects synaptic function in the hippocampal dentate gyrus of rats, facilitating both short- and long-term synaptic plasticity by potentially involving both pre- and postsynaptic mechanisms to alter synaptic function. Further research is needed to elucidate the underlying mechanisms.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Mohammad-Mahdi Ghanbari, Ali Gharibi Loron, Mohammad Sayyah
Summary: The study demonstrated that both DHA and DHEA significantly increased seizure threshold, while EPEA did not have the same effect. Furthermore, it was found that DHEA is more potent than DHA in reducing seizure susceptibility, and it exerts its anti-seizure action by activating CB1 receptors.
BRAIN RESEARCH BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Hassan Maleki, Mohammad Reza Hosseini Najafabadi, Thomas J. Webster, Mahmoud Reza Hadjighassem, Esmaeil Sadroddiny, Hossein Ghanbari, Masood Khosravani, Mahdi Adabi
Summary: The study aimed to co-load paclitaxel and etoposide in mPEG-PLGA NPs for enhanced therapeutic efficacy in treating intracranial glioblastoma, showing improved cytotoxic effects and anti-glioma activity without inducing blood-related issues.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Neurosciences
Soheil Ghassemi, Tara Asgari, Hamid Gholami Pourbadie, Christophe Prehaud, Monique Lafon, Nima Naderi, Alireza Gholami, Kayhan Azadmanesh, Mohammad Sayyah
Summary: Expression of RVG in the hippocampus enhances aversive and spatial learning and memory performance in rats, with the boosting effect mediated through PBM.
JOURNAL OF NEUROVIROLOGY
(2021)
Article
Clinical Neurology
Zeinab Gharaylou, Mohammad Ali Sahraian, Mahmoudreza Hadjighassem, Mohsen Kohanpour, Rozita Doosti, Shima Nahardani, Abdorreza Naser Moghadasi
Summary: This study utilized DTI and NODDI techniques to compare different groups of multiple sclerosis patients and their family members, revealing widespread white matter impairment in familial patients, while changes in sporadic patients and their healthy relatives were not significant.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hoorie Mohaghghegh, Esmaeil Shahsavand Ananloo, Mahmoudreza Hadjighasem, Morteza Karimipour, Shiva Hashemizadeh, Seyyed Ali Ahmadi Abhari
Summary: This study investigated the expression levels of NKCC1 and KCC2 genes in the peripheral blood of patients with schizophrenia and their association with symptom scores. The results showed that the NKCC1 to KCC2 mRNA ratio was significantly increased in the total sample of cases and higher in male patients compared to male controls. There was also a trend towards a significant effect in female patients. The mRNA levels of NKCC1 and KCC2 genes and the NKCC1/KCC2 mRNA ratio were significantly associated with symptom scores.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Soheil Ghassemi, Hamid Gholami Pourbadie, Christophe Prehaud, Monique Lafon, Mohammad Sayyah
Summary: This study evaluated the effects of rabies virus infection on anxiety-like behaviors and the hypothalamic-pituitary-adrenal axis response. The results suggest that a specific protein of the rabies virus interacts with host cell membrane, mediating anxiety-related signaling and potentially contributing to anxiety symptoms in patients with rabies.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Mozhdeh Radpour, Samira Choopani, Hamid Gholami Pourbadie, Mohammad Sayyah
Summary: Toll-like receptor 4 (TLR4) signaling has a detrimental role in traumatic brain injury (TBI) pathology. However, TLR4 priming can alleviate TBI inflammation and seizure susceptibility. In this study, we found that postconditioning with TLR4 agonist monophosphoryl lipid A (MPL) reduces TBI neuroinflammation and epileptogenesis by decreasing neural death and inflammation, while upregulating anti-inflammatory cytokines.
EXPERIMENTAL NEUROLOGY
(2022)
Correction
Cell Biology
Fateme Azizi, Rasoul Ghasemi, Somayeh EbrahimiBarough, Maryam Ardalan, Mahmoudreza Hadjighassem
CELL AND TISSUE BANKING
(2023)
Article
Cell Biology
Fateme Azizi, Rasoul Ghasemi, Somayeh EbrahimiBarough, Maryam Ardalan, Mahmoudreza Hadjighassem
Summary: This study investigated the effect of combined therapy on cell viability after spinal-derived neural injury. The results demonstrated that the combined therapy significantly prevented cell death and reduced the size of the gap, promoting cell survival.
CELL AND TISSUE BANKING
(2023)
Article
Cell Biology
Mozhdeh Radpour, Bahar Khoshkroodian, Tara Asgari, Hamid Gholami Pourbadie, Mohammad Sayyah
Summary: Macrophage/microglia are activated and transformed to inflammatory phenotype (M1) after traumatic brain injury, triggering neuroinflammation and epileptogenesis. Interleukin-4 (IL-4) promotes macrophage/microglia transformation to anti-inflammatory phenotype (M2). This study investigates the effects of IL-4 on the speed of epileptogenesis, expression of cytokines, and lesion size in TBI-injured rats.
Article
Multidisciplinary Sciences
Samira Choopani, Bahereh Kiani, Shayan Aliakbari, Jalal Babaie, Majid Golkar, Hamid Gholami Pourbadie, Mohammad Sayyah
Summary: Investigating long-term potentiation in disease models provides important insights into synaptic dysfunction and behavioral changes. Toxoplasma gondii infection leads to strange changes in host behavior. In this study, hippocampal-dependent behavior and synaptic plasticity were examined in rats with latent toxoplasmosis. The results showed that T. gondii infection disrupted inhibitory synaptic network and caused abnormal neuronal excitability, ultimately leading to abnormal behavior in the infected host.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Saereh Hosseindoost, Ahmad R. Dehpour, Samaneh Dehghan, Seyed A. H. Javadi, Babak Arjmand, Ali Fallah, Mahmoudreza Hadjighassem
Summary: This study suggests that fluoxetine can enhance the antitumor effect of OECs-TK/GCV gene therapy on GBM cells by upregulating Cx43 levels.
DRUG DEVELOPMENT RESEARCH
(2023)