Journal
NEUROLOGIA MEDICO-CHIRURGICA
Volume 56, Issue 3, Pages 102-109Publisher
JAPAN NEUROSURGICAL SOC
DOI: 10.2176/nmc.ra.2015-0303
Keywords
Parkinson; dopamine; induced pluripotent stem cell; midbrain
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Funding
- Highway Project for Realization of Regenerative Medicine from the Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Research Center Network for Realization of Regenerative Medicine from the Japan Agency for Medical Research and Development (AMED)
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In Parkinson's disease (PD), dopamine neurons in the substantia nigra are degenerated and lost. Cell therapy for PD replaces the lost dopamine neurons by transplanting donor dopamine neural progenitor cells. Cell therapy for PD has been performed in the clinic since the 1980s and uses donor cells from the mesencephalon of aborted embryos. Regenerative medicine for PD using induced pluripotent stem (iPS) cell technology is drawing attention, because it offers a limitless and more advantageous source of donor cells than aborted embryos.
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