Article
Cell Biology
Xiaolong Sheng, Jinyun Zhao, Miao Li, Yan Xu, Yi Zhou, Jiaqi Xu, Rundong He, Hongbin Lu, Tianding Wu, Chunyue Duan, Yong Cao, Jianzhong Hu
Summary: The study demonstrated that BMSC-Exos treatment enhances the phagocytic ability of macrophages to clear myelin debris, promoting nerve injury repair and facilitating axon regeneration and functional recovery. Additionally, the promotion of MARCO expression in macrophages by BMSC-Exos contributes to improved myelin debris clearance and tissue repair following SCI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Bowen Wan, Cong Li, Ming Wang, Fanqi Kong, Qirui Ding, Chenliang Zhang, Hao Liu, Dingfei Qian, Wenlin Deng, Jian Chen, Pengyu Tang, Qian Wang, Shujie Zhao, Zheng Zhou, Tao Xu, Yifan Huang, Jun Gu, Jin Fan, Guoyong Yin
Summary: The study demonstrates the crucial role of GIT1 in promoting MECs clearance of myelin debris and stimulating angiogenesis, making it a promising target for accelerating SCI recovery.
Review
Neurosciences
Sandra Zivkovic, Maryam Ayazi, Grace Hammel, Yi Ren
Summary: Neutrophils are crucial components of the innate immune system, playing a key role in defense against infections and tissue injuries by recognizing and neutralizing pathogens. They are proficient in various immune response mechanisms, such as phagocytosis, granule release, and formation of NETs. In the pathologic changes in injured spinal cord, neutrophils play a significant role.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Maryam Ayazi, Sandra Zivkovic, Grace Hammel, Branko Stefanovic, Yi Ren
Summary: Reviewed the formation of fibrotic scars in central nervous system trauma and their unique characteristics, and discussed therapeutic targets that may enhance CNS regeneration.
Article
Biotechnology & Applied Microbiology
Jinxin Li, Zhenyu Zhu, Yiteng Li, Yihao Chen, Xuyang Hu, Yanchang Liu, Yi Shi, Yao Hu, Yihui Bi, Xinzhong Xu, Meige Zheng, Li Cheng, Juehua Jing
Summary: We found that D-4F can promote the clearance of myelin debris and reduce the formation of foamy macrophages, leading to neuroprotection and motor function recovery. These beneficial effects may be associated with the upregulation of ABCA1 expression by D-4F.
Review
Neurosciences
Anne Huntemer-Silveira, Nandadevi Patil, Megan A. Brickner, Ann M. Parr
Summary: Traumatic brain and spinal cord injuries often result in loss of the myelin sheath, impacting functional recovery of the nervous system. Current research focuses on enhancing endogenous responses and cell-based replacement strategies due to limited mechanisms for remyelination in the CNS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Fei Yao, Yang Luo, Yihao Chen, Yiteng Li, Xuyang Hu, Xingyu You, Ziyu Li, Shuisheng Yu, Dasheng Tian, Meige Zheng, Li Cheng, Juehua Jing
Summary: Clearance of myelin debris is crucial for functional restoration after spinal cord injury. Researchers found that myelin debris uptake impairs tight junctions and promotes migration of endothelial cells, suggesting that myelin debris clearance is important for maintaining blood-spinal cord barrier integrity and facilitating recovery.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Yang Liu, Grace Hammel, Minjun Shi, Zhijian Cheng, Sandra Zivkovic, Xiaoqi Wang, Pingyi Xu, Xijing He, Bing Guo, Yi Ren, Li Zuo
Summary: The study found that some infiltrated bone marrow-derived macrophages are early contributors to NG2/CSPG4 expression after spinal cord injury, showing enhanced proliferation and decreased phagocytic capacity under the influence of lesion-related cellular debris from damaged myelin sheaths. This suggests a more nuanced role for these macrophages in secondary spinal cord injury, including their contribution to the NG2 component of the glial scar.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Mostafa Seblani, Patrick Decherchi, Jean-Michel Brezun
Summary: Edema after spinal cord injury is a significant concern and can worsen the condition. The mechanisms behind the increase in water content after SCI are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Bruce Harland, Zaid Aqrawe, Maria Vomero, Christian Boehler, Ernest Cheah, Brad Raos, Maria Asplund, Simon J. O'Carroll, Darren Svirskis
Summary: This study presents the development of a very thin flexible bioelectronic implant that can be inserted directly into the spinal cord of rats and maintain contact. The implant does not negatively impact the functionality of the rats' limbs and can record electrical signals of spinal cord activity. This device is important for monitoring spinal cord injury and recovery, and has the potential for localized treatments.
Article
Neurosciences
Chengjie Wu, Yalan Pan, Lining Wang, Mengmin Liu, Pengcheng Tu, Sixian Chen, Lei Shi, Danqing Yan, Yong Ma, Yang Guo
Summary: This study aimed to find an effective strategy for promoting microvascular endothelial cells (MECs) to phagocytize myelin debris and reduce secretion of inflammatory factors following spinal cord injury (SCI). A coculture model of myelin debris and vascular-like structures was established, and the efficiency of MECs phagocytizing myelin debris under different conditions was examined. The HDAC6 inhibitor Tubastatin-A was used to interfere with the coculture model, and its anti-inflammatory effects were observed.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Nicole Pukos, Christina M. Marion, W. David Arnold, Benjamin T. Noble, Phillip G. Popovich, Dana M. McTigue
Summary: Our previous study found that a large number of new oligodendrocytes (OLs) are generated in the injured spinal cord of mice, with peak oligodendrogenesis occurring between 4 and 7 weeks post-injury. We also observed new myelin formation up to 2 months post-injury. Our current research expands on these findings, quantifying new myelin formation up to 6 months post-injury and investigating indices of demyelination. We discovered that remyelination reaches its peak during the third month post-injury and continues for at least 6 months. Additionally, we observed chronic demyelination through the expression of Nav1.2 and nodal protein disorganization. Our study also revealed a potential mechanism for initiating post-injury myelination, showing that oligodendrocyte progenitor cells (OPCs) make contact with glutamatergic axons in an activity-dependent manner. Increasing OPC/axon contacts through chemogenetic activation of axons may serve as a therapeutic target for enhancing post-spinal cord injury myelin repair.
Review
Pharmacology & Pharmacy
Yasmeen Saeed
Summary: Spinal cord injury (SCI) is a challenging disorder without a standard treatment. Immune responses could enhance the injury sequel, but they are also necessary for healing. Immunotherapeutic strategies targeting SCI can benefit from the dual nature of immune responses. This study aims to provide an overview of previous research on immunotherapeutic strategies for functional recovery after SCI and address the limitations of DNA and cell-based vaccination strategies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Souptik Basu, Indra N. Choudhury, Jia Yu Peppermint Lee, Anu Chacko, Jenny A. K. Ekberg, James A. St John
Summary: The study suggests that modulating macrophages using growth factors such as VEGF and PDGF may improve the outcomes of olfactory ensheathing cell transplantation in spinal cord injury therapy. The growth factor-treated macrophage-conditioned medium promoted phagocytosis by olfactory ensheathing cells and also modulated gene expression associated with nerve repair and myelin expression.
Article
Chemistry, Multidisciplinary
Xue Wang, Jin Wu, Xinlong Liu, Kaicheng Tang, Liting Cheng, Jie Li, Yixuan Tang, Xiangrong Song, Xiaoyou Wang, Chong Li
Summary: A novel orally administered targeted delivery system was designed in this study, utilizing selenium-stabilized apamin and a non-covalent cross-linked chitosan oligosaccharide lactate layer, effectively targeting local cells for comprehensive spinal cord injury (SCI) therapy. This research may offer new insights into the oral administration route as a bypass for multiple interventions and targeted therapy in diseases involving the gut-organ axis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Emergency Medicine
Bartlomiej Kulesza, Marek Mazurek, Adam Nogalski, Radoslaw Rola
Summary: The aim of the study was to identify factors with the strongest predictive value for in-hospital mortality among patients undergoing surgery for EDH and SDH. The study included 128 patients with isolated craniocerebral injuries who underwent surgery for EDH and SDH. The strongest prognostic factors included GCS score, respiratory rate, glycaemia, blood saturation, systolic blood pressure, midline shift, and type of hematoma.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Article
Neurosciences
Dorota Siwicka-Gieroba, Chiara Robba, Jan Poleszczuk, Malgorzata Debowska, Jacek Waniewski, Rafael Badenes, Andrzej Jaroszynski, Ewa Piasek, Katarzyna Kotfis, Jowita Biernawska, Wojciech Dabrowski
Summary: This study showed that SEVR decreases in patients with severe TBI but improves following surgical decompression. The findings suggest a connection between brain injury and myocardial function.
BRAIN CONNECTIVITY
(2021)
Review
Obstetrics & Gynecology
Agata Klimkowicz, Rafal Rutyna, Edyta Kotlinska-Hasiec, Wojciech Dabrowski
Summary: Regional anaesthesia is the preferred method for obstetric pain relief, but it comes with certain risks and complications. Despite the low incidence rate, a better understanding of these complications can enhance the safety of parturients during labor.
GINEKOLOGIA POLSKA
(2021)
Article
Biotechnology & Applied Microbiology
Subhendu Mukherjee, Maya Kuroiwa, Wendy Oakden, Brandon T. Paul, Ayesha Noman, Joseph Chen, Vincent Lin, Andrew Dimitrijevic, Greg Stanisz, Trung N. Le
Summary: Moderate noise exposure can lead to acute loss of cochlear synapses without affecting hearing threshold, which cannot be detected by standard clinical tests. This study demonstrates the potential benefit of magnetic delivery of gene therapy for noise-induced hearing loss by effectively targeting and enhancing gene expression in the inner ear.
Review
Biochemistry & Molecular Biology
Marek Mazurek, Dariusz Szczepanek, Anna Orzylowska, Radoslaw Rola
Summary: This article summarizes the current knowledge on the differences in the level of emitted fluorescence in glial tumors. It discusses how the level of fluorescence may depend on the histological type and genetic profile of the tumor, as well as the activity and expression of enzymes involved in the intracellular metabolism of fluorescent dyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
A. Jaroszynski, T. T. Schlegel, T. Zaborowski, T. Zapolski, W. Zaluska, A. Janion-Sadowska, D. Koziel, S. Gluszek, W. Dabrowski
Summary: Abnormal ventricular gradient optimized for right ventricular pressure overload (VG-RVPO) is not only able to detect pulmonary hypertension (PHT) but also predict all-cause and cardiovascular mortality in hemodialysis (HD) patients.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Weronika Wasyluk, Agnieszka Zwolak, Joop Jonckheer, Elisabeth De Waele, Wojciech Dabrowski
Summary: This review analysed the challenges and limitations of using indirect calorimetry in patients with sepsis, finding differences in methodology and presentation of results in studies. Multi-center and large sample patient evaluations, along with meta-analysis, could provide a more comprehensive understanding of metabolism in sepsis.
Review
Biochemistry & Molecular Biology
Artur Bekala, Wlodzimierz Plotek, Dorota Siwicka-Gieroba, Joanna Solek-Pastuszka, Romuald Bohatyrewicz, Jowita Biernawska, Katarzyna Kotfis, Magdalena Bielacz, Andrzej Jaroszynski, Wojciech Dabrowski
Summary: Brain injury, especially TBI, can cause dysfunction of extracerebral organs, including the heart. Melatonin, a hormone released by the pineal gland, plays a crucial role in preventing and treating TBI-induced cardiac disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Physical
Wojciech Czyzewski, Jakub Jachimczyk, Zofia Hoffman, Michal Szymoniuk, Jakub Litak, Marcin Maciejewski, Krzysztof Kura, Radoslaw Rola, Kamil Torres
Summary: This study investigates the use of 3D printing technology to produce polymer-based prostheses, aiming to improve the accessibility of cranioplasty. Patient-specific 3D printed prostheses are modeled using CAD software, and budget 3D-printed endoprostheses are found to be cheaper and reliable.
Review
Health Care Sciences & Services
Dorota Siwicka-Gieroba, Chiara Robba, Jakub Golacki, Rafael Badenes, Wojciech Dabrowski
Summary: Organism survival relies on the balance of oxygen delivery and utilization, especially crucial for the brain after acute injuries. Clinical protocols play an important role in improving oxygen delivery and reducing mortality in brain-injured patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biology
Rita Jacobs, Robert D. Wise, Ivan Myatchin, Domien Vanhonacker, Andrea Minini, Michael Mekeirele, Andrew W. Kirkpatrick, Bruno M. Pereira, Michael Sugrue, Bart De Keulenaer, Zsolt Bodnar, Stefan Acosta, Janeth Ejike, Salar Tayebi, Johan Stiens, Colin Cordemans, Niels Van Regenmortel, Paul W. G. Elbers, Xavier Monnet, Adrian Wong, Wojciech Dabrowski, Philippe G. Jorens, Jan J. De Waele, Derek J. Roberts, Edward Kimball, Annika Reintam Blaser, Manu L. N. G. Malbrain
Summary: This review summarizes the current knowledge on the association between fluid administration and intra-abdominal pressure in patients at risk of intra-abdominal hypertension and abdominal compartment syndrome. Most studies confirm the association between fluid resuscitation and intra-abdominal hypertension, but optimal fluid management strategies for these patients remain controversial.
Article
Biochemistry & Molecular Biology
Monika Szeliga, Radoslaw Rola
Summary: This study identified a considerable amount of TrxR1 protein in GBM tissues, suggested TrxR1 as an attractive drug target, and highlighted AF as a potential off-patent drug candidate in GBM therapy. Treatment with AF decreased viability of GBM cells, increased ROS levels, and its cytotoxic effect was potentiated by treatment with MEN.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Igor Karolak, Rafal Hrynkiewicz, Paulina Niedzwiedzka-Rystwej, Kacper Lechowicz, Jerzy Sienko, Aleksandra Szylinska, Wojciech Dabrowski, Katarzyna Kotfis
Summary: This study evaluated the effects of potassium canrenoate on inflammatory markers in patients with COVID-19 pneumonia. The results showed significant changes in certain inflammatory markers in the potassium canrenoate group compared to the placebo group, potentially related to alleviating pulmonary fibrosis. However, these observations did not reach statistical significance, and further research is needed to investigate the potential benefits of potassium canrenoate as a treatment for COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Salar Tayebi, Robert Wise, Ashkan Zarghami, Luca Malbrain, Ashish K. Khanna, Wojciech Dabrowski, Johan Stiens, Manu L. N. G. Malbrain
Summary: This study aimed to validate a new continuous intra-abdominal pressure (IAP) monitoring device, TraumaGuard, and compare different measurement technologies. The results showed that TraumaGuard can measure IAP in an empty bladder, and all the studied devices demonstrated excellent IAP monitoring ability, with intra-vesical measurement methods appearing to be more reliable. TraumaGuard, Accuryn, and Serenno showed better accuracy and smaller percentage errors compared to intra-gastric measurement devices.
JOURNAL OF CLINICAL MEDICINE
(2023)