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Neurosciences
Xiangling Li, Tieyuan Zhang, Chaochao Li, Wenjing Xu, Yanjun Guan, Xiaoya Li, Haofeng Cheng, Shengfeng Chen, Boyao Yang, Yuli Liu, Zhiqi Ren, Xiangyu Song, Zhibo Jia, Yu Wang, Jinshu Tang
Summary: Low-frequency electrical stimulation (ES) promotes nerve regeneration by accelerating Wallerian degeneration (WD) and upregulating the expression of neurotrophic factors, leading to accelerated early axonal and vascular regeneration while delaying muscle atrophy.
Article
Neurosciences
Yi Wang, Nannan Gao, Yumei Feng, Min Cai, Yuting Li, Xi Xu, Huanhuan Zhang, Dengbing Yao
Summary: This study investigates the role of Prkcq in regulating nerve degeneration and regeneration, with findings showing that modulation of Prkcq expression can affect the function of Schwann cells and related signaling pathways. The results provide insights into the molecular mechanisms involved in Prkcq-mediated processes during peripheral nerve repair.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoon Kyung Shin, Young Rae Jo, Seoung Hoon Lee, Hwan Tae Park, Jung Eun Shin
Summary: After peripheral nerve injury, demyelinating Schwann cells release myelin debris and macrophages degrade myelin, leading to demyelination of degenerating axons, which is necessary for nerve regeneration. This study identifies ATP6V0D2, which is highly upregulated in injured mouse nerves, as a key player in this process. Knockout of ATP6V0D2 delays peripheral nerve demyelination and impairs myelin lipid digestion, while recruitment of macrophages and dedifferentiation of Schwann cells are unaffected. These findings highlight the specific role of ATP6V0D2 in macrophages during the demyelination process of Wallerian degeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Jiawei Xu, Jinkun Wen, Lanya Fu, Liqiang Liao, Ying Zou, Jiaqi Zhang, Junyao Deng, Haowen Zhang, Jingmin Liu, Xianghai Wang, Daming Zuo, Jiasong Guo
Summary: The depletion of RhoA in macrophages has a negative impact on Wallerian degeneration and nerve regeneration, mainly due to impaired migration and phagocytosis of macrophages resulting from disrupted RhoA/ROCK/MLCK pathway. Since previous research has shown that RhoA inhibition in neurons promotes axonal regeneration, the study highlights the importance of considering cellular specificity of RhoA-targeted drugs in future applications for treating peripheral nerve injuries.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Lixia Li, Yizhou Xu, Xianghai Wang, Jingmin Liu, Xiaofang Hu, Dandan Tan, Zhenlin Li, Jiasong Guo
Summary: Ascorbic acid accelerates Wallerian degeneration by promoting the degradation of axons and myelin in injured nerves, inducing Schwann cell dedifferentiation, and enhancing macrophage recruitment and phagocytosis.
NEURAL REGENERATION RESEARCH
(2021)
Article
Cell Biology
Min Cai, Jian Shao, Bryant Yung, Yi Wang, Nan-Nan Gao, Xi Xu, Huan-Huan Zhang, Yu-Mei Feng, Deng-Bing Yao
Summary: Wallerian degeneration is a complex biological process that occurs after nerve injury, involving nerve degeneration and regeneration. This study reveals that BIRC3 plays an important role in peripheral nerve injury repair and regeneration by affecting Schwann cell migration, proliferation, and apoptosis through the activation of the c-fos and ERK signal pathways.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Jingmin Liu, Xinrui Ma, Xiaofang Hu, Jinkun Wen, Haowen Zhang, Jiawei Xu, Ye He, Xianghai Wang, Jiasong Guo
Summary: Our study found that RhoA knockdown or inhibition can alleviate the proliferation, migration, and differentiation of Schwann cells. In this study, we developed two lines of conditional RhoA knockout (cKO) mice to investigate the role of RhoA in Schwann cells during nerve injury and repair. Our results indicate that RhoA cKO in Schwann cells can accelerate axonal regrowth and remyelination after sciatic nerve injury, promoting the recovery of nerve conduction and hindlimb gait. Mechanistic studies revealed that RhoA cKO facilitates Schwann cell dedifferentiation via the JNK pathway, subsequently promoting Wallerian degeneration and stimulating the production of neurotrophins.
Article
Biology
Xiao-Feng Zhao, Lucas D. Huffman, Hannah Hafner, Mitre Athaiya, Matthew C. Finneran, Ashley L. Kalinski, Rafi Kohen, Corey Flynn, Ryan Passino, Craig N. Johnson, David Kohrman, Riki Kawaguchi, Lynda J. S. Yang, Jeffery L. Twiss, Daniel H. Geschwind, Gabriel Corfas, Roman J. Giger
Summary: This study performed single-cell analysis to investigate the pathological changes following nerve injury in mice. It was found that macrophages rapidly accumulated at the site of nerve injury and underwent metabolic reprogramming. The blood-nerve barrier showed partial leakiness, resulting in proliferation of stromal cells and entry of serum proteins. Distinct immune compartments were identified in response to mechanical nerve injury and Wallerian degeneration. Delayed Wallerian degeneration affected the distribution of immune cells in both the injured nerve and the distal nerve.
Article
Neurosciences
Angela Yu-Huey Hsu, Sung-Tsang Hsieh
Summary: Dectin-1 plays a role in peripheral nerve injury, and inhibiting it can delay nerve degeneration and angiogenesis.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Lei Han, Xianzhen Dong, Tong Qiu, Zhaona Dou, Lin Wu, Honglian Dai
Summary: This study investigates the promotion of nerve regeneration through the use of a functional electrospinning scaffold with iron chelating ability. The results demonstrate that the scaffold can alleviate oxidative stress caused by iron overload and improve cell apoptosis, indicating its potential for therapeutic applications.
MATERIALS TODAY BIO
(2022)
Article
Neurosciences
Ying Zou, Jiaqi Zhang, Jingmin Liu, Jiawei Xu, Lanya Fu, Xinrui Ma, Yizhou Xu, Shuyi Xu, Xianghai Wang, Jiasong Guo
Summary: SIRT6 acts as a negative regulator for Schwann cell dedifferentiation during Wallerian degeneration in injured peripheral nerve, with c-Jun identified as a direct downstream partner of SIRT6 in this process.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Marta Pellegatta, Paolo Canevazzi, Maria Grazia Forese, Paola Podini, Serena Valenzano, Ubaldo Del Carro, Angelo Quattrini, Carla Taveggia
Summary: ADAM17 in glial cells plays a crucial role in nerve regeneration by promoting remyelination through regulating p75(NTR). Its absence hampers effective nerve repair.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Chen Liu, Fangzhen Shan, Feng Gao, Qingjie Ji, Yunfeng Chen, Changying Wang, Zihao Wang, Pengcheng Gao, Zhanyun Lv, Yuzhong Wang
Summary: The expression of DAP12 in Schwann cells and its roles in the peripheral nervous system (PNS) were investigated. DAP12-deficiency mice showed age-related motor deficits and thinner myelin, but faster clinical recovery after sciatic nerve crush injury. Proteomic analysis revealed differentially expressed proteins related to myelin loss and macrophage accumulation in DAP12 KO mice. DAP12 deletion promoted the phenotype conversion of macrophages from M1 to M2, suggesting dual roles of DAP12 in the PNS.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eun-Jung Sohn, Yun-Kyeong Nam, Hwan-Tae Park
Summary: The study revealed differential expression of miRNAs in cAMP-treated Schwann cells, with upregulation of miRNA363-5p targeting P2X purinoceptor 4 (P2RX4). The study suggests a double-negative feedback loop between miRNA363-5p and P2RX4 contributes to Schwann cell dedifferentiation and migration after nerve injury. Additionally, a P2RX4 antagonist was found to counteract myelin degradation after nerve injury, further increasing the levels of miRNA363-5p.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Brian M. Balog, Anisha Sonti, Richard E. Zigmond
Summary: The role of inflammation in nervous system injury and disease is receiving more attention. Previous research has focused on microglia and macrophages, while the role of neutrophils has been overlooked. This article reviews the biology and functions of neutrophils, as well as their involvement in CNS and PNS diseases and injuries. It also highlights new findings on the beneficial effects of neutrophils and the potential for modifying their actions to improve health.
PROGRESS IN NEUROBIOLOGY
(2023)