Neuroprotective Effects of Paeoniflorin on 6-OHDA-Lesioned Rat Model of Parkinson’s Disease

Alpha synuclein protein is involved in Aluminum-induced cell death and oxidative stress in PC12 cells

(2016) Jamileh Saberzadeh et al.   BRAIN RESEARCH

Paeoniflorin inhibition of 6-hydroxydopamine-induced apoptosis in PC12 cells via suppressing reactive oxygen species-mediated PKCδ/NF-κB pathway

(2015) H. Dong et al.   NEUROSCIENCE

Ca2+in quality control

(2013) Daniel A East et al.   Autophagy

RNA interference targeting α-synuclein attenuates methamphetamine-induced neurotoxicity in SH-SY5Y cells

(2013) Ling Chen et al.   BRAIN RESEARCH

How Parkinsonian Toxins Dysregulate the Autophagy Machinery

(2013) Ruben Dagda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels

(2013) Anne Baron et al.   TOXICON

ER stress inhibits neuronal death by promoting autophagy

(2012) Antoine Fouillet et al.   Autophagy

Physiological and Pathological Functions of Acid-Sensing Ion Channels in the Central Nervous System

(2012) Xiang-Ping Chu et al.   CURRENT DRUG TARGETS

Animal models of Parkinson’s disease

(2012) Fabio Blandini et al.   FEBS Journal

Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis

(2012) Wei Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Pathogenesis of Parkinson's disease

(2012) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

Lysosome-dependent pathways as a unifying theme in Parkinson's disease

(2012) George K. Tofaris   MOVEMENT DISORDERS

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

The Parkinson disease protein α-synuclein inhibits autophagy

(2011) Ashley R. Winslow et al.   Autophagy

ASICs mediate the modulatory effect by paeoniflorin on alpha-synuclein autophagic degradation

(2011) Xue Sun et al.   BRAIN RESEARCH

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Heteromeric Acid-Sensing Ion Channels (ASICs) Composed of ASIC2b and ASIC1a Display Novel Channel Properties and Contribute to Acidosis-Induced Neuronal Death

(2011) T. W. Sherwood et al.   JOURNAL OF NEUROSCIENCE

ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca2+ overload during ischemia and acidosis

(2010) Yelenis Mari et al.   CELL CALCIUM

Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway

(2010) Bi-Yin Cao et al.   JOURNAL OF ETHNOPHARMACOLOGY

A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel

(2010) Ye Yu et al.   NEURON

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy

(2010) Leslie Crews et al.   PLoS One

Current perspectives on acid-sensing ion channels: new advances and therapeutic implications

(2010) Jacques Noël et al.   Expert Review of Clinical Pharmacology

Disruption of PPARγ signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy

(2009) M Jiang et al.   CELL DEATH AND DIFFERENTIATION

Paeoniflorin suppress NF-κB activation through modulation of IκBα and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells

(2008) Hao Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

(2008) T. Pan et al.   BRAIN

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism

(2008) Hon Kit Wong et al.   HUMAN MOLECULAR GENETICS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Amiloride is neuroprotective in an MPTP model of Parkinson's disease

(2008) Robert L. Arias et al.   NEUROBIOLOGY OF DISEASE

The 6-hydroxydopamine model: News from the past

(2008) Fabio Blandini et al.   PARKINSONISM & RELATED DISORDERS