Journal
NEUROCHEMICAL RESEARCH
Volume 42, Issue 1, Pages 141-150Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-016-2109-4
Keywords
Torpor; Thermoregulation; Obesity; Arctic ground squirrel; Adenosine; Glutamate
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Funding
- National Science Foundation [NSF IOS-1258179]
- National Institute Of Neurological Disorders And Stroke of the National Institutes of Health [R03NS081637]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1258179] Funding Source: National Science Foundation
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Despite an epidemic in obesity and metabolic syndrome limited means exist to effect adiposity or metabolic rate other than life style changes. Here we review evidence that neural signaling metabolites may modulate thermoregulatory pathways and offer novel means to fine tune energy use. We extend prior reviews on mechanisms that regulate thermogenesis and energy use in hibernation by focusing primarily on the neural signaling metabolites adenosine, AMP and glutamate.
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