Article
Biochemistry & Molecular Biology
Ammar Ali, Shahid Ali Shah, Nasib Zaman, Muhammad Nazir Uddin, Wajid Khan, Abid Ali, Muhammad Riaz, Atif Kamil
Summary: The study demonstrates the antioxidant potential of Vitamin D against D-Galactose induced oxidative stress mediated Alzheimer disease pathology in male adult albino mice, improving memory and neuronal synapse, and reducing AD pathophysiology. Vitamin D could potentially serve as a drug candidate in neurodegenerative diseases.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Marwa Mohamed Atef, Marwa Nagy Emam, Rehab E. Abo El Gheit, Eman M. Elbeltagi, H. A. Alshenawy, Doaa A. Radwan, Reham L. Younis, Rania Nagi Abd-Ellatif
Summary: This study aimed to examine the protective effect of Geraniol (GE) on D-galactose (D-gal) induced cognitive impairment. The results showed that GE effectively improved aging-related memory impairment through increasing GSH, BDNF, Ach levels, and SOD activity. Additionally, GE treatment caused a decrease in the levels of MDA, inflammatory mediators, ER stress sensors, and AchE activity, as well as improved neuronal architecture and spatial memory.
NEUROCHEMICAL RESEARCH
(2022)
Article
Biology
Niklas Lonnemann, Shirin Hosseini, Melanie Ohm, Robert Geffers, Karsten Hiller, Charles A. Dinarello, Martin Korte
Summary: IL-37 has immunomodulatory effects in the central nervous system, protecting neuronal structure and function, inhibiting microglial activation, enhancing long-term potentiation, and exerting anti-inflammatory effects in chronic neuroinflammatory conditions like Alzheimer's disease.
Article
Pharmacology & Pharmacy
Sareer Ahmad, Amjad Khan, Waqar Ali, Myeung Hoon Jo, Junsung Park, Muhammad Ikram, Myeong Ok Kim
Summary: In this study, Fisetin was found to protect against d-galactose-induced oxidative stress, neuroinflammation, and memory impairment in mice by regulating antioxidant mechanisms, inhibiting inflammatory pathways, and preventing ROS accumulation. This suggests that Fisetin may be beneficial in addressing age-related neurological disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Ying-Ying Nie, Long-Jian Zhou, Yan-Mei Li, Wen-Cong Yang, Ya-Yue Liu, Zhi-You Yang, Xiao-Xiang Ma, Yong-Ping Zhang, Peng-Zhi Hong, Yi Zhang
Summary: The study suggests that Hizikia fusiforme functional oil (HFFO) has potential as a neuroprotective agent, capable of preventing memory impairment caused by cholinergic deficiency and neuroinflammation. The main components of HFFO, arachidonic acid and phytol, show good affinity with anti-inflammatory targets and have acceptable drug-like properties and ADMET profiles.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biology
Noreen Samad, Muhammad Abubaker Hassan Azdee, Imran Imran, Tanveer Ahmad, Faleh Alqahtani
Summary: This study found that the fruit peel of Mukia madrespatana has powerful antioxidative and neuromodulatory properties, which can improve behavioral and cognitive impairments caused by aging.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Inayat Ur Rehman, Riaz Ahmad, Ibrahim Khan, Hyeon Jin Lee, Jungsung Park, Rahat Ullah, Myeong Jun Choi, Hee Young Kang, Myeong Ok Kim
Summary: Alzheimer's disease is a prevalent age-related neurodegenerative disease characterized by the accumulation of amyloid beta A beta(1-42) and tau hyperphosphorylation in the brain. Nicotinamide (NAM) Vitamin B3 has shown neuroprotective effects against A beta(1-42)-induced neurotoxicity by ameliorating neuronal inflammation and apoptosis. This study suggests that NAM may be a potential preventive and therapeutic candidate for A beta(1-42)-induced neuroinflammation, neurodegeneration, and neurotoxicity.
Article
Biochemistry & Molecular Biology
Kimberly Barber, Patricia Mendonca, Jasmine A. Evans, Karam F. A. Soliman
Summary: Chronic oxidative stress and inflammation play a role in neurodegenerative diseases. Natural compounds, such as cardamonin, have been investigated for their ability to protect cells from oxidative stress. This study found that cardamonin has antioxidant and anti-inflammatory effects on LPS-activated BV-2 microglial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jinghao Huang, Dengchao Chen, Xinyi Lin, Chengxia Yang, Xianzhong Lin
Summary: MiRNA-124 plays a significant role in memory formation and neurodegenerative diseases. This study investigated the involvement of miRNA-124 in memory impairment induced by d-galactose and explored the underlying neuroprotective mechanism. The results showed that d-galactose administration caused memory impairments in mice, which were alleviated by miRNA-124 agomir injection in the hippocampus, leading to reduced neural damage and neuroinflammation. Molecular analysis and immunohistochemistry revealed that miRNA-124 reduced neuroinflammation through microglial polarization and downregulation of inflammatory mediators. These findings suggest that miRNA-124 may be a potential target for the pathogenesis of memory impairment and neurodegenerative diseases.
Article
Nutrition & Dietetics
Wei Xiong, Rongzi Li, Boying Li, Xifan Wang, Huihui Wang, Yanan Sun, Xiaoyu Wang, Yixuan Li, Fazheng Ren
Summary: Memory impairment is a characteristic of brain aging, and enhancing neurogenesis is a potential method for mitigating it. Nobiletin (NOB), a natural flavonoid derived from citrus peels, was found to attenuate memory impairment and restore hippocampal neurogenesis in aging mice. Furthermore, NOB inhibited inflammation and improved viability and differential ability of cells. Overall, NOB is a potential candidate for improving brain function by enhancing neurogenesis.
Article
Biochemistry & Molecular Biology
Marika Cordaro, Sergio Modafferi, Ramona D'Amico, Roberta Fusco, Tiziana Genovese, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Davide Di Paola, Daniela Impellizzeri, Salvatore Cuzzocrea, Vittorio Calabrese, Rosanna Di Paola, Rosalba Siracusa
Summary: By activating the NF-E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) redox system and increasing lipoxin A4, the combination of Hericium erinaceus and Coriolus versicolor fungi can modulate antioxidant stress and neuroinflammation, showing potential as a nutraceutical choice for preventing Parkinson's disease.
Article
Nutrition & Dietetics
Yang Li, Miao Sun, Fuyang Cao, Yu Chen, Linlin Zhang, Hao Li, Jiangbei Cao, Jie Song, Yulong Ma, Weidong Mi, Xiaoying Zhang
Summary: The study found that the ferroptosis inhibitor liproxstatin-1 can ameliorate inflammation-related cognitive impairment by reducing the release of inflammatory mediators and oxidative stress, and by regulating iron metabolism and iron ferroptosis-related proteins.
Article
Biochemistry & Molecular Biology
Rengasamy Balakrishnan, Ju-Young Park, Duk-Yeon Cho, Jae-Yong Ahn, Dong-Sun Yoo, Sang-Ho Seol, Sung-Hwa Yoon, Dong-Kug Choi
Summary: AD-1 small molecule protects against cognitive decline and memory impairment induced by oxidative brain damage, by inhibiting AChE activity, reducing oxidant factors, alleviating neuroinflammation and neuronal apoptosis. It also increases the expression of neuroprotective markers and improves spatial learning behavior and memory formation.
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Davide Decandia, Francesca Gelfo, Eugenia Landolfo, Francesca Balsamo, Laura Petrosini, Debora Cutuli
Summary: Alzheimer's disease (AD) is a growing epidemic with significant social and economic burden. Inflammation and neurodegeneration play a major role in AD pathogenesis. This review focuses on the effects of dietary supplementation in AD-like animal models, specifically in relation to neuroinflammation induced by lipopolysaccharide (LPS) injection. Various compounds, such as curcumin and krill oil, have been found to counteract cognitive decline and neuroinflammatory responses in rodents. Overall, dietary interventions offer potential neuroprotection and immune regulation in AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)