Article
Biochemistry & Molecular Biology
Chinami Matsumoto, Hitomi Sekine, Nana Zhang, Sachiko Mogami, Naoki Fujitsuka, Hiroshi Takeda
Summary: Chemotherapy-induced sarcopenia is a negative prognostic factor that affects postoperative complications and quality of life in cancer patients. Cisplatin, a commonly used chemotherapy drug, causes skeletal muscle loss by affecting mitochondrial function and activating muscle-specific ubiquitin ligases Atrogin-1 and muscle RING finger 1 (MuRF1). Although p53 has been implicated in muscle atrophy, it is unclear if it plays a role in cisplatin-induced atrophy. This study investigated the effect of a p53-specific inhibitor, pifithrin-alpha (PFT-a), on cisplatin-induced muscle atrophy in C2C12 myotubes. The results showed that cisplatin increased p53 levels and upregulated the expression of p53 target genes in C2C12 myotubes. PFT-a reduced reactive oxygen species production, mitochondrial dysfunction, and the increase in the Bax/Bcl-2 ratio induced by cisplatin. However, PFT-a did not ameliorate the decrease in muscle protein synthesis. Overall, this study suggests that cisplatin-induced muscle degradation is p53-dependent, but p53 has minimal involvement in the reduction of muscle protein synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Cong Wu, Zhiming Shen, Yi Lu, Fei Sun, Hongcan Shi
Summary: This study demonstrates that Fe3O4 nanoparticles can induce ferroptosis in macrophages and elucidates the molecular mechanisms involved in this process. It provides important theoretical insights into the impact of nanoparticles on macrophages and their associated biotoxicity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Mingyuan Wang, Qiong Huang, Min Liu, Tianjiao Zhao, Xiangping Song, Qiaohui Chen, Yongqi Yang, Yayun Nan, Zerun Liu, Yuntao Zhang, Wei Wu, Kelong Ai
Summary: Increased incidence of inflammatory bowel disease (IBD) has negatively impacted patients' quality of life. The authors developed a novel oral nanomedicine (OPEN) that inhibits excessive intestinal epithelial cell apoptosis, providing a new strategy for comprehensive IBD therapy.
ADVANCED MATERIALS
(2023)
Article
Microbiology
Li Xu, Zhijie Chen, Yu Zhang, Lu Cui, Zheyi Liu, Xuefeng Li, Shengwang Liu, Hai Li
Summary: This study reveals that the P53 inhibitor Pifithrin-alpha can suppress the replication of avian infectious laryngotracheitis virus (ILTV) and repress the expression of genes involved in nucleotide metabolism and ATP synthesis. These findings provide insight into the mechanisms through which P53 controls ILTV infection and expand our knowledge of chicken P53 target genes.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Chi-Wei Kuo, Ming-Yuan Chang, Hui-Hua Liu, Xiao-Kuo He, Shu-Yen Chan, Ying-Zu Huang, Chih-Wei Peng, Pi-Kai Chang, Chien-Yuan Pan, Tsung-Hsun Hsieh
Summary: The study applied a novel CES scheme with a theta-burst stimulation protocol in a weight drop-induced rat model of TBI and found that after 4 weeks of intervention, CES significantly improved the neurological, sensorimotor, and cognitive deficits caused by TBI, with a mitigating effect on the activation of GFAP in the hippocampus.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Neurosciences
Patricia B. de la Tremblaye, JoDy L. Wellcome, Kaitlyn Wiley, Carolyn A. Lomahan, Eleni H. Moschonas, Jeffrey P. Cheng, Corina O. Bondi, Anthony E. Kline
Summary: This study investigated the impact of adverse stress during adolescence on behavioral outcomes in adult rats after TBI, as well as how CB1 receptor agonist affects the results. The results suggest that adverse stress experienced during adolescence may provide protection against TBI acquired in adulthood, and CB1 receptor agonism also improves cognitive and emotional performance after TBI.
Article
Neurosciences
Michael C. C. Shaughness, Nathan Pierron, Austin N. N. Smith, Kimberly R. R. Byrnes
Summary: Stretch-injured microglia exhibit significant changes in morphology, function, and gene expression when cultured on a synthetic fibronectin substrate. The activation of the RGD binding/integrin pathway and downstream signaling through FAK partially mediates these alterations. Blocking the RGD binding/integrin pathway with an RGD peptide mimics the stretch-induced phenotype, while upregulation of downstream integrin signaling reverses these effects.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Haixia Kuang, Tao Liu, Cui Jiao, Jianmei Wang, Shinan Wu, Jing Wu, Sicong Peng, Andrew M. Davidson, Shelya X. Zeng, Hua Lu, Ricardo Mostany
Summary: The tumor suppressor p53 plays a crucial role in embryonic neuron development and synaptic plasticity. Lack of p53 gene function leads to abnormal neuronal activity and spine development, affecting information transmission between brain regions and texture discrimination ability.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Jazmin Calvo-Alvarez, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo
Summary: Chronic myeloid leukemia (CML) is a hematologic malignancy characterized by BCR-ABL1 gene fusion, with some patients becoming resistant to current treatments. Research shows that TPGS induces apoptosis in K562 cells through an H2O2 signaling mechanism, offering potential as a therapy for CML.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Multidisciplinary Sciences
Siti Ainun Marufa, Tsung-Hsun Hsieh, Jian-Chiun Liou, Hsin-Yung Chen, Chih-Wei Peng
Summary: The study investigated the effects of intermittent theta-burst stimulation (iTBS) on locomotor function, motor plasticity, and axonal regeneration in an animal model of incomplete spinal cord injury (SCI). Multiple sessions of iTBS treatment enhanced motor plasticity in all SCI rats, and iTBS treatment increased GAP-43 expression in the spinal cord, promoting axonal regeneration.
Article
Neurosciences
Chi-Wei Kuo, Ming-Yuan Chang, Hui-Hua Liu, Xiao-Kuo He, Shu-Yen Chan, Ying-Zu Huang, Chih-Wei Peng, Pi-Kai Chang, Chien-Yuan Pan, Tsung-Hsun Hsieh
Summary: The study applied a novel CES scheme with a theta-burst stimulation protocol in a weight drop-induced rat model of TBI and found that after 4 weeks of intervention, CES significantly improved the neurological, sensorimotor, and cognitive deficits caused by TBI, with a mitigating effect on the activation of GFAP in the hippocampus.
FRONTIERS IN NEURAL CIRCUITS
(2021)
Article
Immunology
Alicia Bedolla, Aleksandr Taranov, Fucheng Luo, Jiapeng Wang, Flavia Turcato, Elizabeth M. Fugate, Nigel H. Greig, Diana M. Lindquist, Steven A. Crone, June Goto, Yu Luo
Summary: Comparing two models of microglia ablation, it was found that the genetic ablation model displayed a rapid pathological condition in the brain, while the pharmacological ablation model did not. The results revealed that the CSF/ventricular space shrinkage pathology in the genetic ablation model is caused by the iDTR allele, independent of brain edema formation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Geriatrics & Gerontology
Chi-Wei Kuo, Ming-Yuan Chang, Ming-Yi Chou, Chien-Yuan Pan, Chih-Wei Peng, Hui-Chiun Tseng, Tsu-Yi Jen, Xiao-Kuo He, Hui-Hua Liu, Thi Xuan Dieu Nguyen, Pi-Kai Chang, Tsung-Hsun Hsieh
Summary: This study investigated the therapeutic effects of cortical electrical stimulation (CES) in a rat model of Parkinson's disease (PD). The results demonstrated that early and long-term CES intervention could ameliorate motor dysfunction and exert neuroprotective effects in PD rats.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Tsung-Hsun Hsieh, Xiao-Kuo He, Hui-Hua Liu, Jia-Jin J. Chen, Chih-Wei Peng, Hao-Li Liu, Alexander Rotenberg, Ko-Ting Chen, Ming-Yuan Chang, Yung-Hsiao Chiang, Pi-Kai Chang, Chi-Wei Kuo
Summary: This study investigated the therapeutic effects of rTMS on hemiparkinsonian rats and found that four weeks of rTMS intervention significantly reduced the aggravation of PD-related symptoms post-6-OHDA lesion in rats. Immunohistochemical results showed that rTMS treatment group preserved TH-positive neurons in SNpc and fibers in the striatum. This suggests that long-term rTMS treatment might have clinical relevance and usefulness as an additional treatment approach in individuals with PD.
Article
Biochemistry & Molecular Biology
Jun Tazoe, Chia-Feng Lu, Bao-Yu Hsieh, Cheng-Yu Chen, Yu-Chieh Jill Kao
Summary: This study investigated the diffusion of free water in the cerebrospinal fluid (CSF) system of rat brains using diffusion magnetic resonance imaging (MRI). The results showed a significant decrease in mean diffusivity in the subarachnoid cisterns of stroke rats compared to intact rats and rats with mild traumatic brain injury (mTBI). The diffusivity characteristics in stroke rats also differed significantly from the other two groups in terms of skewness, maximum diffusivity, and diffusivity percentiles. However, there was no difference in mean diffusivity in the lateral ventricles among the three groups.
BIOMEDICAL JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen, John Chung-Che Wu, Jia-Yi Wang, Yi-Syue Tsou, Inho Hwang, Yukyung Kim, Dayeon Gil, Eui Jung Jo, Baek-Soo Han, David Tweedie, Daniela Lecca, Michael T. Scerba, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig, Yung-Hsiao Chiang
Summary: The immunomodulatory drug pomalidomide and its derivatives 3,6'-DP and 1,6'-DP have shown promising anti-inflammatory effects in a rat stroke model. These compounds may have the potential to be valuable therapies for stroke and should be further developed.
Article
Biochemistry & Molecular Biology
Chun-Wei Wu, Jia-Jin Chen, Chou-Ching K. Lin, Chien-An Chen, Chun-Ie Wu, Ing-Shiou Hwang, Tsung-Hsun Hsieh, Bor-Shing Lin, Chih-Wei Peng
Summary: This study investigated the changes in brain tissue optical properties using frequency-domain near-infrared spectroscopy (FD-NIRS) and established the relationship between cerebral hemodynamics and infarct variation in a middle cerebral artery occlusion (MCAO) model. The results suggest that FD-NIRS parameters may be associated with the severity of the infarction and subsequent pathologies in MCAO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Chellappan Praveen Rajneesh, Tsung-Hsun Hsieh, Hung-Chou Chen, Jian-Chiun Liou, Bor-Shing Lin, Chun-Wei George Wu, Chien-Hung Lai, Chih-Wei Peng
Summary: Bladder dysfunction in Parkinson's disease (PD) was studied using a rat model. The results showed a decrease in voiding efficiency and a more significant decrease in bilateral PD rats. The dysfunction was associated with a depletion of dopaminergic neurons in the substantia nigra region of the brain.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Environmental Sciences
Chih-Kuan Wu, Yin-Chou Lin, Chi-Ping Lai, Hsin-Ping Wang, Tsung-Hsun Hsieh
Summary: This study found that dynamic taping can significantly improve landing strategy and knee laxity in athletes, with a more prominent effect in female athletes and high-risk athletes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Behavioral Sciences
Hsin-Yung Chen, Chia-Yen Yang, Tsung-Hsun Hsieh, Chih-Wei Peng, Li-Ling Chuang, Ying-Ling Chang, Huang-Ju Chi, Hsin-Min Lee, Sophie Hsin-Yi Liang
Summary: Behavioral flexibility, impaired in patients with ADHD, may be improved through transcranial direct current stimulation (tDCS). Animal studies using spontaneously hypertensive rats and Wistar-Kyoto rats as models demonstrated that tDCS treatment improved the reaction times and reduced trial omissions in set-shifting and reversal-learning tasks, suggesting its potential therapeutic efficacy in ADHD.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Shu-Yen Chan, Chi-Wei Kuo, Tsai-Tsen Liao, Chih-Wei Peng, Tsung-Hsun Hsieh, Ming-Yuan Chang
Summary: Foot drop is a common gait impairment characterized by the weakness of the foot dorsiflexors, resulting in the inability to raise the foot or toes during walking. The accurate prognosis and treatment protocols for foot drop are not well defined due to the heterogeneity of underlying lumbar spine disorders. In this study, a rat model of foot drop induced by ventral root avulsion (VRA) was developed, and detailed changes in gait pattern were recorded. The results showed significant changes in gait patterns in VRA rats compared to sham lesion rats, providing insights into compensatory changes and recovery in gait patterns.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Po-Chun Chu, Chen-Syuan Huang, Pi-Kai Chang, Rou-Shayn Chen, Ko-Ting Chen, Tsung-Hsun Hsieh, Hao-Li Liu
Summary: This study demonstrates the potential of weak ultrasound stimulation to induce long-lasting neuromodulatory effects and explores its application in future clinical neuromodulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Bao-Yu Hsieh, Yu-Chieh Jill Kao, Ning Zhou, Yi-Pei Lin, Yu-Ying Mei, Sung-Yu Chu, Dong-Chuan Wu
Summary: The specific vascular dynamics of cerebral penetrating vessels during CSD and the potential different contributions of penetrating arterioles and venules to the CSD-related pathological vascular consequences were revealed. Using ultrasound dynamic ultrafast Doppler imaging to investigate CSD-induced cerebral vascular responses could help advance understanding of the mechanism of CSD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Zhao Zhang, Bor-Shing Lin, Chun-Wei George Wu, Tsung-Hsun Hsieh, Jian-Chiun Liou, Yu-Ting Li, Chih-Wei Peng
Summary: The tTIS device uses DDS to generate sine wave potential and convert it to adjustable current. The device achieves electrical isolation of different channels and increases load capacity through a current transformer. In vivo experiments validate the feasibility of the device, indicating that the 2-pole arrangement may provide better cortical targeting.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2022)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)