Review
Biochemistry & Molecular Biology
Rajan Logesh, Sagar Rajendra Prasad, Sandhya Chipurupalli, Nirmal Robinson, Suresh Kumar Mohankumar
Summary: The production of melanin pigment is dependent on tyrosine levels and is regulated by various pathways. Melanin production is stimulated by UV radiation and hormonal factors, and is regulated by multiple factors. Melanin production can affect melanoma development and immune responses. Studying the effects of natural products on melanin production can help develop adjuvant therapies for melanotic melanoma.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Medicine, General & Internal
Lorenza Burzi, Aurora Maria Alessandrini, Pietro Quaglino, Bianca Maria Piraccini, Emi Dika, Simone Ribero
Summary: Immunotherapy with checkpoint inhibitors has shown significant improvement in the outcome for stage III and IV melanoma patients, but cutaneous adverse events are commonly reported during treatment. These adverse events include pigmentation changes such as vitiligo, the Sutton phenomenon, melanosis, and toxicities affecting hair and nails.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Kiwon Kim, Soyeon Kim, Woojae Myung, Injeong Shim, Hyewon Lee, Beomsu Kim, Sung Kweon Cho, Joohyun Yoon, Doh Kwan Kim, Hong-Hee Won
Summary: The study found that an increased genetic risk of PD may be associated with an increased risk of schizophrenia, supporting the intrinsic nature of psychotic symptoms in PD. Future research will explore possible comorbidities and shared genetic structure between the two diseases.
Article
Cell Biology
Silvia Muccioli, Valentina Brillo, Tatiana Varanita, Federica Rossin, Elisabetta Zaltron, Angelo Velle, Giorgia Alessio, Beatrice Angi, Filippo Severin, Anna Tosi, Manuela D'Eletto, Luca Occhigrossi, Laura Falasca, Vanessa Checchetto, Roberto Ciaccio, Amelia Fasci, Leonardo Chieregato, Ana Paula Rebelo, Marta Giacomello, Antonio Rosato, Ildiko Szabo, Chiara Romualdi, Mauro Piacentini, Luigi Leanza
Summary: This article investigates the plasticity of melanoma and the role of Transglutaminase Type-2 (TG2) in regulating melanoma formation and invasiveness. The results suggest that TG2 expression can affect melanoma invasiveness and may contribute to unraveling the vulnerabilities of melanoma.
CELL DEATH & DISEASE
(2023)
Article
Medicine, General & Internal
Georgina Long, Susan M. Swetter, Alexander M. Menzies, Jeffrey E. Gershenwald, Richard A. Scolyer
Summary: Cutaneous melanoma is a malignancy derived from skin melanocytes, primarily caused by ultraviolet radiation. Diagnosis is based on clinical and histopathological findings, and treatment options vary depending on disease stage and characteristics. Multidisciplinary care, including systemic drug therapies, has significantly improved melanoma survival rates.
Article
Genetics & Heredity
Muyi Yang, Per Johnsson, Lars Brautigam, Xiaohong R. Yang, Kim Thrane, Jiwei Gao, Nicholas P. Tobin, Yitian Zhou, Rong Yu, Noemi Nagy, Par G. Engstrom, Rainer Tuominen, Hanna Eriksson, Joakim Lundeberg, Margaret A. Tucker, Alisa M. Goldstein, Suzanne Egyhazi-Brage, Jian Zhao, Yihai Cao, Veronica Hoiom
Summary: This study identifies a novel melanoma susceptibility gene, DENND5A, and investigates its role in melanoma development. The research finds that DENND5A is enriched in pigmented melanoma tissue and loss of its function leads to a decrease in melanin content and pigmentation defects. These findings provide evidence of DENND5A's physiological role in the skin and its association with melanoma susceptibility.
GENETICS IN MEDICINE
(2022)
Article
Clinical Neurology
Remi Stevelink, Jurjen J. Luykx, Bochao D. Lin, Costin Leu, Dennis Lal, Alexander W. Smith, Dick Schijven, Johannes A. Carpay, Koen Rademaker, Roiza A. Rodrigues Baldez, Orrin Devinsky, Kees P. J. Braun, Floor E. Jansen, Dirk J. A. Smit, Bobby P. C. Koeleman
Summary: The study found a strong genetic correlation between genetic generalized epilepsy (GGE) and background EEG oscillations, particularly in the beta frequency band. Individuals with higher beta and theta polygenic risk scores have a significantly increased risk of generalized epilepsy. Mendelian randomization analyses suggest a causal effect of GGE genetic liability on beta oscillations.
Article
Multidisciplinary Sciences
Ke-Jun Chen, Feng-Zeng Li, Qian Ye, Meng Jia, Sheng Fang
Summary: Heat shock protein 105 (HSP105) is overexpressed in cutaneous malignant melanoma (CMM) and is closely associated with different clinicopathological variables. Lesions in exposed sites, recurrent and metastatic lesions, nodular melanoma, and lentigo maligna melanoma show higher HSP105 expression, suggesting HSP105 as a potential target for the diagnosis, treatment, and prognostic prediction of CMM.
Review
Biochemistry & Molecular Biology
Kyuri Kim, YoonJung Huh, Kyung-Min Lim
Summary: Hyper-activated melanocytes are the main cause of skin hyper-pigmentary disorders, leading to a high demand for anti-pigmentary natural compounds without toxicity concerns. Research has focused on finding such compounds from various natural sources, including the ocean, plants, and bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Kristina Navrazhina, Sandra Garcet, Samuel C. Williams, Nicholas Gulati, Felix Kiecker, John W. Frew, Hiroshi Mitsui, James G. Krueger
Summary: The study demonstrates the importance of using laser capture microdissection (LCM) to accurately identify molecular changes in melanoma samples, without being affected by inflammatory infiltration. LCM analysis identified a greater number of differentially expressed genes, including melanocyte-specific genes, and revealed pathways related to cell proliferation.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Madison Ernst, Alessio Giubellino
Summary: Malignant melanoma is the leading cause of death among cutaneous malignancies. The introduction of immunotherapies and targeted therapies have contributed to a small decrease in mortality rate. However, toxicity and resistance remain critical challenges in the field.
Article
Oncology
Gabriela Vilas Boas Gomez, Gustavo Jacob Lourenco, Lummy Maria Oliveira Monteiro, Rafael Silva Rocha, Kimberly Anne McGrail Fernandez, Juan Angel Recio, Caroline Torricelli, Lilian Oliveira Coser, Alexandre Leite Rodrigues Oliveira, Juliana Carron, Aparecida Machado Moraes, Carmen Silvia Passos Lima
Summary: This study found that inherited abnormalities in the JAK-STAT signaling pathway are associated with the development and clinical characteristics of CM. Specific genotypes are associated with an increased risk of CM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Maria Teresa Perinan, Daniel Macias-Garcia, Silvia Jesus, Juan Francisco Martin-Rodriguez, Laura Munoz-Delgado, Maria Valle Jimenez-Jaraba, Dolores Buiza-Rueda, Marta Bonilla-Toribio, Astrid Daniela Adarmes-Gomez, Pilar Gomez-Garre, Pablo Mir
Summary: Elevated homocysteine levels are associated with cognitive impairment in Parkinson's disease, but not with polymorphisms in genes involved in homocysteine metabolism.
JOURNAL OF NEUROLOGY
(2023)
Article
Engineering, Biomedical
Yibo Hu, Hongliang Zeng, Jiaxing Jiang, Sheng Yang, Jinhua Huang, Jing Chen, Qinghai Zeng
Summary: This study comprehensively evaluated an RBFP that successfully detected tyrosinase in melanoma cells and melanocytes, emitting red fluorescence. The probe showed good selectivity to tyrosinase and sensitivity to changes in tyrosinase levels or activity. Additionally, there were no toxic effects at concentrations of < 20 mu mol/L.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Dermatology
M. Scatolini, A. Patel, E. Grosso, M. Mello-Grand, P. Ostano, R. Coppo, M. Vitiello, T. Venesio, A. Zaccagna, A. Pisacane, I Sarotto, D. Taverna, L. Poliseno, D. Bergamaschi, G. Chiorino
Summary: The study identified a significant association between metastases, BRAF mutation, and low GJB5 expression in melanoma, suggesting a potential prognostic role for GJB5 in cutaneous melanoma.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Clinical Neurology
Joshua Stevenson-Hoare, Amanda Heslegrave, Ganna Leonenko, Dina Fathalla, Eftychia Bellou, Lauren Luckcuck, Rachel Marshall, Rebecca Sims, Bryan Paul Morgan, John Hardy, Bart de Strooper, Julie Williams, Henrik Zetterberg, Valentina Escott-Price
Summary: Plasma biomarkers for Alzheimer's disease-related pathologies have made significant progress in recent years, with well-validated blood tests available for the detection of amyloid and tau pathology, as well as neurodegeneration and astrocytic activation. This study demonstrates that a combination of five plasma biomarkers, along with genetic variants associated with these biomarkers, can be used to accurately diagnose and predict the onset of Alzheimer's disease.
Article
Biochemistry & Molecular Biology
Yann C. Klimentidis, Zhao Chen, Manuel L. Gonzalez-Garay, Dionysios Grigoriadis, Ege Sackey, Alan Pittman, Pia Ostergaard, Karen L. Herbst
Summary: This study used bioelectrical impedance analysis and anthropometric data to identify potential genetic risk factors for lipedema. Genome-wide association study identified several significant loci associated with lipedema, and two of them were replicated in an independent study. Follow-up analyses suggested enrichment of genes expressed in blood vessels and adipose tissue. These findings provide a starting point for better understanding the genetic and physiological basis of lipedema.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Ella F. Whittle, Madison Chilian, Ehsan Ghayoor Karimiani, Helga Progri, Daniela Buhas, Melis Kose, Rebecca D. Ganetzky, Mehran Beiraghi Toosi, Paria Najarzadeh Torbati, Reza Shervin Badv, Ivan Shelihan, Hui Yang, Houda Zghal Elloumi, Sukyeong Lee, Yalda Jamshidi, Alan M. Pittman, Henry Houlden, Erika Ignatius, Shamima Rahman, Reza Maroofian, Wan Hee Yoon, Christopher J. Carrol
Summary: This study aimed to identify the genetic cause of a novel autosomal recessive neurodevelopmental disorder characterized by global developmental delay, movement disorder, and metabolic abnormalities. Through clinical characterization and genetic analysis, the researchers identified three novel homozygous variants in the OGDH gene. Functional studies demonstrated that these variants interfered with the structure and function of the OGDH protein, leading to the observed neurodevelopmental disorder. This research highlights the importance of studying genetic causes of neurodevelopmental disorders for understanding their underlying mechanisms and developing targeted therapies.
GENETICS IN MEDICINE
(2023)
Letter
Clinical Neurology
John Hardy, Catherine Mummery
Article
Clinical Neurology
Pierre-Emmanuel Sugier, Elise A. Lucotte, Cloe Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq-Daian, Anne Boland-Auge, Robert Olaso, Jean-francois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guenel, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Roedstroem, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Therese Truong, Alexis Elbaz
Summary: By using genome-wide association studies, this study found that Parkinson's disease (PD) is genetically correlated with melanoma and prostate cancer, while it is inversely correlated with ovarian cancer. These findings suggest that pleiotropic genes contribute to the association between PD and specific cancers.
MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Christos Koros, Kathrin Brockmann, Athina-Maria Simitsi, Anastasia Bougea, Hui Liu, Ann-Kathrin Hauser, Claudia Schulte, Stefanie Lerche, Ioanna Pachi, Nikolaos Papagiannakis, Roubina Antonelou, Athina Zahou, Isabel Wurster, Efthymia Efthymiopoulou, Ion Beratis, Matina Maniati, Marina Moraitou, Helen Michelakakis, Georgios Paraskevas, Sokratis G. Papageorgiou, Constantin Potagas, Dimitra Papadimitriou, Maria Bozi, Maria Stamelou, Thomas Gasser, Leonidas Stefanis
MOVEMENT DISORDERS
(2023)
Correction
Neurosciences
Regina H. Reynolds, Aaron Z. Wagen, Frida Lona-Durazo, Sonja W. Scholz, Maryam Shoai, John Hardy, Sarah A. Gagliano Taliun, Mina Ryten
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Regina H. Reynolds, Aaron Z. Wagen, Frida Lona-Durazo, Sonja W. Scholz, Maryam Shoai, John Hardy, Sarah A. Gagliano Taliun, Mina Ryten
Summary: Genetic correlation (r(g)) can provide insights into shared biological mechanisms. Neurodegenerative and neuropsychiatric diseases have minimal global r(g), but local r(g) can exist. Applying LAVA, researchers found local r(g) between several neurodegenerative and neuropsychiatric diseases, highlighting potential common therapeutic targets.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Harald Hampel, Yan Hu, John Hardy, Kaj Blennow, Christopher Chen, George Perry, Seung Hyun Kim, Victor L. Villemagne, Paul Aisen, Michele Vendruscolo, Takeshi Iwatsubo, Colin L. Masters, Min Cho, Lars Lannfelt, Jeffrey L. Cummings, Andrea Vergallo
Summary: This summary reviews the evidence supporting the role of the amyloid-b (Ab) pathway in Alzheimer's disease (AD) and emphasizes the importance of targeting this pathway in early stages of the disease. Understanding and targeting the A beta pathway can lead to better therapeutic outcomes and management of AD.
NEURODEGENERATIVE DISEASE MANAGEMENT
(2023)
Article
Medicine, General & Internal
Tom A. Yates, Katie Devlin, Abed Arnaout, William Hurt, Neil Stone, Kate V. Everett, Alan Pittman, Hardik Patel, Susan Heenan, Paul Hart, Thomas S. Harrison
Summary: This case report presents a British Indian woman in her late 30s with presacral malakoplakia, presenting with complex unilateral foot drop. The patient had a history of prolonged intrapelvic sepsis after a caesarean delivery. Surgical resection was not possible, but she responded well to medical management.
JOURNAL OF MEDICAL CASE REPORTS
(2023)
Correction
Genetics & Heredity
Joohyun Park, Arianna Tucci, Valentina Cipriani, German Demidov, Clarissa Rocca, Jan Senderek, Michaela Butryn, Ana Velic, Tanya Lam, Evangelia Galanaki, Elisa Cali, Letizia Vestito, Reza Maroofian, Natalie Deininger, Maren Rautenberg, Jakob Admard, Gesa-Astrid Hahn, Claudius Bartels, Nienke J. H. van Os, Rita Horvath, Patrick F. Chinnery, May Yung Tiet, Channa Hewamadduma, Marios Hadjivassiliou, Susan M. Downes, Andrea H. Nemeth, Nicholas W. Genomics England Res Consortium, Nicholas W. Wood, Stefanie N. Hayer, Friedemann Bender, Benita Menden, Isabell Cordts, Katrin Klein, Huu Phuc Nguyen, Joachim K. Krauss, Christian Blahak, Tim M. Strom, Marc Sturm, Bart van de Warrenburg, Holger Lerche, Boris Macek, Matthis Synofzik, Stephan Ossowski, Dagmar Timmann, Marc E. Wolf, Damian Smedley, Olaf Riess, Ludger Schols, Henry Houlden, Tobias B. Haack, Holger Hengel
GENETICS IN MEDICINE
(2023)
Article
Clinical Neurology
Mona M. Almramhi, Chris Finan, Catherine S. Storm, Amand F. Schmidt, Demis A. Kia, Rachel Coneys, Sandesh Chopade, Aroon D. Hingorani, Nick W. Wood
Summary: The study suggests that RAC2 is a genetic modifier of MS risk and supports a causal effect of HDL-C on MS risk.
Article
Medicine, Research & Experimental
Xiaopu Zhou, Yu Chen, Fanny C. F. Ip, Yuanbing Jiang, Han Cao, Ge Lv, Huan Zhong, Jiahang Chen, Tao Ye, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M. N. Lo, Estella P. S. Tong, Vincent C. T. Mok, Timothy C. Y. Kwok, Qihao Guo, Kin Y. Mok, Maryam Shoai, John Hardy, Lei Chen, Amy K. Y. Fu, Nancy Y. Ip
Summary: Zhou et al. utilize deep learning to improve polygenic risk analysis for Alzheimer's disease. Their computational approach outperforms existing statistical methods and helps to identify potential biological mechanisms of Alzheimer's disease risk.
COMMUNICATIONS MEDICINE
(2023)
Article
Cell Biology
Karri Kaivola, Ruth Chia, Jinhui Ding, Memoona Rasheed, Masashi Fujita, Vilas Menon, Ronald L. Walton, Ryan L. Collins, Kimberley Billingsley, Harrison Brand, Michael Talkowski, Xuefang Zhao, Ramita Dewan, Ali Stark, Anindita Ray, Sultana Solaiman, Pilar Alvarez Jerez, Laksh Malik, Ted M. Dawson, Liana S. Rosenthal, Marilyn S. Albert, Olga Pletnikova, Juan C. Troncoso, Mario Maselis, Julia Keith, Eric Int LBD Genomics Consortium, Ali Int ALS FTD Consortium, Pentti PROSPECT Consortium, Toshiko Tanaka, Eric Topol, Ali Torkamani, Pentti Tienari, Tatiana M. Foroud, Bernardino Ghetti, John E. Landers, Mina Rtyen, Huw R. Morris, John A. Hardy, Letizia Mazzini, Sandra D'Alfonso, Cristina Moglia, Andrea Calvo, Geidy E. Serrano, Thomas G. Beach, Tanis Ferman, Neill R. Graff-Radford, Bradley F. Boeve, Zbigniew K. Wszolek, Dennis W. Dickson, Adriano Chio, David A. Bennett, Philip L. De Jager, Owen A. Ross, Clifton L. Dalgard, J. Raphael Gibbs, Bryan J. Traynor, Sonja W. Scholz
Summary: This study characterized the role of structural variants in Lewy body dementia (LBD) and frontotemporal dementia (FTD)/amyotrophic lateral sclerosis (ALS). The researchers discovered a novel risk locus for LBD and found associations between known structural variants and FTD/ALS. Rare pathogenic structural variants were also identified in both LBD and FTD/ALS. The study provides a catalog of structural variants for further understanding of the pathogenesis of these forms of dementia.
Article
Clinical Neurology
Riccardo Ronco, Cecilia Perini, Riccardo Curro, Natalia Dominik, Stefano Facchini, Alice Gennari, Roberto Simone, Skye Stuart, Sara Nagy, Elisa Vegezzi, Ilaria Quartesan, Amar El-Saddig, Timothy Lavin, Arianna Tucci, Agnieszka Szymura, Luiz Eduardo Novis De Farias, Alexander Gary, Megan Delfeld, Priscilla Kandikatla, Nifang Niu, Sanjukta Tawde, Joseph Shaw, James Polke, Mary M. Reilly, Nick W. Wood, Emmanuele Crespan, Christopher Gomez, Jin Yun Helen Chen, Jeremy Dan Schmahmann, David Gosal, Henry Houlden, Soma Das, Andrea Cortese
Summary: This study expands the genotypic spectrum of CANVAS by identifying sequence variants in the RFC1-coding region. The findings provide diagnostic recommendations for CANVAS and shed further light on its pathogenesis.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)