Article
Cell Biology
Jong Youl Lee, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, So Jeong Lee, Hyeong Seok An, Kyung Eun Kim, Won-Ho Kim, Yong Chul Bae, Heeyoung Kang, Gu Seob Roh
Summary: Age-related microglial activation is associated with cognitive impairment. TonEBP plays important roles in age-related microglial activation and memory deficits. TonEBP haploinsufficiency reduces microglial activation, synaptic pruning, dendritic spine loss, and memory deficits in middle-aged and amyloid beta oligomer-treated mice. Additionally, TonEBP knockdown attenuates migration and phagocytosis in amyloid beta oligomer-treated BV2 cells.
Article
Clinical Neurology
Emma Nichols, Adam M. M. Brickman, Kaitlin B. B. Casaletto, Kristen Dams-O'Connor, Kristen M. M. George, Raj G. G. Kumar, Priya Palta, Jennifer S. S. Rabin, Claudia L. L. Satizabal, Julie Schneider, Judy Pa, Renaud La Joie
Summary: This study used causal mediation methods to investigate the effects of the APOE genotype on cognitive decline and dementia. The results revealed that the detrimental effect of APOE epsilon 4 on cognition was mediated by both Alzheimer's disease (AD) and non-AD neurodegenerative neuropathologies, while non-AD vascular pathologies did not mediate this effect. Additionally, the protective effect of APOE epsilon 2 on cognition was partly mediated by AD neuropathology and was stronger in women.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Jenna N. Adams, Soyun Kim, Batool Rizvi, Mithra Sathishkumar, Lisa Taylor, Alyssa L. Harris, Abanoub Mikhail, David B. Keator, Liv McMillan, Michael A. Yassa
Summary: This study examined the relationship between functional connectivity (FC) within the entorhinal-hippocampal circuit, mnemonic discrimination, and amyloid-P (AP) pathology. The findings suggest that low object mnemonic discrimination performance is associated with increased FC between the anterior-lateral entorhinal cortex (alEC) and dentate gyrus (DG)/CA3, which is related to AP pathology and decreased entorhinal cortex volume. In contrast, spatial mnemonic discrimination is not associated with altered FC.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Paula Duarte-Guterman, Arianne Y. Albert, Cindy K. Barha, Liisa A. M. Galea
Summary: The study found that females exhibit greater neuropathology and cognitive decline in Alzheimer's disease, but these effects vary depending on diagnosis and APOE genotype. Females may experience more severe memory decline compared to males, and the APOE genotype has different effects on AD neuropathology in males and females.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jan Hendrik Boerner, Oliver Rawashdeh, Abdelhaq Rami
Summary: Research indicates that aging Per1(-/-) mice exhibit slowed autophagy in the hippocampus, leading to changes in microglia morphology, increased A beta 42 deposition, overexpression of presenilin, and accumulation of lipofuscin, which may contribute to higher neuronal vulnerability.
Article
Geriatrics & Gerontology
Yanting Chen, Tingting Hong, Feng Chen, Yuanhong Sun, Yan Wang, Lili Cui
Summary: Microglia play a crucial role in the progression of AD, especially in relation to the risk factors of APOE genotype, sex, and aging. The interaction between microglia and these risk factors can exacerbate neurodegeneration and contribute to the risk of AD. Additionally, new microglia replacement after depletion shows promise in AD treatment as a potential strategy.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Elizabeth Williams, Ashli Alex, Xi Wei Chin, Tara Spires-Jones, Szu-Han Wang
Summary: This study aimed to investigate whether cognitive training in mid-adulthood could improve subsequent cognition and reduce AD pathology in mice. The results showed that mid-adulthood cognitive training improved accuracy in AD mice and efficiency in all mice in the spatial task, but had no clear benefit on memory or amyloid pathology.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Ina S. Almdahl, Ingrid Agartz, Kenneth Hugdahl, Maria S. Korsnes
Summary: Understanding the biological changes that occur prior to onset of late-life depression (LLD) is key to its prevention. This study investigated predictors of LLD and found that baseline cortical amyloid burden, cerebrospinal fluid (CSF) amyloid beta levels, and white matter hyperintensity volume (WMH) were significant predictors of incident depression. Cognitive scores declined in the incident depression group compared to the never-depressed group, and hippocampal volume was reduced following depression.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Eric W. Buss, Nicola J. Corbett, Joshua G. Roberts, Natividad Ybarra, Timothy F. Musial, Dina Simkin, Elizabeth Molina-Campos, Kwang-Jin Oh, Lauren L. Nielsen, Gelique D. Ayala, Sheila A. Mullen, Anise K. Farooqi, Gary X. D'Souza, Corinne L. Hill, Linda A. Bean, Annalise E. Rogalsky, Matthew L. Russo, Dani M. Curlik, Marci D. Antion, Craig Weiss, Dane M. Chetkovich, M. Matthew Oh, John F. Disterhoft, Daniel A. Nicholson
Summary: Behaviors relying on the hippocampus are affected by chronological aging, with some aged animals maintaining cognition while others show impairments. Maintenance of synaptic architecture may contribute to cognitive abilities, but redistribution of synaptic weights in the hippocampus CA3 of learning-impaired animals may lead to abnormal firing characteristics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, General & Internal
Shizuo Hatashita, Daichi Wakebe
Summary: This study found that some initially amyloid-negative non-demented subjects converted to globally amyloid-positive during a long-term follow-up, with some association with the APOE epsilon 4 allele. Early regional increases in PIB DVR were most frequently observed in the right lateral temporal cortex.
Article
Cell Biology
Victor Montal, Ibai Diez, Chan-Mi Kim, William Orwig, Elisenda Bueicheku, Raquel Gutierrez-Zuniga, Alexandre Bejanin, Jordi Pegueroles, Oriol Dols-Icardo, Patrizia Vannini, Georges El-Fakhri, Keith A. Johnson, Reisa A. Sperling, Juan Fortea, Jorge Sepulcre
Summary: This study reveals the network foundation and genetic associations of tau spreading in the human brain cortex. A set of 577 genes, including APOE and glutamatergic synaptic genes, were found to play a central role in the spatial spreading of tau. The findings suggest that targeting the expression of these genes may be a potential strategy for reducing or preventing pathological tau accumulation.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Eric E. Abrahamson, Julia K. Kofler, Carl R. Becker, Julie C. Price, Kathy L. Newell, Bernardino Ghetti, Jill R. Murrell, Catriona A. McLean, Oscar L. Lopez, Chester A. Mathis, William E. Klunk, Victor L. Villemagne, Milos D. Ikonomovic
Summary: In a post-mortem study, it has been found that the amyloid PET radioligand Pittsburgh compound B (PiB) interacts poorly with cotton wool plaques, which are common in familial Alzheimer's disease but rare in sporadic Alzheimer's disease. This limited interaction may lead to an underestimation of total amyloid burden in patients with familial Alzheimer's disease.
Review
Clinical Neurology
Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K. L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. Nielsen, Kellen K. Petersen, Melissa Petersen, Stefanie D. Pina-Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malu Gamez Tansey, T. C. W. Julia, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L. Worley, Henrik Zetterberg, Maria C. Carrillo
Summary: At the Alzheimer's Association's APOE and Immunity virtual conference, experts discussed recent research advances and insights into the roles of the APOE gene and immunity in neurodegenerative diseases like Alzheimer's. The meeting highlighted the importance of diverse research and presented new directions in drug development for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Keiko Honda, Yuhki Saito, Haruka Saito, Megumi Toyoda, Ruriko Abe, Takashi Saito, Takaomi C. Saido, Makoto Michikawa, Hidenori Taru, Yuriko Sobu, Saori Hata, Tadashi Nakaya, Toshiharu Suzuki
Summary: This study investigated the effect of apoE4 on brain A,B42 accumulation in an AD mouse model. The results showed a linear increase in A,B42 levels in apoE4 mice and a rapid increase in A,B42 levels in 21-month-old apoE3 mice. Furthermore, the study identified genes that may regulate brain A,B burden and AD progression through their association with apoE gene expression.
NEUROBIOLOGY OF AGING
(2023)
Article
Chemistry, Multidisciplinary
Saida Majdoub, Zoltan Garda, Alexandre C. Oliveira, Inga Relich, Agnes Pallier, Sara Lacerda, Christelle Hureau, Carlos F. G. C. Geraldes, Jean-Francois Morfin, Eva Toth
Summary: Metal chelates targeted to amyloid peptides show promising nanomolar affinities for both A beta(1-40) and amylin when separated with a hydrophobic linker. The binding affinity of GdL complexes to A beta(1-40) or amylin varies with concentration and micellar aggregation state, affecting peptide aggregation kinetics. Ex vivo biodistribution experiments using In-111 labeled analogues in healthy mice suggest potential for amylin imaging in diabetic animals.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Clinical Neurology
Johanna Rotta, Valentina Perosa, Renat Yakupov, Hugo J. Kuijf, Frank Schreiber, Laura Dobisch, Jan Oltmer, Anne Assmann, Oliver Speck, Hans-Jochen Heinze, Julio Acosta-Cabronero, Emrah Duzel, Stefanie Schreiber
Summary: Cerebral microbleeds (MBs) are commonly found in patients with cerebral small vessel disease (CSVD), and a study found a link between MBs and the venous vasculature, potentially contributing to the development of CSVD and cerebral amyloid angiopathy (CAA). Further pathological studies are needed to confirm these findings.
Article
Clinical Neurology
Bernadette Wigand, Ina Schlichte, Stefanie Schreiber, Johanna Heitmann, Thomas Meyer, Reinhard Dengler, Susanne Petri, Aiden Haghikia, Stefan Vielhaber, Susanne Vogt
Summary: Pain is prevalent in ALS patients and moderately impairs daily living functions, with pain intensity, quality, and pain-related impairment not significantly changing over time. Additionally, one third of the patients suffer from clinically relevant depressive symptoms, but there is no conclusive evidence of a link between pain intensity and depressive symptoms.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Article
Surgery
Stephan Hause, Robert Schoenefuss, Anne Assmann, Jens Neumann, Frank Meyer, Joerg Tautenhahn, Stefanie Schreiber, Hans-Jochen Heinze, Zuhir Halloul, Michael Goertler
Summary: This study aimed to assess the incidence of post-operative non-ischaemic cerebral complications and examine their relationship with the size of cerebral infarction, timing of surgery, and peri-operative management. The results showed that large infarcts and high intra-operative blood pressure may increase the risk of non-ischaemic complications.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Clinical Neurology
V. Perosa, T. Arts, A. Assmann, H. Mattern, O. Speck, J. Oltmer, H. -J. Heinze, E. Duezel, S. Schreiber, J. J. M. Zwanenburg
Summary: Age may be the driving factor for altered cerebral small vessel hemodynamics. This study also associates cerebral small vessel disease with blood flow characteristics in the basal ganglia region.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Christopher Nelke, Christina B. Schroeter, Frauke Stascheit, Marc Pawlitzki, Liesa Regner-Nelke, Niklas Huntemann, Ercan Arat, Menekse Oeztuerk, Nico Melzer, Philipp Mergenthaler, Asmae Gassa, Henning Stetefeld, Michael Schroeter, Benjamin Berger, Andreas Totzeck, Tim Hagenacker, Stefanie Schreiber, Stefan Vielhaber, Hans-Peter Hartung, Andreas Meisel, Heinz Wiendl, Sven G. Meuth, Tobias Ruck
Summary: This retrospective, observational study provides the first real-world evidence supporting the use of eculizumab for the treatment of refractory, anti-AChR-ab positive MG. However, despite better efficacy, the risk of MC remains high.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Anna Lena Fisse, Kalliopi Pitarokoili, Stefanie Schreiber
Summary: Neuromuscular ultrasound has become an essential part of diagnosing and distinguishing neuromuscular disorders in clinical practice. It is an easily applicable method that can reveal changes in various diseases and play a role in guiding treatment decisions.
KLINISCHE NEUROPHYSIOLOGIE
(2022)
Article
Clinical Neurology
Alicia Northall, Budhaditya Mukhopadhyay, Miriam Weber, Susanne Petri, Johannes Prudlo, Stefan Vielhaber, Stefanie Schreiber, Esther Kuehn
Summary: This study developed an open-source tool called Tongue Tracker (TT) to quantify bulbar function in patients with ALS and stroke by training a neural network to track tongue movements. The results showed that early-stage bulbar-onset ALS patients had slower and fewer tongue sweeps compared to healthy controls and limb-onset patients, and limb-onset patients with bulbar impairment had different tongue kinematic profiles compared to healthy controls. TT may be useful in detecting quantitative markers of bulbar dysfunction.
FRONTIERS IN NEUROLOGY
(2022)
Article
Law
Alexandra C. W. Reitz, Shila Rene Hawk, Henry D. Schwimmer, Tarek Hanna, Diane E. S. Payne
Summary: This study found that 30% of intentional firearm injury survivors experienced a repeat-firearm injury or violent-crime arrest. Risk factors for repeat violence included history of abuse, mental health diagnoses, illegal substance use, prior felony arrest, incarceration, firearm charge, and suspected gang membership.
MEDICINE SCIENCE AND THE LAW
(2023)
Article
Chemistry, Analytical
Christoph Reichert, Lisa Klemm, Raghava Vinaykanth Mushunuri, Avinash Kalyani, Stefanie Schreiber, Esther Kuehn, Elena Azanon
Summary: This study introduces two algorithms, one based on SVM classification combined with dynamic time warping and the other based on LSTM neural network, for decoding hand movement data. The results show that SVM and LSTM have similar accuracy rates in decoding different movement types in across-subject classification, but SVM outperforms LSTM in within-subject classification. Therefore, the SVM-based approach holds promise in developing movement decoding tools, particularly for generalizing across age groups.
Letter
Clinical Neurology
Stefanie Schreiber, Anna-Charlotte John, Cornelius J. Werner, Stefan Vielhaber, Hans-Jochen Heinze, Oliver Speck, Jens Wuerfel, Daniel Behme, Hendrik Mattern
JOURNAL OF NEUROLOGY
(2023)
Article
Criminology & Penology
Marc Doerner, Steffen Lau, Stefanie Schreiber, Madeleine Kassar, Lena Machetanz, Johannes Kirchebner
Summary: The study highlights the importance of social support from family members for patients with SSD during the pandemic, as well as the increased emotional vulnerability of individuals with SSD during this time. It also suggests that more severe symptoms in patients with SSD may impede their ability to receive COVID-19 vaccinations.
JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukas Hoehn, Wilhelm Hussler, Anni Richter, Karl-Heinz Smalla, Anna-Maria Birkl-Toeglhofer, Christoph Birkl, Stefan Vielhaber, Stefan L. Leber, Eckart D. Gundelfinger, Johannes Haybaeck, Stefanie Schreiber, Constanze I. Seidenbecher
Summary: The study investigates changes in the brain's extracellular matrix (ECM) in Alzheimer's disease (AD) and finds spatially segregated molecular rearrangements of the ECM at RNA or protein levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Stefanie Schreiber, Jose Bernal, Philipp Arndt, Frank Schreiber, Patrick Mueller, Lorena Morton, Ruediger Christian Braun-Dullaeus, Maria Del Carmen Valdes-Hernandez, Roberto Duarte, Joanna Marguerite Wardlaw, Sven Guenther Meuth, Grazia Mietzner, Stefan Vielhaber, Ildiko Rita Dunay, Alexander Dityatev, Solveig Jandke, Hendrik Mattern
Summary: Brain vascular health is crucial in preventing and slowing down the progression of amyotrophic lateral sclerosis (ALS). Impaired brain vascular health in ALS leads to decreased levels of vascular endothelial growth factor, compromised endothelial cell formation, and blood-brain barrier integrity. This review discusses the pathogenesis of impaired brain vascular health in ALS and the potential of novel magnetic resonance imaging techniques in its detection. It also highlights the importance of blood supply patterns to the motor cortex as a marker of resistance and resilience against vascular risk and events in ALS, providing insights for ALS management and understanding of the disease.
Article
Medicine, General & Internal
Annkatrin Hildebrand, Frank Schreiber, Luisa Weber, Philipp Arndt, Cornelia Garz, Susanne Petri, Johannes Prudlo, Sven G. G. Meuth, Yannic Waerzeggers, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber
Summary: In this study, nerve ultrasound was used to discriminate between amyotrophic lateral sclerosis (ALS), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and Charcot-Marie-Tooth disease (CMT). The results showed that the nerve cross-sectional area (CSA) was larger in CIDP and CMT, while the blood flow was highest in CIDP. In ALS, larger CSA could indicate an inflammatory disease subtype. Overall, nerve ultrasound can be used to differentiate these three diseases.
MEDICINA-LITHUANIA
(2023)
Article
Clinical Neurology
Benita Klaus, Patrick Mueller, Nora van Wickeren, Milos Dordevic, Marlen Schmicker, Yael Zdunczyk, Tanja Brigadski, Volkmar Lessmann, Stefan Vielhaber, Stefanie Schreiber, Notger G. Mueller
Summary: Myasthenia gravis is an autoimmune disease that causes skeletal muscle weakness and can also lead to systemic inflammation, cognitive deficits, and autonomic dysfunction. This study found structural and functional brain changes in patients with myasthenia gravis, which were associated with cognitive deficits in memory and executive functions.
BRAIN COMMUNICATIONS
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
