Article
Biochemistry & Molecular Biology
Yonghae Son, In-Jun Yeo, Jin-Tae Hong, Seong-Kug Eo, Dongjun Lee, Koanhoi Kim
Summary: The study reveals that elevated levels of IL-1 beta and oxysterols are found in individuals with Alzheimer's disease. Experiments conducted on microglial cells and mice show that side-chain oxysterols can increase the expression of IL-1 beta and activate microglia. These findings suggest that pharmacologic intervention targeting oxysterols could potentially treat neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Tamas Kiss, Yaqub Mir, Gergely Stefancsik, Gantulga Ganbat, Aruzhan Askarova, Eva Monostori, Karolina Dulka, Gabor J. Szebeni, Adam Nyul-Toth, Anna Csiszar, Adam Legradi
Summary: This study found that microglia cells residing in the brain play a crucial role in the manifestation of age-related brain characteristics. Galectin-1, an anti-inflammatory protein, was identified as a regulator of microglia and neuroinflammation in the aging brain. The expression of galectin-1 protein was found to decrease over time in primary cortical cultures, while the presence of an immune activator increased its expression in microglial cells. Analysis of transcriptome and in vitro experiments further supported the association between galectin-1 expression and the activation state of microglial cells during aging.
Review
Biochemistry & Molecular Biology
Ignazio Antignano, Yingxiao Liu, Nina Offermann, Melania Capasso
Summary: This review discusses the latest research on aging microglia, comparing findings in rodent models and human subjects. Understanding the phenotype of aging microglia is crucial for designing better preventive and therapeutic strategies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cristina Fernandez-Mendivil, Enrique Luengo, Paula Trigo-Alonso, Nuria Garcia-Magro, Pilar Negredo, Manuela G. Lopez
Summary: The study revealed that overexpression of HO-1 in microglial cells in aged mice leads to neurotoxic iron accumulation, oxidative stress, and cognitive decline. Inhibiting HO-1 or using an iron chelator can prevent these issues, providing new insights for treating age-related neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Palsamy Periyasamy, Annadurai Thangaraj, Muthukumar Kannan, Abiola Oladapo, Shilpa Buch
Summary: The study reveals that exposure of mouse primary microglial cells to both HIV-1 Tat and cocaine leads to a significant increase in promoter DNA methylation of miR-124, intensifying microglial activation and ultimately culminating in neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Yawen Zhang, Rui Ma, Wencheng Wang, Qian Deng, Chi Cao, Chunyang Yu, Shulin Li, Lei Shi, Jianying Tian
Summary: This study investigated the anti-aging effect of alpha 7nAChR activation on aging rats and BV2 cells induced by D-galactose, as well as its potential mechanism. The results showed that the selective agonist PNU282987 of alpha 7nAChR improved cognitive impairment in aging rats by inhibiting oxidative stress and neuroinflammation. Therefore, targeting alpha 7nAChR may be a viable therapeutic approach for anti-inflammaging and neurodegenerative diseases.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xia Zhao, Jinfeng Sun, Li Xiong, Lingyu She, Liwei Li, Hao Tang, Yuqing Zeng, Fan Chen, Xue Han, Shiju Ye, Wei Wang, Xu Wang, Guang Liang
Summary: Dectin-1, a pattern recognition receptor, is involved in microglia-mediated neuroinflammation and the development of Alzheimer's disease (AD). It directly binds to beta-amyloid (Aβ), activating downstream signaling pathways and inducing the expression of inflammatory factors and AD pathology.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Louise M. Ince, Jeffrey S. Darling, Kevin Sanchez, Kiersten S. Bell, Jennifer K. Melbourne, Lourdes K. Davis, Kimberly Nixon, Andrew D. Gaudet, Laura. K. Fonken
Summary: Aging is associated with changes in immune system reactivity. Male rats show cognitive decline and increased neuroinflammatory responses, while females do not. Sex differences play a crucial role in the mechanism of aging.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Cell Biology
Rui Zhou, Shufang Qian, William C. S. Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W. C. Chan, Hong Zhang
Summary: Aging affects gut microbiota compositions, microglia, and cognition abilities, and is recognized as a risk factor for neurodegenerative diseases. The communication between gut microbiota and microglia plays a crucial role in age-related cognitive declines. This review discusses the changes in gut microbiota compositions, brain changes, especially morphology and functions of microglia, and highlights the role of microbiota-microglia connections in neurodegenerative diseases.
Article
Neurosciences
Houmin Lin, Steven Grant Dixon, Wei Hu, Eric D. Hamlett, Junfei Jin, Adviye Ergul, Gavin Y. Wang
Summary: Research suggests that the accumulation of amyloid beta (Aβ) plaques in the brain is a key factor in the development of Alzheimer's disease (AD). This study found that Aβ(1-40) oligomers stimulate the expression of IL-6 in human microglial cells. The activation of p38 MAPK is associated with this increase in IL-6. Inhibition of p38 MAPK can prevent Aβ-induced IL-6 production. These findings indicate that targeting p38 MAPK could be a potential approach to reduce neuroinflammation caused by Aβ accumulation in AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Daniel P. Nemeth, Xiaoyu Liu, Daniel McKim, Damon DiSabato, Braedan Oliver, Anu Herd, Asish Katta, Christina E. Negray, James Floyd, Samantha McGovern, Paige Pruden, Feiyang Zhutang, Maria Smirnova, Jonathan P. Godbout, John F. Sheridan, Ning Quan
Summary: This study identified cell type-specific IL-1R1 mediated mechanisms involved in the neuroprotection observed in LPS preconditioning. The findings revealed key cellular and molecular contributors to neuroprotection induced by LPS.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Lea L. Weston, Shanya Jiang, Devon Chisholm, Lauren L. Jantzie, Kiran Bhaskar
Summary: The study revealed that genetic deletion of IL-10 exacerbates neuroinflammation and tau phosphorylation, leading to neurodegeneration. Loss of IL-10 activates microglia, enhances IL-6 expression, and results in increased phosphorylation of tau protein under acute systemic inflammation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Shane M. O'Neil, Emma E. Hans, Starr Jiang, Lynde M. Wangler, Jonathan P. Godbout
Summary: The study found that aged mice's hippocampal microglia had an amplified and prolonged neuroinflammatory response to peripheral LPS challenge. Furthermore, astrocytes in the aged hippocampus showed immunosenescence, with deficits in IL-10R signaling and cholesterol biosynthesis.
Review
Cell Biology
Sneha Kumari, Rishika Dhapola, Prajjwal Sharma, Sunil K. Singh, Dibbanti HariKrishna Reddy
Summary: Alzheimer's Disease is an age-related disorder that causes significant social and economic burden. It is characterized by the accumulation of certain proteins and the formation of inflammatory cytokines, leading to cognitive and social behavior impairment. This review explores the various pathways and mechanisms involved in the development of neuroinflammation in Alzheimer's Disease, and highlights the potential of targeting cytokines as a therapeutic approach.
AGEING RESEARCH REVIEWS
(2023)
Article
Immunology
L. van Olst, A. Kamermans, S. M. A. van der Pol, E. Rodriguez, L. A. Hulshof, R. E. van Dijk, D. N. Vonk, M. Schouten, M. E. Witte, H. E. de Vries, J. Middeldorp
Summary: Aging leads to changes in brain immunity, resulting in a decline in neuronal function. This study shows that age-related systemic factors contribute to immunological changes in the brain and circulation. It has been observed that CD8+ T cells accumulate in the aged brain and injections of plasma from aged mice induce the expansion of these cells. These findings provide insights into the mechanisms underlying age-related changes in brain immunity.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Pharmacology & Pharmacy
Stephanie M. Matt, Rodney W. Johnson
CURRENT OPINION IN PHARMACOLOGY
(2016)
Article
Developmental Biology
Tania L. Roth, Stephanie Matt, Kenneth Chen, Jennifer Blaze
DEVELOPMENTAL PSYCHOBIOLOGY
(2014)
Article
Neurosciences
Stephanie M. Matt, Jalisa D. Zimmerman, Marcus A. Lawson, Angela C. Bustamante, Monica Uddin, Rodney W. Johnson
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Immunology
Stephanie M. Matt, Jacob M. Allen, Marcus A. Lawson, Lucy J. Mailing, Jeffrey A. Woods, Rodney W. Johnson
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Neurosciences
S. M. Matt, P. J. Gaskill
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2020)
Article
Immunology
Megan P. Caputo, Emily C. Radlowski, Marcus A. Lawson, Adrienne M. Antonson, Josephine E. Watson, Stephanie M. Matt, Brian J. Leyshon, Aditi Das, Rodney W. Johnson
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Immunology
E. A. Nickoloff-Bybel, P. Mackie, K. Runner, S. M. Matt, H. Khoshbouei, P. J. Gaskill
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Multidisciplinary Sciences
Adrienne M. Antonson, Marcus A. Lawson, Megan P. Caputo, Stephanie M. Matt, Brian J. Leyshon, Rodney W. Johnson
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Review
Neurosciences
Stephanie M. Matt, Peter J. Gaskill
Article
Medicine, Research & Experimental
Phillip M. Mackie, Adithya Gopinath, Dominic M. Montas, Alyssa Nielsen, Aidan Smith, Rachel A. Nolan, Kaitlyn Runner, Stephanie M. Matt, John McNamee, Joshua E. Riklan, Kengo Adachi, Andria Doty, Adolfo Ramirez-Zamora, Long Yan, Peter J. Gaskill, Wolfgang J. Streit, Michael S. Okun, Habibeh Khoshbouei
Summary: Monocyte-derived macrophages play crucial roles in tissue homeostasis and diseases, regulated by various signaling molecules. Recent studies have shown the ability of biogenic amines to control macrophage functions, with a focus on the mechanisms surrounding immune cells remaining unclear. Investigating the functions of norepinephrine transporter (NET) and dopamine transporter (DAT) on human MDMs, researchers found that DAT may play a potential role in regulating innate immunity through an immunomodulatory mechanism mediated by LPS-induced dopamine reverse transport.
Article
Immunology
Stephanie M. Matt
Summary: The increased incidence of multimorbidities and polypharmacy, particularly in the aging population, is a major concern. Further investigation into neuro-immune mechanisms and drug-drug interactions is crucial to better understanding and managing these comorbidities. Expanding research in relevant human in vitro models and preclinical models can help define the mechanisms by which psychiatric drugs alter immune function, leading to more efficacious interventions.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2021)
Article
Immunology
Brian J. Leyshon, Peng Ji, Megan P. Caputo, Stephanie M. Matt, Rodney W. Johnson
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
