Article
Oncology
Chan-Wei Liu, Huai-Che Yang, Chi-Lu Chiang, Chia-I. Shen, Hsiu-Mei Wu, Yung-Hung Luo, Yong-Sin Hu, Chung-Jung Lin, Wen-Yuh Chung, Cheng-Ying Shiau, Wan-Yuo Guo, David Hung-Chi Pan, Cheng-Chia Lee
Summary: This study compared the incidence of leukoencephalopathy in patients with brain metastases who received WBRT plus SRS versus those who received SRS only, and found that SRS is safe for reducing the development of leukoencephalopathy. Patient age and total tumor volume were identified as important factors in assessing the development of leukoencephalopathy. Even at a higher integral dose (> 2 J), the addition of SRS did not increase the incidence of leukoencephalopathy.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Sahel Shafiee Dolat Abadi, Nasim Zamani, Sahar Abbasi, Maziar Shojaei, Hossein Hassanian-Moghaddam
Summary: This is the first documented case of neurological sequelae following phosphide poisoning that emphasizes the importance of brain imaging studies for patients with loss of consciousness.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Marcelo Matiello, Ashby C. Turner, Juan Estrada, Cynthia M. Whitney, Barrett T. Kitch, Patrick T. Lee, Uma Girkar, Rafael Palacios, Pooja Singla, Lee Schwamm
Summary: The study showed that conducting TN consultations for patients with severe neurologic damage and allowing expert supervision for DNC examination is feasible. Having a teleneurologist as part of the ICU assessment team helped differentiate severe neurologic deficits from DNC and was associated with an increase in organ donation.
Article
Mathematical & Computational Biology
Daniel Nevo, Malka Gorfine
Summary: This article investigates the causal effects of the Apolipoprotein E epsilon 4 allele (APOE) on late-onset Alzheimer's disease (AD) and death. A new estimation method is proposed for the scenario in which both AD and death are considered as outcomes, based on a stratification of the population and a novel assumption utilizing the time-to-event nature of the data. Nonparametric and semiparametric estimation methods are implemented to study the complex effect of APOE on AD and death.
Review
Clinical Neurology
Mandara M. Harikar, Tejas Venkataram, Paolo Palmisciano, Gianluca Scalia, Matias Baldoncini, Salvatore Massimiliano Cardali, Giuseppe E. Umana, Gianluca Ferini
Summary: This study compared the efficacy of fractionated stereotactic radiotherapy (FSRT) with staged stereotactic radiosurgery (SSRS) in patients with brain metastases larger than 2 cm. The results showed that both treatment modalities were comparable, but FSRT was associated with lower 12-month overall survival and higher rate of salvage radiotherapy. Further research is needed to support these findings.
WORLD NEUROSURGERY
(2023)
Article
Mathematics
Xifen Huang, Jinfeng Xu
Summary: In this study, we propose a method for estimating the transition functions in a semi-competing risks model under the illness-death model framework. The method does not rely on parametric assumptions and provides smooth estimates that are easy to compute and interpret. Compared to existing approaches, our method does not require the subjective specification of the frailty distribution or the Markov or semi-Markov assumption, making it more applicable in real-world settings.
Article
Oncology
Naoyuki Kanayama, Toshiki Ikawa, Shingo Ohira, Takero Hirata, Masahiro Morimoto, Kazuhiko Ogawa, Teruki Teshima, Koji Konishi
Summary: This study demonstrates that a significant reduction in brain metastases volume at 6 months post-SRT can predict local control. The dose of 80% of the gross tumor volume (GTV) D80 in the LQ model: alpha/beta = 20 may be a predictive factor for volume reduction.
Article
Oncology
Johannes Kraft, Janita E. van Timmeren, Simon Frei, Michael Mayinger, Kim Borsky, Corinna Kirchner, Luisa Sabrina Stark, Stephanie Tanadini-Lang, Fabian Wolpert, Michael Weller, Henry C. Woodruff, Matthias Guckenberger, Nicolaus Andratschke
Summary: This study compared different prognostic scores for patients with brain metastases and found that scores based on both clinical and laboratory parameters performed well in predicting survival. Performance status, systemic disease status, and laboratory parameters were significantly associated with overall survival.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Oncology
Chiara Reverberi, Stefania Volpe, Damiano Balestrini, Michela Buglione, Piera Navarria, Silvia Scoccianti, Pierpaolo Panciani, Marco Krengli, Luigi Pirtoli, Lorenzo Bordi, Giovanni L. Pappagallo, Rolando M. D. Angelillo, Stefano M. Magrini, Stefano Arcangeli
Summary: The systematic review examined the evidence on post-operative management following brain metastasectomy, specifically regarding adjuvant stereotactic radiosurgery. The panel concluded that adjuvant SRS may have a more favorable risk/benefit ratio compared to observation and whole brain radiotherapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Review
Critical Care Medicine
Ariane Lewis, Matthew P. Kirschen, Rafael Badenes
Summary: This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2023. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2023. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from https://link.springer.com/bookseries/8901.
Review
Anesthesiology
Sam D. Shemie, Joel Neves Briard, J. Gordon Boyd, Tenielle Gofton, Andreas Kramer, Michael Chasse, Shaurya Taran, Priti Gros, Jeffrey M. Singh
Summary: There are two globally accepted anatomic definitions of death by neurologic criteria: whole-brain death and brainstem death. A narrative review of the literature was conducted by a Canadian expert working group as part of the Canadian Death Definition and Determination Project. The review concluded that infratentorial brain injury (IBI) consistent with death by neurologic criteria is an irrecoverable injury. However, clinical determination of death cannot differentiate between IBI and whole-brain cessation of function.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Review
Oncology
Varun Yarabarla, Amrutha Mylarapu, Tatiana J. Han, Susan L. Mcgovern, Shaan M. Raza, Thomas H. Beckham
Summary: Meningiomas, which arise from arachnoid cells in the brain, account for approximately one third of all primary intracranial tumors. The management of meningiomas depends on factors such as tumor location, grade, and symptoms, with options including surgery and radiation therapy. Optimal management is crucial due to the generally good prognosis of patients with meningioma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Shinn-Yn Lin, Din-Li Tsan, Chi-Cheng Chuang, Chi-Cheng Yang, Ping-Ching Pai, Chih-Liang Wang, Yi-Ming Wu, Cheng-Chi Lee, Chia-Hsin Lin, Kuo-Chen Wei, Wen-Chi Chou
Summary: In this study, we examined the oncological outcomes of cancer patients undergoing HS-WBRT, and found distinct patterns of neurologic/non-neurologic death and LMD recurrence between patients with intact brain metastases and those with resection cavities.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Laure Kuntz, Clara Le Fevre, Delphine Jarnet, Audrey Keller, Philippe Meyer, Christophe Mazzara, Helene Cebula, Georges Noel, Delphine Antoni
Summary: This retrospective study analyzed the data of patients who received at least two courses of SRT between 2010 and 2020. The results showed that NDFS and OS after SRT were influenced by various factors, including the number of treatments, patient condition, salvage WBRT, and metastasis velocity.
Article
Clinical Neurology
Diana A. Roth O'Brien, Sydney M. Kaye, Phillip J. Poppas, Sean S. Mahase, Anjile An, Paul J. Christos, Benjamin Liechty, David Pisapia, Rohan Ramakrishna, A. G. Wernicke, Jonathan P. S. Knisely, Susan C. Pannullo, Theodore H. Schwartz
Summary: This study evaluated the real-world local recurrence of all brain metastasis patients referred for adjuvant stereotactic radiosurgery (SRS) and identified predictors of SRS timing. The timing of SRS was found to be associated with local recurrence rate and LRFS, with receiving SRS within 4 weeks postoperatively potentially reducing the recurrence rate.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Sara A. Mansfield, M. Beth McCarville, John T. Lucas, Matthew J. Krasin, Sara M. Federico, Victor M. Santana, Wayne L. Furman, Andrew M. Davidoff
Summary: The study showed that neoadjuvant chemotherapy can reduce the number of IDRFs in patients with high-risk neuroblastoma, and the number of IDRFs present after chemotherapy is positively correlated with the extent of tumor resection.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Matthew D. Hall, Stephanie A. Terezakis, John T. Lucas, Eve Gallop-Evans, Karin Dieckmann, Louis S. Constine, David Hodgson, Jamie E. Flerlage, Monika L. Metzger, Bradford S. Hoppe
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Asim K. Bag, Melissa N. Wing, Noah D. Sabin, Scott N. Hwang, Gregory T. Armstrong, Yuanyuan Han, Yimei Li, Scott E. Snyder, Giles W. Robinson, Ibrahim Qaddoumi, Alberto Broniscer, John T. Lucas, Barry L. Shulkin
Summary: This study evaluated the role of C-11-methionine PET in assessing MRI changes in PHGGs patients, to differentiate tumor recurrence from pseudoprogression. The results showed that C-11-methionine PET had slightly higher sensitivity and accuracy in correctly predicting tumor existence, with good interobserver agreement. The study also found that quantitative C-11-methionine PET can predict overall survival.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
John T. Lucas, Austin M. Faught, Chih Yang Hsu, Lydia J. Wilson, Yian Guo, Yimei Li, Raja Khan, Jared B. Becksfort, David A. LeVine, Yousef Ismael, Kaleb Darrow, Vadim P. Moskvin, Fakhriddin Pirlepesov, Paul Klimo, Lucas Elijovich, Daniel J. Indelicato, Fredrick A. Boop, Thomas E. Merchant
Summary: This study investigated vasculopathy in children with craniopharyngioma treated with proton radiation therapy. The type, location, severity, and resolution of vasculopathy were evaluated, and predictors of stenosis were studied. The results showed that vasculopathy often occurred before radiation therapy and was the strongest predictor of stenosis after treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
John T. Lucas, Christopher L. Tinkle, Jie Huang, Arzu Onar-Thomas, Sudharsan Srinivasan, Parker Tumlin, Jared B. Becksfort, Paul Klimo, Frederick A. Boop, Giles W. Robinson, Brent A. Orr, Julie H. Harreld, Matthew J. Krasin, Paul A. Northcott, David W. Ellison, Amar Gajjar, Thomas E. Merchant
Summary: This study characterizes the patterns of progression in medulloblastoma and reveals distinct anatomical failure patterns across molecular subgroups. This suggests that subgroup-specific treatment strategies should be considered.
Article
Oncology
Kris Ann Schultz, Anne K. Harris, Alexander T. Nelson, Dave Watson, John T. Lucas, Doug Miniati, Douglas R. Stewart, Kelly N. Hagedorn, William Mize, Junne Kamihara, Sarah G. Mitchell, David B. Wilson, Katie Gettinger, Arun A. Rangaswami, Laura A. Harney, Carlos Rodriguez Galindo, Gianni Bisogno, Louis P. Dehner, D. Ashley Hill, Yoav H. Messinger
Summary: This study aimed to evaluate the efficacy of the IVADo regimen in the treatment of pleuropulmonary blastoma (PPB) in infants and young children. The results showed that compared to conventional treatment, the IVADo regimen can improve the survival rate of children and serve as a reference for future treatment studies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
V. Rameh, S. Vajapeyam, A. Ziaei, P. Kao, W. B. London, S. J. Baker, J. Chiang, J. Lucas, C. L. Tinkle, K. D. Wright, T. Y. Poussaint
Summary: This study aimed to determine whether radiomics could differentiate molecular types of pontine pediatric high-grade gliomas that have similar/overlapping phenotypes. The results showed that ADC histogram parameters are correlated with the histone H3 mutation status in pontine pediatric high-grade glioma.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Oncology
Kelly N. Hagedorn, Alexander T. Nelson, Alexander J. Towbin, Nicole Frederickson, Paige Mallinger, John T. T. Lucas Jr, Louis P. Dehner, Yoav H. Messinger, Barry L. Shulkin, William A. Mize, Kris Ann P. Schultz
Summary: This study retrospectively analyzed the PET and bone scan data of patients with PPB and found that advanced PPB presents with an FDG-avid lesion on PET imaging and bone metastases can also be detected on PET scans.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Ozgur Ates, Jinsoo Uh, Fakhriddin Pirlepesov, Chia-Ho Hua, Brandon Triplett, Amr Qudeimat, Akshay Sharma, Thomas E. Merchant, John T. Lucas Jr
Summary: This study addresses the challenge of respiratory motion in pediatric patients undergoing proton therapy for total lymphoid irradiation (TLI). The research concludes that 4D plan evaluation and robust optimization techniques can help address respiratory motion challenges in proton TLI treatments. Patient-specific respiratory motion evaluations are crucial to ensure adequate dosimetric coverage in proton therapy for pediatric patients.
Article
Oncology
Soleil Hernandez, Hester Burger, Callistus Nguyen, Arnold C. Paulino, John T. Lucas, Austin M. Faught, Jack Duryea, Tucker Netherton, Dong Joo Rhee, Carlos Cardenas, Rebecca Howell, David Fuentes, Julianne Pollard-Larkin, Laurence Court, Jeannette Parkes
Summary: In this study, we validated an automated planning pipeline for pediatric craniospinal irradiation (CSI), demonstrating its robustness in adjusting to different patient populations. The algorithm automatically generated 15 contours and a comprehensive treatment plan for each patient without the need for physician intervention, indicating the potential for increased planning efficiency and global access to high-quality radiation therapy.
FRONTIERS IN ONCOLOGY
(2023)
Meeting Abstract
Oncology
J. Becksfort, J. T. Lucas, C. Y. Hsu, S. Vajapeyam, C. Wang, E. Simpson, J. C. Chiang, J. Armstrong, M. Soike, M. Young, B. H. Kann, Y. Li, C. Li, Z. Lu, C. Kline, S. Meuller, A. Gajjar, T. E. Merchant, S. Baker, Z. Patay, K. Wright, T. Y. Poussaint, C. L. Tinkle
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
Matthias Karajannis, Arzu Onar Thomas, Patricia Baxter, Nina Butingan, Christine Fuller, Amar Gajjar, Sofia Haque, Nada Jabado, Tong Lin, John Lucas, Shannon MacDonald, Celeste Matsushima, Namrata Patel, Christopher Pierson, Linda Springer, Eileen Stark, Mark Souweidane, Michael Walsh, Wafik Zaky, Maryam Fouladi, Kenneth Cohen
Meeting Abstract
Oncology
Matthew J. Ehrhardt, Qi Liu, John L. Jefferies, Daniel A. Mulrooney, Yadav Sapkota, Jason Goldberg, Stephanie B. Dixon, John Thomas Lucas, Kirsten K. Ness, Deo Kumar Srivastava, Wojciech Mazur, Juan Carlos Plana Gomez, Leslie L. Robison, Yutaka Yasui, Melissa M. Hudson, Gregory T. Armstrong
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Michael W. Bishop, Yimei Li, Rachel Christine Brennan, Sara Michele Federico, Elizabeth Stewart, Mark Edward Hatley, Sara Helmig, John Thomas Lucas, Christopher L. Tinkle, Andrew M. Davidoff, Mary B. McCarville, Karen H. Albritton, Daniel J. Indelicato, Alberto S. Pappo, Matthew J. Krasin
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
John Thomas Lucas, Daniel Victor Wakefield, Michael Doubrovin, Yimei Li, Teresa Santiago, Sara Michele Federico, Thomas E. Merchant, Andrew M. Davidoff, Matthew J. Krasin, Barry L. Shulkin, Victor M. Santana, Wayne Lee Furman
Summary: This retrospective study aimed to identify predictors of metastatic site failure in high-risk neuroblastoma patients. The study found that improvements in systemic therapy influenced the patterns and type of metastatic site failure.
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2022)