Editorial Material
Respiratory System
Patrick Brian Murphy, Bernd Brueggenjuergen, Thomas Reinhold, Qing Gu, Laura Fusfeld, Gerard Criner, Thomas F. Goss, Nicholas Hart
Summary: Home non-invasive mechanical ventilation (HMV) with home oxygen therapy (HOT) can delay hospital readmission in patients with persistent hypercapnia following an acute exacerbation of chronic obstructive pulmonary disease. The cost-effectiveness of this treatment in the UK healthcare system was evaluated using data from a previous efficacy trial. Despite being slightly more expensive, HOT-HMV showed improved quality of life, resulting in a cost-effectiveness ratio of 10 pound 259 per QALY. It was determined to be cost-effective in this clinical population.
Article
Biochemistry & Molecular Biology
Chunman Germain Ho, Stephen Milne, Xuan Li, Chen Xi Yang, Fernando Sergio Leitao Filho, Chung Yan Cheung, Julia Shun Wei Yang, Ana I. Hernandez Cordero, Cheng Wei Tony Yang, Tawimas Shaipanich, Stephan F. van Eeden, Janice M. Leung, Stephen Lam, Don D. Sin
Summary: This study found an association between eosinophilia in bronchoalveolar lavage (BAL) fluid and acute exacerbations of chronic obstructive pulmonary disease (AECOPD), suggesting BAL may be a sensitive marker for eosinophilic inflammation in the distal lung.
Article
Pediatrics
Wen-Jue Soong, Pei-Chen Tsao, Chia-Feng Yang, Yu-Sheng Lee, Chien-Heng Lin, Chieh-Ho Chen
Summary: This study aimed to determine the efficacy of flexible endoscopy (FE) in assessing and changing the clinical management of infants with severe bronchopulmonary dysplasia (sBPD). The results showed that FE with non-invasive ventilation (FE-NIV) is a safe and valuable technique for direct and dynamic visual measurement of the aeroesophageal tract (AET) in sBPD infants, leading to changes in management.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Maximilian Wollsching-Strobel, Iris Anna Bauer, Johannes Julian Baur, Daniel Sebastian Majorski, Friederike Sophie Magnet, Jan Hendrik Storre, Wolfram Windisch, Sarah Bettina Schwarz
Summary: Non-invasive ventilation therapy does not decrease sleep quality in COPD patients and can even improve health-related quality of life, decrease daytime sleepiness and respiratory disturbance index (RDI), especially in patients with comorbid obstructive sleep apnea syndrome (OSAS).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Respiratory System
Judith Elshof, Judith M. Vonk, Anouschka van der Pouw, Cella van Dijk, Petra Vos, Huib A. M. Kerstjens, Peter J. Wijkstra, Marieke L. Duiverman
Summary: This study evaluated guideline adherence to non-invasive ventilation (NIV) initiation for acute exacerbations of chronic obstructive pulmonary disease (COPD) and its impact on mortality. The overall guideline adherence rate was 82%, and better survival was observed in patients who received NIV when indicated. Therefore, increasing awareness and reducing reluctance in utilizing NIV through healthcare professional training can further enhance NIV treatment in clinical practice and improve patient outcomes.
RESPIRATORY RESEARCH
(2023)
Article
Health Care Sciences & Services
Konstantinos Bartziokas, Evgenia Papathanasiou, Andriana I. I. Papaioannou, Ilias Papanikolaou, Emmanouil Antonakis, Ioanna Makou, Georgios Hillas, Theodoros Karampitsakos, Ourania Papaioannou, Katerina Dimakou, Vasiliki Apollonatou, Galateia Verykokou, Spyros Papiris, Petros Bakakos, Stelios Loukides, Konstantinos Kostikas
Summary: In recent years, blood eosinophils have been studied as a biomarker for eosinophilic airway inflammation and a prognostic indicator for COPD outcomes. This study found that low blood eosinophil levels upon admission for COPD exacerbation were associated with more severe disease and predicted the need for NIV. Further research is needed to confirm the use of blood eosinophil levels as a predictor of unfavorable outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mathew Cherian, Veronique Adam, Bryan Ross, Jean Bourbeau, Marta Kaminska
Summary: This study analyzed the survival of patients with chronic obstructive pulmonary disease (COPD) using chronic non-invasive ventilation (NIV) and found that obesity is associated with decreased mortality. Other factors such as gender, medication use, and home oxygen use were also related to mortality. Differences in mortality factors were observed between obese and non-obese patients.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Eleni Papakonstantinou, Maria-Elpida Christopoulou, Meropi Karakioulaki, Leticia Grize, Michael Tamm, Daiana Stolz
Summary: The study aimed to investigate the association between plasma levels of heparan sulphate (HS) and the aetiology of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The results showed that HS levels were higher in COPD patients compared to non-COPD controls, and significantly increased during AECOPD. The increase of HS levels was associated with the aetiology of exacerbations, especially in cases with bacterial and viral coinfections.
Article
Respiratory System
Jens Braeunlich, Kristin Turba, Hubert Wirtz
Summary: After an episode of hypercapnic AECOPD, some patients may remain hypercapnic while others may return to a physiologic gas status. Disease severity, level of hypercapnia at discharge, and arterial CO2 pressure are predictors for persistent hypercapnia.
Article
Respiratory System
Caroline Hedsund, Philip Morkeberg Nilsson, Nils Hoyer, Daniel Bech Rasmussen, Claire Praest Holm, Tine Peick Sonne, Jens-Ulrik Staehr Jensen, Jon Torgny Wilcke
Summary: This study compared COPD patients admitted with AHRF requiring NIV in 2012-2013 and 2017-2018, finding that patients in the 2017-2018 cohort with high IPAP regime had significantly lower in-hospital, 30-day, and 1-year mortality rates, supporting the current strategy of rapid increase and higher pressure.
BMJ OPEN RESPIRATORY RESEARCH
(2022)
Article
Medicine, General & Internal
Athiwat Tripipitsiriwat, Orawan Suppapueng, David M. P. van Meenen, Frederique Paulus, Markus W. Hollmann, Chaisith Sivakorn, Marcus J. Schultz, PRoVENT COVID Investigators
Summary: This study found that patients with chronic obstructive pulmonary disease (COPD) have a higher mortality rate in COVID-19 and higher 28-day mortality compared to non-COPD patients. The ventilation management and the use of prone positioning differed slightly between COPD and non-COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lara Pisani, Gabriele Corsi, Marco Carpano, Gilda Giancotti, Maria Laura Vega, Vito Catalanotti, Stefano Nava
Summary: Nighttime and non-working days often lead to a shortage of staff and resources. Previous studies have shown mixed results on the impact of weekend admissions on patient mortality. This study examined the timing of non-invasive ventilation initiation in COPD patients and found that starting treatment at nighttime did not increase the failure rate in a dedicated treatment center.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Munam Arshad, Khunsha Mehmood, Ismail Lazoglu
Summary: The SARS-CoV-2 pandemic has led to the development and implementation of emergency ventilators. This study examines a non-invasive ventilator that is easy to build and can be used beyond emergency situations. The results show the feasibility of using this device for non-invasive respiratory support, but further testing is needed to evaluate its safety and effectiveness in different clinical settings.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Felix C. F. Schmitt, Daniel Gruneberg, Niko R. E. Schneider, Jan-Ole Foegeling, Moritz Leucht, Felix Herth, Michael R. Preusch, Werner Schmidt, Christian Bopp, Thomas Bruckner, Markus A. Weigand, Stefan Hofer, Erik Popp
Summary: In this study, the use of prehospital non-invasive ventilation (phNIV) to treat patients with acute respiratory insufficiency caused by severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and acute cardiopulmonary oedema (ACPE) was tested. The results showed that phNIV significantly improved oxygenation and reduced the duration of mechanical ventilation and intensive care unit stay compared to endotracheal intubation. This suggests that prehospital implementation of NIV may provide benefits for in-hospital course in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Respiratory System
Neeraj M. Shah, Joerg Steier, Nicholas Hart, Georgios Kaltsakas
Summary: Chronic respiratory disease can worsen sleep quality, and non-invasive ventilation is a complex intervention used for improving sleep-disordered breathing and nocturnal hypoventilation. However, the impact on sleep quality depends on measurement tools and patient population.
Article
Clinical Neurology
Manjunath B. Govindagoudar, Lokesh Kumar Lalwani, Pawan Kumar Singh, Jyotsna Sen, Dhruva Chaudhry
Summary: This study evaluated the utility of ultrasonography as a screening tool for obstructive sleep apnea (OSA). The results showed that ultrasonography provides a near complete picture of the dynamic changes and collapsibility of the oropharynx, and has good diagnostic ability in predicting OSA.
JOURNAL OF SLEEP RESEARCH
(2023)
Letter
Medicine, General & Internal
Yogita Kumar, Pawan Kumar Singh, Dhruva Chaudhry, Amit Sharma, Pooja Yadav
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)