Article
Biochemistry & Molecular Biology
Daniel Antunes Moreno, Aline Paixao Becker, Cristovam Scapulatempo-Neto, Weder Menezes, Jamie Sheren, Aline M. Walter, Carlos Clara, Helio R. Machado, Ricardo S. Oliveira, Luciano Neder, Marileila Varella-Garcia, Rui Manuel Reis
Summary: This study investigated the frequency of NTRK2 alterations in Brazilian pilocytic astrocytomas. The results showed that NTRK2 alterations are rare genetic events in pilocytic astrocytomas, regardless of patients' clinicopathological and molecular features.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pathology
Mari Kirishima, Toshiaki Akahane, Nayuta Higa, Shinsuke Suzuki, Shinichi Ueno, Hajime Yonezawa, Hiroyuki Uchida, Ryosuke Hanaya, Koji Yoshimoto, Shohei Shimajiri, Ikumi Kitazono, Akihide Tanimoto
Summary: This study reported a case of IDH-mutant astrocytoma that recurred with aggressive behavior and increased malignancy, showing genomic evolution during tumor recurrence. The recurrent tumors carried NTRK fusion and CDKN2A/B homozygous deletion, which may promote high-grade transformation and indicate an unfavorable prognosis for IDH-mutant astrocytoma.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Chemistry, Multidisciplinary
Wei Wang, Xiao-kang Chen, Lu Zhou, Feng Wang, Yan-ji He, Bing-jun Lu, Ze-gang Hu, Zhu-xin Li, Xue-wei Xia, Wei Eric Wang, Chun-yu Zeng, Liang-peng Li
Summary: The study reveals that CCL2 promotes cardiac regeneration by activating the STAT3 signaling pathway and stimulating cardiomyocyte proliferation. This finding has significant implications for the treatment of myocardial infarction and associated heart failure.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biology
Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N. Rasband, Jiangong Ren, Congxin Dai, Rocio Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu
Summary: This study reveals the crucial role of Qki in controlling cholesterol biosynthesis in the central nervous system, which is essential for myelinogenesis. Depletion of Qki results in reduced cholesterol concentration in the brain, impairing proper myelin assembly.
Article
Health Care Sciences & Services
Ali Sepehrinezhad, Ali Shahbazi, Ali Bozorgmehr, Babak Kateb, Vicky Yamamoto, Sajad Sahab Negah
Summary: This study investigated the genetic networks between obsessive-compulsive disorder (OCD) and multiple sclerosis (MS) using bioinformatics approaches. The analysis revealed a significant overlap in the genetic components of MS and OCD, with the signal transducer and activator of transcription 3 (STAT3) and neurotrophic receptor tyrosine kinase 2 (NTRK2) genes having strong connections with shared genes between the two diseases. The findings suggest potential pharmacological interventions and biomarkers for MS with OCD comorbidity.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jae Ryoung Hwang, Young-Jae Cho, Ji-Yoon Ryu, Ju-Yeon Choi, Jung-Joo Choi, Jason K. Sa, Hyun-Soo Kim, Jeong-Won Lee
Summary: This study found that ulipristal acetate (UPA) has inhibitory effects on uterine sarcoma in in vitro and in vivo experiments. UPA showed significant anti-tumor effects in uterine sarcoma through the inhibition of the STAT3/CCL2 signaling pathway and could be a potential therapeutic agent for treating this disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Siobhan S. Pattwell, Sonali Arora, Nicholas Nuechterlein, Michael Zager, Keith R. Loeb, Patrick J. Cimino, Nikolas C. Holland, Noemi Reche-Ley, Hamid Bolouri, Damian A. Almiron Bonnin, Frank Szulzewsky, Vaishnavi V. Phadnis, Tatsuya Ozawa, Michael J. Wagner, Michael C. Haffner, Junyue Cao, Jay Shendure, Eric C. Holland
Summary: This article highlights the previously unidentified role of the neurotrophin receptor splice variant TrkB.T1 in neurodevelopment, embryogenesis, transformation, and oncogenesis. TrkB.T1 is an important isoform in these processes and is expressed in both embryonic and adult tumors. The study also reveals its interaction with developmental and oncogenic signaling pathways, suggesting its potential to reshape our understanding of developmental systems and oncology.
Article
Immunology
Jiangong Ren, Congxin Dai, Xin Zhou, Joseph A. Barnes, Xi Chen, Yunfei Wang, Liang Yuan, Takashi Shingu, Amy B. Heimberger, Yiwen Chen, Jian Hu
Summary: This study demonstrates that Qki is an essential regulator of microglial phagocytic activity under demyelinating conditions. Depletion of Qki impairs myelin debris clearance, leading to compromised axon integrity and remyelination.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Developmental Biology
Hsiu-Chi Lee, Shih-Chieh Lin, Meng-Hsing Wu, Shaw-Jenq Tsai
Summary: The study identified that NTRK2 is upregulated in endometriotic lesions and its expression is induced by hypoxia through hypoxia-inducible factor 1 alpha. Treatment with NTRK2 antagonist ANA-12 induced cell death in endometriotic stromal cells and caused regression of ectopic lesions in a mouse model. These findings suggest a potential therapeutic target for endometriosis.
Article
Biochemistry & Molecular Biology
Rocco Cappellesso, Lorenzo Nicole, Paolo Del Fiore, Luisa Barzon, Alessandro Sinigaglia, Silvia Riccetti, Renato Franco, Federica Zito Marino, Giada Munari, Carolina Zamuner, Francesco Cavallin, Marta Sbaraglia, Francesca Galuppini, Franco Bassetto, Mauro Alaibac, Vanna Chiarion-Sileni, Luisa Piccin, Clara Benna, Matteo Fassan, Simone Mocellin, Angelo Paolo Dei Tos
Summary: Merkel cell carcinoma is a rare and aggressive cutaneous malignant tumor with neuroendocrine differentiation. Research found no NTRK fusions in tumors involving neurotrophin receptor tyrosine kinase genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhicong Zhao, Ying Qing, Lei Dong, Li Han, Dong Wu, Yangchan Li, Wei Li, Jianhuang Xue, Keren Zhou, Miao Sun, Brandon Tan, Zhenhua Chen, Chao Shen, Lei Gao, Andrew Small, Kitty Wang, Keith Leung, Zheng Zhang, Xi Qin, Xiaolan Deng, Qiang Xia, Rui Su, Jianjun Chen
Summary: The mRNA internal m7G modification is recognized by Quaking proteins (QKIs), which regulate mRNA stability and translation, affecting cellular drug resistance.
Article
Biochemistry & Molecular Biology
Feng Liu, Xiaobin Liu, Yamin Zhou, Yankun Yu, Ke Wang, Zhengqun Zhou, Hao Gao, Kwok-Fai So, Noga Vardi, Ying Xu
Summary: The study found that treatment with ZD improved visual behavior, delayed photoreceptor degeneration in the rd10 mouse model of RP, and enhanced light responses in photoreceptors, bipolar cells, and retinal ganglion cells. ZD primarily mediated its anti-inflammatory function through the signal transducer and activator of transcription 3, chemokine (C-C motif) ligand 2, and MAPK pathways, making it a potential clinical candidate for RP treatment.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Chongsheng Xia, Yurui Sun, Yang Li, Junli Ma, Jing Shi
Summary: Acquisition of drug resistance is a major reason for treatment failure in cancer. Long non-coding RNA (CCAT1) plays an important role in oxaliplatin resistance in hepatocellular carcinoma. The study found that CCAT1 promotes HCC proliferation and resistance to oxaliplatin through the QKI-5/p38 MAPK signaling pathway. Targeting CCAT1 may be a promising strategy to reverse drug resistance in HCC treatment.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yanming Chen, Qing Zhu, Ye Wang, Xiaoxiao Dai, Ping Chen, Ailin Chen, Sujuan Zhou, Chungang Dai, Shengbin Zhao, Sheng Xiao, Qing Lan
Summary: We report a novel NTRK2 rearrangement and an unexpected IDH1 mutation in a patient with dysembryoplastic neuroepithelial tumor (DNT).
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhao Yan, Banjun Ruan, Shan Wang, Tianshu Du, Xiaolong Shao, Guo Chen, Li Wang, Dongsheng Zhai, Shu Zhu, Zifan Lu, Xiaorui Cao
Summary: This study investigates the role of QKI in bone formation and fat accumulation in mesenchymal stem cells (MSCs). The results show that QKI suppresses osteogenic differentiation of BMSCs by downregulating the expressions of Wnt5b, Fzd7, Dvl3, and β-catenin. Additionally, QKI deficient BMSCs transplantation may provide a new strategy for the treatment of orthopedic diseases such as osteoporosis.
ARCHIVES OF MEDICAL RESEARCH
(2023)